Functional characterization of a common XIa inhibitory Kunitz-domain Shp4 from nine schistosoma secreted proteins with diverse C-terminal fragments. by Xiangdong Ye, Xiaolin Deng, Huanhuan Gao, Shuwen Chen, Li Ding, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xudong Luo, Zongyun Chen

“…Structural modelling of nine schistosoma-derived full-length secreted proteins suggested that the C-terminal non-Kunitz-domain fragments might play important roles in modulating the Kunitz-domain functions by steric hindrance effect and transmembrane helix structure. …”
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Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection by Kátia Nunes da Silva, Fernanda Martins Marim, Gisele Vieira Rocha, Zaquer Suzana Munhoz Costa-Ferro, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Bruno Diaz Paredes, Erik Aranha Rossi, Erick Correia Loiola, Corynne Stephanie Ahouefa Adanho, Rachel Santana Cunha, Mayck Medeiros Amaral da Silva, Fernanda Ferreira Cruz, Vivian Vasconcelos Costa, Dalila Lucíola Zanette, Clarissa Araújo Gurgel Rocha, Renato Santana Aguiar, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza

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Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sh... by Yu Zhang, Kaina Zhu, Fengshuo Zhang, Zhenling Wu, Shengzhen Hou, Linsheng Gui

“…The 14% protein diet with RES and HMB improved the hepatic function through modulating the gene and metabolite in Tibetan sheep.…”
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Reaction of the pulp of cutters of rats to the power module

“…It is shown that in these terms influence of a power spring causes structural and functional violations in pulp cages against fall of activity of alkaline phosphatase, quantity calcium-connecting proteins - osteocalcin and annexin V. …”
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Functional Characterization of LTR12C as Regulators of Germ-Cell-Associated TA-p63 in U87-MG and T98-G In Vitro Models by Lucia Meola, Sohum Rajesh Shetty, Angelo Peschiaroli, Claudio Sette, Camilla Bernardini

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An HuR mutant, HuR-V225I, identified in adult T-cell Leukemia/Lymphoma, alters the pro-apoptotic function of HuR by Bianca Colalillo, Sujitha Sali, Ali H. Aldouhki, Isabelle Aubry, Sergio Di Marco, Michel L. Tremblay, Imed E. Gallouzi

“…Moreover, recent studies have shown that HuR modulates the expression of factors important for tumor growth and progression. …”
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iTRAQ-based quantitative proteomic profiling of the regulatory mechanisms on immune functions and blood lipids in aged mice fed with Lentinula edodes-derived polysaccharides by Xiaofei Xu, Xiaofei Liu, Jin Chen, Jingjing Guan, Donghui Luo

“…L2 reversed immune function declines and modulated the lipid metabolism of aged mice evidenced by increased levels of serum TC, HDL-C, and LDL-C, and reduced levels of serum TG. …”
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Lacticaseibacillus casei IDCC 3451 alleviates cognitive and behavioral functions by reshaping the gut microbiome and regulating intestinal barrier integrity in chronic stress anima... by Anna Kang, Ju Young Eor, Junbeom Lee, Min-Jin Kwak, Daniel Junpyo Lee, Eunsol Seo, Woong Ji Lee, Seon-hui Son, Minho Song, Jun-Mo Kim, Hyung Wook Kim, Jungwoo Yang, Sangnam Oh, Younghoon Kim

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TNFR2/CCR8 bispecific antibody enhances antitumor activity through depleting Ti-Tregs and boosting effector CD8+ T cell function by Ran Wang, Jiefang Xu, Shipeng Cheng, Zhiyang Ling, Wangmo Sonam, Jichao Yang, Fuquan Jin, Jing Wen, Xiao Lu, Liyan Ma, Yaguang Zhang, Xiaoyu Sun, Chunyan Yi, Bing Sun

“…Modulation or depletion of tumor-infiltrating Tregs (Ti-Tregs) is a promising strategy in the field of antitumor immunotherapy. …”
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Functional Analysis of KPvRxLR27, a Novel Plasmopara viticola Effector from a Korean Isolate, and Its Role in Hypersensitive Response by Marc Semunyana, Rahel Dinsa Guta, Guogeng Jia, Soomin Lee, Inyong Jeong, Khaing Shwe Zin Thinn, DoYoon Lim, Siyeon Lim, Bomi Lee, HyunJu Kim, May Moe Oo, Sun Ha Kim, Jiyoung Min, Sang-Keun Oh

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Improvement of iron status with elexacaftor tezacaftor ivacaftor therapy is associated with the correction of systemic inflammation and improvement of lung function: a one-year pro... by Hervé Lobbes, Bruno Pereira, Maël Richard, Marie Roux-Perceval, Isabelle Durieu, Quitterie Reynaud

“…Clinical, biological data and pulmonary function tests were collected prospectively at ETI initiation (V0) and after 1 year of ETI (V12). …”
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Engineering a Dual-Function Starch–Cellulose Composite for Colon-Targeted Probiotic Delivery and Synergistic Gut Microbiota Regulation in Type 2 Diabetes Therapeutics by Ruixiang Liu, Yikang Ding, Yujing Xu, Qifeng Wu, Yanan Chen, Guiming Yan, Dengke Yin, Ye Yang

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Heart Rate Variability (HRV) as a Marker of Improved Autonomic Function in PMS: A Homeopathy Intervention-Based Single Blind Randomized Control Study by Nayana P. Barde, Pradip B. Barde, Ajay O. Dahad, Tripathi Shatrugan, Anagha Kulkarni, Tapas K. Kundu

“…Both groups were followed for 6 months. Autonomic function was assessed using HRV, employing NICOMON, and clinical improvement was evaluated through the Menstrual Distress Questionnaire (MDQ). …”
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Dietary Melatonin Supplementation Improved Intestinal Health and Immune Function of Pacific White Shrimp (<i>Litopenaeus vannamei</i>) Under High Alkali Stress by Yiming Li, Yucong Ye, Haojuan Yuan, Zongli Yao, Yan Li, Zhen Sun, Yuxing Wei, Yunlong Zhao, Qifang Lai

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Modulation of Redox-Sensitive Cardiac Ion Channels by Razan Orfali, Al Hassan Gamal El-Din, Varnika Karthick, Elisanjer Lamis, Vanna Xiao, Alena Ramanishka, Abdullah Alwatban, Osama Alkhamees, Ali Alaseem, Young-Woo Nam, Miao Zhang

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Dietary Tribulus Terrestris as a functional food combined with blood flow restriction to enhance the jump performance of basketball athletes: a randomized crossover study by Junhao Kong, Jinda Li, Mingchen Xu, Tao Liu, Zhiyu Xie, Tianhe Li, Yapu Liang

“…IntroductionTribulus terrestris (TT), a food-derived functional ingredient, may influence neuromuscular function via its bioactive compounds, but its acute effects on BFR-induced PAP and performance remain unknown. …”
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Effect of high-intensity intermittent rehabilitation training on physical function, gut microbiome and metabolite after percutaneous coronary intervention in patients with coronary... by Lei Jiang, Pu Liu, Mei Wang, Qiufeng Deng, Jiangpeng Wang, Yan Jiang, Ye Zhu, Haoyu Meng, Xiao Lu, Xiangqing Kong, Leilei Chen

“…However, the impact of HIIT on cardiopulmonary function, gut microbiome and metabolite remains underexplored.MethodsThis study included 60 patients with CHD who underwent percutaneous coronary intervention (PCI). …”
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A new predictive factor VGF based on IHC experiments, gene pathways and molecular functional groups for tumor immune microenvironment and prognosis of adrenocortical carcinoma by Junpeng Chi, Keyuan Lou, Jiankun Zhang, Jiankun Zhang, Jiankun Zhang, Jitao Wu, Yuanshan Cui, Yuanshan Cui

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Dietary supplementation of polysaccharides from Millettia speciosa Champ. ex Benth on growth performance, immune function, antioxidant abilities and intestinal health of Wenchang c... by Yu-hang Liu, Jie Liu, Xin Feng, Quan-Wei Liu, Rui-ping Sun, Wei Wu, Kun Ouyang, Jing-li Yuan, Yan Zhang, Xiu-ping Wang, Gui-Ping Zhao, Li-Min Wei

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Linkage of living microbial biomass, function, and necromass to soil organic carbon storage along a chronosequence of Larix principis-rupprechtii plantation in North China by Mengyun Yang, Xiaomeng He, Jingfei Liang, Qiang Liu, Lihua Fu, Xiaodong Cui, Shaohui Huang, Haoan Luan

“…The partial least squares path model highlighted that SOC stocks were primarily regulated by MRC, while the microbial community altered SOC stability by modulating exo-enzyme activities.DiscussionThese results offered novel insights into elucidating the coupling connections between microbial attributes and SOC sequestration during forest development in northern China.…”
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