Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E by Junqian Zhang, Xiaobo Zhang, Ruixin Wu, Chang-Sheng Dong

“…The by-products of purine metabolic reprogramming are extensively engaged in tumor immune modulation, influencing the functions and recruitment of immune cells and molding an immune microenvironment that is propitious for tumor growth.MethodsWe harnessed single-cell transcriptomics and spatial transcriptomics to concurrently analyze the purine metabolism (PM) features of the PC microenvironment. …”
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Stimulator of Interferon Genes (STING)-Type I Interferon Signaling: Bridging Immunity and Pain by Ti-Chuan Chiu, Yu-Yu Li, Chia-Hung Yu, Kuo-Chuan Hung, Chin-Chen Chu, Ping-Hsun Feng, Ping-Heng Tan

“…Interferons (IFNs) are cytokines with diverse functions, possessing antiviral, antiproliferative, and immunomodulatory effects. …”
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PLZT-Based Shutters for Free-Space Optical Fiber Switching by Fan Zhang, Hsi-Hsir Chou, W. A. Crossland

“…With the increasing demand for optical fiber switching technologies from data center networks, shutter-based free-space optical fiber switching technology is promising for such network applications as the major advantages of this switching technology are that multicast switching, which is a vital functionality required in data center networks, can be easily achieved through its optical fan-out mechanism and that the switching performance can also be significantly strengthened while new materials with a faster response time are used as a spatial light modulator (SLM) to act as shutters. …”
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Core Molecular Clock Factors Regulate Osteosarcoma Stem Cell Survival and Behavior via CSC/EMT Pathways and Lipid Droplet Biogenesis by Sukanya Bhoumik, Yool Lee

“…Despite growing evidence for the circadian clock’s involvement in regulating CSC functions, its precise regulatory mechanisms remain largely unknown. …”
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Metamodels of Educational and Methodological Activity in the University by S. M. Shcherbakov, K. K. Kalugyan, I. I. Miroshnichenko

“…Such concepts as “competence”, “type of activity”, “tasks of professional activity”, “labor functions”, etc. appear and then transform. The present work aims to track the dynamics of these changes and assess the increase in the complexity of educational methodological support. …”
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Vitamin B6, cardiovascular diseases, and diabetes mellitus by A.A. Serhiyenko, T.T. Dolinay, V.B. Sehin, V.A. Serhiyenkо

“…It inhibits the production of reactive oxygen species and advanced glycation end products, which are genotoxic compounds linked to aging and diabetes mellitus (DM), so it works as an antioxidant. In addition, PLP functions as a modulator of transcription factors, affects the activity of a number of enzymes, and can bind to steroid hormone receptors, playing a role in membrane transport. …”
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Single-cell sequencing reveals PTX3 involvement in ovarian cancer metastasis by Shuangyan Liu, Tianhao Wu, Xueying Song, Linru Quan, Xinyi Wang, Qing Liu, Xin Zhou

“…Methods Single-cell RNA sequencing (scRNA-seq) and immunohistochemistry (IHC) were conducted to determine the expression profiles, potential functionalities, and underlying mechanisms of PTX3 within the context of OC. …”
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Bacterial symbiont as game changers for Aphis craccivora Koch’s fitness and survival across distinct climate types by Minoo Heidari Latibari, Diana Carolina Arias-Penna, Mostafa Ghafouri Moghaddam, Buntika A. Butcher

“…Following the eradication of B. aphidicola, this facultative symbiont continues to complement the functions of B. aphidicola in the host’s survival. …”
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Augmentation of PRDX1–DOK3 interaction alleviates rheumatoid arthritis progression by suppressing plasma cell differentiation by Wenzhen Dang, Xiaomin Wang, Huaying Li, Yixuan Xu, Xinyu Li, Siqi Huang, Hongru Tao, Xiao Li, Yulin Yang, Lijiang Xuan, Weilie Xiao, Dean Guo, Hao Zhang, Qiong Wu, Jie Zheng, Xiaoyan Shen, Kaixian Chen, Heng Xu, Yuanyuan Zhang, Cheng Luo

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In silico evaluation of the immunogenic profile of lung cancers with SMARCA4 genetic alterations by Cristina Nieto-Jiménez, Esther Garcia-Lorenzo, Cristina Diaz-Tejeiro, Lucía Paniagua-Herranz, Adrián Sanvicente, Bernard Doger, Irene Moreno, Manuel Pedregal, Jorge Bartolomé, Arancha Manzano, Gyöngyi Munkácsy, Balázs Győrffy, Pedro Pérez-Segura, Emiliano Calvo, Victor Moreno, Alberto Ocana

“…Enriched biological functions for downregulated genes included “Antigen processing and presentation, endogenous lipid antigen via MHC class Ib. …”
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Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics by Yuexi Yu, Huiru Liu, Kaipeng Liu, Meiqi Zhao, Yiyan Zhang, Runci Jiang, Fengmei Wang

“…Further analysis revealed significant differences in clinical features, biological functions, mutation profiles, and immune cell infiltration between high-risk and low-risk groups. …”
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Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients by Giovana W. C. Almeida, Martha T. Oliveira, Isabella G. L. Martines, Giuliano C. Fiori, Michael M. Nevels, Ian J. Groves, John Sinclair, José Medina-Pestana, Rayra Sampaio da Silva, Monica Nakamura, Lucio Requião-Moura, Emma Poole, Maria C. Carlan da Silva

“…Other isoforms are produced (C to H) but have unknown functions. Here, we investigated the expression of the most abundant transcripts, cmvIL-10 and LAcmvIL-10, in productively and latently infected cells and in peripheral blood mononuclear cells from renal transplant recipients up to 60 days post-transplantation. …”
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Indoleamine 2,3-dioxygenase 1-mediated immune suppressive status is positively associated with brain metastasis in patients with non-small cell lung cancer by Weiwei Chen, Li Yang, Victor Ho-fun Lee, Liangliang Xu, Lingyu Ma, Zhenghao Ye, Wanli Xu, Caining Zhao, Danyang Zheng, Karrie Mei-Yee Kiang, Stella Sun, Yuan Qu, Jiandong Zha, Dazhi Pang, Yan Zhang, Zhibing Liang, Wenchu Lin, Jinliang Zhang, Jitian Zhang, Min Luo, Zhiyuan Xu, Ding Li, Xiaoling Liang, Gilberto Ka-Kit Leung, Aya El Helali, Chiming Che, Feng-Ming (Spring) Kong

“…Here, we aimed to examine whether IDO1 activity is correlated with OS in NSCLC patients with brain metastasis (Bramet) and has negative effect on modulating the anti-tumor functions of immune cells. …”
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Alteration of vasopressin-aquaporin system in hindlimb unloading mice by Marianna Ranieri, Maria Venneri, Giuseppina Storlino, Angela Ferrulli, Mariagrazia D’Agostino, Mariangela Centrone, Annarita Di Mise, Annarita Di Mise, Roberta Zerlotin, Grazia Tamma, Maria Grano, Giovanna Valenti

“…Murine hindlimb unloading (HU) is considered a model of choice for simulating the physiological effects of microgravity on several functions, including fluid and electrolyte homeostasis. …”
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5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth by Xinning Guo, Meng Jiang, Zhengyu Tao, Huijuan Dai, Chen Wu, Yinan Wang, Zi Wang, Xiaoning Wang, Zhixuan Zhang, Kun Qian, Shanshan Zeng, Yihua Bei, Jun Pu

“…Conclusions: This study reveals a previously unrecognized dual role of 5-oxoproline, which functions both as an early biomarker for DOX-induced cardiotoxicity detection and as a therapeutic target that simultaneously inhibits cancer growth and protects the myocardium.…”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…ABSTRACT Honeybees (Apis mellifera), as social insects, exhibit complex social behaviors and cognitive functions. The short lifespan and stable gut microorganisms of honeybees provide certain availability as a rapid and high-flux animal model for aging research. …”
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Exploring physiological and molecular dynamics of drought stress responses in plants: challenges and future directions by Sajad Ali, Rakeeb Ahmad Mir, Md Azizul Haque, Danishuddin, Mohammed A. Almalki, Mohammad Alfredan, Ashraf Khalifa, Henda Mahmoudi, Mohammad Shahid, Anshika Tyagi, Zahoor Ahmad Mir

“…For instance, the role of calcium (Ca2+), reactive oxygen species (ROS) and abscisic acid (ABA) in modulating different cellular responses like stomata functioning, osmotic adjustment, and other adaptive traits. …”
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Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo by Xiaowen Yang, Yiting Zhan, Yifei Li, Yifei Li, Xinzhuang Shen, Xinzhuang Shen, Yuqiu Ma, Zongjun Liu, Zongjun Liu, Yipeng Liu, Chengjin Liang, Xiaoyuan Zhang, Yehao Yan, Wenzhi Shen

“…This research underscores the potential of MPM-1 as a tumor suppressor and lays a robust foundation for the future development of innovative anticancer therapies that target mitochondrial functions.…”
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A strain of Lactobacillus plantarum from piglet intestines enhances the anti-PoRV effect via the STING-IFN-I pathway by Anqi Sun, Xin Shan, Ruihan Liu, Zhengxu Tang, Jingshu Huang, Shihan Zhang, Lihong Bian, Yumeng Shi, Zixuan Liu, Jingtao Hu, Chunfeng Wang

“…Lactobacillus plantarum, a ubiquitous probiotic in natural ecosystems, has demonstrated multifaceted biological functions. The stimulator of the interferon gene (STING) is involved in type I interferon (IFN-I) mediated host antiviral innate immunity, which is a pivotal adaptor in response to the microbial DNA/RNA-activated signaling pathways. …”
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RETRACTED ARTICLE: Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer by Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos, Francisco Eduardo Martinez

“…Abstract Background Toll-like receptors (TLRs) are effector molecules expressed on the surface of ovarian cancer (OC) cells, but the functions of the TLR2/TLR4 signaling pathways in these cells remain unclear. …”
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