Functionalized selenium nanoparticles ameliorated acetaminophen-induced hepatotoxicity through synergistically triggering PKCδ/Nrf2 signaling pathway and inhibiting CYP 2E1 by Si Zou, Yetao Gong, Xiujie Li, Yanbin Wu, Jinzhong Wu, Jianguo Wu, Ka-Hing Wong

“…Selenium nanoparticles (SeNPs) have been demonstrated potential for use in diseases associated with oxidative stress. Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value. …”
Get full text

Testicular function and fertility outcomes in males with CF: A multi center retrospective study of men with congenital bilateral absence of the vas deferens based on CFTR mutation... by Rossella Cannarella, Danielle Velez Leitner, Marissa Weiss, Sarah C. Vij

“…This study retrospectively examines testicular function and intracytoplasmic sperm injection outcomes of the partners of males with CBAVD, stratified by CF mutation status (CF, CF carriers, no known mutation). …”
Get full text

Efficacy of Repetitive Transcranial Magnetic Stimulation (Ipsilateral Cortex) along with Physiotherapy to Contralateral Side on Tone and Function of Subacute Stroke Survivors: Prot... by Pallavi Lalchand Harjpal, Raghuveer Raghumahanti, Mohammed Irshad Qureshi

“…The Modified Ashworth Scale (MAS), Stroke Rehabilitation Assessment of Movement (STREAM), Functional Reach Test (FRT) and 10-Metre Walk Test (10-MWT) will be used to assess each patient before and after therapy. …”
Get full text

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells by Jeffrey S Miller, Martin Felices, Shee Kwan Phung, Anders W Matson, Sam Wang, Ryan R Friess, Bruce Walcheck, Kate J Dixon, Jianming Wu, Rob Hullsiek, Anders J Lindstedt, Tanya S Freedman, Emily N Truckenbrod

“…In this study, we investigated the underlying mechanism of this process.Methods Peripheral blood mononuclear cells (PBMCs) or enriched NK cells from human peripheral blood, either unlabeled or labeled with a cell proliferation dye, were cultured for up to 7 days in the presence of rhIL-15±an ADAM17 function-blocking antibody. Different fully human versions of the antibody were generated; Medi-1 (IgG1), Medi-4 (IgG4), Medi-PGLALA, Medi-F(ab′)2, and TAB16 (anti-ADAM17 and anti-CD16 bispecific) to modulate CD16A binding. …”
Get full text

APPLICATION OF MICROPROCESSOR SYSTEMS IN AUTOMOTIVE INDUSTRY by V. G. Mikhailov

“…The analysis of systems and the functions which are subject to automation for truck and special cars is carried, questions of application of microprocessor systems for reception of experimental data on roads (microprofile and longitudinal cross-section) and their use at car modelling, and also maintenance of road safety: distance maintenance between cars, control of blind zones; an exception засыпания the driver during movement, reduction of harmful influence from noise and vibrations.It is offered complexing realised functions and systems of their control. …”
Get full text

Marine fish species recognition based on improved YOLOv5s by ZHANG Haifeng, LU Xinchun, FENG Bo, YANG Jin

“…ObjectiveIn order to improve the recognition accuracy of different kinds of marine fish, an improved YOLOv5s marine fish species recognition method was proposed.MethodsK⁃means++algorithm was used to cluster the real frames of marine fish, and more matching anchor frames were obtained with the self built data set. CIoU Loss function was replaced by SIoU Loss function as the boundary box regression algorithm to improve the accuracy and rate of convergence of the boundary box regression. …”
Get full text

Toward improving precision and complexity of transformer-based cost-sensitive learning models for plant disease detection by Manh-Tuan Do, Manh-Hung Ha, Duc-Chinh Nguyen, Oscal Tzyh-Chiang Chen, Oscal Tzyh-Chiang Chen

“…In particular, we introduced a transformer module, a fusion of the SPP and C3TR modules, to synthesize features in various sizes and handle uneven input image sizes. …”
Get full text

Identifying critical modules and biomarkers of intervertebral disc degeneration by using weighted gene co‐expression network by Daqian Zhou, Tao Liu, Yongliang Mei, Jiale Lv, Kang Cheng, Weiye Cai, Silong Gao, Daru Guo, Xianping Xie, Zongchao Liu

Get full text

Soil carbon metabolizing microorganisms affect the storage and stability of carbon pool in degraded alpine meadows by Qian Liu, Wenquan Yang, Jiancun Kou, Yangcan Zhang, Yanghua Yu, Weiliang Kou, Jing Zhang, Xilai Li

“…Co-occurrence network analysis showed that two major methanotrophs modules (pmoA_Mod2,4), one major soil carbon-fixing microbe module (cbbL_Mod5) and two major chitinase-producing microorganism modules (chiA_Mod1,4) were significantly affected by meadow degradation. …”
Get full text

Exploration of floral motifs for modular textile and apparel design by Edem Kwami Buami, Christiana Agbo, Daniel Akuoko Adjei, Richard Gbadegbe, Bernard Sprehe Godomey, Valeria Makafui Dzidzornu

Get full text

Revealing and modulating catalyst reconstruction for highly efficient electrosynthesis of ammonia by Xinyue Shi, Wei-Hsiang Huang, Ju Rong, Minghui Xie, Qingbo Wa, Ping Zhang, Hainan Wei, Huangyu Zhou, Min-Hsin Yeh, Chih-Wen Pao, Jie Wang, Zhiwei Hu, Xiaohua Yu, Jiwei Ma, Hongfei Cheng

Get full text

Evaluating the effectiveness of using the intelligent adaptive training system for design modules based on printed circuit boards by K. K. Hoang, Yu. V. Donetskaya

“…The target indicators of the effectiveness of training in the design modules based on PCB are highlighted. A fully functional algorithm for assessing the effectiveness of learning the design modules based on PCB in intelligent adaptive systems is determined by the step of technological operations to ensure the uniformity of the learning quality control. …”
Get full text

Diurnal dynamics of different circadian transcription modules in Chinese pine needles and roots during dormancy induction by Junhe Yang, Kai Qu, Huili Wang, Yousry A. El-Kassaby, Wei Li

“…Some transcriptional factors with functional similarities and synergistic effects were found to play a role in the regulatory pathway, which provided some data support for mining gene functions and analyzing related regulatory pathways. …”
Get full text

Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study by Maurizio De Pittà, Nicolas Brunel

“…Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two experimentally well-identified gliotransmitter pathways, (i) modulations of synaptic release and (ii) postsynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse. …”
Get full text

Tumor-derived vesicles in immune modulation: focus on signaling pathways by Fei Yin, Yangfang He, Yue Qiao, Yan Yan

“…They enhance tumor progression and immune evasion by inhibiting the effector function of immune cells and by altering critical processes of immune cell recruitment, polarization, and functional suppression by different signaling pathways. …”
Get full text

Identification of Key Modules of Lung Cancer in Gene Regulatory Network using Greedy Modularity Optimization Approach by Zahra Sadat Mirghadery, Mehrdad Kargari, Mostafa Akhavan-Safar

“…These abnormalities are transferred to other genes through specific interactions between genes, leading to disruptions in the normal function of cells. The result of these cell abnormalities will be the occurrence of cancer. …”
Get full text

Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses by Yinan Du, Aozhuo Zhang, Zhiwei Li, Yukui Zhao, Shuyi Liu, Chunling Wei, Qiaohua Zheng, Yanning Qiao, Yihui Liu, Wei Ren, Jing Han, Zhiqiang Liu, Fei Gao

Get full text

Identification of key proteins and pathways in myocardial infarction using machine learning approaches by Chang Liu, Xing Zhang, Qian Xie, Binbin Fang, Fen Liu, Junyi Luo, Gulandanmu Aihemaiti, Wei Ji, Yining Yang, Xiaomei Li

“…In this study, we identified 437 DEPs with 291 up-regulated and 146 down-regulated proteins. Functional enrichment analysis revealed key pathways involved in inflammation, immunity, metabolism, and cellular stress responses, among others. …”
Get full text

Tip60 HAT activators as therapeutic modulators for Alzheimer’s disease by Akanksha Bhatnagar, Christina M. Thomas, Gu Gu Nge, Aprem Zaya, Rohan Dasari, Neha Chongtham, Bijaya Manandhar, Sandhya Kortagere, Felice Elefant

“…Here, we test Tip60 histone acetyltransferase (HAT) activation as a therapeutic strategy for selectively restoring cognition-associated histone acetylation depleted in AD by developing compounds that enhance Tip60’s neuroprotective HAT function. Several compounds show high Tip60-binding affinity predictions in silico, enhanced Tip60 HAT action in vitro, and restore Tip60 knockdown mediated functional deficits in Drosophila in vivo. …”
Get full text

Cholesterol modulates membrane elasticity via unified biophysical laws by Teshani Kumarage, Sudipta Gupta, Nicholas B. Morris, Fathima T. Doole, Haden L. Scott, Laura-Roxana Stingaciu, Sai Venkatesh Pingali, John Katsaras, George Khelashvili, Milka Doktorova, Michael F. Brown, Rana Ashkar

Get full text