Amino Acid Substitutions in Bacteriocin Lactolisterin BU Reveal Functional Domains Involved in Biological Activity Against <i>Staphylococcus aureus</i> by Lazar Gardijan, Milka Malešević, Miroslav Dinić, Aleksandar Pavić, Nikola Plačkić, Goran Jovanović, Milan Kojić

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Hybrid Assistive Neuromuscular Dynamic Stimulation Therapy: A New Strategy for Improving Upper Extremity Function in Patients with Hemiparesis following Stroke by Toshiyuki Fujiwara, Michiyuki Kawakami, Kaoru Honaga, Michi Tochikura, Kaoru Abe

“…Paretic upper extremity motor function improved after 3 weeks of HANDS therapy. Functional improvement of upper extremity motor function and spasticity with HANDS therapy is based on the disinhibition of the affected hemisphere and modulation of reciprocal inhibition. …”
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The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling by Stefanie Lichtenberg, Laura Vinnenberg, Falk Steffen, Isabelle Plegge, Nicholas Hanuscheck, Vera Dobelmann, Joel Gruchot, Christina B. Schroeter, Haribaskar Ramachandran, Beatrice Wasser, Derya Bachir, Christopher Nelke, Jonas Franz, Christoph Riethmüller, Stefan Tenzer, Ute Distler, Christina Francisca Vogelaar, Kristina Kusche-Vihrog, Boris V. Skryabin, Timofey S. Rozhdestvensky, Albrecht Schwab, Jean Krutmann, Andrea Rossi, Thomas Budde, Stefan Bittner, Sven G. Meuth, Tobias Ruck

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The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress. by Raymond Buser, Vanessa Kellner, Andre Melnik, Caroline Wilson-Zbinden, René Schellhaas, Lisa Kastner, Wojciech Piwko, Martina Dees, Paola Picotti, Marija Maric, Karim Labib, Brian Luke, Matthias Peter

“…Our results suggest that the Rtt101(Mms22) E3 ligase does not induce Mrc1 degradation, but specifically counteracts Mrc1's replicative function, possibly by modulating its interaction with the CMG (Cdc45-MCM-GINS) complex at stalled forks.…”
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Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor by Guang-ju Zhao, Jia-yi Zheng, Jia-lan Bian, Long-wang Chen, Ning Dong, Yan Yu, Guang-liang Hong, Arvine Chandoo, Yong-Ming Yao, Zhong-qiu Lu

“…Gas6 has a direct effect on the functions of CD4+CD25+Tregs mainly through its interaction with Axl receptor.…”
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Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone–Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation by Yu Wang, Xiaoyu Tong, Yan Xiao, Yicong Wang, Wei Hu, Wenhan Lu, Yuning Chen, Jiajia Li, Wenhao Gao, Hongru Gao, Yicheng Tian, Sizhe Dai, Yi Feng

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Mutations of Key Functional Residues in CRM1/XPO1 Differently Alter Its Intranuclear Localization and the Nuclear Export of Endogenous Cargos by Miren Josu Omaetxebarria, Maria Sendino, Liher Arrizabalaga, Irune Mota, Ana Maria Zubiaga, José Antonio Rodríguez

“…CRM1 (XPO1) has been well-characterized as a shuttling receptor that mediates the export of protein and RNA cargos to the cytoplasm, and previous analyses have pinpointed several key residues (A541, F572, K568, S1055, and Q742) that modulate CRM1 export activity. CRM1 also has a less studied nuclear function in RNA biogenesis, which is reflected by its localization to the Cajal body and the nucleolus. …”
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CD317 stabilizes TNFR1 and confers the anti-inflammatory functions of MSCs via NF-κB/TSG6 pathway by Si Chen, Lan Yao, Xin Wen, Xianqi Wang, Lin Chen, Jingting Zhang, Jianyong Xu

“…Methods In the current study, we performed both in vitro and in vivo investigations to delineate whether and how CD317 regulates the immune modulation function of MSCs. Results Our data here indicate that the CD317 directly contributes to the immune suppression function of MSCs stimulated by TNF-α through up-regulating TSG6 via CD317/lipid-raft/TNFR1 complex. …”
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Functional Expression of NMDA Receptors in SH-SY5Y Neuroblastoma Cells Following Long-Term RA/BDNF-Induced Differentiation by Ya-Jean Wang, Yun-Hsiang Chen, Eric Hwang, Che-Jui Yeh, You-Xuan Liu, Hwei-Hsien Chen, Sheng-Nan Wu

“…Differentiated SH-SY5Y cells exhibited neurite outgrowth, evoked action potential firing, and functional NMDA receptor-mediated currents. Notably, atorvastatin significantly modulated the duration and firing of action potentials as well as NMDA receptor-mediated currents in differentiated SH-SY5Y cells. …”
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Change in striatal functional connectivity networks across 2 years due to stimulant exposure in childhood ADHD: results from the ABCD sample by Adam Kaminski, Hua Xie, Brylee Hawkins, Chandan J. Vaidya

“…Thus, stimulant exposure for a two-year period under real-world conditions modulated striatal-cortical functional networks broadly, had a normalizing effect on a subset of networks, and was associated with potential therapeutic effects involving visual attentional control.…”
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Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana. by Christian Kappel, Gerda Trost, Hjördis Czesnick, Anna Ramming, Benjamin Kolbe, Son Lang Vi, Cláudia Bispo, Jörg D Becker, Cornelia de Moor, Michael Lenhard

“…As shown by their different mutant phenotypes, these three isoforms are functionally specialized, with PAPS1 modifying organ growth and suppressing a constitutive immune response. …”
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The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psy... by Tadahiro Numakawa, Ryutaro Kajihara

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Multi-functionalized probiotics through layer-by-layer coating with tannic acid-Mg2+ and casein phosphopeptide complexes for preventing ulcerative colitis by Zhanyin Qian, Zihan Zhai, Mingjin Ren, Yuanyuan Cheng, Mingxin Cao, Yue Wang, Linyi Dong, Chunyu Li, Hailong Cao, Yinsong Wang

“…In summary, this study provides an efficient coating strategy to develop multi-functionalized probiotics for preventing UC.…”
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ZnO-SnO2/WO3-x heterojunction artificial synapse for realization and integration of multiple biological cognitive functions by Pengfei Sun, Ruidong Li, Haotian Meng, Tao Sun, Song Gao, Yang Li

“…In current memristor-based neuromorphic computing research, several studies face the challenge of realizing only a single function at a time or having isolated functions. This limitation is particularly evident when simulating biological cognition, as the overall synergy between multiple cognitive functions is difficult to represent. …”
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Effects of two-year adapted physical exercise program and nutritional counselling on cardio-sarcopenia syndrome in older adults with low muscle function by Giovanna Pelà, Sara Tagliaferri, Elisa Adorni, Marina Aiello, Marco Salvi, Irene Zucchini, Riccardo Calvani, Emanuele Marzetti, Fulvio Lauretani, Giampaolo Niccoli, Marcello Maggio

“…However, we captured the longitudinal effects of cardiovascular aging, including the reduction of left ventricular volumes and an impairment of systolic and diastolic function of both ventricles. We found a significant relationship between left ventricular mass and skeletal muscle mass, suggesting the existence of cardiac-skeletal muscle axis. …”
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In silico identification of potential calcium dynamics and sarcomere targets for recovering left ventricular function in rat heart failure with preserved ejection fraction. by Stefano Longobardi, Anna Sher, Steven A Niederer

“…However, the link between cellular level modulations and whole organ pump function is incompletely understood. …”
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PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling by Alican Güran, Yanlong Ji, Pan Fang, Kuan-Ting Pan, Henning Urlaub, Metin Avkiran, Christof Lenz, Kate L. Weeks

“…These findings reaffirm a key role for B56α as a mediator of physiologically important cardiac responses to β-AR stimulation and reveal potential new molecular mechanisms for this regulatory function, including putative cardiac B56α substrates.…”
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Functionally graded scaffold with M2 macrophage-derived LncRNA-Encoded peptide: Mechanistic and therapeutic evaluation for rotator cuff repair by Hao Feng, Gonghao Zhang, Li Xiong, Panpan Shang, Xiao Yu, Bin Chai, Lu Han, Shuqi Lou, Muhammad Shafiq, Yiying Zhang, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Zhengchao Yuan, Xiumei Mo, Yunhan Ji

“…During rotator cuff repair process, the scaffold functioned as an augmentation patch, with mechanical properties (Young's modulus, ca. 280 MPa) comparable to native tendons, prevented rotator cuff re-tearing in an early stage. …”
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Characterization of DnaJ gene family in Castanea mollissima and functional analysis of CmDnaJ27 under cold and heat stresses by Liyang Yu, Yujuan Tian, Jinxin Wang, Dongsheng Wang, Xuan Wang, Haie Zhang, Jingzheng Zhang, Xiangyu Wang

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Plant species diversity and abundance of functional groups influence net nitrogen mineralization along productivity gradients in montane Calluna‐dominated heathlands by José Manuel Fernández‐Guisuraga, Leonor Calvo, Elena Marcos

“…Societal Impact Statement Heathlands are globally important ecosystems that provide key functions and services but are increasingly threatened by land use changes. …”
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