Functional Involvement of TANK-Binding Kinase 1 in the MyD88-Dependent NF-κB Pathway Through Syk by Han Gyung Kim, Ji Hye Kim, Tao Yu, Jae Youl Cho

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Computational Insights into the Antioxidant Activity of Luteolin: Density Functional Theory Analysis and Docking in Cytochrome P450 17A1 by Antônio Sérgio Nakao de Aguiar, Lucas Barbosa Ribeiro de Carvalho, Clayson Moura Gomes, Murillo Moraes Castro, Frederico Severino Martins, Leonardo Luiz Borges

“…<b>Methods</b>: Density Functional Theory (DFT) calculations were employed to determine luteolin’s electronic and structural characteristics. …”
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IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody. by Simone I Richardson, Bronwen E Lambson, Andrew R Crowley, Arman Bashirova, Cathrine Scheepers, Nigel Garrett, Salim Abdool Karim, Nonhlanhla N Mkhize, Mary Carrington, Margaret E Ackerman, Penny L Moore, Lynn Morris

“…Antibody isotype is a modulator of this binding with the IgG3 subclass mediating potent Fc effector function and is associated with HIV vaccine efficacy and HIV control. …”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…The impact of sorafenib on tumor growth, MDSC infiltration, differentiation, and immunosuppressive function was assessed, alongside the modulation of these processes by PPARα. …”
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MicroRNA expression profile and functional analysis reveal that miR‐382 is a critical novel gene of alcohol addiction by Jingyuan Li, Jing Li, Xiaojun Liu, Shanshan Qin, Yanzhong Guan, Yuwei Liu, Yunhui Cheng, Xiuwen Chen, Wen Li, Shenming Wang, Ming Xiong, Eldo V. Kuzhikandathil, Jiang‐Hong Ye, Chunxiang Zhang

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Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons. by Nadine Thau-Habermann, Thomas Gschwendtberger, Colin Bodemer, Susanne Petri

“…Dysregulation of microglial and astrocyte properties and function has been described also in the fatal degenerative motor neuron disease amyotrophic lateral sclerosis (ALS). …”
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Functional Live-Cell Imaging Demonstrates that β-Integrin Promotes Type IV Collagen Degradation by Breast and Prostate Cancer Cells by Mansoureh Sameni, Julie Dosescu, Kenneth M. Yamada, Bonnie F. Sloane, Dora Cavallo-Medved

“…The ability of tumor cells to adhere to, migrate on, and remodel extracellular matrices is mediated by cell surface receptors such as β 1 -integrins. Here we conducted functional live-cell imaging in real time to investigate the effects of modulating β 1 -integrin expression and function on proteolytic remodeling of the extracellular matrix. …”
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Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers by Syed K. Hasan, Sundarraj Jayakumar, Eliezer Espina Barroso, Anup Jha, Gianfranco Catalano, Santosh K. Sandur, Nelida I. Noguera

“…This review provides a comprehensive overview of Nrf2 regulation and function, highlighting its unique features in cancer biology, particularly its role in metabolic adaptation and drug resistance. …”
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p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases by Madison E. Gamble, Sruthi Sureshkumar, Maria Janina Carrera Espinoza, Natalie L. Hakim, Claudia M. Espitia, Fangchao Bi, Kevin R. Kelly, Wei Wang, Steffan T. Nawrocki, Jennifer S. Carew

“…In this review, we detail the structural and functional roles of p47phox, mechanisms of its regulation, and its multifaceted contributions to disease pathogenesis. …”
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Baseline gene expression in BALB/c and C57BL/6 peritoneal macrophages influences but does not dictate their functional phenotypes by Carlos M. Restrepo, Carlos M. Restrepo, Alejandro Llanes, Alejandro Llanes, Lizzi Herrera, Esteban Ellis, Esteban Ellis, Esteban Ellis, Iliana Quintero, Patricia L. Fernández, Patricia L. Fernández

“…Macrophages are effector cells of the immune system and essential modulators of immune responses. Different functional phenotypes of macrophages with specific roles in the response to stimuli have been described. …”
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NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT. by Michael V LeVine, Harel Weinstein

“…Application of the new method to molecular dynamics (MD) trajectories of the occluded state of the bacterial leucine transporter LeuT identifies a channel of allosteric coupling between the functionally important intracellular gate and the substrate binding sites known to modulate it. …”
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Watercress (<i>Nasturtium officinale</i>) as a Functional Food for Non-Communicable Diseases Prevention and Management: A Narrative Review by Chikondi Maluwa, Blecious Zinan’dala, Hataichanok Chuljerm, Wason Parklak, Kanokwan Kulprachakarn

“…With growing interest in dietary strategies for NCDs prevention and management, functional foods like watercress (<i>Nasturtium officinale</i>) have attracted attention for their rich phytochemical content and potential health benefits. …”
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Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function by Hao Han, Lei Tian, Yajing Dong, Yanyang Han, Xiaoman Wang, Qian Cheng, Haibo Zhang, Yan Zhang

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PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function by Huafang Wang, Xiaohang Ye, Haowen Xiao, Ni Zhu, Cong Wei, Xiang Sun, Limengmeng Wang, Binsheng Wang, Xiaohong Yu, Xiaoyu Lai, Shan Fu, He Huang

“…Collectively, our data suggested that PTPN21 acted as a pleiotropic factor in modulating the function of human BM-MSCs.…”
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A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function by Suzi Elizabeth Adams, Andrew Kenneth Cawley, David Arnold, Michael John Hoptroff, Vera Slomka, Jane Reid Matheson, Robert Edward Marriott, Matthew Ronald Gemmell, Philip David Marsh

“…Our findings provide the first understanding of the beneficial modulation of microbiome composition and function by zinc-containing toothpaste in-vivo for oral care benefits.…”
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Orkambi® and amplifier co‐therapy improves function from a rare CFTR mutation in gene‐edited cells and patient tissue by Steven V Molinski, Saumel Ahmadi, Wan Ip, Hong Ouyang, Adriana Villella, John P Miller, Po‐Shun Lee, Kethika Kulleperuma, Kai Du, Michelle Di Paola, Paul DW Eckford, Onofrio Laselva, Ling Jun Huan, Leigh Wellhauser, Ellen Li, Peter N Ray, Régis Pomès, Theo J Moraes, Tanja Gonska, Felix Ratjen, Christine E Bear

“…Here, we demonstrate that patients bearing the rare mutation: c.3700 A>G, causing protein misprocessing and altered channel function—similar to ΔF508‐CFTR, are unlikely to yield a robust Orkambi® response. …”
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Functional Requirement of Niacinamide for Blood Profiles, Antioxidant Status, and Intestinal Health in Finishing Pigs Fed a Low-Protein Diet by Yan Zhao, Fangli Tang, Yunlong Shi, Qinyu Tan, Qingxin Ju, Ziyi Yang, Guanqing Yang, Pengfei Gao, Sung Woo Kim, Lin Xi, Guoqing Cao, Bugao Li

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Secondhand smoke exposure among United States children with functional disabilities: National Health and Nutrition Examination Survey, 2021–2023 by Raed A. Bahelah

“…This study aims to examine the prevalence and factors associated with SHSe among 5–17 years old U.S. children with functional disabilities. Methods: NHANES 2021–2023 applied Child Functioning Module to assess functional disabilities among 5–17 years old U.S. children. …”
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Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation. by Saima Rehman, Lubov S Grigoryeva, Katherine H Richardson, Paula Corsini, Richard C White, Rosie Shaw, Theo J Portlock, Benjamin Dorgan, Zeinab S Zanjani, Arianna Fornili, Nicholas P Cianciotto, James A Garnett

“…However, it is unclear how these enzymes are able to carry out this dual function. Legionella pneumophila is the causative agent of Legionnaires' disease, an often-fatal pneumonia and its chitinase ChiA is essential for the survival of L. pneumophila in the lung. …”
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Mechanical behavior and energy absorption capability of trigonometric function curved rod cell-based lattice structures under compressive loading by Linlin Zhang, Junwei Wu, Yuejing Zhao, Zhiying Qin

“…This study proposes a novel lattice design methodology utilizing trigonometric function-modulated strut axes, yielding three novel trigonometric function curved rod cell-based lattice structures (TCRC, SCRC, and CCRC). …”
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