Cascading effects of malaria on hepatic function and gut microbiota: Investigating the prospective therapeutic utility of Phyllanthus amarus alkaloid extract by Innocent Onyesom, Chinwendu Obogheneophruhe Elu, Ugochukwu Uzuegbu, Cyril Chukwudi Dunkwu

“…Administration of P. amarus alkaloid extract in a dose-dependent manner effectively restored liver function markers, reduced Kupffer cell hyperplasia, normalized bile acid levels, and modulated gut microbiota composition, thereby mitigating both hepatic inflammation and apoptosis. …”
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FAM20B Gain-of-Function Blocks the Synthesis of Glycosaminoglycan Chains of Proteoglycans and Inhibits Proliferation and Migration of Glioblastoma Cells by Lydia Barré, Irfan Shaukat, Mohamed Ouzzine

“…Here, we demonstrated that <i>FAM20B</i> gain-of-function decreased, in a dose dependent manner, the synthesis of both CS- and HS-attached PGs. …”
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High-Quality Assembly of the Apple Fungal Pathogen <i>Marssonina coronaria</i> Genome and Functional Analysis of Candidate Effectors by Huiting Guo, Yicong Fu, Lichi Zhong, Qiang Cheng

“…Based on genome annotation, 97 candidate effector proteins (CEPs) were identified, and 61 CEPs were successfully cloned for functional analysis. Transient expression assays in <i>Nicotiana benthamiana</i> revealed that eight CEPs significantly suppressed BAX-induced cell death, with McCEP12, McCEP23, McCEP24, and McCEP52 concurrently inhibiting flg22-triggered reactive oxygen species bursts. …”
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A functional genomics approach identifies candidate effectors from the aphid species Myzus persicae (green peach aphid). by Jorunn I B Bos, David Prince, Marco Pitino, Massimo E Maffei, Joe Win, Saskia A Hogenhout

“…Overall, we identified aphid salivary proteins that share features with plant pathogen effectors and therefore may function as aphid effectors by perturbing host cellular processes.…”
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Exploring the functional and immune landscape of E-β thalassemia patients through RNA sequencing of peripheral blood mononuclear cells by Nibedita Mitra, Prosanto Chowdhury, Anupam Basu

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Interplay between circulating von Willebrand factor and neutrophils: implications for inflammation, neutrophil function, and von Willebrand factor clearance by Alua Kuanyshbek, Hamideh Yadegari, Jens Müller, Nasim Shahidi Hamedani, Samhitha Urs Ramaraje, Johannes Oldenburg

“…These findings suggest that VWF binding can modulate neutrophil function, potentially influencing their role in immune responses and inflammation. …”
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Current source density and functional connectivity extracted from resting-state electroencephalography as biomarkers for chronic low back pain by Keita Ueno, Keiko Yamada, Masaya Ueda, Yasuo Naito, Ryouhei Ishii

“…To compare current source density (CSD) and functional connectivity (FC) extracted from resting electroencephalography (EEG) between patients with CLBP and healthy controls and to examine the correlations between EEG indices and symptoms. …”
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Case Report: Clinical, molecular, and functional characterization of autoimmune lymphoproliferative syndrome—a family study with a multimodal diagnosis by Bruna Cândido Guido, Ricardo Camargo, Caroliny Victoria dos Santos Silva, Anna Carolina Silva Dias, Robéria Mendonça de Pontes, Agenor de Castro Moreira dos Santos Júnior, Raquel Alves Toscano, Fabíola Scancetti Tavares, Alexandre de Albuquerque Antunes, Karina Mescouto de Melo, Karina Mescouto de Melo, Karina Mescouto de Melo

“…We report a comprehensive clinical, immunophenotypic, molecular, and functional evaluation of nine members of a consanguineous Brazilian family harboring the pathogenic FAS (NM_000043.6:c.748C &gt; T) variant. …”
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Cancer-associated fibroblasts in clear cell renal cell carcinoma: functional heterogeneity, tumor microenvironment crosstalk, and therapeutic opportunities by Man Wang, Yuanzhuo Zhao, Kangchun Xu, Chao Liu, Hui Zhong, You Wu, Ke Zhang, Shanzhai Wei

“…Combination therapies employing immune checkpoint inhibitors and VEGF antagonists exhibit promising synergistic effects, although the clinical translation remains hampered by CAF heterogeneity, dual functional roles, and the lack of specific biomarkers. …”
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Exploring the impact of occupational exposure: A study on cardiovascular autonomic functions of male gas station attendants in Sri Lanka by Tania Warnakulasuriya, Kushan Medagoda, Dulani Kottahachchi, Dunya Luke, Dilesha Wadasinghe, Prasanna Rathnayake, Janaki Ariyawansa, Tharuka Dissanayake, Pavani Sandeepani, Deepthi C. De Silva, Niranga Manjuri Devanarayana

“…These workers are exposed to hydrocarbon fuels associated with multiple health effects by modulation of the autonomic nervous system. This study was performed to determine cardiovascular autonomic functions among fuel pump attendants in Sri Lanka. …”
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Joint Transmit-receive Beam Design of FDA-MIMO Dual-function Radar-communication Systems for Radio-frequency Stealth by Haozheng WU, Chenguang SHI, Jianjiang ZHOU

“…Efficient Radio-Frequency (RF) stealth is crucial for Dual-Function Radar-Communication (DFRC) systems that detect radar stealth and con vert communication transmission. …”
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Enhancing functional motor outcomes in chronic stroke: A systematic review of the growing role of non-invasive brain stimulation. by Mirjam Bonanno, Maria Grazia Maggio, Angelo Quartarone, Giovanni Morone, Alessandro Marco De Nunzio, David Militi, Carmela Casella, Svonko Galasso, Rocco Salvatore Calabrò

“…<h4>Introduction</h4>Non-invasive brain stimulation (NIBS) promotes functional recovery by enhancing neuroplasticity and reorganizing brain networks. …”
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Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. by Donatella Valdembri, Patrick T Caswell, Kurt I Anderson, Juliane P Schwarz, Ireen König, Elena Astanina, Francesca Caccavari, Jim C Norman, Martin J Humphries, Federico Bussolino, Guido Serini

“…In conclusion, we propose that Nrp1, in addition to and independently of its role as coreceptor for VEGF-A165 and SEMA3A, stimulates through its cytoplasmic domain the spreading of ECs on fibronectin by increasing the Rab5/GIPC1/Myo6-dependent internalization of active alpha5beta1. Nrp1 modulation of alpha5beta1 integrin function can play a causal role in the generation of angiogenesis defects observed in Nrp1 null mice.…”
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Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells by Sasi Kumar Jagadeesan, Ahmad Galuta, Ryan Vimukthi Sandarage, Eve Chung Tsai

“…While induced pluripotent stem cell (iPSC)-derived NSPCs offer significant therapeutic potential, understanding their molecular and functional alignment with bona fide spinal cord NSPCs is crucial for developing autologous cell therapies that enhance spinal cord regeneration and minimize immune rejection. …”
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Urban Functional Zone Identification Based on Multimodal Data Fusion: A Case Study of Chongqing’s Central Urban Area by Yongchuan Zhang, Yuhong Xu, Jie Gao, Zunya Zhao, Jing Sun, Fengyun Mu

“…Urban Functional Zones (UFZs) are spatial units of the city divided according to specific functional activities. …”
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Assessment of cognitive function in patients with schizophrenia based on virtual reality serious games: a prospective nonrandomized clinical trial by Chenxin Wu, Yu Zhuo, Jianying Yu, Xingxing Li, Wenting Zhao, Xiandong Meng

“…IntroductionConventional neuropsychological tests for assessing cognitive function in schizophrenia face critical limitations in ecological validity and efficiency. …”
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The Phytochemical and Functional Characterization of the Aerial Parts of <i>Artemisa alba Turra</i> (<i>Asteraceae</i>) Grown in Romania by Mădălina Țicolea, Raluca Maria Pop, Marcel Pârvu, Lia-Oxana Usatiuc, Ana Uifălean, Valeria Alvarez Brito, Eva Fischer-Fodor, Floricuța Ranga, Crina Claudia Rusu, Maria Crisan, Bianca Bosca, Florinela Adriana Cătoi, Alina Elena Pârvu

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Dual function of heterotrophic ammonia-oxidizing bacteria in facilitating maize compensatory growth under limited rewatering after drought by Qiang Lv, Ruo-Yu Hao, Xiao-Ling Wang, Li-Ju Zhou, Lin Qi, Peng Song

“…Experiment 2 combined NO3 − supplementation with HAOB inoculation to assess HAOB’s twofold function in promoting compensatory growth under limited rewatering. …”
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ESCRT may function as a tumor biomarker, transitioning from pan-cancer analysis to validation within breast cancer by Xiao-rui Chen, Xiao-rui Chen, Xue-ying Tan, Zong-liang Zhang, Jiang-shui Yuan, Wei-qing Song, Wei-qing Song

“…Enrichment analysis showed that ESCRT is associated with immune-related functions and transport signaling pathways in various tumor cells. …”
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Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study by Zehao Wang, Tianlun Yu, Yuqiao Liu, Yufan Wu, Jingqing Hu, Jingqing Hu

“…BackgroundPalmitoylation, a critical post-translational modification, regulates protein localization and function in cancer. However, its role in glioma progression, immune modulation, and prognosis remains poorly understood.MethodsWe integrated transcriptomic, clinical, and mutation data from multicenter cohorts to analyze 30 palmitoylation-related genes in low-grade gliomas (LGG). …”
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