Ultrasound-driven wireless piezoelectric hydrogel synergizes with cotransplantation of NSCs–hUCMSCs for structural and functional recovery in spinal cord injury by Hao Zhong, Mi Zhou, Junrui Guo, Danyang Chen, Cong Xing, Song Liu, Hongjiang Yang, Hongpeng Ma, Qi Zhang, Jianhai Yang, Shiqing Feng, Guangzhi Ning

“…Neural stem cells (NSCs) have the potential to promote functional recovery after SCI; however, their therapeutic potential is limited by poor survival, restricted proliferation, and suboptimal differentiation. …”
Get full text

Low‐Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients by Etianne Martini Sasso, Etianne Martini Sasso, Etianne Martini Sasso, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Peter Smith, Peter Smith, Katsuhiko Muraki, Katsuhiko Muraki, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik

“…Electrophysiological experiments were conducted to assess TRPM3 ion channel functions modulated by pregnenolone sulfate (PregS) and ononetin.ResultsThe findings from this current research are the first to demonstrate that long COVID patients treated with LDN have restored TRPM3 ion channel function and validate previous reports of TRPM3 ion channel dysfunction in NK cells from individuals with long COVID not on treatment. …”
Get full text

Functional Attributes of Synovial Fluid from Osteoarthritic Knee Exacerbate Cellular Inflammation and Metabolic Stress, and Fosters Monocyte to Macrophage Differentiation by Vanshika Srivastava, Abhay Harsulkar, Shama Aphale, Aare Märtson, Sulev Kõks, Priya Kulkarni, Shantanu Deshpande

“…<b>Background:</b> Besides conventional norms that recognize synovial fluid (SF) as a joint lubricant, nutritional channel, and a diagnostic tool in knee osteoarthritis (kOA), based on the authors previous studies, this study aims to define functional role of SF in kOA. <b>Methods:</b> U937, a monocytic, human myeloid cell line, was induced with progressive grades of kOA SF, and the induction response was assessed on various pro-inflammatory parameters. …”
Get full text

Functional Characterization of Deubiquitinase UBP Family and Proteomic Analysis of Aaubp14-Mediated Pathogenicity Mechanism in <i>Alternaria alternata</i> by Jiejing Tang, Hang Zhou, Chen Jiao, Hongye Li

“…Our findings elucidate <i>Aaubp</i> gene function in development and pathogenicity, particularly the Aaubp14-mediated regulation mechanism, providing insights into ubiquitination-mediated pathogenicity in phytopathogenic fungi.…”
Get full text

Unraveling the structural and functional consequences of non-synonymous single-nucleotide polymorphisms (nsSNPs) in human SOCS2: an in silico approach by Tanvir Hossain, Md. Nur Islam, Md. Anwar Hossain, Md. Mofizur Rahman, Mohammed Mafizul Islam, Shipan Das Gupta

“…Multiple non-synonymous SNPs (nsSNPs) have been found in the SOCS2 gene, which could affect protein function. However, there is limited understanding of disease susceptibility and abnormal functioning associated with these mutated SOCS2 gene. …”
Get full text

GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development by Jun Ma, Peng Yang, Zhibin Zhou, Tengfei Song, Liang Jia, Xiaofei Ye, Wei Yan, Jiuyi Sun, Tianwen Ye, Lei Zhu

Get full text

Transcriptome analysis of hsp18.3 functions and regulatory systems using RNA-sequencing in the red flour beetle, Tribolium castaneum by Wen-feng XIONG, Jia XIE, Lu-ting WEI, Si-si ZHANG, Xiao-wen SONG, Shan-shan GAO, Bin LI

“…Additionally, 569 differentially expressed genes (DEGs) were identified from the ds-Tchsp18.3 and control groups, of which 246 DEGs were annotated in the 47 Gene Ontology (GO) functional groups and 282 DEGs were assigned to 147 Kyoto Encyclopedia of Genes and Genomes (KEGG) biological signaling pathways. …”
Get full text

Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma by Weifeng Zeng, Furong Liu, Yachong Liu, Ze Zhang, Haofan Hu, Shangwu Ning, Hongwei Zhang, Xiaoping Chen, Zhibin Liao, Zhanguo Zhang

“…Meanwhile, TM4SF1-mediated AKT phosphorylation enhanced PD-L1 expression while reducing major histocompatibility complex class I level on tumor cells, leading to impaired cytotoxic function of CD8+ T cells and an increased proportion of exhausted CD8+ T cells. …”
Get full text

Co-exposure of ferruginous components of subway particles with lipopolysaccharide impairs vascular function: A comparative study with ambient particulate matter by Oluwatoyin Hannah Owokoniran, Akiko Honda, Takamichi Ichinose, Raga Ishikawa, Megumi Nagao, Natsuko Miyasaka, Zaoshi Wang, Satsuki Takai, Issei Omori, Kerui Zhang, Wei Liu, Yuya Higaki, Takayuki Kameda, Tomonari Matsuda, Taku Fujiwara, Tomoaki Okuda, Hirohisa Takano

“…Thus, iron oxide-rich subway particulate poses more health risks than outdoor ambient particles since they can significantly impair endothelial function, particularly through gross cellular and vascular homeostatic protein damage, and induce exacerbated inflammatory responses during co-exposure. …”
Get full text

AMF30a promotes survival and function of human corneal endothelial cells by regulating TGF-β/ROCK/HIPPO pathway by Yunkyoung Ryu, Hye-Jin Son, Jin Sun Hwang, Kyung Bo Noh, Sun-Hee Oh, Eun-Kyoung Choi, Young Joo Shin

“…In this study, we investigated the effect of AMF30a, PAD2 inhibitor, on survival and function of CECs. Cultured human CECs (hCECs) were treated with AMF30a, followed by treatments with or without AMF30a under transforming growth factor-beta (TGF-β). …”
Get full text

Acupuncture Alters Brain’s Dynamic Functional Network Connectivity in Stroke Patients with Motor Dysfunction: A Randomised Controlled Neuroimaging Trial by Yahui Wang, Mengxin Lu, Ruoyi Liu, Liping Wang, Yue Wang, Lingling Xu, Kang Wu, Chen Chen, Tianzhu Chen, Xinyue Shi, Kuangshi Li, Yihuai Zou

“…Acupuncture has the potential to modulate abnormal temporal properties and promote the balance of separation and integration of brain function. …”
Get full text

Functional and quality of life outcomes after partial glossectomy: a multi-institutional longitudinal study of the head and neck research network by Agnieszka Dzioba, Daniel Aalto, Georgina Papadopoulos-Nydam, Hadi Seikaly, Jana Rieger, Johan Wolfaardt, Martin Osswald, Jeffrey R. Harris, Daniel A. O’Connell, Cathy Lazarus, Mark Urken, Ilya Likhterov, Raymond L. Chai, Erika Rauscher, Daniel Buchbinder, Devin Okay, Risto-Pekka Happonen, Ilpo Kinnunen, Heikki Irjala, Tero Soukka, Juhani Laine, Head and Neck Research Network

“…Abstract Background While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their communicative function, swallowing ability, and quality of life after primary surgery [with or without adjuvant (chemo)radiation therapy] for tongue cancer over the course of the first year post-operation. …”
Get full text

Chicken GLUT4 function via enhancing mitochondrial oxidative phosphorylation and inhibiting ribosome pathway in skeletal muscle satellite cells by Lin Zhang, Pengna Luo, Huihong Li, Yuxian Pan, Huaiyong Zhang, Xuemeng Si, Wen Chen, Yanqun Huang

Get full text

Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis by Erica Ferrini, Costanza Bonfini, Giovanna Marchese, Martina Buccardi, Matteo Zoboli, Primetta Faccioli, Nicola Sverzellati, Gino Villetti, Simone Ottonello, Maria Ravo, Franco F. Stellari

Get full text

Association of over-the-counter mouthwash use with markers of nitric oxide metabolism, inflammation, and endothelial function—a cross-sectional study by Kai Guo, Kaumudi Joshipura, Karina Ricart, Rakesh P. Patel, Barbara A. Gower, Oelisoa Mireille Andriankaja, Evangelia Morou-Bermudez

“…IntroductionRegular use of mouthwash can disrupt nitrate reduction by oral bacteria and may affect systemic nitric oxide (NO) levels, which are important for inflammation and endothelial function. We aim to assess the association between over-the-counter (OTC) mouthwash use and nitrate/nitrite, markers of inflammation (IL-6, TNF-α, CRP) and endothelial function (sICAM-1, sVCAM-1) in serum and saliva, and to assess the relationship between nitrate/nitrite levels and these biomarkers, as well as how OTC mouthwash modulated this relationship. …”
Get full text

11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats. by M. V. Korokin, V. O. Soldatov, A. A. Tietze, M. V. Golubev, A. E. Belykh, M. V. Kubekina, O. A. Puchenkova, T. A. Denisyuk, V. V. Gureyev, T. G. Pokrovskaya, O. S. Gudyrev, M. A. Zhuchenko, M. A. Zatolokina, M. V. Pokrovskiy

“…P-αB, or erythropoietin (EPO), was used for therapy at the dose of 2.5 µg/100 g × 3 times for 7 days, the total dose was 7.5 µg/100 g. The function of endothelium was estimated by an endothelium-dependent and endothelium-independent vasodilation. …”
Get full text

Metformin-Enhanced Secretome from Periodontal Ligament Stem Cells Promotes Functional Recovery in an Inflamed Periodontal Model: In Vitro Study by Han Na Suh, Ju Young Ji, Jung Sun Heo

“…Here, we aimed to assess the composition of CM from periodontal ligament stem cells (PDLSCs) grown in metformin-preconditioned media (Met-CM) compared to normal PDLSC-CM and assess the ability of Met-CM to recover the function of inflamed PDLSCs. Methods: Met-CM and normal CM were collected from PDLSCs grown with or without 50 µM metformin, respectively, under healthy culture conditions. …”
Get full text

Integrated functional genomic analysis identifies regulatory variants underlying a major QTL for disease resistance in European sea bass by Robert Mukiibi, Serena Ferraresso, Rafaella Franch, Luca Peruzza, Giulia Dalla Rovere, Massimiliano Babbucci, Daniela Bertotto, Anna Toffan, Francesco Pascoli, Sara Faggion, Carolina Peñaloza, Costas S. Tsigenopoulos, Ross D. Houston, Luca Bargelloni, Diego Robledo

“…To identify the mechanisms and genetic factors underpinning resistance to VNN in European sea bass, we employed integrative analyses of multiple functional genomics assays in European sea bass. Results The estimated heritability of VNN resistance was high (h 2 ~ 0.40), and a major QTL explaining up to 38% of the genetic variance of the trait was confirmed on chromosome 3, with individuals with the resistant QTL genotype showing a 90% survivability against a VNN outbreak. …”
Get full text

Transcutaneous Spinal Stimulation Combined with Locomotor Training Improves Functional Outcomes in a Child with Cerebral Palsy: A Case Study by Darryn Atkinson, Kristen Barta, Fabian Bizama, Hazel Anderson, Sheila Brose, Dimitry G Sayenko

“…He was classified in the Gross Motor Function Classification System (GMFCS) at Level III. …”
Get full text

Effects of guanidinoacetic acid supplementation on growth performance, serum biochemical parameters, immune function, and antioxidant capacity in Xinjiang Hu sheep by Wenshu Zhu, Jiancheng Liu, Yakun Wang, Xucheng Mo, Wenshuai Zeng, Zixuan Ye, Mengjian Liu

“…Antioxidant capacity improved in both groups, with RPGAA uniquely enhancing glutathione activity (P&lt;0.05) alongside increased SOD, T-AOC, and CAT activities (P&lt;0.05) and reduced MDA (P&lt;0.05).ConclusionDietary supplementation with 1.0 g/kg guanidinoacetic acid (GAA) or rumen-protected GAA (RPGAA) significantly enhances growth performance, nutrient metabolism, antioxidant capacity, and immune function in Hu sheep while mitigating inflammation in northern Xinjiang region. …”
Get full text