Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway by Yangxin Fang, Lin Chen, Yin Yuan, Sining Zhou, Jiamin Fu, Qi Zhang, Ning Zhang, Yuqi Huang, Yifei Li, Li Yuan, Lijun Chen, Charlie Xiang

“…Abstract Background Human menstrual blood-derived stem cells (MenSCs), a major class of mesenchymal stem cells (MSCs), modulate intercellular signals via paracrine factors. …”
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Deciphering the anticoccidial mechanism of Qinghao Changshan formula through network pharmacology and molecular docking by Dong Tian, Hui Fu, Hongxia Tao, Miaolan Li, Qinghua Zhang, Weidong Deng

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to explore relevant biological functions and pathways. Molecular docking was used to validate interactions between selected active compounds (isorhamnetin, kaempferol, quercetin) and key targets (epidermal growth factor receptor [EGFR], estrogen receptor 1 [ESR1], progesterone receptor [PGR]). …”
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Characterization of the small RNAs carried by outer membrane vesicles produced by hlyF-positive Shiga toxin-producing Escherichia coli by Giorgia Barbieri, Giorgia Barbieri, Alessia Stefano, Agostina Pietrantoni, Federica Fratini, Serena Cavallero, Rosangela Tozzoli, Paola Chiani, Arianna Boni, Stefano Morabito, Valeria Michelacci

“…Interestingly, a copy of STnc_100 sequence is harbored downstream the stx2 operon carried by Stx2-encoding phages in both the strains and has a complementarity region for stxB gene, suggesting a modulation in Stx production or release. Our results indicate that OMVs release may exert regulatory functions, putatively influencing the crosstalk with the host and the gut microbiota during the infection process.…”
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Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models by Chuanbin Chen, Qingmin Chen, Shenghai Liu, Guoxi Li, Jiawei Zhao, Jingting Huang, Tianyi Ye, Xinting Yang, Zigui Huang, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Weizhong Tang, Jungang Liu, Xiaoliang Huang

“…Abstract Objective This study aims to explore the differences in composition, abundance, and biological functions of the gut microbiota between colorectal cancer (CRC) patients with peripheral nerve invasion (PNI) and those without peripheral nerve invasion (NPNI). …”
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Artemisinin supplementation in concentrated cottonseed protein basal diets enhances growth, antioxidant capacity, intestinal immunity and microbiota in hybrid grouper (Epinephelus... by Ling Pan, Qi Wang, Weikang Li, Xiaohui Dong, Shiwei Xie, Beiping Tan, Hongyu Liu, Yan Wang

“…In recent years, its potential in aquaculture has gained attention, but the physiological functions of its bioactive components in aquatic animal production remain underexplored and require further investigation. …”
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Effects of integrated exercise approach on total testosterone levels in eumenorrheic women: a randomized controlled trial by Wajiha Shahid, Rabiya Noor

“…Abstract Testosterone modulated by exercise plays a pivotal role in maintaining the overall health of both males and females. …”
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Impact of pediatric tracheostomy on family caregivers’ burden and quality of life: a systematic review and meta-analysis by Win Thu Aung, Natasha Yixuan Ong, Shina Qing Chun Yeo, Nur Syahindah Binti Juhari, Gwyneth Kong, Nicole-Ann Lim, Zubair Amin, Zubair Amin, Yvonne Peng Mei Ng, Yvonne Peng Mei Ng

“…Seven studies (469 caregivers) using Pediatric Quality of Life Family Integrated Module underwent meta-analysis. The pooled mean total family impact score, parental health-related QOL, family functioning score were 70.29 [95% CI, 61.20–79.37], 69.27 [95% CI, 60.88–77.67], and 72.96 [95% CI, 65.92–80.00] respectively. …”
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Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer by Xiaopeng Yu, Junjie Niu, Jinyang Hu

“…Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate gene functions, while clinical feature correlation analysis and single-sample gene set enrichment analysis (ssGSEA) were utilized to assess immune infiltration characteristics. …”
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In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells by Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter

“…Transcriptomic analysis further revealed seven overlapping DEGs between IFN-γ– and TGF-β1–licensed MSCs, including both upregulated (GPR68, LIMK2, LIPG) and downregulated (EFNA5, PRKG1, DCLK1, TRIM2) genes, several of which are functionally implicated in EV-mediated immune regulation. …”
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Ruminal Yeast Strain with Probiotic Potential: Isolation and Characterization and Its Effect on Rumen Fermentation In Vitro by Pin Song, Xiaoran Yang, Manman Hou, Yue Chen, Liping Liu, Yuyan Feng, Yingdong Ni

“…At the phylum and genus taxonomic levels, <i>Candida rugosa</i> (NJ-5) yeast culture addition increased the relative abundance of several functionally important bacterial groups in the rumen microbial community. …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…UL16-binding protein 2 (ULBP2), always expressed or elevated on cancer cells, functions as a key NKG2D ligand. ULBP2-NKG2D ligation initiates NK cell activation and subsequent targeted elimination of cancer cells. …”
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Effect of major royal jelly proteins (MRJPs) on proliferation activity of Chang's liver cell line and their mechanism of action by Yu Zhangying, Chen Di, Wang Yiran, Shen Lirong

“…MRJP1-MRJP9 and MRJPψ, whose biological functions include enhancing cell proliferation, inducing differentiation, modulating immune responses, accelerating wound healing, etc. …”
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Solar-thermoelectric mobile storage system integrated with electric vehicles for reducing postharvest and microbial losses in agro produce transportation by Lalith Pankaj Raj Nadimuthu, Kirubakaran Victor, Mohit Bajaj, Vojtech Blazek, Lukas Prokop

“…Functioning as an off-grid refrigeration unit, the system is supported by a 12 V/40Ah battery energy storage system. …”
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Agreement Between Child Self- and Parent Proxy-Reports of Health-Related Quality of Life in Spinal Muscular Atrophy: Preliminary Insights from a Nationwide Patient Registry in Germ... by Landfeldt E, Leibrock B, Hussong J, Thiele S, Walter MC, Moehler E, Zemlin M, Dillmann U, Flotats-Bastardas M

“…The lowest levels of concordance were found for school and family life, as well as mental well-being, as opposed to physical functioning and disability.Conclusion: We show that the agreement between child self- and parent proxy-reports of HRQoL in SMA varies markedly across HRQoL measures and examined domains, ranging from poor/fair to excellent. …”
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The P2X7 receptor in depression: Novel insights and therapeutic implications by Yue-ting Zhong, Chao Pi, Ying Zuo, Yan Wei, Wen Li, Yong-qiang Jiang, Lei Tao, Wen-wu Zheng, Jun Jiang, Yan Yang, Shi-feng Chu, Bin-yan Liu, Ke-zhi Liu, Yu-meng Wei, Ling Zhao

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Effect of Resistance Training on Hepatic Bile Acid, beta-Klotho Protein and Expression of Farnesoid X Receptor, Fibroblast Growth Factor 15 and Fibroblast Growth Factor Receptor 4... by Mehri Gholipour, Najme Rezaeian, Mohammad Karimi, Sadegh Cheragh-Birjandi

“…Recent studies describe bile acids as messenger molecules with diverse functions that have a wide range of receptors in the body. …”
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Melatonin Alleviates Photosynthetic Injury in Tomato Seedlings Subjected to Salt Stress via OJIP Chlorophyll Fluorescence Kinetics by Xianjun Chen, Xiaofeng Liu, Yundan Cong, Yao Jiang, Jianwei Zhang, Qin Yang, Huiying Liu

“…The findings suggest that exogenous MT mitigates salt stress-induced photoinhibition by (1) modulating endogenous MT concentrations, (2) augmenting PSII reaction center functionality, (3) safeguarding the oxygen-evolving complex (OEC), (4) reinstating PSI redox potential, (5) facilitating photosynthetic electron transport, and (6) optimizing energy absorption and dissipation. …”
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Musical Expertise Reshapes Cross-Domain Semantic Integration: ERP Evidence from Language and Music Processing by Xing Wang, Tao Zeng

“…Crucially, this study is the first to demonstrate that musical expertise may gradually reorganize these shared mechanisms, enabling two initially independent but functionally analogous semantic mechanisms into a domain-general processing system. …”
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Transcranial Direct Current Stimulation (tDCS) for Borderline Personality Disorder (BPD): Why and How? by Lionel Cailhol, Kamilia Soltani, Cécilia Neige, Marine Mondino, Jérôme Brunelin, Martin Blay

“…Pilot randomized controlled trials report moderate effect sizes for improvements in emotional regulation, inhibitory control, and rejection sensitivity, along with ancillary gains in executive functioning and reductions in depressive and substance-use symptoms when stimulating the left dorsolateral prefrontal cortex. …”
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Yield performance and optimal nitrogen and phosphorus application rates in wheat and faba bean intercropping by Jing-xiu XIAO, Ying-an ZHU, Wen-lian BAI, Zhen-yang LIU, Li TANG, Yi ZHENG

“…Thus, it was concluded that modulated N and P rates could maximize the economic and ecological functions of intercropping. …”
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