Functional validation to explore the protective role of miR-223 in Staphylococcus aureus-induced bovine mastitis by Xueqin Liu, Siyuan Mi, Gerile Dari, Siqian Chen, Jiuzhou Song, David E. MacHugh, Ying Yu

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511 Functional link between myelination integrity in the connectome of the cingulum bundle and information processing speed in RRMS by Ashley Pike, Ashley Pike, Tatiana Wolfe, G. Andrew James, Sienna Colonese, Maegan Calvert, Chrystal Fullen, Jennifer Gess, Jennifer Kleiner, Clint Kilts, Lee Archer R.

“…We hypothesize that the structural integrity of the cingulum bundle and its structural network – or connectome – is distinctly associated with IPS function in people with RRMS (vs. …”
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An enhanced gene function analysis platform for Gastrodia Elata integrating further omics data and analysis tools by Bingbing Pan, Jingjie Zhang, Jiangxin Yang, Hang Yang, Qi Pan, Panpan Zhu, Jun Li, Jiaotong Yang

“…The growing multi-omics data demands an updated platform to include the latest G.elata genome and transcriptome, thereby enhancing gene function analysis for researchers. In this study, we built co-expression network using four versions of the G.elata genome, incorporated the latest transcriptome data, and annotated genes with sequences from TAIR, Uniprot, NR, and Swisprot databases. …”
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Changes in Functional Properties and In Vitro Digestibility of Black Tartary Buckwheat Starch by Autoclaving Combination with Pullulanase Treatment by Faying Zheng, Fuxin Nie, Ye Qiu, Yage Xing, Qinglian Xu, Jianxiong Chen, Ping Zhang, Hong Liu

“…This study reveals the effects of autoclaving combined with debranching on the processing properties and functional characteristics of black Tartary buckwheat starch.…”
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A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. by David Burgner, Sonia Davila, Willemijn B Breunis, Sarah B Ng, Yi Li, Carine Bonnard, Ling Ling, Victoria J Wright, Anbupalam Thalamuthu, Miranda Odam, Chisato Shimizu, Jane C Burns, Michael Levin, Taco W Kuijpers, Martin L Hibberd, International Kawasaki Disease Genetics Consortium

“…In four genes (ZFHX3, NAALADL2, PPP1R14C, and TCP1), the neighboring markers were more significantly associated than the originally associated variants. Investigation of functional relationships between the eight fine-mapped genes using Ingenuity Pathway Analysis identified a single functional network (p = 10(-13)) containing five fine-mapped genes-LNX1, CAMK2D, ZFHX3, CSMD1, and TCP1-with functional relationships potentially related to inflammation, apoptosis, and cardiovascular pathology. …”
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Temporal Dynamics of Functional Connectivity in Temporal and Extra-Temporal Lobe Epilepsy: A Magnetoencephalography-Based Study by Suhas M.V, N. Mariyappa, Karunakar Kotegar, Ravindranadh Chowdary M, Raghavendra K, Ajay Asranna, Viswanathan L.G, Sanjib Sinha, Anitha H

“…<italic>Goal:</italic> This study aims to explore the temporal dynamics of functional connectivity in drug-resistant focal epilepsy, focusing on Temporal Lobe Epilepsy (TLE) and Extra-Temporal Lobe Epilepsy (ETLE), using magnetoencephalography (MEG). …”
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Whole-Body and Segmental Phase Angles and Cognitive Function in the Older Korean Population: Cross-Sectional Analysis by Jiaren Chen, Jong-Hwan Park, Chien-Yu Lin, Ting-Fu Lai, Du-Ri Kim, Myung-Jun Shin, Eunsoo Moon, Jung Mo Kang, Jong Won Lee, Yoon Jae Cho, Yung Liao, Tae Sik Goh, Jung Sub Lee

“…However, few studies have explored the relationship between PhAs, especially segmental PhAs, and the psychological aspects of health, particularly cognitive function. ObjectiveWe aimed to investigate the association between whole-body and segmental PhAs and cognitive function in older adults. …”
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Effects of Mnemonic Strategy Training on Brain Activity and Cognitive Functioning of Left-Hemisphere Ischemic Stroke Patients by Alana X. Batista, Paulo R. Bazán, Adriana B. Conforto, Maria da Graça M. Martin, Sharon. S. Simon, Benjamin Hampstead, Eberval Gadelha Figueiredo, Eliane C. Miotto

“…Volunteers underwent 2 sessions of functional magnetic resonance imaging (fMRI) during face-name association task: one prior and the other after the cognitive training. …”
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The mediating effect of frailty between social isolation and cognitive function in elderly patients with type 2 diabetes by Wu Nixiao, Dai Xia, Li Sulan, Xu Zilan, Huang Zheng

“…[Objective] To analyze the mediating effect of frailty between social isolation and cognitive function in elderly patients with type 2 diabetes mellitus. …”
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Characterizing the influence of varying functional traits from remotely sensed data on forest productivity acquired from selected NEON sites by Paige T. Williams, Valerie A. Thomas, Randolph H. Wynne, Karl F. Huemmrich, David J. Harding, K. Jon Ranson, Petya K. Campbell, Elizabeth M. Middleton

“…Airborne remote sensing observations and in situ flux tower measurements used in this analysis were acquired from selected forested sites from the National Ecological Observatory Network (NEON) data portal. We investigated hyperspectral indices and lidar derived products as proxies of remotely sensed plant functional traits. …”
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Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease by Yuxia Li, Xiaoni Wang, Yongqiu Li, Yu Sun, Can Sheng, Hongyan Li, Xuanyu Li, Yang Yu, Guanqun Chen, Xiaochen Hu, Bin Jing, Defeng Wang, Kuncheng Li, Frank Jessen, Mingrui Xia, Ying Han

“…However, little is known about functional characteristics of the conversion from MCI to AD. …”
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Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo by Yan Fan, Yi-Jin Wu, Yi-Jin Wu, Kai Guo, Xia-Qing Zhou, Abulizi Abulaiti, Opeyemi Joshua Olatunji, Cong-Lan Ji, Jian Zuo, Jian Zuo

“…An IGF1R inhibitor picropodophyllin antagonized functions of IGF1/IGF1R too, but didn’t reinforce the effects of IGFBP5.ConclusionIGFBP5 eases inflammation by interacting with ANXA2, an activator of NF-κB; as an antagonist of IGF1/IGF1R, IGFBP5 may disrupt immune homeostasis in vivo, due to impairment of the latter’s anti-inflammatory functions; excessive IGFBP from adipocytes would be a pathogenic factor in certain diseases.…”
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Analysis of Soil Microbial Community Structure and Function in <i>Morchella esculenta</i> Habitats in Jilin Province by Qi Yan, Peng Wang, Zhushan Liu, Ya Yu, Xiao Tan, Xiao Huang, Jiawei Wen, Weidong Zhang

“…Metagenome sequencing technology was employed to analyze the structure and function of the rhizosphere microbial communities. …”
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Mechanism of acute liver injury alleviation by Zhuyeqing liquor based on UPLC-Q-TOF-MS/MS technology and network pharmacology by TU Muxin, MENG Yihao, WANG Qingliang, ZHANG Xin, YANG Chen, JIANG Tao, TIAN Junsheng

Subjects: “…zhuyeqing liquor|network pharmacology|ultra-high performance liquid chromatography-quadrupole-time of flight-tandem mass spectrometry|acute liver injury|functional components|molecular docking…”
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Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Fahrul Nurkolis, Isma Kurniatanty, Elvan Wiyarta, Happy Kurnia Permatasari, Nelly Mayulu, Nurpudji Astuti Taslim, Raymond Rubianto Tjandrawinata, Hardinsyah Hardinsyah, Trina Ekawati Tallei, Apollinaire Tsopmo, Son Radu, Edwin Hadinata, Bonglee Kim, Rosy Iara Maciel Azambuja Ribeiro, Rony Abdi Syahputra

“…The discovery of new molecules from natural sources for the treatment of tumors such as breast cancers is of importance for the development of functional foods and to the pharmaceutical industry. …”
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Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study by Kai-Cheng Chuang, Maryam Naseri, Sreekrishna Ramakrishnapillai, Kaitlyn Madden, Julia St Amant, Kevin McKlveen, Kathryn Gwizdala, Ramasudhakar Dhullipudi, Lydia Bazzano, Owen Carmichael

“…The HRFs of each participant within seventeen brain regions of interest (ROIs) previously identified as activated by this task were calculated using a convolutional neural network approach. Faster and more efficient neurovascular functioning was characterized in terms of five HRF characteristics: faster time to peak (TTP), shorter full width at half maximum (FWHM), smaller peak magnitude (PM), smaller trough magnitude (TM), and smaller area under the HRF curve (AUHRF). …”
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Morc4 is a novel functional gene associated with lipid metabolism in BXD recombinant inbred population by Zhanyi Yang, Jiaai Xu, Xiaoyu Yang, Pengcheng Yi, Jian Ruan, Yingying Wu, Yushan Li, Geng Tian, Fuyi Xu, Jia Mi, He Li, Chunhua Yang

“…This research aims to elucidate the function of MORC4 in hepatic lipid metabolism, thereby improving the understanding of the molecular mechanisms underlying lipid metabolism disorders.MethodsData regarding circulating lipid traits and hepatic Morc4 expression in BXD mice were obtained from GeneNetwork. …”
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GSFM: A genome-scale functional module transformation to represent drug efficacy for in silico drug discovery by Saisai Tian, Xuyang Liao, Wen Cao, Xinyi Wu, Zexi Chen, Jinyuan Lu, Qun Wang, Jinbo Zhang, Luonan Chen, Weidong Zhang

“…However, current computational approaches neglected the associations within gene‒gene functional networks and unrevealed the systematic relationship between drug efficacy and the reversal effect. …”
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Diversity and functional roles of endophytic and rhizospheric microorganisms in Ophioglossum vulgatum L.: implications for bioactive compound synthesis by Xian-Nv Long, Xian-Nv Long, Xian-Nv Long, Xing-Kai Zhang, Yue Wu, Shu-Shuang Tang, Tai-Xiong Zheng, Di Chen, Guan-Hua Cao, Guan-Hua Cao, Guan-Hua Cao, Xu-Hong Zhou, Sen He, Sen He, Sen He

“…Network analysis highlighted Basidiomycota as keystone taxa, with modular community structure. …”
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Prediction of antipsychotic drug efficacy for schizophrenia treatment based on neural features of the resting-state functional connectome by Song Liu, Meng Wang, Weiyi Han, Anran Chen, Xuzhen Liu, Kang Liu, Xue Li, Yi Chen, Luwen Zhang, Qing Liu, Xiaoge Guo, Xiujuan Wang, Ning Kang, Yong Han, Yuanbo Li, Xi Su, Luxian Lv, Bing Liu, Wenqiang Li, Yongfeng Yang

“…These functional features can be used to predict the PANSS total score reduction rate of SZ patients through a model. …”
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