The Regulation of the NF-κB p65 and Nrf2/HO-1 Signaling Pathways by Fucoxanthin in Human THP-1 Monocyte Macrophages Under a Lipopolysaccharide-Induced Inflammation Model by Linyi Zhang, Tong Li, Jingyi Liu, Jiyan Sun, Jinkun Niu, Dandan Ren, Yichao Ma, Yunhai He, Shu Liu, Qiukuan Wang

“…Our study provides compelling evidence that fucoxanthin’s antioxidant and anti-inflammatory activities are functionally interrelated, with the Nrf2 signaling pathway serving as a critical node in this protective mechanism against LPS-induced cellular damage.…”
Get full text

Prognostic and immunological landscape of DDX17 in pan-cancer analysis: a comprehensive study by Yu Lei, Xin He, Peng Chen, Yiping Qin, Bin Ge, Yan Liu, Pu Li, Xing Wei

“…DDX17 is additionally involved in modulating immune functions and influencing the tumor microenvironment. …”
Get full text

Salivary proteomics profiling reveals potential biomarkers for chronic kidney disease: a pilot study by Bianca Uliana Picolo, Nathália Rabello Silva, Mário Machado Martins, Hebréia Oliveira Almeida-Souza, Letícia Cristina Machado de Sousa, Richard Costa Polveiro, Luiz Ricardo Goulart Filho, Robinson Sabino-Silva, Vivian Alonso-Goulart, Luciana Saraiva da Silva

“…Gene ontology (GO) analysis revealed data on molecular functions, biological processes, cellular components, and protein classes.ConclusionWe can conclude that the salivary API5, PI-PLC, and Sgsm2 can be potential biomarker candidates for CKD detection. …”
Get full text

Home-based self-administered transcranial direct current stimulation for women affected by primary dysmenorrhoea in Northeastern Brazil: a protocol study by Thiago Anderson Brito De Araújo, Edson Silva-Filho, Rodrigo Pegado, Tatiana Camila de Lima Alves da Silva, Yvinna Tamiris Rodrigues, Paloma Cristina Alves de Oliveira, Ervinas Bernatavicius, Alexander Anthony Cook, Emilè Radytè, Maria Thereza Micussi

“…In this sense, strategies focused on the central nervous system are important to re-establish normal functioning. Home-based self-administered transcranial direct current stimulation (tDCS) emerges as a strategy to modulate dysfunctional brain areas and improve the symptoms. …”
Get full text

The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model by A. Fidilio, M. Grasso, S. Spoto, S. Varrasi, M. Al-Khrasani, F. Caraci, C. Parenti, L. Pasquinucci

“…In neuropathic pain (NP), a dysregulation of glial functions in the central and peripheral nervous systems has been described, and the balance between pro-inflammatory and anti-inflammatory mediators is lost in the transition from acute to chronic pain. …”
Get full text

Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity by Wen-lin Pang, Wen-lin Pang, Tian-gang Li, Tian-gang Li, Yin-ying Wang, Yin-ying Wang, Li-yun Song, Li-yun Song, Li Li, Li Li, Xiao-ya Li, Xiao-ya Li, Yong Qiu, Yong Qiu, Zhong-shan Yang, Zhong-shan Yang

“…In addition, analysis of 16S rRNA gene sequencing indicated that SC reduced harmful bacterial populations, such as Proteobacteria, while simultaneously enhancing the levels of beneficial bacteria like Lactobacillus, thereby contributing to the improvement of UC pathology.ConclusionThis study highlights the therapeutic potential of SC in managing UC through its ability to attenuate inflammatory responses, restore intestinal barrier functionality, and modulate gut microbiota composition, which findings offer insights into potential strategies for advancing UC treatment.…”
Get full text

SENP1-SIRT3 axis mediates glycolytic reprogramming to suppress inflammation during Listeria monocytogenes infection by Yan Xiong, Yongliang Du, Feng Lin, Beibei Fu, Dong Guo, Zhou Sha, Rong Tian, Rui Yao, Lulu Wang, Zixuan Cong, Bohao Li, Xiaoyuan Lin, Haibo Wu

“…We have demonstrated that sentrin-specific protease 1 (SENP1) functions as a protective gene in the host, suppressing the inflammatory response triggered by Listeria monocytogenes. …”
Get full text

Transcriptome Analysis Revealed the Regulatory Mechanism of DIMBOA Affecting Early Somatic Embryogenesis in <i>Dimocarpus longan</i> Lour. by Xiaoqiong Xu, Chunyu Zhang, Ning Tong, Xiaoyuan Lan, Jing Cui, Awais Muhammad, Zhilin Zhang, Zihao Zhang, Yukun Chen, Yuling Lin, Zhongxiong Lai

“…These DEGs are significantly enriched in the biosynthetic and metabolic functions of various substances such as vitamin B₆ (VB₆) biosynthesis, phenylpropanoid pathways, and carbohydrate metabolism. …”
Get full text

Bio-orthogonally double cross-linked alginate-gelatin hydrogels with tunable viscoelasticity for cardiac tissue engineering by Daniele Testore, Alice Zoso, Camilla Paoletti, Sara Groppo, Elena Marcello, Valeria Chiono

“…Alginate and gelatin were functionalized with azide groups and cross-linked by a 4-arm-dibenzocyclooctyne (DBCO) crosslinker using strain-promoted azide-alkyne cycloaddition (SPAAC) with 0.5:1 (AG_Click(R0.5)) and 1:1 (AG_Click(R1)) DBCO:azide molar ratios. …”
Get full text

A brief exploration of the physical properties of single living cells under dynamic loading conditions by Dasen Xu, Chongyu Zhang, Ruining Peng, Ruining Peng, Ru Zhang, Haoyu Chen, Yulong Li, Yulong Li, Hui Yang, Hui Yang

“…Introduction:Single living cells exhibit both active biological functions and material-like mechanical behaviors. While extensive research has focused on static or quasi-static loading, the purely mechanical properties under high-rate impact remain underexplored. …”
Get full text

Physiological mechanisms of 2,4-epibrassinolide treatment in enhancing salt-alkali stress tolerance in Corylus heterophylla × C. avellana hybrid seedlings by MA Chao, CHEN Weiqing, LIU Zaiguo, HAO Jing, ZHAO Mengjiong, LU Juan

“…These findings indicated that EBR played a role in modulating ion homeostasis, which was essential for maintaining cellular functions and reducing the toxic effects of sodium ions. …”
Get full text

Psychological flexibility mediates the long-term impact of adverse interpersonal experiences in childhood and adolescence by Leonardo Fazio, Cristina Semeraro, Teresa Claudia Pennacchio, Martina Grazia Asselti, Marianna Russo, Rosalinda Cassibba, Alessandro Bertolino, Antonio Rampino, Ignazio Grattagliano, Giulio Pergola, Linda Antonella Antonucci

“…Abstract Background Early exposure to interpersonal adverse events, such as traumatic childhood events or exposure to bullying, abuse, or harassment, can impact an adult’s psychological functioning. The negative effects on quality of life and the increased risk of psychopathological outcomes may underscore long-lasting vulnerabilities. …”
Get full text

Danggui Shaoyao San Alleviates Early Cognitive Impairment in Alzheimer's Disease Mice Through IRS1/GSK3β/Wnt3a‐β‐Catenin Pathway by Kai‐Xin Zhang, Ning Sheng, Peng‐Li Ding, Ji‐Wei Zhang, Xiang‐Qing Xu, Ya‐Han Wang

“…We explored the potential mechanism by which Danggui Shaoyao San (DSS) modulates central glucose metabolism via the insulin receptor substrate 1 (IRS1)/glycogen synthase kinase‐3β (GSK3β)/Wnt3a‐β‐catenin pathway, thereby exerting protective effects on cognitive functions. …”
Get full text

RNF213 governs divergent tumor-immune dynamics across human cancers: a prognostic biomarker for immunotherapy stratification by Jinpeng Wen, Zhekuan Lv, Mojiao Lu, Chuanming Zheng, Changtian Yin

“…Conclusion This study highlights RNF213’s dual functionality in tumor progression and immune modulation, underscoring its potential as both a prognostic biomarker and a therapeutic target. …”
Get full text

LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1 by Shuaihui Wu, Qian Cheng, Yang Shi, Kunlei Wang, Zhinan Chen, Xinyin Li, Ping Jiang, Zhixiang Cheng, Zhiyong Yang, Bo Liao

“…Results The data revealed that TGF-β1 upregulates PVT1, while Smad3 functions as a transcription factor to modulate PVT1. …”
Get full text

Behavioral tests for the assessment of social hierarchy in mice by Hao Zheng, Dantong Chen, Zilong Zhong, Ziyi Li, Meng Yuan, Zhenkun Zhang, Xiaoping Zhou, Guohui Zhu, Hongwei Sun, Lin Sun

“…Existing research indicates that social hierarchy is closely associated with immune responses, neural regulation, metabolic processes, and endocrine functions. These physiological systems collectively modulate an individual’s sensitivity to stress and influence adaptive responses, thereby playing a critical role in the development of psychiatric disorders such as depression and anxiety. …”
Get full text

The Acute-Phase Serum Amyloid A Promotes Cytokines Production in Oyster <i>Crassostrea gigas</i> by Junlei Cheng, Weilin Wang, Xuemei Cheng, Xuesong Li, Luyi Lun, Xingye Lian, Lingling Wang, Linsheng Song

“…By comparison, SAA is rarely identified in aquatic species and its physical functions are also not well studied. The present study identified the only one gene encoding SAA protein in oyster <i>Crassostrea gigas</i>. …”
Get full text

Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1 by Ran An, Fang Liu, Niuniu Dai, Fangmin Li, Xingyun Liu, Haijian Cai, Lijian Chen, Jian Du

“…Results The interaction between TgCDPK3 and Arginase-1 is functionally correlated and leads to a reduction in Arginase-1 activity, ultimately, contributing to the M1-biased phenotype of the host macrophages, which is related to restraining the proliferation of parasites. …”
Get full text

Deciphering the tumor-suppressive role of RBMS3 in lung adenocarcinoma through genomic insights into prognosis and mechanisms by Li Lv, Tengxiang Zhong, Zhenkun Li, Wenhui Zhang, Yi Zhang, Ying Liang, Rongqing Li, Mingxia Ding, Jie Lin

“…Clinically, elevated RBMS3 expression was independently associated with improved overall survival (HR = 0.766, 95% CI 0.602–0.973, P = 0.029), validated by Kaplan–Meier analysis (Log-rank P = 0.027). Functionally, RBMS3 overexpression in A549 and PC-9 LUAD cells suppressed invasion (66.53% and 52.46% reduction, respectively; P < 0.01) and induced apoptosis (total apoptosis increased by 6.53% and 8.57%; P < 0.05). …”
Get full text

Optimizing Energy and Spectral Efficiency in Mobile Networks: A Comprehensive Energy Sustainability Framework for Network Operators by Luis Mata, Marco Sousa, Pedro Vieira, Maria Paula Queluz, Antonio Rodrigues

“…An additional analysis, based on domain expertise, provided evidence of potential causal relationships between the class and observed variables involving channel quality, Multiple Input Multiple Output (MIMO) utilisation, network topology and energy-saving functionalities. For example, the results show that using higher order modulation coding schemes reduces the probability of a BS falling into class D by 50%. …”
Get full text