Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells by Yuri M. Poluektov, Olga D. Lopina, Olga D. Lopina, Maria A. Strelkova, Iuliia D. Kuleshova, Alexander A. Makarov, Irina Yu. Petrushanko

“…Hence, alterations of CTS levels in bloodstream significantly affect the functionality of blood cells, contributing to the organism’s adaptive response. …”
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Pirfenidone Attenuates the EMT Process and the Secretion of VEGF in TGF-β2-Induced ARPE-19 Cells via Inhibiting the Activation of the NF-κB/Snail Signaling Pathway by Hongsong Li, Lijun Wang, Meilin Shao, Meimei Ren, Wenyi Zhang, Jian Zhou, Jianming Wang

“…Pirfenidone (PFD), an antifibrotic drug, has various beneficial functions such as antioxidant, antifibrotic, and anti-inflammatory effects. …”
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From traditional remedy to modern therapy: a comprehensive review of palmatine’s multi-target mechanisms and ethnopharmacological potential by Zhoujing Shi, Lutuo Han, Huasen Yang, Geling Lu, Zhouying Shi, Boyan Ma

“…In anticancer applications, palmatine functions through multiple mechanisms encompassing direct tumor cell cytotoxicity, metastasis suppression, and angiogenesis inhibition, while maintaining dose-dependent safety characteristics.ConclusionPalmatine serves as a bridge connecting traditional medicine and modern therapy, offering novel strategies for complex diseases through its polypharmacological actions. …”
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Application of the Double Approximation Method for Constructing Stiffness Matrices of Volumetric Finite Elements by P. P. Gaidzhurov, N. A. Saveleva

“…The mathematical apparatus of the double approximation method based on the principle of a separate representation of the distribution functions of displacements and deformations inside the element, was used to construct the stiffness matrices of volumetric FE. …”
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Effects of Gut Bacteria on the Fitness of Rice Leaf Folder <i>Cnaphalocrocis medinalis</i> by Qinjian Pan, Qingpeng Wang, Ikkei Shikano, Fang Liu, Zhichao Yao

“…Although this pest possesses diverse bacterial communities in its gut, functions of these bacteria in modulating host fitness, including development durations, pupal weight, adult longevity, and fecundity, remain unknown. …”
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Research on the detection of obstacles in front of unmanned vehicles in opencast mines based on binocular vision by Shunling RUAN, Huiguo ZHANG, Qinghua GU, Caiwu LU, Di LIU, Jing MAO

“…The Feffol network model proposed in this paper selects Efficient-v2 as the backbone network structure for feature extraction in the feature extraction stage, selects the Ebifpn feature pyramid module based on the SppCSP structure with SppCSP structure to improve the feature sensing field while enhancing the feature information of different sizes, uses the Focal Loss and CIoU Loss loss functions to balance positive and negative samples, and solve the problem of method failure when there is no intersection between the prediction frame and the real detection frame. …”
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Post-translational modification acts as a digital like switch influencing AtPIP2;1 water and cation permeability by Jiaen Qiu, Samantha A. McGaughey, Caitlin S. Byrt, Steve D. Tyerman

“…Subsequently, sub-sets of plant AQPs have exhibited diverse functionalities beyond water transport. The aquaporin AtPIP2;1, an abundant Plasma membrane Intrinsic Protein in Arabidopsis thaliana, can transport water but also CO2, H2O2 and monovalent cations under certain conditions. …”
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m6A-modified lncRNA GAS5 promotes M1-polarization of microglia in alcohol use disorder by Shuang Zhu, Peng Wang, Jian Hu

“…Long noncoding RNA (lncRNA) are essential for modulating the onset and progression of alcohol use disorder (AUD). …”
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Stat3 oxidation-dependent regulation of gene expression impacts on developmental processes and involves cooperation with Hif-1α. by Michela Grillo, Carolyn Palmer, Nadine Holmes, Fei Sang, Andrew C Larner, Rahul Bhosale, Peter E Shaw

“…Our data suggest that Stat3 and Hif-1α cooperate to regulate genes involved in immune functions and developmental processes in response to oxidative stress.…”
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An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure by Cristina Manuela Drăgoi, Anca Zanfirescu, Ion-Bogdan Dumitrescu, Anca Ungurianu, Denisa Marilena Margină, Alina-Crenguţa Nicolae

“…Tryptophan, an essential amino acid, serves as a vital structural element in proteins and a precursor for bioactive compounds like serotonin and melatonin, which impact various physiological functions. Methods: Experimental studies have been conducted to reveal the interaction mechanisms of these endogenous indole derivatives with calf thymus DNA (ct-DNA). …”
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Probiotic treatment induces sex-dependent neuroprotection and gut microbiome shifts after traumatic brain injury by Morgan Holcomb, Austin G. Marshall, Hannah Flinn, Mariana Lozano-Cavazos, Sirena Soriano, Fernando Gomez-Pinilla, Todd J. Treangen, Sonia Villapol

“…Immunohistochemical, in situ hybridization, and histological analyses were performed to assess neuroinflammation post-TBI, while behavioral assessments were conducted to evaluate sensorimotor and cognitive functions. Results Our findings suggest that a 7-week PP administration induces specific microbial changes, including increased abundance of beneficial bacteria such as Lactobacillaceae, Limosilactobacillus, and Lactiplantibacillus. …”
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Agent-Based Intelligent Fuzzy Traffic Signal Control System for Multiple Road Intersection Systems by Tamrat D. Chala, László T. Kóczy

“…The proposed system is designed to operate in a decentralized manner, with each intersection having its own agent (fuzzy controller) functioning concurrently. The intelligent fuzzy controller of the system can recognize emergency vehicles, assess the queue length and waiting time of vehicles, measure the distance of vehicles from intersections, and consider the cumulated waiting times of short vehicle queues. …”
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Protocol for project MHISS: Mental Health and Immunodynamics of Social Stress by Daniel P. Moriarity, Andrea C.M. Miller, Japneet Kaur, Ritika Prasad, Matthew B. Figueroa, George M. Slavich

“…In particular, social stress has been demonstrated to be a particularly potent type of stress that modulates immune activity. Typically, this effect has been tested in the lab with acute social stressors. …”
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ATP6V0B promotes the tumorigenesis of bladder cancer by activating PAQR4/PI3K/AKT signaling by Xinsheng Wang, Yanqing Qu, Yanbo Sun, Tong Yang, Wei Wang, Xinmeng Dou, Yong Jia

“…Additionally, our results showed that ATP6V0B functions as an oncogene and stimulates the proliferation, invasion, and migration of BCa cells in vitro. …”
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Expression of ApoE and Spp1 in the cochlea and auditory cortex of age-related hearing loss mice by Yingxue Yuan, Junhong Zhang, Jingyi Zhao, Xiru Zhang, Zhixin Cao

“…GO and KEGG enrichment analyses revealed significant enrichment of differentially expressed proteins in functions and signaling pathways associated with neurodegenerative diseases and neurotransmission. …”
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6-Methoxyflavone inhibits glycolytic energy metabolism in HeLa cells by Chaihong Zhang, Lihong Chen

“…Abstract Background Enhanced glycolytic levels in cancer cells are a common characteristic of many cancer types. Modulation of glycolytic metabolism is crucial for enhancing the efficacy of cancer therapy. …”
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Transcription factor TCF3 promotes bladder cancer development via TMBIM6-Ca2+-dependent ferroptosis by Wei-Feng Yang, Wei-Ming Guo, Qing-Tian Luo, Jingfen Lu, Zhou-Ke Tan, Yuan-Chun Ye, Gang Fan

“…The bladder cells were overexpressed or silenced with TCF3/TMBIM6 with ferroptosis inducer (Erastin)/Ca2+ blocker (BAPTA-AM) to investigate the effects on Ca2+-dependent ferroptosis and other functions. Finally, tumorigenicity was validated in nude mice. …”
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Sorghum-peanut intercropping under salt stress mediates rhizosphere microbial community shaping in sorghum by affecting soil sugar metabolism pathways by Xia Shao, Chunmei Yang, Yuxuan Chen, Chang Liu, Chunjuan Liu, Xiaolong Shi, Yufei Zhou

“…These correlations indicate that sorghum intercropped with peanuts can promote the enrichment of microbial taxa under salt stress, thereby enhancing soil metabolic functions and stress tolerance by optimizing the rhizosphere microbial community. …”
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Global lncRNA expression signature in pre-metastatic lung and their regulatory effects in pulmonary metastasis by Huifang Shi, Peng Wang, Jiaan Wang, Lei Chen, Yan Qin, Jie Lv

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to infer the prospective functions of the differentially expressed lncRNAs. …”
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Clinical usefulness of hemoencephalography beyond the neurofeedback by Serra-Sala M, Timoneda-Gallart C, Pérez-Álvarez F

“…It is available to any research group for its relative simplicity and low cost and is a useful tool for assessing prefrontal-dependent functions. Older teenagers pose peculiarities in the prefrontal maturation, and we aim to establish HEG patterns that might have clinical applicability. …”
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