Modified Xi-Jiao-Di-Huang Decoction Alleviates Sepsis via Regulating Macrophage Polarization by Inhibiting the PIM2/NF-κB Pathway by Ge F, Tian F, Zhu Y, Yan Q, Sun Q, Lu J

“…Finally, we examined the expression and tissue distribution of macrophages in the sepsis-induced mice.Results: MXJDH effectively reduces inflammation in sepsis mice, leading to a progressive recovery of organ functions. Moreover, MXJDH facilitates the conversion of macrophages from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype. …”
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A novel pulse-current waveform circuit for low-energy consumption and low-noise transcranial magnetic stimulation by Xinhua Tan, Ao Guo, Jiasheng Tian, Yingwei Li, Yingwei Li, Jian Shi

“…The duration and slope of the rising and falling segments of the current waveform were adjusted by the PWM pulse duration.ResultsThe optimized current waveform, represented by three segmented functions, reduces heat loss and noise while inducing a greater change in neural membrane potential compared with those obtained with conventional symmetric waveforms. …”
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RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers by Paramita Sarkar, Linda Popella, Sandra Pérez-Jiménez, Jörg Vogel

“…ABSTRACT Antisense oligomers (ASOs) hold promise as antibiotics for the selective targeting of bacterial pathogens and as tools for the modulation of gene expression in microbes that are not amenable to genetic engineering. …”
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Integrated omics reveal the mechanisms underlying softening and aroma changes in pear during postharvest storage and the role of melatonin by Jiayu Xu, Ying Zhang, Hongliang Huo, Dan Qi, Xingguang Dong, Luming Tian, Chao Liu, Yufen Cao

“…Mdm-miR10988-p3 was functionally diverse and as major regulatory components in ceRNA network. …”
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ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity by Domonkos Czárán, Péter Sasvári, Kende Lőrincz, Krisztina Ella, Virág Gellén, Roland Csépányi-Kömi

“…Our group previously demonstrated that the leukocyte-specific GTPase-activating protein ARHGAP25 regulates phagocyte effector functions and is crucial in the pathomechanism of autoantibody-induced arthritis. …”
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How short peptides interact with oral cells? A systematic review by Giulia Tetè, Aleksandr Trofimov, Natasha Cinta Vinskid, Giuseppe Tafuri, Fabia Profili, Bruna Sinjari

“…Results 8 in vitro studies dealing with different short peptides with different biological functions against oral cavity cells and tissues were included. 4 articles highlighted the ability of short peptides to positively influence the proliferation of cells in the oral cavity. 2 articles highlighted the antitumour activity of short peptides. 1 article highlighted the antimicrobial activity of the peptide DJK-15. …”
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Profile of miRNAs induced during sheep fat tail development and roles of four key miRNAs in proliferation and differentiation of sheep preadipocytes by Wei Zhang, Shiyin Wang, Liwei Yang, Li Gao, Chengcheng Ning, Mengsi Xu, Shuangyi Deng, Shangquan Gan

“…MicroRNAs (miRNAs) have been demonstrated to play crucial roles in the regulation of tail fat deposition.MethodsIn this study, miRNA-Seq was employed to investigate the expression profiles of miRNAs during different developmental stages of sheep fat tails and elucidate the functions of differentially expressed miRNAs (DE miRNAs).ResultsA total of 350 DE miRNAs were identified, among which 191, 60, 26, and 21 were significantly upregulated in tail fat tissues of fetal, lamb, hogget Altay sheep, and adult Xinjiang fine wool (XFW) sheep but downregulated in other stages. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…Conclusions: SIRT1 expression seems to be involved in different molecular pathways either suppressing or promoting tumor growth depending on the subtype of BC. These molecular functions require further investigations and validation on larger BC cohorts.…”
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Interactions of silicon and arbuscular mycorrhizal fungi on phosphorus uptake during rice vegetative growth by Li-Xue Qiu, Dong-Xing Guan, Yi-Wen Liu, Yu Luo, H. Henry Teng, Yakov Kuzyakov, Lena Q. Ma

“…Under low P availability, Si reduces AMF functioning by decreasing colonization rates, while under high P availability, Si reinforces the P-promoting effects of AMF by stimulating PSB abundance. …”
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Chemotherapeutic efficacy of curcumin against plasma and cardio-hepatorenal electrolyte disruption in dichlorvos-challenged rats via augmentation of Na⁺/K⁺-ATPase and Ca²⁺/Mg²⁺-ATP... by Adio J. Akamo, Boluwatife A. Olagunju, Iyabode A. Kehinde, Naomi M. Akamo, Adetutu O. Ojelabi, Ofem E. Eteng, Ibiyemi O. Opowoye, Adedayo A. Adebisi, Taiwo S. Oguntona, Mushafau A. Akinsanya, Tobi S. Adekunbi, Olufemi M. Ajagun-Ogunleye, Opeyemi E. Popoola, Jacob K. Akintunde, Oluseyi A. Akinloye

“…Conclusion: These results demonstrated that curcumin chemotherapy improved visceral functions and corrected ionoregulatory disruptions in DDVP-treated rats via modulation of adenosine triphosphatases pump.…”
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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

“…We characterized the differences between serplulimab with approved PD-1/PD-L1 inhibitors (pembrolizumab and nivolumab) in terms of their binding features and functions in vitro and anti-tumor activity in vivo. …”
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Ubiquitin-specific peptidases in lymphoma: a path to novel therapeutics by Maryam Samareh Salavatipour, Shirin Tavakoli, Aram Halimi, Aram Halimi, Shima Tavoosi, Amir-Hossein Baghsheikhi, Abdolkarim Talebi-Taheri, Mehdi Niloufari, Zahra Salehi, Javad Verdi, Soheila Rahgozar, Alireza Mosavi-Jarrahi, Mohammad Ahmadvand

“…Understanding the intricate functions of USPs in lymphoma offers new insights into potential therapeutic strategies, emphasizing the significance of these enzymes in the context of cancer biology.…”
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Targeting the mTOR Signaling Pathway Through miR‐100 and miR‐101 in De Novo Acute Myeloid Leukemia: Implications for Therapeutic Intervention by Maryam Kargar, Mehdi Allahbakhshian Farsani, Javad Garavand, Mahnaz Gorji, Mohammad Rafiee, Seyed Sobhan Bahreiny, Mohammad Hossein Mohammadi

“…ABSTRACT Background Microribonucleic acid (MicroRNAs/miRNAs) play a significant role in cancer progression by changing cellular functions through the modulation of protein expressions. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…Furthermore, we functionally demonstrate the inhibitory effect of the selected nanobodies in cell-based transmigration assays of the human colorectal cancer cell line HT-29.DiscussionIn summary, our study has identified and characterized four novel inhibitory high-affinity gp130 nanobodies with potential for use in cytokine-dependent autoimmunity or cancer therapy.…”
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Mitigating fines migration in low salinity water flooding of clay rich sandstones using TiO2 Saponin Zr nanocomposites by Yuman Li, Farag M. A. Altalbawy, Nikunj Rachchh, T. Ramachandran, Aman Shankhyan, A. Karthikeyan, Dhirendra Nath Thatoi, Deepak Gupta, Mohammad R. K. M. Al-Badkubi, Dilsora Abduvalieva, Samim Sherzod, Mohammad Mahtab Alam

“…Characterization through FT-IR confirmed successful functionalization, indicated by the Zr–O band at 480 cm−1 and saponin bands around 1030–1085 cm−1 and 2919–2850 cm−1. …”
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Kolmogorov–Arnold–Enhanced Nonlinear Expansions for Fine-Grained Feature Amplification in Robust Near-Shore SAR Vessel Discrimination by Hankang Wang, Gaopeng Huang, Zhao Huang, Xingru Huang, Zhaoyang Xu, Zhiwen Zheng, Shanwei Liu, Shiqing Wei, Jin Liu, Xiaoshuai Zhang

“…By integrating Gram polynomials and B-spline-based activation functions, KAN Block dynamically calibrates feature responses to suppress background clutter (e.g., shore structures) while amplifying subtle intensity patterns and edge transitions unique to ships. …”
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Engineering the T6SS of Pseudomonas for targeted delivery of antibacterial and antifungal effectors by Alicia Isabel Pérez-Lorente, Mario Araujo-Garrido, Antonio de Vicente, Diego Romero, Carlos Molina-Santiago

“…Future advancements in bioinformatics and protein engineering will further increase the specificity and functionality of T6SS-based delivery systems, offering innovative tools for managing microbial ecosystems and addressing global challenges in health and agriculture.…”
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Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization by Zixian Xu, Xin Fang, Shan Wang, Jiabei Mu, Qixian Gai, Yantong Chen, Zheyi Sun, Jiemei Zhai

“…Further investigation demonstrated a significant association between exosomal miR-21-5p and M2 polarization of tumor-associated macrophages (TAMs). Functionally, TSCC-derived exosomes promoted the polarization of M0 macrophages towards the M2 phenotype. …”
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Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility by Rosalyn W Sayaman, Masaru Miyano, Eric G Carlson, Parijat Senapati, Arrianna Zirbes, Sundus F Shalabi, Michael E Todhunter, Victoria E Seewaldt, Susan L Neuhausen, Martha R Stampfer, Dustin E Schones, Mark A LaBarge

“…The mammary epithelium is a bilayer of two major phenotypically and functionally distinct cell lineages: luminal epithelial and myoepithelial cells. …”
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Inhibition of VEGF signaling prevents exhaustion and enhances anti-leukemia efficacy of CAR-T cells via Wnt/β-catenin pathway by Suwan Wu, Yiyi Wei, Yingqi Qiu, Kexin Ai, Mu Chen, Hao Wang, Honghao Zhang, Qingyan Cen, Peiyun Liao, Xiangyang Ding, Xiaoling Xie, Yuhua Li

“…Methods The effects of Axitinib, a VEGFR inhibitor, on the biological functions of CAR-T cells in vitro and in vivo were investigated by comparing CAR-T cells pre-treated ex vivo with Axitinib, as well as utilizing a B-ALL mouse model. …”
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