Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α by Chang Liu, Huayong Zhang, Xiaojun Tang, Ruihai Feng, Genhong Yao, Weiwei Chen, Wenchao Li, Jun Liang, Xuebing Feng, Lingyun Sun

“…Impaired osteogenic differentiation functions were indicated by decreased ALP activity (P<0.001) and reduced mRNA and protein levels of osteogenic marker genes (P<0.05) in CIA mice compared with DBA/1 mice. …”
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CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer by Viviana Longo, Pellegrino Mazzone, Giovanni Calice, Pietro Zoppoli, Giuseppina Di Paola, Giuseppe Cesta, Margherita Luongo, Claudia Sabato, Sabino Russi, Simona Laurino, Tiziana Notarangelo, Giuseppe Patitucci, Chiara Balzamo, Valeria Lucci, Elena Amendola, Giuseppina Amodio, Paolo Remondelli, Valentina Pagliara, Maria Rita Milone, Roberta Guadagno, Cristofaro De Stefano, Ferdinando De Vita, Geppino Falco, Francesco Albano

“…Abstract Chloride intracellular channels (CLICs) are a family of six evolutionarily conserved proteins with diverse functions. Previously, we identified CLIC2, as the fifth-ranked master regulator associated with diffuse-type gastric cancer (dGC) showing increased expression in tumors. …”
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Integrated analysis of electrical stimulation effects on Pseudomonas aeruginosa PAO1 inoculated denitrifying community: targeted and untargeted metabolomic analysis of phenazine bi... by Li Wu, Li Wu, Yong Liu, Yong Liu, Jianping Deng, Jianping Deng, Shuanglin Gui, Shuanglin Gui, Hanbing Nie, Hanbing Nie

“…Among these, indole, a signaling molecule with QS-like functionality, exhibited the highest VIP score as an upregulated metabolite, and another indole derivative, brassicanal A, was also elevated. …”
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Good Manufacturing Practice Validation and Radiation Dosimetry for the Clinical Application of a Novel α7-nAChR Radioligand: [¹¹C]KIn83 by Zhisheng Jia, Martin Bolin, Anton Forsberg Morén, Prodip Datta, Heba Asem, Hans Ågren, Bengt Långström, Agneta Nordberg, Christer Halldin, Sangram Nag

“…Nicotinic acetylcholine receptor (α7-nAChR) plays a crucial role in cognitive functions like memory and attention. Positron emission tomography (PET) imaging of α7-nAChR is gaining attraction for understanding and monitoring central nervous system disorders, such as Alzheimer’s disease, Parkinson’s disease, and schizophrenia. …”
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Neuroanatomical mapping of huntingtin-associated protein 1 across the rostral and caudal clusters of mouse raphe nuclei and its immunohistochemical relationships with serotonin by Marya Afrin, Marya Afrin, Md Nabiul Islam, Mirza Mienur Meher, Mirza Mienur Meher, Mir Rubayet Jahan, Kanako Nozaki, Koh-hei Masumoto, Akie Yanai, Koh Shinoda, Koh Shinoda

“…These suggest that HAP1 is crucial for modulating/protecting serotonergic functions, plausibly by upholding 5-HT neuronal plasticity/integrity by raising the threshold for neurodegeneration. …”
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Identification, Detection, and Management of Soft Rot Disease of Ginger in the Eastern Himalayan Region of India by Utpal Dey, Shatabhisa Sarkar, Durga Prasad Awasthi, Mukesh Sehgal, Ravinder Kumar, Biman De, Nayan K. Adhikary, Abhijit Debnath, Rahul Kumar Tiwari, Milan Kumar Lal, Subhash Chander, Ph. Ranjit Sharma, Amulya Kumar Mohanty

“…BCAs can suppress the phytopathogenic fungi and modulate different functions in plants.…”
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Enhancing Ion Transport in Polymer Electrolytes by Regulating Solvation Structure via Hydrogen Bond Networks by Yuqing Gao, Yankui Mo, Shengguang Qi, Mianrui Li, Tongmei Ma, Li Du

“…Herein, we demonstrate a molecular design strategy to overcome these limitations by regulating the Li⁺ solvation structure through the synergistic interplay of conventional Lewis acid–base coordination and engineered hydrogen bond (H–bond) networks, achieved by incorporating specific H–bond donor functionalities (N,N′–methylenebis(acrylamide), MBA) into the polymer architecture. …”
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Effect of cations substitution in lead-free double perovskite Cs2AgBiBr6 solar cells by Nathan Daem, Anthony Maho, Pierre Colson, Gilles Spronck, Cédric Malherbe, Thi Hieu Hoang, Mohamed-Nawfal Ghazzal, Guorui He, Felix Lang, Rudi Cloots, Jennifer Dewalque

“…Cationic substitution can be exploited as strategy to modulate the structural, electronic, and optical properties of perovskite materials. …”
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Ectopic fat accumulation in human astrocytes impairs insulin action by Martin Heni, Sabine S. Eckstein, Jens Schittenhelm, Anja Böhm, Norbert Hogrefe, Martin Irmler, Johannes Beckers, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Harald Staiger

“…Furthermore, astrocytes are important for glucose sensing, possess neuroendocrine functions and also play an important role in cerebral lipid metabolism. …”
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Molecular mechanism of PANoptosis and programmed cell death in neurological diseases by Ketian Hou, Wenhan Pan, Lianhui Liu, Qianqian Yu, Jiahao Ou, Yueqi Li, Xi Yang, Zhenlang Lin, Jun Hui Yuan, Mingchu Fang

“…Emerging PANoptosis-targeted therapies show preclinical promise in alleviating neurovascular dysfunction while preserving physiological microglial surveillance functions. Accumulating evidence linking dysregulated cell death pathways (particularly PANoptosis) to neurological disorders underscores the urgency of deciphering its molecular mechanisms and developing precision modulators as next-generation therapies. …”
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Hybrid Photonic Integrated Circuits for Wireless Transceivers by Tianwen Qian, Ben Schuler, Y. Durvasa Gupta, Milan Deumer, Efstathios Andrianopoulos, Nikolaos K. Lyras, Martin Kresse, Madeleine Weigel, Jakob Reck, Klara Mihov, Philipp Winklhofer, Csongor Keuer, Laurids von Emden, Marcel Amberg, Crispin Zawadzki, Moritz Kleinert, Simon Nellen, Davide de Felipe, Hercules Avramopoulos, Robert B. Kohlhaas, Norbert Keil, Martin Schell

“…This work leverages hybrid integration technology, which combines indium phosphide (InP) active elements, silicon nitride (Si₃N₄) low-loss waveguides, and high-efficient thermal-optical tunable polymers with micro-optical functions to achieve fully integrated wireless transceivers. …”
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A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening by Zachary Caterer, Rachel V. Horejsi, Carly Weber, Blake Mathisen, Chase N. Nelson, Maggie Bagatta, Ireland Coughlin, Megan Wettstein, Ankit Kulshrestha, Hui Siang Benjamin Lee, Leonardo R. Nunn, Mostafa Zamanian, Nicolas J. Wheeler

“…GUI development required a substantial reorganization of the wrmXpress backend codebase, which allowed for the addition of a new pipeline for high-resolution tracking of worm behavior, and we demonstrate its functionality by showing that praziquantel modulates the behavior of Schistosoma mansoni miracidia. …”
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An effective fluorescence strategy based on xanthine oxidase catalysis and the carbon dots’ specific response to ·OH for aminophylline pharmacokinetic studies by Chenfang Miao, Menghan Zhang, Ying Zheng, Xiaoyan Lin, Shuangying Yang, Linlin Xu, Sitong Lu, Zhengjun Huang, Jianyong Huang, Yanjie Zheng, Shaohuang Weng

“…In this study, high quantum yield carbon dots (CA/EDA-CDs) were synthesized via a hydrothermal method using riboflavin as the carbon source, citric acid and ethylenediamine as functionalizing agents and dopants. The luminescent structure of CA/EDA-CDs, featuring a π-conjugated system (aromatic C=C and graphite N) and surface chromophores (C=N/C=O) connected via C-N, C-O, and hydrogen bonds, was controllably modulated by hydroxyl radical (·OH). …”
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Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…This article describes a conceptual framework for testing different radiation therapy regimens as separate models of how radiation itself functions as an immunomodulatory ‘drug’ to provide alternatives to the widely adopted ‘one-size-fits-all’ strategy of frequently used 8 Gy×3 regimens immunomodulation.…”
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Novel potential neuroprotective targets for DengZhanXiXin injection in middle cerebral artery occlusion rats recommended by quantitative proteomics and simulated docking by Min Li, Min Li, Linshuang Wang, Haiting An, Xin Li, Xin Li, Yaojing Chen, Yaojing Chen, Dongfeng Wei, Zhanjun Zhang, Zhanjun Zhang

“…DZXI influenced the expression levels of proteins in 13 specific biological functions, with cell signaling and chemical synaptic transmission-associated proteins being most affected. …”
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Proactive and reactive movement behaviours shape the antipredator sequence in a large herbivore by Charlotte Vanderlocht, Benjamin Robira, Andrea Corradini, Simone Dal Farra, Federico Ossi, Davide Righetti, Heidi C. Hauffe, Luca Pedrotti, Francesca Cagnacci

“…Using an exhaustive inventory of red deer hunting events and very high-resolution canopy cover density (LiDAR), we combined movement metric (displacement and path length) models and integrated step selection functions to investigate antipredator movement responses to lethal risk on various spatiotemporal scales, considering a dynamic landscape of risk. …”
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Secretagogin Mediates the Regulatory Effect of Electroacupuncture on Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Surgical Trauma by Mizhen Zhang, Jingxian Sun, Yu Wang, Zhanzhuang Tian

“…When SCGN expression in the PVN was functionally knocked down by a constructed CsCI virus, we found that SCGN knockdown decreased the serum CRH, ACTH, and CORT levels in the SCGN shRNA+hepatectomy group compared with the hepatectomy group, and it also attenuated CRH expression in the PVN. …”
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NeXtMD: a new generation of machine learning and deep learning stacked hybrid framework for accurate identification of anti-inflammatory peptides by Chengzhi Xie, Yijie Wei, Xinwei Luo, Huan Yang, Hongyan Lai, Fuying Dao, Juan Feng, Hao Lv

“…NeXtMD systematically extracts four functionally relevant sequence-derived descriptors—residue composition, inter-residue correlation, physicochemical properties, and sequence patterns—and utilizes a two-stage prediction strategy. …”
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Age-related differences in the weighting of kinematic and contextual information during action prediction by Elisa Ravizzotti, Alessandra Finisguerra, Gaia Bonassi, Carola Cosentino, Susanna Mezzarobba, Susanna Mezzarobba, Alessandro Botta, Martina Putzolu, Sara Terranova, Valentina Bianco, Valentina Bianco, Laura Avanzino, Laura Avanzino, Elisa Pelosin, Elisa Pelosin, Cosimo Urgesi, Cosimo Urgesi

“…While it is well known that motor and cognitive functions face age-related changes, research examining how action prediction abilities evolve across the lifespan remains limited.MethodsHere, we compared the action prediction performance of 30 young and 30 older adults in a temporal occlusion paradigm displaying everyday actions embedded in breakfast scenarios. …”
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Molecular Docking, Dynamics, and Preclinical Studies Reveal Morin Hydrate as a Potent PPARγ and Nrf2 Agonist That Mitigates Colon Inflammation by Aya A. Touny, Balaji Venkataraman, Saeeda Almarzooqi, Rajesh B. Patil, Bhoomendra A. Bhongade, Miroslav Harjaček, Tahir A. Rizvi, Shreesh Ojha, Shamanth Neralagundi Harihar Gowdru, Sandeep B. Subramanya

“…ABSTRACT Peroxisome proliferator‐activated receptors (PPARs), functioning as nuclear receptors, regulate the expression of genes associated with inflammation, lipid metabolism, and glucose metabolism. …”
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