Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes by Sa Feng, Sa Feng, Linyan Liu, Linyan Liu, Yuelin Cheng, Yuelin Cheng, Mengmeng Zhou, Mengmeng Zhou, Haoqiang Zhu, Haoqiang Zhu, Xinyan Zhao, Xinyan Zhao, Ziyu Chen, Ziyu Chen, Shunli Kan, Shunli Kan, Xuanhao Fu, Xuanhao Fu, Wei Hu, Wei Hu, Rusen Zhu, Rusen Zhu

“…This study aims to investigate how icariin (ICA) interacts with reactive astrocytes in the treatment of spinal cord injury.MethodsA rat SCI model was constructed, and the recovery of motor function was observed after treatment with ICA.HE staining, LFB staining, immunofluorescence staining, and Western blotting were employed to assess ICA's ability to inhibit astrocyte proliferation in rats following spinal cord injury by modulating YAP, as well as to evaluate the reparative effects of ICA on the injured spinal cord tissue. …”
Get full text

One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidn... by Mengsi Zhou, Mengsi Zhou, Mengsi Zhou, Xiaoya Li, Xiaoya Li, Nenqun Xiao, Nenqun Xiao, Zhoujin Tan, Zhoujin Tan

Get full text

A Note on the Dynamics of Modified rf-SQUIDs: Simulations and Possible Control over Oscillations by Nikolay Kyurkchiev, Tsvetelin Zaevski, Anton Iliev, Todor Branzov

“…It is based on the Fourier transform and, as a consequence, on the characteristic function of some probability distributions.…”
Get full text

Preprocessing-Free Convolutional Neural Network Model for Arrhythmia Classification Using ECG Images by Chotirose Prathom, Ryuhi Fukuda, Yuto Yokoyanagi, Yoshifumi Okada

“…Second, we implement a focal loss (FL) function during model training to prioritize minority classes. …”
Get full text

Single-cell nuclear transcriptomics reveal root tip adaptations to nitrogen scarcity in wheat by Chuangbei Hai, Yan Li, Chaojun Peng, Lin Hu, Weigang Xu

“…The gene TaGS1.2, which is involved in glutamine synthesis, exhibited increased expression under nitrogen-deficient conditions, validating its functional significance in nutrient acquisition. Serving as a key functional gene that adapts to nitrogen-deficient conditions this gene also positively regulated root development. …”
Get full text

Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study by Meng Qi, Yiting Huang, Runru Mai, Zhaoxian Yan, Biyun Xu, Bo Liu, Yue Zhang

“…This study investigated whether transcutaneous auricular vagus nerve stimulation (taVNS) modulates BF functional connectivity (FC) in patients with PI and whether baseline FC predicts taVNS treatment response. …”
Get full text

Lifestyle as a Modulator of the Effects on Fitness of an Integrated Neuromuscular Training in Primary Education by Blanca Roman-Viñas, Fidanka Vasileva, Raquel Font-Lladó, Susana Aznar-Laín, Fabio Jiménez-Zazo, Abel Lopez-Bermejo, Victor López-Ros, Anna Prats-Puig

Get full text

Identification of common genetic variation that modulates alternative splicing. by Jeremy Hull, Susana Campino, Kate Rowlands, Man-Suen Chan, Richard R Copley, Martin S Taylor, Kirk Rockett, Gareth Elvidge, Brendan Keating, Julian Knight, Dominic Kwiatkowski

Get full text

Conceptual Basis for Developing Electric Plot Combine Harvester with Combined Power-Generating Plant by Mikhail E. Chaplygin, Ivan A. Starostin, Alexander S. Ovcharenko

“…There have been developed the recommendations for using the electric drive of the working bodies, options for using various power plants including removable energy modules, and a functional diagram of a plot grain combine harvester with an automated electric drive of the main units powered by a removable energy module. …”
Get full text

pET28g: A Golden Gate-compatible pET vector for protein expression in Escherichia coli, validated by production of functional human ACE2. by Inês M Luís, Mariana Parada, João B Vicente, Isabel A Abreu

“…Notably, this represents the first report of the successful purification of a functional human ACE2 protein from the Escherichia coli soluble protein fraction. …”
Get full text

MODULATED KINESIOTHERAPY IN PATIENTS WITH COMPLICATED CORONARY HEART DISEASE by A. I. Olesin, A. V. Belova, Z. Yu. Smolin

“…To study the effects of modulated kinesiotherapy (MK) on the clinical course of atrial fibrillation (AF) and chronic heart failure (CHF) in patients with coronary heart disease (CHD). …”
Get full text

Enhancement and evaluation for deep learning-based classification of volumetric neuroimaging with 3D-to-2D knowledge distillation by Hyemin Yoon, Do-Young Kang, Sangjin Kim

Get full text

Development and Study of Demodulators for Frequency Hopping Spread Spectrum Signals by D. I. Kaplun, V. V. Gulvanskiy, I. I. Kanatov, D. M. Klionskiy, A. B. Khachaturyan, D. N. Butusov, V. F. Lapizkiy, V. I. Bobrovskiy

“…The paper considers the tasks beginning with message type determination.Message type determination can be carried out several ways: using the cross-correlation function, spectral analysis, etc. Since the structure of a synchrosequence is known, it is possible to obtain more precise results using the crosscorrelation function. …”
Get full text

Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions by Birendra Sharma, Birendra Sharma, Krysten A. Jones, Krysten A. Jones, Robert M. Lober, Candice N. Hatcher-Solis

“…Stimulation techniques that target the brain, spinal cord, trigeminal nerve, and vagus nerve (VN) use electrical impulses to modulate neural functions. Among these, vagus nerve stimulation (VNS) is distinguished for its use to stimulate the VN to modulate neural functions. …”
Get full text

Docosahexaenoic acid (DHA) is a driving force regulating gene expression in bluefin tuna (Thunnus thynnus) larvae development by William Koven, Eran Yanowski, Luke Gardner, Oriya Nixon, Barbara Block

Get full text

Sleep Fragmentation Modulates the Neurophysiological Correlates of Cognitive Fatigue by Oumaïma Benkirane, Peter Simor, Olivier Mairesse, Philippe Peigneux

Get full text

The protective effects of active ingredients from acrorus tatarinowii on sperm and their molecular mechanisms by Zonglin Lu, Haiyang Zhao, Hui Wang, Xin Wang, Zixue Sun

“…These findings highlight its potential as a natural remedy for male infertility associated with sperm function disorders.…”
Get full text

Non-coding RNA-mediated granulosa cell dysfunction during ovarian aging: From mechanisms to potential interventions by Li Dong, Haicui Wu, Fanghua Qi, Yuan Xu, Wen Chen, Yuqi Wang, Pingping Cai

“…Recent advancements in research and biotechnology have highlighted the importance of non-coding RNAs (ncRNAs), including micro RNAs, long non-coding RNAs, and circular RNAs, in regulating the biological functions of GCs through gene expression modulation. …”
Get full text

A role for preparatory midfrontal theta in autism as revealed by a high executive load brain–computer interface reverse spelling task by Camila Dias, Teresa Sousa, Aniana Cruz, Diana Costa, Susana Mouga, João Castelhano, Gabriel Pires, Miguel Castelo-Branco

“…Abstract Midfrontal theta oscillations have been linked to executive function, yet their role in autism—where this function is often compromised—remains unclear. …”
Get full text

Dynamic activation and enhanced image contour features for object detection by Jun Wu, Jiahui Zhu, Xin Tong, Tianliang Zhu, Tianyi Li, Chunzhi Wang

“…This paper proposes a lightweight and efficient object detection model based on YOLOv4, first using the lightweight network GhostNet to extract image features and reduce the number of parameters and computation of the backbone structure; then combining AFmodule and Meta-ACON activation function to enhance the feature extraction capability of the backbone network, which strengthen the mode’s ability to capture image spatial feature information; this paper also designs the RL-PAFPN feature fusion structure is with the Reslayer module to further improve the model’s ability to extract and fuse image features. …”
Get full text