Natural killer cells: origin, phenotype, function by E. V. Tyshchuk, V. A. Mikhailova, S. A. Selkov, D. I. Sokolov

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Phenotypic and functional heterogeneity of bovine blood monocytes. by Jamal Hussen, Anna Düvel, Olivier Sandra, David Smith, Iain Martin Sheldon, Peter Zieger, Hans-Joachim Schuberth

“…Murine and human peripheral blood monocytes are heterogeneous in size, granularity, nuclear morphology, phenotype and function. Whether and how bovine blood monocytes follow this pattern was analyzed in this study. …”
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Functional and transcriptomic insights into plant response to arginine-functionalized nanohydroxyapatite treatment by Chinenye L. Izuegbunam, Beate Wone, Bernard W.M. Wone

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Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells by Gap Ryol Lee

“…This review summarizes recent results relating to Treg cells in the tumor microenvironment, with particular emphasis on their accumulation, phenotypic, and functional properties, and targeting to enhance the efficacy of anticancer treatment.…”
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GAMMA DELTA (γδ) T CELLS: ORIGIN, PHENOTYPE, FUNCTIONS by Dmitry Sokolov

“…Therefore, the purpose of this review was to systematize data on the biology of γδT cells, including their origin, phenotype, functions and methods of application in the clinic. …”
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Mapping of Functional Metabolic Phenotypes in Acute Myeloid Leukemia by Sissel Dyrstad, Kimberley Joanne Hatfield, Endre Stigen, Marte Karen Brattås, Karl Johan Tronstad, Håkon Reikvam

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Dynamics of neutrophil phenotype and function in sickle cell disease by Aafke E. Gaartman, Aafke E. Gaartman, Lydian A. de Ligt, Lydian A. de Ligt, Lydian A. de Ligt, Boukje M. Beuger, Anton T. J. Tool, Martijn Veldthuis, Taco W. Kuijpers, Taco W. Kuijpers, Rob van Zwieten, Bart J. Biemond, Robin van Bruggen, Erfan Nur, Erfan Nur

“…IntroductionWhile sickle cell disease (SCD) is primarily acknowledged as an erythrocyte disorder, emerging evidence suggests a role for altered neutrophil phenotype and function in SCD pathophysiology and disease severity. …”
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Macrophages in bacterial lung diseases: phenotype and functions (review) by E. G. Churina, A. V. Sitnikova, O. I. Urazova, S. P. Chumakova, M. V. Vins, A. E. Beresneva, V. V. Novitskii

“…The article summarizes information about the origin of macrophages, their phenotypic and functional heterogeneity. The mechanisms of impaired protective function of innate immunity are associated with the polarization of the program of maturation and activation of macrophages in the direction to tolerogenic or immunoregulatory cells with phenotype of M2. …”
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Genotypic, functional, and phenotypic characterization in CTNNB1 neurodevelopmental syndrome by Nina Žakelj, David Gosar, Špela Miroševič, Stephan J. Sanders, Alicia Ljungdahl, Sayeh Kohani, Shouhe Huang, Lok I Leong, Ying An, Miou-Jing Teo, Fiona Moultrie, Roman Jerala, Duško Lainšček, Vida Forstnerič, Petra Sušjan, Leszek Lisowski, Andrea Perez-Iturralde, Jasna Oražem Mrak, Ho Yin Edwin Chan, Damjan Osredkar

“…This study describes the genetic, functional, and phenotypic characteristics in individuals with CTNNB1 neurodevelopmental syndrome. …”
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Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro by Sara Rakočević, Vanja Mališ, Ljiljana Kozić, Anđela Dubovina, Marija Drakul, Dejan Bokonjić, Miodrag Čolić, Dušan Mihajlović

“…Here, we examined how different aspects of neutrophil functions are affected by dapsone. Peripheral blood neutrophils from healthy donors were stimulated with phorbol-12-myristate-13-acetate (PMA), N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), or calcium ionophore (CaI) or primed with cytokines prior to stimulation, in the presence of different concentrations of dapsone (from 10 to 50 µg/mL), followed by analyses of their survival, phenotype, and functional properties. …”
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Platelet phenotypes and practical aspects of platelet function testing in cardiology by Zh. D. Kobalava, A. S. Pisaryuk, A. A. Filkova, E. S. Tukhsanboev, A. A. Boldyreva, D. P. Lazutova, I. A. Meray, M. A. Panteleev

Subjects: “…platelet function testing…”
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PHENOTYPIC PROFILE AND FUNCTIONAL ACTIVITY OF MONOCYTES IN THE PATIENTS WITH ACUTE PANCREATITIS by A. A. Savchenko, A. G. Borisov, D. E. Zdzitovetskiy, I. V. Kudryavtsev, A. Yu. Medvedev, A. V. Moshev, I. I. Gvozdev

“…In the patients with acute pancreatitis, we have found certain changes in blood monocyte subpopulations and their functional activity. The changes in monocyte subpopulations in acute pancreatitis were characterized by increased numbers of inflammatory cell forms in blood (CD14lowCD16+), along with while near-normal contents of the cells with «classic» (CD14+CD16- ) and «non-classical» phenotype (CD14dimCD16+), having been within reference ranges. …”
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Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome by Emilie Montellier, Nathanaël Lemonnier, Judith Penkert, Claire Freycon, Sandrine Blanchet, Amina Amadou, Florent Chuffart, Nicholas W. Fischer, Maria-Isabel Achatz, Arnold J. Levine, Catherine Goudie, David Malkin, Gaëlle Bougeard, Christian P. Kratz, Pierre Hainaut

“…Class A carriers recapitulated all phenotypic traits of fully penetrant LFS, whereas class B carriers showed a slightly less penetrant form dominated by specific cancers, consistent with the notion that these classes identify variants with distinct functional properties. …”
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Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice by Jonathan E. Layne, Dustin M. Snapper, Dustin M. Snapper, Molly E. Czachor, Charles Lam, Jacob D. Matityahu, Dane R. G. Lind, Matthieu Huard, Johnny Huard, Kazuhito Morioka, Julian C. Motzkin, Julian C. Motzkin, Allan I. Basbaum, Jarret A. P. Weinrich, Jarret A. P. Weinrich, Chelsea S. Bahney, Chelsea S. Bahney

“…Although fracture stabilization is a well-established factor modulating bone repair, there remains a notable gap in sophisticated non-destructive technologies that can rapidly and objectively quantify functional recovery in preclinical settings. We introduce a novel behavioral phenotyping approach enabling rapid quantification of post-fracture weightbearing and kinematic metrics in freely behaving mice. …”
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Phenotypic, Functional, and Safety Control at Preimplantation Phase of MSC-Based Therapy by Wioletta Lech, Anna Figiel-Dabrowska, Anna Sarnowska, Katarzyna Drela, Patrycja Obtulowicz, Bartlomiej Henryk Noszczyk, Leonora Buzanska, Krystyna Domanska-Janik

“…Thus, in this paper we highlight the urgent necessity to develop the more sensitive and selective methods for prediction and control cells fate and functioning during the time of growth in vitro.…”
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Phenotypic and Functional Diversities of Myeloid-Derived Suppressor Cells in Autoimmune Diseases by Huijuan Ma, Chang-Qing Xia

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EFFECTS OF DEHYDROEPIANDROSTERONE SULFATE UPON PHENOTYPE AND IN VITRO FUNCTIONS OF DENDRITIC CELLS by N. V. Seledzova, N. A. Khonina, M. A. Tikhonova, A. A. Ostanin, N. M. Passman, E. R. Chernykh

“…The study deals with evaluation of dehydroepiandrosterone sulfate (DHEAS) effects upon phenotype and functions of dendritic cells (DCs), generated from blood monocytes of pregnant women by means of GM-CSF and IFN-alpha. …”
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Unbiased functional clustering of gene variants with a phenotypic-linkage network. by Frantisek Honti, Stephen Meader, Caleb Webber

“…To discern molecular pathways relevant to complex disease, we have inferred functional associations between human genes from diverse data types and assessed them with a novel phenotype-based method. …”
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P703: The phenotypic effects of loss-of-function variants in WDR45 by Yu An, Qianqian Ou

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Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity by Leonore Raudszus, Farbod Bahreini, Susanne Allan, Kai-Uwe Kalies, Charles C. Caldwell, Kathrin Kalies

“…However, recent evidence highlights a phenotypic and functional heterogeneity of neutrophils that extends well beyond their traditional - potentially harmful- role as first responders. …”
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