An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model by Gourango Talukdar, Lisa Duvick, Praseuth Yang, Brennon O’Callaghan, Gavin J. Fuchs, Marija Cvetanovic, Harry T. Orr

“…Abstract Background and objectives Ataxin-1 (ATXN1) is a protein in which expansion of its polyglutamine tract causes the neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) via a gain-of-function. Wild type ATXN1 was recently shown to have a protective role in regulating severity of experimental autoimmune encephalomyelitis (EAE), a well-established mouse model for Multiple sclerosis (MS). …”
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Deciphering the secret codes in N7‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases by Huan Fang, Jing He, Dan Du, Xue Wang, Xinyu Xu, Linping Lu, Yefan Zhou, Yangyang Wen, Fucheng He, Yingxia Li, Hongtao Wen, Mingxia Zhou

“…This review describes the various biological functions of METTL1, summarises recent advances in understanding its pathogenic and disease‐suppressive functions and discusses the underlying molecular mechanisms. …”
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The impact of combined thymol and rosmarinic acid on the intestinal microbiota and barrier function of the piglets challenged by Escherichia coli K88 by Runlin Li, Xuedong Ding, Mingkang Lei, Panpan Li, Ilias Giannenas, Jing Wang, Weiyun Zhu

“…The effects of Thy and Ros-A separately or in combination (Thy × Ros-A) on the intestinal function and health of piglets challenged with Escherichia coli K88 (E. coli K88) were investigated. …”
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Glymphatic and neurofluidic dysfunction in classical trigeminal neuralgia: a multimodal MRI study of brain-CSF functional and structural dynamics by Fenyang Chen, Zhiliang Zhang, Jianliang Miao, Yvting Zhang, Ding Wang, Juncheng Yan, Lei Pan, Haiqi Ye, Zhongxiang Ding, Xiuhong Ge

“…All participants underwent multimodal MRI, including high-resolution structural imaging, resting-state functional MRI, and diffusion tensor imaging. Key indices included choroid plexus (CP) volume as a proxy for CSF production, global BOLD-CSF coupling as a measure of functional neurofluidic interaction, and the DTI-based ALPS index reflecting glymphatic clearance. …”
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Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease by Guus A. de Waard, Sukhjinder S. Nijjer, Martijn A. van Lavieren, Nina W. van der Hoeven, Ricardo Petraco, Tim P. van de Hoef, Mauro Echavarría‐Pinto, Sayan Sen, Peter M. van de Ven, Paul Knaapen, Javier Escaned, Jan J. Piek, Justin E. Davies, Niels van Royen

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Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson’s disease model by Xiaoyu Sun, Jianyi Shen, Yimei Shu, Tianshi Wang, Lu He, Ruinan Shen, Yifan Zhou, Jinke Cheng, Suzhen Lin, Jianqing Ding

“…However, the pathway(s) through which MPTP impairs mitochondrial CI function remain to be elucidated. In this study, we aim to identify the molecular mechanisms through which MPTP modulates CI function and define the specific subunits of mitochondrial CI affected by MPTP. …”
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Effects of different negative pressure cupping interventions on inflammatory response and motor function recovery in delayed onset muscle soreness by Xu Song, Teng Ma, XianYou Cui

“…IntroductionThis study examined the impacts of different negative pressure cupping therapies (NPCT) on pain relief, functional recovery, and inflammatory regulation in delayed onset muscle soreness (DOMS) after high-intensity exercise, with the aim of clarifying the dose-effect relationship.MethodsIn this study, 55 healthy male participants aged 18–25 were selected and divided into 5 groups: the control group (CTR; n = 11) and NPCT groups at different levels (−25 kPa, −35 kPa, −45 kPa, and −55 kPa; n = 11 in each group). …”
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Repetitive magnetic stimulation with iTBS600 induces persistent structural and functional plasticity in mouse organotypic slice cultures by Han Lu, Shreyash Garg, Maximilian Lenz, Andreas Vlachos

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Design and evaluation of indacenothienothiophene based functional materials for second and third order nonlinear optics properties via DFT approach by Saadia Haq, Muhammad Khalid, Ataualpa Albert Carmo Braga, Norah Alhokbany, Ke Chen

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Experimental Evidence on Acupuncture Targeting Ferroptosis for Neurological Function Improvement in Cerebral Stroke: A Systematic Review and Meta‐Analysis by Wenyu Zhang, Xiaoxi Liu, Xuyang Feng, Donglei Lu, Ruiyu Li, Haizhen Guo, Kun Nie, Xuezhu Zhang

“…Conclusions Acupuncture effectively inhibits ferroptosis and enhances neurological function in animal models of cerebral stroke by modulating brain iron metabolism, decreasing lipid peroxidation, and improving brain antioxidant capacity.…”
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PO26 | Non-canonical coagulation platelets function: monocyte-platelet interaction a bridge between inflammation and coagulation

“… Background and Aims: Platelet activation leads to the release of various molecules with immunoregulatory functions. While these factors play a limited role in thrombosis, they have a significant impact on modulating host immune responses. …”
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Selective Glycopolymer Inhibitors of Galectin-3: Supportive Anti-Cancer Agents Protecting Monocytes and Preserving Interferon-Gamma Function by Filipová M, Tavares MR, Hovorková M, Heine V, Nekvasilová P, Křen V, Etrych T, Chytil P, Bojarová P

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Effects of on-farm hatching versus hatchery hatching on growth performance, gut development, and intestinal health and function in broiler chickens by Muhammad Zeeshan Akram, Ester Arévalo Sureda, Matthias Corion, Luke Comer, Nadia Everaert

“…High-throughput qPCR analyzed 79 ileal genes regarding barrier integrity, immune function, nutrient transporters, gut hormones, metabolism, and oxidation. …”
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Mesenchymal stem cells improve ovarian function by suppressing fibrosis through CTGF/FAK signalling in systemic lupus erythematosus by Min Xu, Hui Yang, Lingyun Sun, Hongwei Chen, Yueyang Zhang, Haiwei Zhang, Yingyi Wu, Yirui Shi

“…This study investigated the therapeutic efficacy of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in ameliorating ovarian impairment and restoring ovarian function through the inhibition of fibrosis in a lupus mouse model.Methods Serum levels of sex hormones were quantified via ELISA. …”
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Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

“…This allowed us to investigate the differential capacity of PEVs to alter cancer hallmark functions such as proliferation, invasion, and pro-angiogenic potential using melanoma as a model. …”
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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

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Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods by Mehmet Cengiz Baloglu, Lutfiye Yildiz Ozer, Buket Pirci, Yasemin Celik Altunoglu, Sanam Iram Soomro, Gokhan Zengin, Mehmet Veysi Cetiz, Simone Carradori, Zoltán Cziáky, József Jekő

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Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum? by Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A. Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R. Grosshans, Radhe Mohan

“…Further analysis showed that microdosimetric spectrum (the probability density function of the stochastic physical quantity lineal energy y) was helpful for interpreting observed differences in biological effects. …”
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Differential Cortical Responses of Functional and Sensory Electrical Stimulation in Closed-Loop Tremor Suppression for Parkinson’s Disease by Xiaoqi Zhao, Tinglan Huang, Mengyue Jin, Hongbo Zhao, Yu Shi, Yanlin Wang, Xiao Shen, Zhen Li, Qingqing Shi, Xiaodong Zhu, Lin Meng

“…Functional electrical stimulation (FES) and sensory electrical stimulation (SES) are widely used in tremor suppression for Parkinson’s disease (PD), however, their therapeutic efficacy varies significantly across individuals. …”
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Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease by Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang

“…However, the regulating roles of ADSC‐EVs in CrF (CrF‐EVs) in CD, especially in modulating lymphatic function and mitigating the progression of mesenteritis and colitis, remains elusive. …”
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