Slit-Robo signaling supports motor neuron avoidance of the spinal cord midline through DCC antagonism and other mechanisms by Kelsey R. Nickerson, Kelsey R. Nickerson, Ferass M. Sammoura, Ferass M. Sammoura, Yonghong Zhou, Yonghong Zhou, Alexander Jaworski, Alexander Jaworski

“…This includes motor neuron wiring, where Robos help prevent both motor neuron cell bodies and axons from aberrantly crossing the spinal cord midline. These functions had been ascribed to Robo signaling being required to counter DCC-mediated attraction to Netrin-1 at the midline, either by mediating repulsion from midline-derived Slits or by silencing DCC signaling. …”
Get full text

ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation by Guangrui Pan, Mingquan Huang, Shaozhi Fu, Yu Wang, Lijia He, Bin Wu, Jinping Yang, Sheng Lin, Yu Fan

“…The observations demonstrates that ADCY4 is a significant tumor suppressor and that loss of ADCY4 functions by DNA methylation hampers cAMP signaling and triggers FAK/AKT and ERK signaling during breast tumorigenesis.…”
Get full text

Estrogen receptor α regulates SVCT2 protein level in human breast cancer cells by Soon Young Jang, Eunbi Hong, Yebin Jo, Jiyun Kim, Jong-Ho Kim, Yuran Na, Chang-Hwan Yeom, Yoon Jung Yang, Emanuela Jacchetti, Manuela Teresa Raimondi, Seyeon Park

“…Notably, silencing XIAP restored SVCT2 stability, underscoring its regulatory role. Functionally, ERα or SVCT2 knockdown decreases doxorubicin-induced cytotoxicity, accompanied by increased expression of ATP-binding cassette (ABC) transporter genes, which mediate drug efflux and contribute to chemoresistance. …”
Get full text

Comparative Proteomic Insights into the Immune Response of <i>Conogethes punctiferalis</i> Challenged with <i>Beauveria bassiana</i> by Shaohua Li, Zhiwei Kang, Xiangdong Li, Hailei Wei, Xiangchu Yin, Fangqiang Zheng, Fanghua Liu

“…On the basis of proteomic analysis, 4195 quantifiable proteins were identified from a total of 29,155 peptides. The functions of the identified proteins were annotated in four databases (GO, COG, KEGG, and IPR). …”
Get full text

Research progress on the microbial metabolism and transport of polyamines and their roles in animal gut homeostasis by Chong Zhang, Yongkang Zhen, Yunan Weng, Jiaqi Lin, Xinru Xu, Jianjun Ma, Yuhong Zhong, Mengzhi Wang

“…These polyamines are then transported into the bloodstream, through which they are distributed to various tissues and organs to exert their biological functions. Polyamines synthesized by intestinal microorganisms serve dual critical roles. …”
Get full text

A Reconfigurable Polarimetric Photodetector Based on the MoS₂/PdSe₂ Heterostructure with a Charge-Trap Gate Stack by Xin Huang, Qinghu Bai, Yang Guo, Qijie Liang, Tengzhang Liu, Wugang Liao, Aizi Jin, Baogang Quan, Haifang Yang, Baoli Liu, Changzhi Gu

“…However, conventional filter-integrated polarimetric sensing systems require complex optical components and a complicated fabrication process, severely limiting their on-chip miniaturization and functionalities. Herein, the reconfigurable polarimetric photodetection with photovoltaic mode is developed based on a few-layer MoS₂/PdSe₂ heterostructure channel and a charge-trap structure composed of Al₂O₃/HfO₂/Al₂O₃ (AHA)-stacked dielectrics. …”
Get full text

ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin−mediated degradation and facilitate viral replication by Yingying Ren, Yingying Ren, Yishuo Liu, Rui Pang, Gang Xu, Yining Lei, Yining Lei, Hang Fai Kwok, Yingliang Wu, Zhijian Cao, Zhijian Cao, Zhijian Cao, Zhijian Cao

“…However, how ZIKV-PIM1 interactions affect the viral life cycle are not fully understood.Methods and resultsHere, we demonstrated that ZIKV replication was suppressed by the PIM1 kinase inhibitor SGI-1776 in both wt and Ifnar1-/- murine peritoneal macrophages, indicating that PIM1 functions independently of type I IFN signaling. Co-immunoprecipitation and GST pull-down assays revealed that the ZIKV structural protein precursor membrane (prM) interacted with PIM1. …”
Get full text

Targeted-theranostic nanoparticles induce anti-tumor immune response in lung cancer by Zeinaf Muradova, Léna Carmès, Needa Brown, Fabien Rossetti, Romy Guthier, Sayeda Yasmin-Karim, Michael Lavelle, Toby Morris, Eder Jose Guidelli, Mileni Isikawa, Sandrine Dufort, Guillaume Bort, Olivier Tillement, François Lux, Ross Berbeco

“…In the present study, we introduced cRGD peptides onto the surface of AGuIX-Bi NPs using a PEG spacer to form an amide bond with the free amino functions present at the surface of the NPs. In vitro, AGuIX-Bi-cRGD showed enhanced internalization of NPs via integrin binding and increased radiosensitization. …”
Get full text

Indices of carbohydrate metabolism and antioxidant system state during germination of aged wheat and triticale seeds treated with H(2)S donor by T. O. Yastreb, A. I. Kokorev, A. I. Dyachenko, M. V. Shevchenko, M. M. Marenych, Yu. E. Kolupaev

“…Hydrogen sulfide is a gasotransmitter molecule involved in the realization of many functions of the plant organism, including seed germination. …”
Get full text

Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein by Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver

“…There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and functions of phase-separated condensates, as a potential therapeutic modality. …”
Get full text

Alterations in neutrophil mRNA profiles in multiple sclerosis and identification of candidate genes for further investigation by Huining Zhang, Huining Zhang, Huining Zhang, Ruoyi Guo, Ruoyi Guo, Ruoyi Guo, Yusen Han, Yusen Han, Yusen Han, Zhichao Yao, Zhichao Yao, Zhichao Yao, Moyuan Quan, Moyuan Quan, Moyuan Quan, Bin Li, Bin Li, Bin Li, Li Guo, Li Guo, Li Guo

“…These results lay the groundwork for future studies exploring therapeutic strategies targeting neutrophil functions in MS.…”
Get full text

Identification of hub genes and prediction of the ceRNA network in adult sepsis by Kangyi Xue, Kan Wu, Haoxian Luo, Haihua Luo, Zhaoqian Zhong, Fen Li, Lei Li, Li Chen

“…A comprehensive bioinformatics investigation was conducted, encompassing Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses using the “clusterProfiler” package in R, as well as gene set enrichment analysis (GSEA) to further elucidate the biological functions and pathways associated with the DEGs. Weighted gene co-expression network analysis (WGCNA) was performed to identify a module significantly associated with sepsis. …”
Get full text

Effects of alginate oligosaccharides on depression-like behavior and gut microbiota in zebrafish induced by chronic unpredictable mild stress by LONG Yan, SHI Yanxia, QIU Yue, NONG Huiting, ZHU Wuchang, SU Hongmei, HE Naihuan, QIN Zhuwen, WEI Jinbin

“…Conclusion AOS can ameliorate depressive-like behavior and increase body mass index in CUMS zebrafish, and its effects are related to the modulation of neurotransmitters, the composition of the gut microbiota, and their metabolic and substance transport functions.…”
Get full text

Overactive bladder symptoms profile and related factors among women during the perinatal period: a latent profile analysis by Xiaojiao Wang, Lingling Li, Guoying Zhang, Chunxiang Zhu, Hui Min, Xinli Zhu, Chunyi Gu

“…Abstract Background Women's pelvic floor muscle functions can be impaired during the perinatal period, which not only affects their normal social and other quality of life and physical health, but also causes mental and psychological abnormalities. …”
Get full text

Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex by Seth R. Batten, Alec E. Hartle, Leonardo S. Barbosa, Beniamino Hadj-Amar, Dan Bang, Natalie Melville, Tom Twomey, Jason P. White, Alexis Torres, Xavier Celaya, Samuel M. McClure, Gene A. Brewer, Terry Lohrenz, Kenneth T. Kishida, Robert W. Bina, Mark R. Witcher, Marina Vannucci, Brooks Casas, Pearl Chiu, Pendleton R. Montague, William M. Howe

Get full text

MvfR Shapes <i>Pseudomonas aeruginosa</i> Interactions in Polymicrobial Contexts: Implications for Targeted Quorum-Sensing Inhibition by Kelsey M. Wheeler, Myung Whan Oh, Julianna Fusco, Aishlinn Mershon, Erin Kim, Antonia De Oliveira, Laurence G. Rahme

“…Using a collection of <i>P. aeruginosa</i> QS mutants of the three major systems, LasR/LasI, MvfR/PqsABCDE, and RhlR/RhlI, and mutants of several QS-regulated functions, we reveal that MvfR and, to a lesser extent, LasR and RhlR, control competition between <i>P. aeruginosa</i> and other microbes, possibly through their positive impact on pyoverdine, pyochelin, and phenazine genes. …”
Get full text

Ferulic Acid Alleviates Radiation-Induced Immune Damage by Acting on JAK/STAT Signaling Pathway by Mingyue Huang, Anping Ye, Haoyu Zhang, Junru Chen, Tingyu Yang, Xue Wei, Yue Gao, Zengchun Ma

“…The disruption of hematopoietic and immune functions is a significant consequence of the long-term effects of radiation exposure. …”
Get full text

In Silico Analysis Determining the Binding Interactions of NAD(P)H: Quinone Oxidoreductase 1 and Resveratrol via Docking and Molecular Dynamic Simulations by Santosh Kumar Behera, Christoffer B Lambring, Albina Hashmi, Sriharika Gottipolu, Riyaz Basha

“…IM interaction between complexed protein and compound was demonstrated using LigPlot+ and the Schrödinger ligand interaction module. Molecular dynamics tools were employed to examine the physical movement of molecules to evaluate how macromolecular structures relate to their functions.Results: The results of this investigation depicted a strong affinity of resveratrol againstNQO1followed byMDsimulations (NQO1- resveratrol complex-binding energy: -2.847kcal/mol). …”
Get full text

Physiological performance and cardiac morphology of Atlantic salmon reared under slow and fast growth conditions by Malthe Hvas, Ole Folkedal, Marco A. Vindas, Ida B. Johansen

“…We therefore conclude that while early rearing environment clearly modulates cardiac morphology, recently seawater adapted Atlantic salmon do not yet show signs of compromised functionality associated with cardiac morphological differences at the whole-animal level. …”
Get full text

Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis by Li Cui, Donglei Lu, Sijie Tan, Liquan Cao

“…PMT improved lipid metabolism and insulin sensitivity by reducing stress hormone levels and modulating endocrine and nervous system functions. A precise exercise prescription combining ART, PMT, AT, RT, and ACT is recommended to optimize metabolic health in T2DM patients. …”
Get full text