A reporter assay in lamprey embryos reveals both functional conservation and elaboration of vertebrate enhancers. by Hugo J Parker, Tatjana Sauka-Spengler, Marianne Bronner, Greg Elgar

“…We find instances of both functional conservation and lineage-specific functional evolution of CNEs across vertebrates, emphasising the utility of functionally testing homologous CNEs in their host species.…”
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The dual function of EMB1579 in transcription and splicing governs tissue patterning in the Arabidopsis root meristem by Fatimah Aljedaani, Yinghui Luo, Yanming Deng, Wouter Smet, Zeeshan Nasim, Xinjing Xu, Umar F. Shahul Hameed, Ting Ting Xiao, Jose Kenyi Gonzalez-Kise, Stefan Arold, Ikram Blilou

“…However, the molecular mechanisms through which it functions in the root meristem remain largely unclear. …”
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Bridged emulsion gels from polymer–nanoparticle enabling large-amount biomedical encapsulation and functionalization by Chuchu Wan, Si He, Quanyong Cheng, Kehan Du, Yuhang Song, Xiang Yu, Hao Jiang, Caili Huang, Jiangping Xu, Cong Ma, Jintao Zhu

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Techno-Functionalities of White Bean Protein Concentrate: A Comparative Study with Soy and Pea Proteins by Paula Zambe Azevedo, Juliana Eloy Granato Costa, Jessica da Silva Matos, Breno Rodrigues de Souza, Sueli Rodrigues, Fabiano André Narciso Fernandes, Vanelle Maria Silva, Márcia Cristina Teixeira Ribeiro Vidigal, Paulo Cesar Stringheta, Evandro Martins, Pedro Henrique Campelo

“…The study of the techno-functional properties of novel plant-based proteins has gained importance due to their as alternatives to conventional proteins in food systems. …”
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Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity by Da‐Hye Jeong, Seokhwi Kim, Han‐Hee Park, Kyoung‐Jin Woo, Jae‐Il Choi, Minji Choi, Jisoo Shin, So Hyun Park, Myung‐Wook Seon, Dakeun Lee, Jong‐Ho Cha, You‐Sun Kim

“…Moreover, the functional module of optoMLKL significantly enhances innate immune responses by promoting the release of iDAMPs and cDAMPs, which are critical for initiating antitumor immunity. …”
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Discovering the interactome, functions, and clinical relevance of enhancer RNAs in kidney renal clear cell carcinoma by Zhaohui Sun, Haojie Du, Xudong Zheng, Hepeng Zhang, Huajie Hu

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Bilateral functional connectivity of the basal ganglia in patients with Parkinson's disease and its modulation by dopaminergic treatment. by Simon Little, Huiling Tan, Anam Anzak, Alek Pogosyan, Andrea Kühn, Peter Brown

“…However, little is known about the functional connectivity of the two basal ganglia across hemispheres and specifically the role beta plays in this. …”
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Dihydroartemisinin induces tumor suppression in the Drosophila brain tumor with functional recovery and a rescue in lethality by Sushree Sulava, Bhavishya Vashist, Kaustubh Sawant, Debasmita Pankaj Alone

“…The behavioral assay conducted to correlate tumor suppression with the restoration of brain function demonstrated restored locomotory abilities comparable to those of the wild-type strain. …”
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Reconfigurable neuromorphic functions in antiferroelectric transistors through coupled polarization switching and charge trapping dynamics by Jing Gao, Yu-Chieh Chien, Jiali Huo, Lingqi Li, Haofei Zheng, Heng Xiang, Kah-Wee Ang

“…Additionally, we further demonstrate synaptic and neuronal functions for implementing unsupervised learning rules and spiking behavior in spiking neural networks. …”
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MicroRNAs in Liver Fibrosis: Unraveling Intercellular Crosstalk and the Regulatory Functions of MicroRNA-223 by Chinnatam Phetkong, Chaiyaboot Ariyachet

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Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. by Ge Li, Elaine R Peskind, Steven P Millard, Peter Chi, Izabela Sokal, Chang-En Yu, Lynn M Bekris, Murray A Raskind, Douglas R Galasko, Thomas J Montine

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Adaptive evolution and functional significance of the PPARGC1A gene across diverse animal species by Seyed Mahdi Hosseini, Farman Ullah, Muhammad Zulfiqar Ahmad, Majid Pasandideh, Aixin Liang, Guohua Hua, Liguo Yang

“…Supporting these genetic insights, the phylogenetic analysis highlighted relationships among the PPARGC1A sequences and domain analysis confirmed conserved features across species, while protein–protein interaction networks suggested a complex web of functional interdependencies. …”
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AI post-intervention operational and functional outcomes prediction in ischemic stroke patients using MRIs by Emily Wittrup, John Reavey-Cantwell, Aditya S. Pandey, Dennis J. Rivet II, Kayvan Najarian

“…Abstract Background Despite the potential clinical utility for acute ischemic stroke patients, predicting short-term operational outcomes like length of stay (LOS) and long-term functional outcomes such as the 90-day Modified Rankin Scale (mRS) remain a challenge, with limited current clinical guidance on expected patient trajectories. …”
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Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors by Jun Chen, Na Cui, Shao-Hui He, Chun-Yan Xia, Wei-Qing Li

“…Methods Immune cells were isolated from 13 bone tumor samples and profiled via scRNA-seq to delineate cellular compositions, metabolic adaptations, and intercellular communication networks. Differential gene expression analysis, metabolic pathway enrichment, and pseudotime trajectory inference were employed to characterize functional states and differentiation processes of immune cell subsets. …”
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Genome-wide identification and functional characterization of NOD-like receptors (NLRs) in snakehead (Channa argus) by Xiaochen Zhu, Beibei Wang, Lu Zhang, Xiaoyan Zhang, Chao Li

“…This study offers robust evidence that enhances our understanding of the immune regulatory mechanisms and functional roles of NLR genes in snakehead.…”
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Expansins in Salt and Drought Stress Adaptation: From Genome-Wide Identification to Functional Characterisation in Crops by Siarhei A. Dabravolski, Stanislav V. Isayenkov

“…Despite substantial progress, limitations remain in understanding the broader regulatory networks influenced by expansins. Future research should focus on elucidating their downstream molecular targets, transcriptional interactions, and functional diversity across different plant species. …”
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The RhoGEF trio functions in sculpting class specific dendrite morphogenesis in Drosophila sensory neurons. by Srividya Chandramouli Iyer, Dennis Wang, Dennis Wang, Eswar Prasad R Iyer, Sarah A Trunnell, Ramakrishna Meduri, Riaz Shinwari, Mikolaj J Sulkowski, Daniel N Cox

“…Moreover, the specification of class specific dendrite arborization is critically important in establishing neural connectivity and the formation of functional networks. Cytoskeletal modulation provides a key mechanism for establishing, as well as reorganizing, dendritic morphology among distinct neuronal subtypes. …”
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Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery by Bingyong Xie, Haoyu Ni, Jiyuan Yao, Zhibin Xu, Sicheng Bian, Haoxiang Wang, Kun Zhu, Xianyong Wu, Peiwen Song, Yuanyuan Wu, Yongqiang Yu, Fulong Dong

“…Moreover, macrostructural changes manifest more gradually, with the recovery of brain function depending more on compensation and remodeling within neural networks than solely on structural restoration.…”
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Impact of effective connectivity within the Papez circuit on episodic memory: moderation by perivascular space function by Ling-Ling Li, Jie Ma, Jia-Jia Wu, Xin Xue, Mou-Xiong Zheng, Xu-Yun Hua, Qi-Hao Guo, Jian-Guang Xu

“…Recently, the role of the perivascular space (PVS) in cognitive function has garnered increasing attention. However, the role of PVS function between neural circuits and cognitive function in amnestic mild cognitive impairment (aMCI) patients remains unknown. …”
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Functional characteristics of sleep monitoring devices in China: A real-world cross-sectional study by Le Yang, Bingtao Weng, Xingyan Xu, Zhi Huang, Run Ding, Miaomiao Si, Yingxin Fu, Yurui Zhu, Yu Jiang, Beibei Rao, Xinyi Zhang, Qingwei Zhou, Shenglan Lin, Yansong Guo, XiaoXu Xie

“…This study investigates the functional characteristics of existing sleep monitoring devices in the Chinese market and delves into population preferences. …”
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