A Novel Multimodal Deep Learning Approach With Loss Function for Detection of Sleep Apnea Events by Alireza Fakhim Babaei, Jafar Tanha, Mohammad Ali Balafar, Seyedehsan Roshan

“…To promote model diversity and robustness, we further introduce a novel loss function that encourages the network’s key modules to learn disparate feature representations. …”
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A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs by Sarah Cherkaoui, Stephan Durot, Jenna Bradley, Susan Critchlow, Sebastien Dubuis, Mauro Miguel Masiero, Rebekka Wegmann, Berend Snijder, Alaa Othman, Claus Bendtsen, Nicola Zamboni

“…These were functionally confirmed by 13C‐flux analysis, lipidomics, and analysis of sensitivity to perturbations. …”
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White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder by Xiaofu He, Diana V. Rodriguez-Moreno, Yael M. Cycowicz, Keely Cheslack-Postava, Huilan Tang, Zhishun Wang, Lawrence V. Amsel, Megan Ryan, Lupo Geronazzo-Alman, George J. Musa, Adam Bisaga, Christina W. Hoven

“…Compared to FH-, FH + adolescents showed significantly greater functional connectivity between posterior regions of the Default Mode Network (DMN) and the Fronto-Parietal Network (FPN). …”
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Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. by Henry H Jerng, Jay M Patel, Tamor A Khan, Benjamin R Arenkiel, Paul J Pfaffinger

“…Even though Kv channels have been intensely studied for over 70 year, surprisingly little is known about how specific channels expressed in various neurons and their functional properties impact neuronal network activity and behavior in vivo. …”
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Power System Transient Stability Assessment Based on Intelligent Enhanced Transient Energy Function Method by Tianxiao Mo, Jun Liu, Jiacheng Liu, Guangyao Wang, Yuting Li, Kaiwei Lin

“…Based on the transient stability judgment mechanism of the response-driven transient energy function, this paper proposes a transient energy function stability judgment method based on a two-machine equivalent model and enhanced by a convolutional neural network. …”
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Urban Resilience and Energy Demand in Tropical Climates: A Functional Zoning Approach for Emerging Cities by Javier Urquizo, Hugo Rivera-Torres

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Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. by Julio E Molineros, Amit K Maiti, Celi Sun, Loren L Looger, Shizhong Han, Xana Kim-Howard, Stuart Glenn, Adam Adler, Jennifer A Kelly, Timothy B Niewold, Gary S Gilkeson, Elizabeth E Brown, Graciela S Alarcón, Jeffrey C Edberg, Michelle Petri, Rosalind Ramsey-Goldman, John D Reveille, Luis M Vilá, Barry I Freedman, Betty P Tsao, Lindsey A Criswell, Chaim O Jacob, Jason H Moore, Timothy J Vyse, Carl L Langefeld, Joel M Guthridge, Patrick M Gaffney, Kathy L Moser, R Hal Scofield, Marta E Alarcón-Riquelme, BIOLUPUS Network, Scott M Williams, Joan T Merrill, Judith A James, Kenneth M Kaufman, Robert P Kimberly, John B Harley, Swapan K Nath

“…We experimentally validated function of the intronic SNP by DNA electrophoresis, protein identification, and in vitro protein binding assays. …”
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Aspartate beta-hydroxylase is a prognostic factor in gallbladder cancer with the function of promoting tumorigenesis and chemoresistance by Luo Yuan, Huang Yunpeng, Li Xiong, Yu Wen, Wang Yongxiang

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Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review by Rajiv Mohanraj, Manoj Sivan, Kajal Patel, Abhijit Das, Siddarth Kannan, Daniela Di Basilio, Antonia Kirkby, Anthony Jones

“…Thalamocortical dysrhythmia was identified as a potential unifying concept, characterised by abnormal theta and beta oscillations that enhance pain perception in CP and trigger functional symptoms in FND. Both conditions also exhibit reduced alpha oscillations, likely amplifying sensory sensitivity and emotional responsiveness.Conclusion This review highlights shared neural abnormalities (Triple Network model) and introduces thalamocortical dysrhythmia as a novel explanatory framework linking FND and CP. …”
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Hiking with Tobler: Tracking Movement and Calibrating a Cost Function for Personalized 3D Accessibility by Christopher D Higgins

“…This paper analyzes the author's travel trajectories to calibrate a bespoke walking cost function based on Tobler's Hiking Function (THF) and uses it to estimate personalized accessibility on a 3D network in Hong Kong. …”
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The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis by Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang

“…For VBM analysis, individuals with TUD showed decreased gray matter volume (GMV) in the left superior temporal gyrus, right superior frontal gyrus, right anterior cingulate/paracingulate gyrus, left superior frontal gyrus, and right anterior thalamic region and increased GMV in the right lingual gyrus.ConclusionThis meta-analysis illustrates structural and functional abnormalities of the default mode network, executive control network, and salience network in individuals with TUD. …”
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Illuminating the dark kinome: utilizing multiplex peptide activity arrays to functionally annotate understudied kinases by Abdul-rizaq Hamoud, Khaled Alganem, Sean Hanna, Michael Morran, Nicholas Henkel, Ali S. Imami, William Ryan, Smita Sahay, Priyanka Pulvender, Austin Kunch, Taylen O. Arvay, Jarek Meller, Rammohan Shukla, Sinead M. O’Donovan, Robert McCullumsmith

“…Using this hybrid approach, we identified 195 novel kinase-substrate interactions with variable degrees of affinity and linked extended functional networks for these kinases to biological processes that are impaired in psychiatric and neurological disorders. …”
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Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs by Jingjing Xia, Tiancheng Xie, Jinli Liu, Weikang Cheng, Longyan Liao, Ming Chen, Haibing Hua, Xiaobing Hou

“…Cytoscape was used to construct the TCM-compound-target-disease network and the disease-target pathway network for visual representation. …”
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Unsupervised clustering of biochemical markers reveals health profiles associated with function and survival in active aging by Raquel González-Martos, Javier Galeano, Carmen Ramirez-Castillejo, Narcis Gusi, Eva Gesteiro, German Vicente-Rodriguez, Ignacio Ara, Amelia Guadalupe-Grau

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Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome by Shengyang Ge, Qingfeng Hu, Yijun Guo, Ke Xu, Guowei Xia, Chuanyu Sun

“…Patients with CP/CPPS had alterations in brain function, which consisted of the default mode network’s compromised integrity. …”
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Using Machine Learning for Analysis of Wideband Acoustic Immittance and Assessment of Middle Ear Function in Infants by Shan Peng, Yukun Zhao, Xinyi Yao, Huilin Yin, Bei Ma, Ke Liu, Gang Li, Yang Cao

“…Objectives: Evaluating middle ear function is essential for interpreting screening results and prioritizing diagnostic referrals for infants with hearing impairments. …”
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Effects of long-term continuous cropping on microbial community structure and function in tobacco rhizosphere soil by Bingye Yang, Changchun Feng, Hong Jiang, Yulan Chen, Mengjiao Ding, Huaxin Dai, Zhen Zhai, Mengmeng Yang, Taibo Liang, Yanling Zhang

“…The results of the correlation network analysis and the functional analysis mutually confirmed each other, both emphasizing the important role of soil carbon and iron in shaping the structure of the tobacco rhizosphere microbial community. …”
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Characterising grey-white matter relationships in recent-onset psychosis and its association with cognitive function by Yoshito Saito, Christos Pantelis, Vanessa Cropley, Liliana Laskaris, Cassandra M.J. Wannan, Warda T. Syeda

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Changes in brain functional connectivity associated with transcutaneous auricular vagus nerve stimulation in healthy controls by Daniel A. Monti, Nancy Wintering, Faezeh Vedaei, Alicia Steinmetz, Feroze B. Mohamed, Andrew B. Newberg, Andrew B. Newberg

“…Interestingly, cognitive areas were also involved including parts of the temporal lobe, salience network, and default mode network.ConclusionThis study is an initial step toward understanding the functional connectivity changes associated with TaVNS. …”
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Association of Long-Term Physical Activity Levels With Dementia Risk and Cognitive Function in US Adults by Yuhan Li, Yanping Li, Xiao Gu, Yuxi Liu, Danyue Dong, Jae H Kang, Molin Wang, A Heather Eliassen, Walter C Willett, Meir J Stampfer, Dong D Wang

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