Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation by Chiara Sassoli, Federica Pierucci, Alessia Tani, Alessia Frati, Flaminia Chellini, Francesca Matteini, Ambra Vestri, Giulia Anderloni, Daniele Nosi, Sandra Zecchi-Orlandini, Elisabetta Meacci

“…Our findings demonstrate for the first time the trophic role of S1P/S1PR1 signalling in maintaining BM-MSCs’ ability to modulate MMP-2 function, necessary for cytoskeleton reorganization and cell proliferation in both normoxia and hypoxia. …”
Get full text

Bacillus paralicheniformis LN33 fermented feed improves growth performance in Cherry Valley ducks by enhancing immune function and intestinal barrier integrity by Yilong Jiang, Xiaofei Yang, Yi Lei, Songlin Li, Xianxin Chen, Li Jiang

“…The relative abundances of Faecalibacterium, Odoribacter, and Butyricicoccus increased significantly and were positively correlated with intestinal and immune function.DiscussionThese results suggest that B. paralicheniformis-fermented feed enhances growth performance and overall health in Cherry Valley ducks by boosting antioxidant defenses, modulating immune responses, and reshaping the gut microbiota.…”
Get full text

Enhancing cognitive abilities through transcutaneous auricular vagus nerve stimulation: Findings from prefrontal functional connectivity analysis and virtual brain simulation by Sora An, Se Jin Oh, Shinhee Noh, Sang Beom Jun, Jee Eun Sung

“…The simulation results demonstrated that the brain's functional state could vary depending on the network coupling parameter—capable of reflecting loss of structural brain connectivity associated with aging—and that the modulation effects induced by taVNS may also differ based on those functional states. …”
Get full text

Cend1, a Story with Many Tales: From Regulation of Cell Cycle Progression/Exit of Neural Stem Cells to Brain Structure and Function by Maria Gaitanou, Katerina Segklia, Rebecca Matsas

“…During these processes, coordinated regulation of cell cycle progression/exit and differentiation is essential for generation of the appropriate number of neurons and formation of the correct structural and functional neuronal circuits in the adult brain. Cend1 is a neuronal lineage-specific modulator involved in synchronization of cell cycle exit and differentiation of neuronal precursors. …”
Get full text

Diminished negative emotion regulation through affect labeling and reappraisal: insights from functional near infrared spectroscopy on lateral prefrontal cortex activation by Yoshimura Shinpei, Shimomura Kouga, Onoda Keiichi

“…The interaction between affect labeling and reappraisal appears to modulate prefrontal cortex activity, potentially reflecting changes in cognitive processing during emotion regulation attempts. …”
Get full text

The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI by Shengyang Ge, Yunting Xiang, Xuyun Hua, Zening Wang, Qingfeng Hu, Yijun Guo, Jingqiang Huang, Chengpeng Zhao, Jiajia Wu, Xianli Wang, Chuanyu Sun

“…Analysis using ReHo and DC revealed that brain alterations associated with varying symptom severities were localized in pain perception and modulation regions. Specifically, the DC values in the right ACC showed a linear correlation with the severity of symptoms measured by the NIH-CPSI (AUC = 0.9654, p < 0.0001).ConclusionIn CP/CPPS, we first discovered differences in brain function among patients with varying degrees of severity. …”
Get full text

Circuit training intervention for cognitive function, gut microbiota, and aging control: study protocol for a longitudinal, open-label randomized controlled trial by Keishi Soga, Michio Takahashi, Akari Uno, Takamitsu Sinada, Kentaro Oba, Keisei Kawashima, Yasuko Tatewaki, Taizen Nakase, Yasuyuki Taki

“…Although the interaction between exercise and cognitive function is multifaceted, most studies have only examined a direct pathway from exercise to cognitive function. …”
Get full text

The Cardioprotective Potential of Herbal Formulas in Myocardial Infarction-Induced Heart Failure through Inhibition of JAK/STAT3 Signaling and Improvement of Cardiac Function by Youn-Jae Jang, Hye-Yoom Kim, Se-Won Na, Mi-Hyeon Hong, Jung-Joo Yoon, Ho-Sub Lee, Dae-Gill Kang

“…DHT treatment significantly improved cardiac function, as evidenced by increased ejection fraction (EF) from 62.1% to 70.1% (100 mg/kg) and fractional shortening (FS) from 32.3% to 39.4% (200 mg/kg) compared to the MI control group. …”
Get full text

A Postbiotic Derived from <i>Lactobacillaceae</i> Protects Intestinal Barrier Function in a Challenge Model Using Colon Organoid Tubules by Colin I. Cercamondi, Igor Bendik, Erik Eckhardt, Tim Mak, Nicole Seifert, Karin Kuratli, Nathalie Richard, Balint Tamasi, Bernd Mussler, Eva Wintergerst

“…Postbiotics may help strengthen intestinal barrier function. This study assessed the effects of a postbiotic derived from <i>Limosilactobacillus fermentum</i> and <i>Lactobacillus delbrueckii</i> subsp. …”
Get full text

Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease by Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

Get full text

Dietary resistant starch protects against post-antibiotic intestinal damage by restoring microbial homeostasis and preserving intestinal barrier function in meat duck by Simeng Qin, Yifeng Zhu, Gang Tian, Martin Blomberg Jensen, Keying Zhang, Xuemei Ding, Shiping Bai, Jianping Wang, Yue Xuan, Qiufeng Zeng

“…Resistant starch (RS) is recognized as a nutritional strategy that supports gut and overall host health by modulating gut microbiota. To directly assess the effects of RS on gut microbiota and its role in improving intestinal barrier function in meat ducks, this study first established an antibiotic-induced microbial dysbiosis model, which was characterized by reduced gut microbial diversity, intestinal dysfunction, and an inflammatory outburst following antibiotic exposure. …”
Get full text

Bioprospection for antiviral compounds from selected medicinal plants against RNA polymerase of rotavirus A using molecular modelling and density functional theory by Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha

“…Furthermore, the ability of the resulting compounds to modulate the investigated target was assessed using molecular dynamics (MD) simulation, while density functional theory (DFT) calculations were conducted to predict the molecular properties of the top-ranked compounds. …”
Get full text

Corticospinal Intermittent Theta Burst Stimulation Propelling Sensorimotor Function Recovery in Complete Spinal Cord Injury: Protocol for a Randomized Controlled Trial by Deeksha Patel, Rohit Banerjee, Kamran Farooque, Deepak Gupta, Bhavuk Garg, Nand Kumar, Kanwal Preet Kochhar, Suman Jain

“…The results of this study will uncover the effectiveness of iTBS stimulation on (1) recovery of motor and sensory function in cSCI, (2) excitability of the corticospinal tract, (3) neurological recovery and modulation of pain, and (4) cortical reorganization after injury. …”
Get full text

Itaconate derivative 4-OI inhibits M1 macrophage polarization and restores its impaired function in immune thrombocytopenia through metabolic reprogramming by Qiang Liu, Anli Liu, Shaoqiu Leng, Xiaoyu Zhang, Xiaolin Wang, Zhang Cheng, Shuwen Wang, Jun Peng, Qi Feng, Sihan Zhou, Xiuyuan Hao

“…Macrophage polarization, antigen-presenting functions, and phagocytic capability were measured via flow cytometry and enzyme-linked immunosorbent assay (ELISA). …”
Get full text

Complex Medium-Chain Triglycerides Mitigate Porcine Epidemic Diarrhea Virus Infection in Piglets by Enhancing Anti-Inflammation, Antioxidation, and Intestinal Barrier Function by Tingting Hu, Yunhao Liu, Sihui Gao, Xiaonan Zhao, Huangzuo Cheng, Youjun Hu, Huaqiao Tang, Zhiwen Xu, Chunlin Fang

“…These results demonstrate that CMCTs mitigate PEDV infection by enhancing anti-inflammation, antioxidation, and intestinal barrier function, as well as modulating gut microbiota composition. …”
Get full text

USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins by Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q

“…Small extracellular vesicles (sEVs) encapsulate diverse bioactive components, making them potential therapeutic agents. Designing functional scaffolds that incorporate sEVs is a promising approach for scarless vaginal defect repair.Methods: sEVs-loaded scaffolds were developed through electrostatic interactions between negatively charged sEVs secreted by urine-derived stem cells (USC-sEVs) and positively charged human acellular amniotic membranes. …”
Get full text

Genome-wide characterization of monoacylglycerol lipase (MAGL) gene family in soybean and functional analysis of GmMAGLs in storage lipid metabolism and drought resistance by Haiqing Jing, Yan Sun, Bicheng Wang, Juhua Ma, Kun Wan, Zhanqian Li, Yali Zhou, Runzhi Li, Haiping Zhang, Jinai Xue

“…Although MAGL is critical for TAG metabolism, its physiological roles in plants remain poorly understood, compared to its functions in mammals. Results Eighteen GmMAGL genes were identified from the genome of soybean (Glycine max), a major food and oil crop worldwide, with them being classified into 8 distinct subfamilies. …”
Get full text

Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer by Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Da Li, Da Li, Da Li, Da Li, Chao Quan, Chao Quan, Zhu Yu, Zhu Yu, Zhu Yu, Yue Feng, Yue Feng, Yue Feng, Yue Feng, Shengyu Wang, Shengyu Wang, Shengyu Wang, Shengyu Wang, Yong Li, Yong Li, Yong Li, Yong Li, Tongtong Qi, Tongtong Qi, Tongtong Qi, Tongtong Qi, Junqiang Chen, Junqiang Chen, Junqiang Chen, Junqiang Chen

“…To investigate the functional impact of FZD2, loss-of-function experiments were carried out in gastric cancer cell lines using siRNA-mediated knockdown. …”
Get full text

An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell by Yunchen Gong, Yoshito Kakihara, Nevan Krogan, Jack Greenblatt, Andrew Emili, Zhaolei Zhang, Walid A Houry

“…Abstract Molecular chaperones are known to be involved in many cellular functions, however, a detailed and comprehensive overview of the interactions between chaperones and their cofactors and substrates is still absent. …”
Get full text

4D-printed intelligent reflecting surface with improved beam resolution via both phase modulation and space modulation by Kyounghwan Kim, Ratanak Phon, Eiyong Park, Sungjoon Lim

“…The functions are first theoretically and numerically analyzed and then experimentally verified, demonstrating that additional angles of −46°/+50°, −22°/+14°, and −16°/+12° are achieved with space modulation and −60°/+62°, −30°/+22°, and ±16° are achieved by phase modulation alone. …”
Get full text