Chronic stress and cytogenesis ablation disrupt hippocampal neuron connectivity, with fluoxetine restoring function with sex-specific effects by Inês Ribeiro, Tiago Silveira-Rosa, Joana Martins-Macedo, Luísa Marques-Ferraz, Ana Rita Dourado, Gonçalo Martins-Ferreira, Fanny Farrugia, Ana João Rodrigues, Djoher Nora Abrous, Nuno Dinis Alves, Patrícia Patrício, Luisa Pinto

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Impact of Polystyrene Microplastics on Human Sperm Functionality: An In Vitro Study of Cytotoxicity, Genotoxicity and Fertility-Related Genes Expression by Filomena Mottola, Maria Carannante, Ilaria Palmieri, Lorenzo Ibello, Luigi Montano, Mariaceleste Pezzullo, Nicola Mosca, Nicoletta Potenza, Lucia Rocco

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Expanding structural insights into DNA packaging apparatus and endolysin LysSA05 function of Epsilon15 bacteriophage by Muhammad Saleem Iqbal Khan, Ju Wu, Shenlin Ji, Demeng Tan, Bingrui Sui, Shanshan Peng, Jinbiao Zhan, Jiajun Yin

“…Phage therapy offers a promising solution against MDR Gram-negative infections; however, its clinical application is constrained by the presence of endotoxins, residual cellular debris, the risk of horizontal gene transfer by temperate phages, and an incomplete understanding of how phage structural integrity influences infectivity and enzyme function. In this study, we present a structural and functional analysis of temperate bacteriophage Epsilon15 (ϵ15), focusing on its DNA packaging and injection machinery, along with characterization of the dual-acting endolysin LysSA05. …”
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Association between the proportionality of functional mitral regurgitation and survival after mitral valve operationCentral MessagePerspective by Makoto Mori, MD, PhD, Christina Waldron, BS, Sigurdur Ragnarsson, MD, Soh Hosoba, MD, PhD, Mina Zaky, MD, Dustin Lieu, MD, Markus Krane, MD, Arnar Geirsson, MD

“…Objective: The concept of proportionate and disproportionate functional mitral regurgitation suggests that transcatheter edge-to-edge mitral repair may benefit patients with a smaller left ventricle relative to a higher regurgitant burden. …”
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Genomic basis and functional characterization of the exopolysaccharide production by a thermotolerant Bacillus isolated from Tolhuaca hot spring by Cynthia Meza, Benjamin Sepulveda, Nicolás Flores-Castañón, Francisca Valenzuela, Catherine Ormeño, Alexis Castillo, Alex Echeverría-Vega, Sura Jasem Mohammed Breig, Saja Mohsen Alardhi, Alex Gonzalez, Alex Gonzalez, Bárbara Mora-Lagos, Aparna Banerjee

“…Bacillus licheniformis Tol1, a thermotolerant bacterial strain isolated from the Tolhuaca hot spring in Chile, was investigated for its genomic features and the functional properties of its exopolysaccharide (EPS). …”
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Natural ligand 3,3’-diindolylmethane functions as an AHR agonist to modulate angiogenesis and organ development in chicken embryos by Gee-yea Lim, Hao Chen, Woo-seon Song, Dong-hee Koh, Dong-ha Kim, Hisato Iwata, Eun-Young Kim

“…Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that is crucial for regulating various toxicological responses and physiological functions. Recent studies have highlighted that interactions between AHR and certain natural ligands can modulate inflammation and immune responses, offering therapeutic potential for a wide range of diseases. …”
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Antioxidant functionalized double-net/TA dynamic hydrogel promotes cartilage regeneration through stabilization of chondrocyte phenotype by Xu Wu, Honglei Wang, Chenlong Li, Yaying Zhu, Qixuan Wang, Tianyu Zhang, Yaoyao Fu, Aijuan He

“…To endow the scaffold with antioxidant functionality, TA (tannic acid) was incorporated by hydrogen bonding to the CNF network, forming an antioxidant DN-TA hydrogel system.To evaluate whether attenuating aerobic metabolism could preserve chondrocyte phenotype, P3 (passage 3) chondrocytes were cultured within the hydrogel scaffold in vitro and then implanted subcutaneously into nude mice. …”
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Associations of Pretransplant Patient-Reported Outcomes Measurement Information System Physical Function Score With Kidney Transplant Outcomes by Junji Yamauchi, Amy M. Cizik, Katalin Fornadi, Dominik Thomas, Divya Raghavan, Duha Jweehan, Suayp Oygen, Silviana Marineci, Michelle Buff, Motaz Selim, Michael Zimmerman, Istvan Mucsi, Istvan Mucsi, Miklos Z. Molnar

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The absence of IL17A favours cytotoxic cell function and improves antigen‐specific immunotherapies in pancreatic adenocarcinoma by Giorgia Tiberi, Alessandro Scagliotti, Claudia Curcio, Ermes Candiello, Paula Ariadna Diez Villegas, Silvia Brugiapaglia, Gianluca Mucciolo, Cecilia Roux, Giancarlo Castellano, Roberta Curto, Maddalena Arigoni, Raffaele A. Calogero, Giuseppina Barutello, Niccolò Bolli, Mauro Giulio Papotti, Giulia Adriani, Francesco Novelli, Paola Cappello

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Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice by Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

“…Results Here, we show that enhancer mutation of MEF2C reduces own gene expression and consequently impairs mitochondrial function in motor neurons. MEF2C localizes and binds to the mitochondria DNA, and directly modulates mitochondria-encoded gene expression. …”
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Function of B8N6S4 in Regulating the Growth and Aflatoxin B1 Biosynthesis of Aspergillus flavus by Xinze ZHANG, Ruisi PU, Jinlu NIU, Wenjie HUANG, Shijuan YAN, Wenyang ZHANG, Shaowen WU

“…【Objective】The objective of this study is to examine the function of Zn(Ⅱ)2Cys6 transcription factor B8N6S4 in Aspergillus flavus, and to analyze the role of B8N6S4 in the growth, development, and Aflatoxin B1 (AFB1) biosynthesis of A. flavus.…”
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Interoception as a key node in the multidimensional psychological structural model of depression: a structural equation model analysis of integrating environmental, cognitive and b... by Jikang Liu, Jiaxu Li, Tiantian Wang, Yuqing Wu, Xiaohong Liu, Xuezheng Gao, Zhenhe Zhou, Hongliang Zhou

“…Abstract Background The psychological structural model of major depressive disorder (MDD) is complex and multifaceted, consisting of the environment factors (EF), cognitive function (CF), and behavioral-emotional manifestations (BEM). …”
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Changes in public transport service demand under the influence of seasonal components by Mykola Zhuk, Halyna Pivtorak, Ivanna Gits, Maryan Hits

Subjects: “…conditions of the route network functioning…”
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Can intelligent virtual assistants improve cognitive function in older adults? A two-wave mediation study by Tianxin Cai, Shilong Ma, Renyao Zhong

“…Results Constant and new IVAs use significantly affected cognitive function, mediated by social networks and physical exercise. …”
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UAV-Enabled Diverse Data Collection via Integrated Sensing and Communication Functions Based on Deep Reinforcement Learning by Yaxi Liu, Xulong Li, Boxin He, Meng Gu, Wei Huangfu

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In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety. by Julie E Cooper, Conor J McCann, Dipa Natarajan, Shanas Choudhury, Werend Boesmans, Jean-Marie Delalande, Pieter Vanden Berghe, Alan J Burns, Nikhil Thapar

“…We aimed to investigate the potential of enteric neural stem cell therapy approaches for such disorders by transplanting mouse enteric neural crest cells (ENCCs) into ganglionic and aganglionic mouse gut in vivo and analysing functional integration and long-term safety.<h4>Design</h4>Neurospheres generated from yellow fluorescent protein (YFP) expressing ENCCs selected from postnatal Wnt1-cre;R26R-YFP/YFP murine gut were transplanted into ganglionic hindgut of wild-type littermates or aganglionic hindgut of Ednrbtm1Ywa mice (lacking functional endothelin receptor type-B). …”
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THE SNP-MED SYSTEM FOR ANALYSIS OF THE EFFECT OF SINGLE-NUCLEOTIDE POLYMORPHISMS ON THE FUNCTION OF GENES ASSOCIATED WITH SOCIALLY SIGNIFICANT DISEASES by N. L. Podkolodnyy, D. A. Afonnikov, Yu. Yu. Vaskin, L. O. Bryzgalov, V. A. Ivanisenko, P. S. Demenkov, M. P. Ponomarenko, D. A. Rasskazov, K. V. Gunbin, I. V. Protsyuk, I. Yu. Shutov, P. N. Leontyev, M. Yu. Fursov, N. P. Bondar, E. V. Antontseva, T. I. Merkulova, N. A. Kolchanov

“…This paper describes the SNP-MED modular computer-based information system for estimation of the influence of single nucleotide polymorphisms (SNPs) on the function of genes associated with the risk of socially significant diseases. …”
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The correlation between neutrophil/lymphocyte ratio and the MRI burden and cognitive function in patients with cerebral small vessel disease by Mengyao Zhao, Mengyao Zhao, Xiaohua Xie, Xiaohua Xie, Zhiwei Hao, Zhiwei Hao, Mengsi Ren, Zhenjie Teng, Zhenjie Teng, Jing Xu, Jing Xu, Chunhui Shan, Yanhong Dong, Yanhong Dong, Peiyuan Lv, Peiyuan Lv

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Context-dependent PSIICOS: A novel framework for functional connectivity estimation accounting for task-related power leakage by Daria Kleeva, Alexei Ossadtchi

“…The results demonstrate that CD-PSIICOS outperforms the original PSIICOS in suppressing artifacts at the lower projection ranks, maintaining robust detection of functional networks across theta and gamma frequency bands. …”
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Drought Influences the Structure, Diversity, and Functionality of the Fungal Community Inhabiting the Grapevine Xylem and Enhances the Abundance of Phaeomoniella chlamydospora by C. Leal, R. Bujanda, M. J. Carbone, T. Kiss, A. Eichmeier, D. Gramaje, M. M. Maldonado-González

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