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14261
The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023
Published 2025-05-01“…Therefore, early control of periodontal inflammation, along with the exploration of how to harness the protective functions of autophagy, may provide future research directions for managing periodontal disease.…”
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14262
Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration
Published 2025-06-01“…Notably, emerging evidence reveals context-dependent tumor-suppressive functions of YAP/TAZ in specific CRC subtypes, such as via suppression of Wnt signaling. …”
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14263
Short light/dark cycles favour photosynthetic efficiency and growth in grapevines
Published 2025-07-01“…Light and temperature in greenhouses or growth chambers are major regulatory factors in plant functioning, which can be easily modulated. Shortening the photo-/nycti-periods, compared to the standard cycle (12 h light/12 h dark), has been shown to enhance the photosynthetic activity and growth in annual crops, but its effect on perennial crops such as grapevines remains unexplored. …”
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14264
Elucidating the role of PPARG inhibition in enhancing MERS virus immune response: A network pharmacology and computational drug discovery
Published 2024-11-01“…Furthermore, gene ontology (GO), pathway enrichment analysis, and protein-protein interaction (PPI) network were performed to understand the gene’s functions. A possible drug target was identified, and an FDA-approved drug library was screened against the selected target using molecular docking and validated the findings through molecular dynamics simulation, principal component analysis, free energy landscape, and MM/GBSA calculations. …”
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14265
Improved Coulomb collision operator for kinetic ion transport with EMC3-EIRENE simulating Nitrogen seeding in medium density ITER L-mode scenario
Published 2025-03-01“…We have now implemented a new Coulomb collision operator in EIRENE, where the Coulomb collisions are described by a linear kinetic equation in Fokker-Planck form utilizing the Trubnikov-Rosenbluth potential functions, which includes scattering of the kinetic ions as well as friction with the background plasma. …”
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14266
Effects of isoquinoline alkaloids as an alternative to antibiotic on oxidative stress, inflammatory status, and cecal microbiome of broilers under high stocking density
Published 2025-01-01“…HSD altered metabolic pathways related to carbohydrate and lipid metabolism, and amino acid biosynthesis. BCT50 modulated microbial functions, particularly those related to cell wall synthesis, while isoquinoline alkaloids upregulated pathways involved in energy production, secondary metabolite biosynthesis, and antioxidant production. …”
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14267
Decreased Serum microRNA-21, microRNA-25, microRNA-146a, and microRNA-181a in Autoimmune Diabetes: Potential Biomarkers for Diagnosis and Possible Involvement in Pathogenesis
Published 2019-01-01“…Furthermore, target genes and pathways potentially modulated by these four miRNAs were predicted by bioinformatics analysis to investigate the possible functions of these miRNAs in autoimmune diabetes. …”
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14268
Psychometric property of the Japanese version of self-efficacy for managing chronic disease scale in individuals with chronic diseases
Published 2024-11-01“…Pearson's correlation analyses indicated that SEMCD-J was significantly associated with PHQ-9 (r = −0.57, p < 0.001) and the dimensions of CDC-HRQOL-4, namely, the degree of general health (r = −0.55, p < 0.001), physically unhealthy days (r = −0.46, p < 0.001), mentally unhealthy days (r = −0.48, p < 0.001), and functionally unhealthy days (r = −0.50, p = < 0.001). …”
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14269
Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
Published 2016-07-01“…Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), play an important role in central nervous system functioning, development, and modulation of pain. This study investigates whether polymorphisms in the BDNF and NGF genes are associated with migraine disease in a Turkish case&ndash;control population. …”
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14270
1.7 MV Tandem Accelerator Beam Tuning Optimization
Published 2025-03-01“…This interface empowered efficient upper-level control and real-time monitoring functions, thereby significantly bolstering the usability and practicality of the system. …”
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14271
Identification and Evaluation of Lipocalin-2 in Sepsis-Associated Encephalopathy via Machine Learning Approaches
Published 2025-03-01“…Enrichment analysis revealed the biological functions of these genes. Subsequently, neuroinflammation-related genes were obtained to construct a neuroinflammation-related signature. …”
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14272
STYLISTIC MEANS OF IMPLEMENTING THE IDEA OF THE WORLD’S IRIDESCENCE IN PH.K. DICK’S “UBIK” IN THE CONTEXT OF TRANSLATION TRANSFORMATIONS
Published 2024-12-01“…The method of stylistic analysis was applied to interpret stylistic phenomena inherent in the novel in relation to their contribution to the studied idea as those were found functioning in the relevant textu- al microcontexts and enhancing the aforementioned semantic dominants. …”
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14273
The Sensitive Genes for Cervical Cancer: Two-Sample Mendelian Randomization with Experimental Validation
Published 2025-05-01“…Finally, we further validated the functions of the selected target genes in cervical cancer cells and analyzed their Gene Set Enrichment Analysis (GSEA) results, drug sensitivity, and prognostic value.Results: We identified 2,801 upregulated and 1,646 downregulated DEGs. …”
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14274
Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells
Published 2025-07-01“…Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. …”
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14275
Sex-related differences in postoperative patient-reported outcomes among lung cancer patients: a multicenter cohort study
Published 2025-04-01“…On a daily assessment schedule, we evaluated patients’ symptoms and their impact on functioning from the day before surgery until discharge using the MD Anderson Symptom Inventory–Lung Cancer module. …”
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14276
Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells
Published 2024-10-01“…The results indicate that ethosomes are delivery systems able to maintain nutlin-3a’s functionality and specific biological action, as evidenced by the molecular activation of the p53 pathway and the biological events leading to cell cycle block and apoptosis in p53<sup>wild-type</sup> cells. …”
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14277
HD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice
Published 2025-04-01“…ABSTRACT Background G protein–coupled receptor 40 (GPR40) acts as a modulator of various physiological functions, including glycaemic lowering, anti‐inflammation and antioxidative stress, in several tissues. …”
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14278
Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy
Published 2024-11-01“…LAMP1 expression remained unchanged during autophagy modulation but decreased with LC3C knockdown and vice versa. …”
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14279
The cold immunological landscape of ATM-deficient cancers
Published 2025-05-01“…Background Mutations in genes encoding DNA repair factors, which facilitate mismatch repair, homologous recombination, or DNA polymerase functions, are known to enhance tumor immunogenicity. …”
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14280
Neuroprotective effects of essential oils in animal models of Alzheimer’s and Parkinson’s disease: a systematic review
Published 2025-07-01“…Behavioral assessments showed consistent enhancements in memory, learning, and motor functions across studies. The systematic analysis provides compelling evidence for EOs’ neuroprotective efficacy, particularly in early-stage intervention. …”
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