Nanopathways modulating postoperative cognitive dysfunction: extracellular vesicles by Yunmeng Zhang, Zengsheng Yin, Zhiyong Zou, Shangzhi Feng, Huayang Xu

“…In this paper, we will summarize studies related to extracellular vesicles in the treatment of postoperative cognitive dysfunction and discuss the potential function of extracellular vesicles in nerve repair and inhibition of acute neurological inflammation, which will expand the therapeutic strategies for postoperative cognitive dysfunction and may represent the development of novel cell-free therapeutic pathways for modulating postoperative cognitive dysfunction.…”
Get full text

Reconstruction of self-oscillating systems with delay time modulation by Ponomarenko, Vladimir Ivanovich, Prokhorov, Mihail Dmitrievich

“…With their help, one can estimate the mean delay time and recove the nonlinear function of the system. The proposed method, aimed at application to time-delay systems with delay time modulation, allows one to estimate the frequency and amplitude of delay time modulation. …”
Get full text

Approaches to anticancer therapy based on modulation of DNA methylation by V. P. Maksimova, J. V. Makus, V. G. Popova, O. G. Usalka, G. A. Belitsky, M. G. Yakubovskaya, K. I. Kirsanov

“…Disturbances in DNA methylation mechanism are associated with various malignancies such as acute myeloid leukaemia, breast cancer, prostate cancer, etc. Influencing the functional status of DNA methyltransferases (DNMTs) enzymes and TET family proteins (TETs), which regulate DNA methylation and demethylation, is the basis of epigenetic anticancer therapy approach. …”
Get full text

GLYPROLINES AS MODULATORS OF IMMUNOREACTIVITY WITHIN CONDITIONS OF “SOCIAL” STRESS by M. A. Samotrueva, A. L. Yasenyavskaya, O. A. Bashkina, N. F. Myasoedov, L. A. Andreeva

Get full text

Role of NLRC3 in modulating inflammatory responses in neonates by Meng Zhang, Mingming Zhang

Get full text

Modulation of the human GlyT1 by clinical drugs and cholesterol by Na Li, Yiqing Wei, Renjie Li, Yufei Meng, Jun Zhao, Qinru Bai, Gang Wang, Yan Zhao

“…Abstract Glycine transporter 1 (GlyT1) is a key player in shaping extracellular glutamatergic signaling processes and holds promise for treating cognitive impairments associated with schizophrenia by inhibiting its activity and thus enhancing the function of NMDA receptors. Despite its significant role in physiological and pharmacology, its modulation mechanism by clinical drugs and internal lipids remains elusive. …”
Get full text

Modulation of anti-tumour immunity by XPO1 inhibitors by Jack G. Fisher, Laura G. Bartlett, Trinayan Kashyap, Christopher J. Walker, Salim I. Khakoo, Matthew D. Blunt

“…As such, selective inhibitors of XPO1 (XPO1i) function have been developed to inhibit cancer cell proliferation and induce apoptosis. …”
Get full text

Training‐Augmented Ionic Switch for Logic Signal Modulation by Rui Jia, Xiaozheng Duan, Kaige Wang, Fengqiang Sun, Teng Li, Zhu Chen, Le Wang, Gang Wang, Liang‐Wen Feng, Hengda Sun, Meifang Zhu

“…One of the main challenges in the field is to develop materials that not only transit between distinct conductive states but also exhibit evolvable properties to enhance their functional capabilities. Addressing this, a reversible phase‐transition hydrated salt crystal ionic gel (RPSIG) for innovative ionic switch design is introduced. …”
Get full text

Aminergic and peptidergic modulation of insulin-producing cells in Drosophila by Martina Held, Rituja S Bisen, Meet Zandawala, Alexander S Chockley, Isabella S Balles, Selina Hilpert, Sander Liessem, Federico Cascino-Milani, Jan M Ache

“…We characterized functional inputs to IPCs using single-nucleus RNA sequencing analysis, anatomical receptor expression mapping, connectomics, and an optogenetics-based ‘intrinsic pharmacology’ approach. …”
Get full text

Monoglyceride supplementation modulates microbiom of small intestine in piglets by A. V. Gavrylenko, D. M. Masiuk

Get full text

Modulation of biofilm growth by shear and fluctuations in turbulent environments by Federico Pizzi, Francesc Peters, Elena Sorribes, Isabel Marín-Beltrán, Cristina Romera-Castillo, Joan Grau, Mona Rahmani, Lluís Jofre, Francesco Capuano

Get full text

Acute Immobilization Stress Modulate GABA Release from Rat Olfactory Bulb: Involvement of Endocannabinoids—Cannabinoids and Acute Stress Modulate GABA Release by Alejandra Delgado, Erica H. Jaffé

“…Apparently, stress increases the endocannabinoid system, modulating GABAergic synaptic function in a primary sensory organ.…”
Get full text

Brain creatine metabolism modulated by hydrogen-enriched water by Dragana Zanini, Nikola Todorovic, Korovljev Darinka, Stajer Valdemar, Bogdan Andjelic, Marijana Ranisavljev, Jovan Kuzmanovic, Sergej M. Ostojic

“…Background Creatine (Cr) plays a crucial role in aging by supporting cognitive function and promoting neuroprotection. Optimizing Cr levels in the aging brain is therefore of significant interest. …”
Get full text

Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Results We identified common molecular aging signatures across the nine mouse strains, which included genes associated with photoreceptor function and immune activation. Genetic background strongly modulated these aging signatures. …”
Get full text

Metabolic Effects of the Cancer Metastasis Modulator MEMO1 by Marziyeh Ghanbarian, Natalia Dolgova, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah Michel, Anas El-Aneed, Oleg Y. Dmitriev

“…Our previous genome-wide analysis of <i>MEMO1</i> genetic interactions across multiple cancer cell lines revealed that gene sets involved in mitochondrial respiration and the TCA cycle are enriched among the gain-of-function interaction partners of <i>MEMO1</i>. Based on these findings, we measured the TCA cycle metabolite levels in breast cancer cells with varying levels of <i>MEMO1</i> expression. …”
Get full text

Flavonoids as Potential Modulators of Pancreatic Lipase Catalytic Activity by Sílvia Rocha, Carina Proença, Alberto N. Araújo, Marisa Freitas, Ismael Rufino, Natália Aniceto, Artur M. S. Silva, Félix Carvalho, Rita C. Guedes, Eduarda Fernandes

Get full text

Microtubule-modulating drugs alter sensitivity to isoflurane in mice by Na Li, Zerong You, Yang Ren, Hyung Hwan Kim, Jinsheng Yang, Ge Li, Jason T. Doheny, Weihua Ding, Suyun Xia, Shiyu Wang, Xue Zhou, Xinbo Wu, Shiqian Shen, Yuanlin Dong, Zhongcong Xie, Lucy Chen, Jianren Mao, J. A. Jeevendra Martyn

“…Microtubule-targeting chemotherapy drugs and opioids affect MT stability and function. However, the impact of prolonged administration of these drugs on anesthetic potency and anesthesia induction and emergence times remain unelucidated. …”
Get full text

Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels by Katharina Imkeller, Giulia Ambrosi, Nancy Klemm, Ainara Claveras Cabezudo, Luisa Henkel, Wolfgang Huber, Michael Boutros

“…Abstract Wnt pathways are important for the modulation of tissue homeostasis, and their deregulation is linked to cancer development. …”
Get full text

Protective Effect of Ganjang, a Traditional Fermented Soy Sauce, on Colitis-Associated Colorectal Cancer in Mice by Hyeon-Ji Lim, In-Sun Park, Min Ju Kim, Ji Won Seo, Gwangsu Ha, Hee-Jong Yang, Do-Youn Jeong, Seon-Young Kim, Chan-Hun Jung

“…These findings suggest that ganjang has potential as a functional food for CRC prevention or mitigation, primarily through the modulation of CAC symptoms, tumor growth, inflammatory responses, intestinal epithelial barrier integrity, and gut microbiota composition.…”
Get full text

Strategies and Challenges for Unmanned Aerial Vehicle-Based Continuous Inspection and Predictive Maintenance of Solar Modules by Ghulam E. Mustafa Abro, Amjad Ali, Sufyan Ali Memon, Tayab Din Memon, Faheem Khan

“…Our review paper emphasizes instant functionality and practical insights for predictive maintenance, without necessitating complex computing resources or optimization tools. …”
Get full text