miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren’s syndrome by suppressing Th17 cells via targeting RORC/IL-17A signaling axis by Yufei Xie, Maosheng Chai, Yixiao Xing, Peiru Zhou, Pan Wei, Hong Hua

“…These small RNAs are essential for EV-mediated functions, particularly in regulating gene expression and modulating the immune microenvironment. …”
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M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer by Eva M Garrido-Martin, Toby W P Mellows, James Clarke, Anusha-Preethi Ganesan, Oliver Wood, Angelica Cazaly, Gregory Seumois, Serena J Chee, Aiman Alzetani, Emma V King, Gareth Thomas, Peter S Friedmann, Pandurangan Vijayanand, Tilman Sanchez-Elsner

“…Background The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activities and phenotypes by integration of signals in the tumor microenvironment. …”
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Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression by Jingya Zhang, Xinru Wang, Xu Wang, Songyue Li, Jianli Hou, Yibin Zhang, Xinyue Song, Shukun Cao, Ya Xu, Jing Qi, Baoshan Zhao, Xiaodong Zheng, Yan Xing

“…Conclusions Circ‐myh8 RNA, which functions jointly with KAT7, enhances H3K27ac enrichment, thereby promoting SE activity for FOSL2 transcription. …”
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Targeting microRNA methylation: Innovative approaches to diagnosing and treating hepatocellular carcinoma by Albert Sufianov, Murad Agaverdiev, Andrey Mashkin, Tatiana Ilyasova

“…These miRNAs are integral to a wide array of cellular functions, including proliferation, apoptosis, and differentiation, and their dysregulation is closely associated with the pathogenesis of various cancers, notably HCC. …”
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Transcutaneous and transcranial electrical stimulation for enhancing military performance: an update and systematic review by Onno van der Groen, Sara A. Rafique, Nick Willmot, Margaret G. Murphy, Margaret G. Murphy, Eulalia Tisnovsky, Tad T. Brunyé, Tad T. Brunyé

“…Various types of ES, such as transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), modulate neuronal membrane potentials and cortical excitability, potentially improving cognitive functions relevant to military training and operations.MethodsThis systematic review updates previous findings by examining studies published between 2019 and 2024 that investigated electrical stimulation effects on cognitive performance in military personnel and tasks. …”
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The Application of Eye Movement Registration Systems in the Assessment of Visuospatial Memory in Preschool Children by Elizaveta A. Panfilova, Margarita S. Aslanova, Sergey V. Leonov, Pavel Yu. Sukhochev, Evgeny A. Sedogin, Irina S. Polikanova

“…The results were also compared with the results of tests on cognitive flexibility, nonverbal intelligence, and fine motor skills, allowing for a clearer separation of visual working memory functions from other control processes. The level of cognitive flexibility, nonverbal intelligence, and fine motor skills did not affect these differences. …”
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Assessment of nutritional contents and microbial community of three populations of cultured Beluga sturgeon (Huso huso) broodfish by Omolola C. Betiku, Toyesha Simpson, Makayla Hightower, Robinson Orozco, Sahar Mejri, Stephen Leong, Paul S. Wills, Grace Johnny

“…More studies should be directed to address the functionality of the microbiota highlighted in the gut sections in this study and their involvement in the metabolism of essential amino acids to improve the conditions and optimal nutrient requirements of farm‐raised Beluga sturgeon.…”
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Design and Optimization of Intelligent High-Altitude Operation Safety System Based on Sensor Fusion by Bohan Liu, Tao Gong, Tianhua Lei, Yuxin Zhu, Yijun Huang, Kai Tang, Qingsong Zhou

“…By fusing five modes, it realizes the functions of safety status detection and precise positioning. …”
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Comprehensive profiling of candidate biomarkers and immune infiltration landscape in metabolic dysfunction-associated steatohepatitis by Zhangliu Jin, Jianyun Cao, Zhaoxun Liu, Mei Gao, Hailan Liu

“…Furthermore, the biological processes and molecular functions of the IR-DEGs were analyzed. To characterize the hub IR-DEGs, we employed a protein-protein interaction network. …”
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Anticancer Mechanisms of Ginsenoside Compound K: A Review by Yu-Po Lee, Hui-Ting Chan, Tzu-Hsuan Li, Lichieh (Julie) Chu, Sheau-Long Lee, Yu-Quan Chang, Robert YL Wang

“…The underlying rationale is that CK exhibits a multitude of effects within the realm of cancer research, including but not limited to the mitigation of inflammation, the suppression of cancerous cell proliferation, and the safeguarding of cardiovascular, hepatic, and renal functions. This review methodically identifies and organizes CK-related journals according to the following key points of cancer treatment: the effects on cancer cells themselves, angiogenesis inhibition, modulation of immune response to identify cancer cells, and inflammation regulation. …”
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Developmental changes in dopamine-related neurophysiology and associations with adolescent substance use and incentive-boosted cognitive control by Jessica S. Flannery, Ashley C. Parr, Kristen A. Lindquist, Eva H. Telzer

“…Developmental changes in dopaminergic functioning may be involved in substance use initiation and escalation during adolescence. …”
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CRISPRi screening reveals E. coli’s anaerobic-like respiratory adaptations to gentamicin: membrane depolarization by CpxR by Donghui Choe, Eunju Lee, Yoseb Song, Sun Chang Kim, Ki Jun Jeong, Bernhard Palsson, Byung-Kwan Cho, Suhyung Cho

“…ABSTRACT Bacterial genes serve diverse cellular functions and many affect fitness in response to environmental challenges. …”
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Integrative analysis of semaphorins family genes in colorectal cancer: implications for prognosis and immunotherapy by Jiahao Zhu, Benjie Xu, Zhixing Wu, Zhixing Wu, Zhiwei Yu, Shengjun Ji, Jie Lian, Haibo Lu

“…Moreover, distinct biological functions, mutation burden, immune cell infiltration, and immunotherapy response were observed between the high- and low-SRS groups. scRNA-seq and ST demonstrated unique cellular heterogeneity in CRC. …”
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Recent advancements in metal oxide‐based hybrid nanocomposite resistive random‐access memories for artificial intelligence by Anirudh Kumar, Kirti Bhardwaj, Satendra Pal Singh, Youngmin Lee, Sejoon Lee, Mohit Kumar, Sanjeev K. Sharma

“…Optoelectronic neuromorphic computing architectured ReRAMs can simulate neural functionalities, such as light‐triggered long‐term/short‐term plasticity. …”
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Molecular features and diagnostic modeling of synovium- and IPFP-derived OA macrophages in the inflammatory microenvironment via scRNA-seq and machine learning by Chao Lin, Yue Wan, Yong Xu, Qingsong Zou, Xiaoxiao Li

“…This study investigates the functions of OA-macrophages and their clinical significance. …”
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The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration by Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou

“…This study aimed to investigate the functions and mechanisms of mitochondria-anchored protein ligase (MAPL), a mitochondrial SUMO E3 ligase, during IVDD progression. …”
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Isolation and identification of Alternaria alstroemeriae causing postharvest black rot in citrus and its control using curcumin-loaded nanoliposomes by Jie Li, Zuyun Zhang, Ping Yang, Yu Zhao, Jiaxin Fang, Tingting Yang, Ruopeng Yang, Ruopeng Yang

“…Overall, our findings revealed that curcumin-loaded nanoliposomes, functioning as a plant elicitor, could effectively modulate physiological enzyme activities to confer the black rot resistance in citrus, which highlighted the potential of curcumin-loaded nanoliposomes for sustainable agricultural practices.…”
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Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation by Tessa Nelemans, Ali Tas, Nina L. de Beijer, George M. C. Janssen, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert

“…P62 thus plays an antiviral role during USUV infection, although this antiviral effect might also be related to its functions outside the autophagy pathway, such as modulation of the immune response. …”
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Indole-3-Carbinol Enhances Alternative Activation of Macrophages via AHR Pathway and Glucose Transporter Regulation by Delara Omrani, Saeed Mohammadi, Moein Malekzadeh, Mohsen Saeidi, Fakhri Sadat Seyedhosseini, Ahmed Al-Harrasi, Yaghoub Yazdani

“…Our study aimed to investigate how AHR activation by I3C and TCDD could impact glucose transporters and macrophage phenotypes and functions in human macrophages. Human monocyte-derived macrophages (hMDMs) and THP-1 cell-derived macrophage-like cells were treated for 24 h with 100 ng/mL LPS, 100 nM TCDD, and 10 ng/µL I3C. …”
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Mutation of the histone demethylase Gasc1 causes ASD-like symptoms in mice by Tetsushi Kagawa, Yuhei Yamaguchi, Yasuhiro Kokubu, Genki Sudo, Aoi Ebisawa, Satoko Hattori, Keizo Takao, Kohtarou Konno, Naomi Nakagata, Takafumi Inoue, Masahiko Watanabe, Johji Inazawa, Tsuyoshi Miyakawa, Tetsuya Taga

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