503 A novel approach to developing and validating a predictive model of functional recovery for adults with stroke in post-acute rehabilitation by Alison Cogan, Dongze Ye, Dingyi Nie, Mary Lawlor, Nicolas Schweighofer

“…Objectives/Goals: To use patient-level Center for Medicare and Medicaid Services (CMS) mandated quality metrics for inpatient rehabilitation facilities (IRFs) to develop and validate predictive models of functional recovery and interactions of baseline characteristics with therapy time. …”
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Dual-transcriptomics on microdissected cells reveals functional specialisation of symbiont-bearing-cells and contrasted responses to nutritional stress in the cereal weevil by Nikoletta Galambos, Nicolas Parisot, Agnès Vallier, Claudia Bevilacqua, Séverine Balmand, Carole Vincent-Monégat, Rita Rebollo, Benjamin Gillet, Sandrine Hughes, Abdelaziz Heddi, Anna Zaidman-Rémy

“…We found that central bacteriocytes overexpress transport and G-protein signalling-related genes when compared to peripheral bacteriocytes, indicating a signalling and/or transport function of these cells. Diet composition strongly impacts host and endosymbiont gene expression and reveals a molecular trade-off among metabolic pathways. …”
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Species and functional composition of cecal microbiota and resistance gene diversity in different Yunnan native chicken breeds: A metagenomic analysis by Zonghui Jian, Hao Wu, Shixiong Yan, Tengchuan Li, Ruohan Zhao, Jingying Zhao, Xiannian Zi, Kun Wang, Ying Huang, Dahai Gu, Sumei Zhao, Changrong Ge, Junjing Jia, Lixian Liu, Zhiqiang Xu, Tengfei Dou

“…The gut microbiota of chickens not only modulates host immune function and production performance through nutrient metabolism but also serves as a reservoir for antibiotic resistance genes (ARGs), whose accumulation exacerbates bacterial resistance. …”
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Proteins derived from Bombyx batryticatus utilizing variable ultrasound powers: Evaluation of structural attributes, functional characteristics, and antioxidant capacities by Jing-ya Wang, Xi Peng, Qiao-Ling Deng, Zhi-Kun Wang, Kui-Xu Gao, Yao Wang, Yu-jie Liu, Mei-bian Hu

“…Furthermore, ultrasound extraction (UAE) at the appropriate UP broke down PBB into small and evenly dispersed fragments, and it also reshaped disordered PBB aggregates into a more regular, dispersed, and ordered arrangement. Also, it favorably modulated the functional properties of PBB, with notable improvements in solubility, water-holding capacity, emulsification properties, and emulsion stability. …”
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A Dual-Stream Deep Learning Architecture With Adaptive Random Vector Functional Link for Multi-Center Ischemic Stroke Classification by Mahesh Anil Inamdar, Anjan Gudigar, U. Raghavendra, Massimo Salvi, Raja Rizal Azman Bin Raja Aman, Nadia Fareeda Muhammad Gowdh, Izzah Amirah Binti Mohd Ahir, Mohd Salahuddin Bin Kamaruddin, Khairul Azmi Abdul Kadir, Filippo Molinari, Ajay Hegde, Girish R. Menon, U. Rajendra Acharya

“…Three significant innovations are included in the suggested architecture: (1) a hybrid Dual Attention Mechanism that combines Dynamic Routing and Cross-Attention for improved region-specific feature discrimination; (2) a Multi-Scale Feature Extraction Module with parallel convolutional pathways that captures both contextual and fine-grained features; and (3) an Adaptive Random Vector Functional Link layer that significantly reduces training time while maintaining high classification performance. …”
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Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling by Anu Jain, Rafaela Muniz de Queiroz, Jayanta K. Chakrabarty, Karl A. T. Makepeace, Carol Prives, Lewis M. Brown

“…Results: Protein ontology and function were analyzed, revealing which pathways are affected by modulation of the proteins that form the complex. …”
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Association between Scale-Free Brain Dynamics and Behavioral Performance: Functional MRI Study in Resting State and Face Processing Task by Masato Kasagi, Zirui Huang, Kosuke Narita, Hitoshi Shitara, Tomokazu Motegi, Yusuke Suzuki, Kazuyuki Fujihara, Sean Tanabe, Hirotaka Kosaka, Koichi Ujita, Masato Fukuda, Georg Northoff

“…In this functional fMRI study in the resting state and face processing + control task, we investigated PLE during both the resting state and task-evoked activities, as well as its relationship with behavior measured using mean reaction time (mRT) during the task. …”
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Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line. by Aditya J Desai, David J Roberts, Gareth O Richards, Timothy M Skerry

“…Furthermore, we show that normal RAMP1 function is required for intracellular responses to ligands. …”
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The validity and reliability of the Juvenile Arthritis Functional Assessment Report (JAFAR) in children/adolescents with Juvenile Idiopathic Arthritis: The Turkish version study by Selcuk Yuksel, Zahide Ekici Tekin, Gülçin Otar Yener, Bilge Başakçı Çalık, Merve Bali, Elif Gur Kabul

“…The aim of the study was to describe the validity and reliability of the Turkish version of Juvenile Arthritis Functional Assessment Report (JAFAR) in children/adolescents with Juvenile Idiopathic Arthritis (JIA). …”
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An Integral of Fox’s H-Functions With Application to the Performance of Hybrid FSO/RF Systems Over Generalized Fading Channels by Wagdy Ameen Alathwary, Essam Saleh Altubaishi

“…New expressions for average bit error rate (ABER) and ergodic capacity are obtained in terms of bivariate Fox’s H-function (BFHF) under subcarrier intensity modulation (SIM) and heterodyne detection (HD). …”
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LuCSD3 enhances salt stress tolerance in flax: genome-wide profiling and functional validation of the SOD gene family by Yuan Zhang, Ruinan Wang, Hengping Wang, Huiyan Wang

“…Transcriptomic profiling demonstrated ubiquitous high expression of LuSOD genes in leaf tissues. qRT-PCR validation under cold, drought, and salt stresses revealed significant upregulation of nine LuSOD genes, implicating their involvement in antioxidant defense mechanisms. Functional characterization of LuCSD3 in transgenic Arabidopsis confirmed its role in enhancing salt tolerance through ROS homeostasis modulation. …”
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Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation by Kendra R. Vann, Rajal Sharma, Chih-Chao Hsu, Maeva Devoucoux, Adam H. Tencer, Lei Zeng, Kevin Lin, Li Zhu, Qin Li, Catherine Lachance, Ruben Rosas Ospina, Qiong Tong, Ka Lung Cheung, Shuai Yang, Soumi Biswas, Hongwen Xuan, Jovylyn Gatchalian, Lorena Alamillo, Jianlong Wang, Suk Min Jang, Brianna J. Klein, Yue Lu, Patricia Ernst, Brian D. Strahl, Scott B. Rothbart, Martin J. Walsh, Michael L. Cleary, Jacques Côté, Xiaobing Shi, Ming-Ming Zhou, Tatiana G. Kutateladze

“…We find that ASH1LPHD recognizes H3K4me2/3, whereas the neighboring ASH1LBD and ASH1LBAH have DNA binding activities. The DNA binding function of ASH1LBAH is a driving force for the association of ASH1L with the linker DNA in the nucleosome, and the large interface with ASH1LPHD stabilizes the ASH1LBAH fold, merging two domains into a single module. …”
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Regulation of immune responses by a tumor necrosis factor in pearl oysters: insights from PmTNF gene expression and function by Wu Yifan, Liang Bidan, Liang Haiying

“…Tumor necrosis factor (TNF) is a multifunctional cytokine that regulates cellular processes such as inflammation, apoptosis, differentiation, and proliferation and activates various functions of the immune system. This article reports the discovery and characterization of a novel tumor necrosis factor gene in the pearl oyster Pinctada fucata martensii, which is named PmTNF. …”
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Two functional indel polymorphisms in the promoter region of the Brahma gene (BRM) and disease risk and progression-free survival in colorectal cancer. by Yajun Yu, Dangxiao Cheng, Patrick Parfrey, Geoffrey Liu, Sevtap Savas

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BIOCHEMICAL INDICES OF ORAL FLUID AS MARKERS FOR THE FEATURES OF THE STRUCTURAL AND FUNCTIONAL STATE OF THE STOMATOGNATIC SYSTEM IN PERSONS WHO WERE BORN WITH MACROSOMIA by O.V. Garmash

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The effects of copper-loaded montmorillonite on intestinal morphology, microbiota, barrier function, antioxidant capacity, and gut-related gene expression in broilers by Xinru Hu, Yiwen Rao, Peiqianng Yuan, Xingyong Chen, Cheng Zhang

“…In conclusion, Cu-MMT enhances the growth of broilers by enhancing intestinal barrier integrity, modulating gut microbiota, augmenting intestinal antioxidant capacity and promoting intestinal digestion and absorption functions, making it a promising feed additive.…”
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Application of the Monaco-serial biological function for cardiac dose constraints in DIBH-IMRT treatment planning for left-sided breast cancer by Haili Hu, Haili Hu, Zhou Jueyi, Jiang Hao, Jianjun Lai, Jianjun Lai

“…BackgroundThe Serial function in the Monaco treatment planning system is essential for cardiac dose optimization in left breast cancer radiotherapy; however its optimal K-value for deep-inspiration breath-hold intensity-modulated radiotherapy (DIBH-IMRT) has not been established. …”
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Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice by Ditte Gry Ellman, Matilda Degn, Minna Christiansen Lund, Bettina Hjelm Clausen, Hans Gram Novrup, Simon Bertram Flæng, Louise Helskov Jørgensen, Lujitha Suntharalingam, Åsa Fex Svenningsen, Roberta Brambilla, Kate Lykke Lambertsen

“…In addition, microglial and leukocyte infiltration, activation state (Iba1, CD11b, CD11c, CD45, and MHCII), lesion size, and functional outcome after moderate SCI were comparable between genotypes. …”
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Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma by Junjie Wang, Pixu Gong, Qingqing Liu, Menglei Wang, Dengfang Wu, Mengyu Li, Shujie Zheng, Han Wang, Han Wang, Qiaoming Long

“…BackgroundDendritic cells (DCs) are versatile professional antigen-presenting cells and play an instrumental role in the generation of antigen-specific T-cell responses. Modulation of DC function holds promise as an effective strategy to improve anti-tumor immunotherapy efficacy and enhance self-antigen tolerance in autoimmune diseases.MethodsWild-type (WT) and TLR2 knockout (KO) mice at 2 weeks of age were injected intraperitoneally (i.p.) with a single dose of diethylnitrosamine (DEN) to induce hepatocellular carcinoma (HCC). …”
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Beat‐to‐Beat Blood Pressure Variability Within 24 Hours of Ischemic Stroke Onset: A Potential Predictor of Functional Prognosis by Jia‐Xin Ren, Yang Qu, Yi Gao, Hong‐Yin Ma, Peng Zhang, Zhen‐Ni Guo, Yi Yang

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