Knockdown of nrf2 Exacerbates TNF-α-Induced Proliferation and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes through Activating JNK Pathway by Yu Du, Qian Wang, Na Tian, Meng Lu, Xian-Long Zhang, Sheng-Ming Dai

“…In this study, we aimed to explore the expression and upstream regulatory factors of nrf2 and revealed its functions in modulating the proliferation and invasion in RA-FLS. …”
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Arsenic Trioxide Enhances the Efficacy of PD‐1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway by Xionghui Wang, Simo Cheng, Yannan Xu, Tianxiao Zheng, Changquan Ling, Juan Du

“…ATO‐treated HCC cells exhibited enhanced immunogenicity, functioning as prophylactic and therapeutic vaccines to stimulate antitumor immunity. …”
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Development of a Solar-Powered Edge Processing Perimeter Alert System with AI and LoRa/LoRaWAN Integration for Drone Detection and Enhanced Security by Mateo Mejia-Herrera, Juan Botero-Valencia, José Ortega, Ruber Hernández-García

“…The system incorporates a PDM microphone based on an Arduino Nano 33 BLE with a trained model to identify a drone or a UH-60 from an audio spectrogram to demonstrate its functionality. It is complemented by two PIR motion sensors and a microwave sensor with a range of up to 11 m. …”
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Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and... by Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Edwin R. Manuel

“…Transcriptional analysis of AZA-treated samples revealed decreased cell type scores for suppressive subsets and increased pathway scores for T and B cell functions. Comparisons of gene ontology annotations enriched from genes differentially regulated by AZA in human and mouse blood samples revealed overlap in numerous biological pathways including adhesion, thrombosis, and angiogenesis. …”
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Different expression of circulating microRNA profile in tibetan OSAHS with metabolic syndrome patients by Xue-feng Shi, Xiang He, Ze-rui Sun, Jie Duo, Hao Yang

“…Abstract Recent empirical investigations reinforce the understanding of a profound interconnection between metabolic functions and Obstructive Sleep Apnea-hypopnea Syndrome (OSAHS). …”
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Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction by Xuemei Shi, Zhonghan Yan, Ruilin Ding, Fenfen Xia, Yan Du, Xiaojie Wang, Qing Peng

“…Methods Four GEO datasets (GSE79962, GSE267388, GSE229925, GSE229298) were analyzed using Limma and WGCNA to identify overlapping genes from differentially expressed genes (DEGs), cuproptosis-related DEGs (DE-CRGs), and module-associated genes. Gene Set Enrichment Analysis (GSEA) and single-sample GSEA (ssGSEA) were performed to assess biological functions and immune cell infiltration, respectively. ceRNA and transcription factor networks were constructed to explore gene regulatory mechanisms, while consensus clustering was employed to define cuproptosis-related subtypes. …”
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The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction by Nestor Ruiz, Jiawei Xing, Igor B. Zhulin, Chad A. Brautigam, David R. Hendrixson

“…The Campylobacter jejuni BumSR TCS is unusual in that the BumS sensor exclusively functions as a phosphatase rather than a kinase to control phosphorylated levels of its cognate BumR response regulator (P-BumR). …”
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Trajectory, interactions, and predictors of higher symptom burden during induction therapy for multiple myeloma by Mona Kamal, Qiuling Shi, Shu-En Shen, Charles Cleeland, Xin Shelley Wang

“…Quality of life (QOL) and affective and physical functioning status were assessed. Predictors of high symptom burden were examined by regression analysis. …”
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The Potential of <i>Zanthoxylum acanthopodium</i> DC. as Immunomodulators: Formulation, Activity Testing, and Extract Profiling by Damaris Br. Hutapea, Yasmiwar Susilawati, Muhaimin Muhaimin, Riezki Amalia, Aisyah Tri Mulyani, Anis Yohana Chaerunisaa

“…This stability is attributed to the presence of the Tween 80 emulsifier, which has superior wetting and washing functions, strong detergency, and good emulsifying properties compared to the PEG emulsifier used in formulation F3.3E. …”
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Correlations between expression levels of genes encoding multifunctional YB-1 protein, inflammatory cytokines and multidrug resistance P-gp protein in surgical material from patien... by M. V. Erokhina, E. N. Pavlova, E. A. Scherbakova, E. Yu. Rybalkina, L. N. Lepekha, R. V. Tarasov, E. K. Tarasova

“…We suggest that the YB-1 protein can potentially have different functions: (1) being a participant in tuberculous inflammation via the cytokine expression; (2) modulating the P-gp activity and changing the pharmacokinetics of anti-tuberculosis drugs, thus requiring future studies.…”
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Tangeretin Improves the Memory of Swiss Mice, Suggesting Potential Molecular Interventions Through Animal Behavior Assessments and In Silico Studies by Md. Sakib Al Hasan, Mohd Shahnawaz Khan, Arusha Ayub, Raihan Chowdhury, Emon Mia, Md. Shadin, Md. Showkot Akbor, Muhammad Torequl Islam, Md. Shimul Bhuia

“…Results TAN significantly (p < 0.05) improved cognitive functions, including memory, anxiety, and motor coordination, in a dose‐dependent manner, with 20 mg/kg showing the most notable effect. …”
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MICRORNA IN MONITORING OF THE EVOLUTION OF GLIAL CEREBRAL TUMORS by R. Yu. Seliverstov, M. I. Zaraiskiy, R. V. Tyurin, A. G. Naryshkin, V. G. Valerko, V. V. Semiglazov, Ch. Takahachi

“…It was shown that miRNA-21 has antiapoptotic and invasive functions by means of silencing of the PTEN tumor suppressor. …”
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The effects of elastic band resistance training on serum levels of growth differentiation factor 11, myostatin, and insulin resistance in overweight elderly women by Akbar Azamian Jazi, Elias Abdellah

“…Even though these two factors have similar structural and signaling pathways, they can have different functions, and the available information about their effects on the regeneration of degenerated muscles during old age is contradictory. …”
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Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time by André Luiz Musmanno Branco Oliveira, Gabriel Dias Rodrigues, Gabriel Dias Rodrigues, Bruno Moreira Silva, Philippe de Azeredo Rohan, Pedro Paulo da Silva Soares

“…IntroductionMales and females differ anatomically and functionally in cardiorespiratory regulation, with males tending to experience greater oxygen desaturation under hypoxia. …”
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Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights by Tung Liu, Yu-Chieh Lin, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li

“…This study examines the prognostic significance, spatial distribution, and immune‐related functions of PTPN7, aiming to elucidate its potential as a prognostic role and therapeutic target in glioma treatment. …”
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Naphthalimide-polyamine conjugates: a promising avenue for targeted anticancer therapy by Zhiyong Tian, Luyao Tian, Chaojie Wang

“…Future research focuses on AI-driven polyamine enhancement, nanoplatforms that can cross the blood-brain barrier (such as Angiopep-2-functionalized Ti@FeAu), and non-apoptotic cell death mechanisms like pyroptosis. …”
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Occupational Exposure to Engine Exhausts and Prostate Cancer Risk by Christine Barul, Marie-Claude Rousseau, Marie-Elise Parent

“…As most associations were not linear, we fitted functions for changes in percentile distributions based on natural cubic splines. …”
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Identification of key genes CCL5, PLG, LOX and C3 in clear cell renal cell carcinoma through integrated bioinformatics analysis by Zhenwei Xie, Cheng Feng, Yude Hong, Libo Chen, Mingyong Li, Weiming Deng

“…In this study, we identified several key genes associated with the prognosis of ccRCC by using integrated bioinformatics.MethodsTwo ccRCC expression profiles were downloaded from Gene Expression Omnibus and one dataset was gained from The Cancer Genome Atlas The Robust Rank Aggregation method was used to analyze the three datasets to gain integrated differentially expressed genes The Gene Ontology and KEGG analysis were performed to explore the potential functions of DEGs. The Search Tool for the Retreival of Interacting Genes/Proteins (STRING) and Cytoscape software were used to construct protein-protein interaction network and module analyses to screen the hub genes. …”
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Shaping viral immunotherapy towards cancer-targeted immunological cell death by Anastasia S. Isaeva, Anastasia S. Isaeva, Adriana D. Trujillo Yeriomenko, Esther Idota, Sofya I. Volodina, Natalia O. Porozova, Evgeny E. Bezsonov, Alexander S. Malogolovkin

“…Genetic engineering, including arming OVs with cancer cell-specific binders and immunostimulatory molecules, further enhances immune responses at various stages of the CIC, improving the specificity and safety of virotherapy.The aim of this study is to update current knowledge in immunotherapy using OVs and to highlight the remarkable plasticity of viruses in shaping the tumor immune microenvironment, which may facilitate anti-cancer treatment through various approaches.MethodologyResearch articles, meta-analyses, and systematic reviews were retrieved from PubMed, using the search terms (‘Oncolytics’ OR ‘Immunotherapy’ OR ‘Virotherapy’ OR ‘Viral vector’) AND ‘gene therapy’, without language restrictions.ResultsIn this review, we discuss current strategies aimed at increasing the tumor specificity of OVs and improving their safety. We summarize and functionally categorize different biochemical approaches, with a focus on virus engineering and advancements in immunotherapy. …”
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The KDM5A/HOXA5 axis regulates osteosarcoma progression via activating the Wnt/β-catenin pathway by Yi Luo, Youzhi He, Yuxia Xu, Yongfu Wang, Li Yang

“…Abstract As an oncogenic driver, lysine-specific demethylase 5A (KDM5A) participates in regulating numerous tumor progression-related processes. Moreover, KDM5A functions as a histone demethylase, modulating the expression levels of its target genes by adjusting methylation levels. …”
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