Corrective effects of original bioflavonoid complex in the cyclophosphamide-induced immunity disorders by I. A. Goldina, E. V. Markova, I. A. Orlovskaya, L. B. Toporkova, V. A. Kozlov

“…Alleviation of Cy-induced suppressive effects upon cellular immune response, proliferation rates of immune cells, as well as stimulation of hematopoietic stem cell functions suggest a sufficient capacity of the original bioflavonoid complex for modulation of immunity and hematopoiesis, thus presenting experimental proofs for its potential usage as an adjuvant treatment of the patients with malignant diseases.…”
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Cerebellar transcranial direct current stimulation improves quality of life in individuals with chronic poststroke aphasia by Zhong Sheng Zheng, Jing Wang, Sharon Lee, Kevin Xing-Long Wang, Ben Zhang, Melissa Howard, Emily Rosario, Caroline Schnakers

“…Recent evidence also highlights the cerebellum’s involvement in affective and social processes, suggesting potential broader effects of cerebellar modulation. This study investigated the efficacy of anodal tDCS over the right cerebellum paired with speech and language therapy in enhancing language functions and quality of life in individuals with PSA. …”
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Identification and Expression Analysis of Na⁺/K⁺-ATPase and NKA-Interacting Protein in Ark Shells by Man Song, Xiao Liu, Jie Zhang, Wuping Li, Jingfen Pan, Yanglei Jia

“…Phylogenetic analysis revealed a high degree of conservation in the NKA-α and NKA-β subunits across ark shells, suggesting strong selective pressures to preserve their functionality. However, the marked divergence observed between the two NKA-β subunits suggests that they may serve distinct roles in ion transport, potentially specialized for specific environmental conditions or stress responses. …”
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MgCuSb as a suitable electrode for contacting pre-compacted pellets of MgAgSb thermoelectric material by Amandine Helt, Amandine Duparchy, Aidan Cowley, Eckhard Müller, Johannes de Boor

“…Here, we investigate the metallization of MgAgSb with MgCuSb, providing microstructural and electrical analyses of the interfaces for functionalized legs obtained from a combined sintering of both materials systematically varying temperature, duration and pressure. …”
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Are Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Central Nervous System (CNS) Penetrant: A Narrative Review by Juliana West, Maggie Li, Sabrina Wong, Gia Han Le, Kayla M. Teopiz, Kyle Valentino, Christine E. Dri, Roger S. McIntyre

“…Abstract Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone that modulates glucose metabolism and insulin secretion. …”
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Development and Comparative Evaluation of Two Polyherbal Nutraceuticals, BobyGuards A and B: Phytochemical Composition, Antioxidant Potential, and Nutritional Value by Borelle Mafogang, Stephane Zingue, Charles Taptue Kotue, Michelle Djouhou, Franck Armand Fozing Fomo, Roger Ponka, Elie Fokou

“…In contrast, BGA’s elevated mineral content, particularly copper and manganese, may enhance enzymatic functions involved in metabolic and redox homeostasis. …”
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Therapeutic Targeting of PPARγ in Nonalcoholic Fatty Liver Disease: Efficacy, Safety, and Drug Development by Zhou Z, Jin R, Gu Y, Ji Y, Lou Y, Wu J

“…This review summarizes the physiological functions of PPARγ in tissues such as adipose tissue, pancreas, intestine, and liver. …”
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Cooperation between Epstein-Barr virus immune evasion proteins spreads protection from CD8+ T cell recognition across all three phases of the lytic cycle. by Laura L Quinn, Jianmin Zuo, Rachel J M Abbott, Claire Shannon-Lowe, Rosemary J Tierney, Andrew D Hislop, Martin Rowe

“…Together, these data firstly indicate which potential immune-evasion functions are actually relevant in the context of lytic virus replication, and secondly identify lytic-cycle phase-specific effects that provide mechanistic insight into the immunodominance pattern seen for CD8+ T cell responses to EBV lytic antigens.…”
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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling by Elise S Bruguera, Jacob P Mahoney, William I Weis

“…Our findings suggest that Tspan12 does not allosterically enhance Fzd4 binding to Norrin or Dvl, but instead functions to directly capture Norrin upstream of signaling.…”
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The value of patient-reported outcomes in patients with type 2 diabetes mellitus receiving insulin therapy: assessment of quality of life and hypoglycemia problems by Tat'yana Ivanovna Ionova, Vitaliy Ivanovich Odin, Tat'yana Pavlovna Nikitina, Kira Aleksandrovna Kurbatova

“…Higher the fear of hypoglycaemia, the more impaired was social functioning, mental health, vitality and general health.Conclusion. …”
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Rolling Bearing Fault Diagnosis Method Based on SWT and Improved Vision Transformer by Saihao Ren, Xiaoping Lou

“…To further enhance generalization, the model combines cross-entropy and mean squared error loss functions. The experimental results show that the proposed method achieves average accuracy rates of 99.96% and 96.51% under constant and varying load conditions, respectively, on the Case Western Reserve University bearing fault dataset, outperforming other methods. …”
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DualPlaqueNet with dual-branch structure and attention mechanism for carotid plaque semantic segmentation and size prediction by Lili Deng, Xingyu Duan, Yongxiang Sun, Yunling Wang, Dongmei Song, Xiaokai Duan

“…However, ultrasound images suffer from high noise, low contrast, and blurred edges, making it difficult for traditional image processing methods to accurately extract plaque information.ObjectiveTo establish a deep learning-based DualPlaqueNet model for semantic segmentation and size prediction of plaques in carotid ultrasound images, thereby providing comprehensive and accurate auxiliary information for clinical risk assessment and personalized diagnosis and treatment.MethodsDualPlaqueNet uses a dual-branch architecture combined with attention mechanisms and joint loss functions to optimize segmentation and regression. …”
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Knowledge of the genetics of human pain gained over the last decade from next-generation sequencing by Dario Kringel, Jörn Lötsch

“…NGS-based pain research faces challenges related to complex data analysis and interpretation of rare genetic variants with unknown biological functions. Nevertheless, NGS offers significant potential for improving personalized pain management and highlights the need for interdisciplinary collaboration to translate findings into clinical practice.…”
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Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound by Min Gon Kim, Chih-Yu Yeh, Kai Yu, Zherui Li, Kalpna Gupta, Bin He

“…Low-intensity transcranial focused ultrasound (tFUS) has recently been shown to noninvasively and non-pharmacologically modulate pain hypersensitivity with high spatial specificity and deep brain penetration. …”
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Multi strategy Horned Lizard Optimization Algorithm for complex optimization and advanced feature selection problems by Marwa M. Emam, Mosa E. Hosney, Reham R. Mostafa, Essam H. Houssein

“…The efficacy of mHLOA is rigorously evaluated using 12 complex benchmark functions from the CEC’22 test suite and 14 standard datasets from the UCI Machine Learning Repository. …”
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RL-Cervix.Net: A Hybrid Lightweight Model Integrating Reinforcement Learning for Cervical Cell Classification by Shakhnoza Muksimova, Sabina Umirzakova, Jushkin Baltayev, Young-Im Cho

“…A novel application of RL for dynamic feature refinement and adjustment based on reward functions was employed to optimize the detection capabilities of the model. …”
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BLIS Fingerprinting as a Tool to Investigate the Distribution and Significance of Bacteriocin Production and Immunity in <i>Streptococcus pyogenes</i> and <i>Streptococcus salivari... by John R. Tagg, John D. F. Hale, Liam K. Harold

“…The study of bacteriocins has significantly enhanced our understanding of microbial interactions, notably within the genus <i>Streptococcus</i>. Among the most functionally diverse and clinically relevant bacteriocins are those belonging to the lantibiotic class, which exhibit potent antimicrobial properties and are central to the competitive dynamics of streptococcal species. …”
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Amylin Receptor 1 Mutagenesis Revealed a Potential Role of Calcitonin Serine 29 in Receptor Interaction by Hyeseon Song, Jaehyeok Jang, Minjae Park, Junsu Yun, Jeongwoo Jin, Sangmin Lee

“…The amylin receptor functions as a heterodimer complex that consists of the calcitonin receptor for peptide hormone calcitonin and an accessary protein. …”
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Effects of beinaglutide on visceral fat area and gut microbiota in obesity by Tianshui Liu, Weizheng Liang, Fanghua Xu, Yun Wu, Jun Su, Chaoxi Li, Weidong Ren, Li Shi

“…Glycolipid metabolism indices, inflammation indices, and hepatic and renal functions were assessed at treatment initiation and 4 and 12 weeks after treatment. …”
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Dermatophytes adaptation to the human host exemplified by Microsporum canis by Xin Zhou, Ricardo Belmonte, Chao Tang, Vania Aparecida Vicente, Sybren de Hoog, Peiying Feng

“…GH18, AA1, AA3) showed strong ecological correlations with either zoophilic or anthropophilic lifestyles. The key functions of these genes from these subfamilies focus on modulating sporulation, endoproteases, lipolysis, pH regulatory adaptability, chitinase, and conidial pigment biosynthesis. …”
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