An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons by Yoshinori Hayashi, Saori Morinaga, Xia Liu, Jing Zhang, Zhou Wu, Takeshi Yokoyama, Hiroshi Nakanishi

“…However, the effect of E-prostanoid receptor agonists on large-conductance Ca2+-activated K+ (BK) channels, which are functionally coupled with NMDA receptors, remains unclear. …”
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Investigation of Antioxidative Enzymes and Transcriptomic Analysis in Response to Foliar Application of Zinc Oxide Nanoparticles and Salinity Stress in <i>Solanum lycopersicum</i> by Mostafa Ahmed, Zoltán Tóth, Roquia Rizk, Donia Abdul-Hamid, Kincső Decsi

“…Gene Ontology (GO) was used to identify the functions and regulatory pathways of the differentially expressed genes (DEGs). …”
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CzcR-dependent reduction of catalase gene expression and induction of catalase activity in Pseudomonas aeruginosa during zinc excess by Ting Li, Zhifeng Mo, Yuying Zhao, Huiluo Cao, Shuo Sheng, Zeling Xu

“…Conclusion This study reported the opposite functions of CzcR in negatively regulating the expression of catalase genes katA and katB but in positively regulating the activity of catalase and H2O2 tolerance during Zn excess in P. aeruginosa.…”
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Choline Alphoscerate: A Therapeutic Option for the Management of Subthreshold Depression in the Older Population by Nicolò Granata, Marco Vercesi, Annamaria Bonfanti, Claudio Mencacci, Ilaria Coco, Mario Mangrella, Roberto Piazza, Giancarlo Cerveri

“…<b>Methods:</b> A comprehensive review of preclinical and clinical studies was conducted, focusing on the efficacy of α-GPC in improving cognitive and behavioral functions in mental conditions and in modulating neurotransmitter systems involved in depression, such as dopamine and serotonin. …”
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Nonlocal Huygens’ meta-lens for high-quality-factor spin-multiplexing imaging by Jin Yao, Yubin Fan, Yunhui Gao, Rong Lin, Zhihui Wang, Mu Ku Chen, Shumin Xiao, Din Ping Tsai

“…Multiplexing meta-lenses present promising candidates for achieving this functionality. However, current multiplexing meta-lenses lack spectral modulation, and crosstalk between different wavelengths hampers the imaging quality, especially for biological samples requiring precise wavelength specificity. …”
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Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity by Jin-Xin Li, Jing Zhang, Cheng-Hao Li, Yun-Fang Li, Hui-Min Chen, Tao Li, Qing Zhang, Qing Zhang, Bei-Hua Kong, Bei-Hua Kong, Pei-Hui Wang, Pei-Hui Wang

“…This study investigates the immunomodulatory functions of HPV16 and HPV11 E1 in suppressing innate antiviral immune signaling pathways. …”
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Autonomous slip control inspired by human physiology for improved shared control strategy by Joana Matos, Patricia Capsi-Morales, Cristina Piazza

“…The human hand is an intricate anatomical structure essential for daily activities, yet replicating its full functionality in upper-limb prostheses remains a significant challenge. …”
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The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci by Jinghan Huang, Yixuan Wang, Thor D. Stein, Ting Fang Alvin Ang, Yibo Zhu, Qiushan Tao, Kathryn L. Lunetta, Jesse Mez, Rhoda Au, Lindsay A. Farrer, Wei Qiao Qiu, Xiaoling Zhang

“…Abstract Monocyte chemoattractant protein-1 (MCP-1), a cytokine involved in peripheral inflammation, has been shown to modulate established Alzheimer’s disease (AD) loci. …”
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Amplification-Free Electrochemiluminescent Biosensor for Ultrasensitive Detection of Fusobacterium nucleatum Using Tetrahedral DNA-Based CRISPR/Cas12a by Xindan Zhang, Minkang Wu, Haoran Shi, Soochan Kim, Shixiang Lu, Ping Wang, Jieling Qin

“…Different from the conventional 1- or 2-dimensional probes, the platform was constructed by tetrahedral DNA nanostructure (TDN) probes conjugated with quenchers and coralliform gold (CFAu) functionalized with luminescent agents. The TDN serves as an exceptional scaffold to modulate the recognition unit, substantially enhancing the recognition and cleavage efficiency of AsCas12a toward the probes. …”
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Exogenous melatonin alleviates drought stress in cotton by enhancing root cortical activity and metabolic adaptation by Haitao Zhang, Congcong Guo, Congcong Guo, Hongchun Sun, Lingxiao Zhu, Ke Zhang, Yongjiang Zhang, Zhanbiao Wang, Cundong Li, Liantao Liu

“…IntroductionThe root cortex plays a critical role in water uptake and metabolic activity, directly influencing root functionality. However, despite melatonin’s known role in plant stress tolerance, its mechanisms in modulating root cortical anatomy and metabolic adaptation under drought remain unclear. …”
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Tumor-microenvironment responsive nanomodulator for near infrared photothermal immunotherapy of hepatocellular carcinoma by Fei Kong, Tian Xia, Xiaorong Zhu, Xueping Zeng, Fengyu Wang, Jianxin Lyu, Lisen Lu, Zhen Wang

“…Remarkably, the PNI also functions as an in situ light-activated cancer vaccine, capable of inducing systemic antitumor immune responses and remodeling the immunosuppressive tumor microenvironment to establish long-lasting immune memory. …”
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The effect of peripheral dopamine on fracture healing: an experimental study in a rat model by Mücahid Osman Yücel, Raşit Emin Dalaslan, Sönmez Sağlam, Mehmet Arıcan, Zekeriya Okan Karaduman, Banu Turhan, Fatih Demir

“…Abstract Background Dopamine is a versatile biomolecule that functions as a neurotransmitter, hormone, and immune modulator in the body. …”
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Cooperative mechanisms of LexA and HtpG in the regulation of virulence gene expression in Pseudomonas plecoglossicida by Rongchao He, Yanfei Zuo, Qiu Li, Qingpi Yan, Lixing Huang

“…Recently, this paradigm—that LexA solely regulates the SOS response—has been challenged as studies reveal its involvement in various biological functions linked to virulence. Pseudomonas plecoglossicida, a major pathogen in mariculture, causes substantial economic losses annually in China. …”
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Natural Killer Cell Immune Checkpoints and Their Therapeutic Targeting in Cancer Treatment by Anqi Lin, Pengxi Ye, Zhengrui Li, Aimin Jiang, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo

“…Immune checkpoint can be expressed on the surface of NK cells and meticulously regulates their activation states and effector functions through complex signaling networks. In recent years, tumor immunotherapy strategies focusing on NK cell immune checkpoints have demonstrated remarkable advancements. …”
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Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells by Sandhya Malla, Carlos Martinez-Gamero, Kanchan Kumari, Cyrinne Achour, Georgios Mermelekas, David Martinez-Delgado, Alba Coego, Diana Guallar, Angel-Carlos Roman, Francesca Aguilo

“…Recently, catalytically independent functions of LSD1, serving as a scaffold for assembling chromatin-regulator and transcription factor complexes, have been identified. …”
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Systematic metabolic engineering enables highly efficient production of vitamin A in Saccharomyces cerevisiae by Yi Shi, Shuhuan Lu, Xiao Zhou, Xinhui Wang, Chenglong Zhang, Nan Wu, Tianyu Dong, Shilong Xing, Ying Wang, Wenhai Xiao, Mingdong Yao

“…Vitamin A is a micronutrient critical for versatile biological functions and has been widely used in the food, cosmetics, pharmaceutical, and nutraceutical industries. …”
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Mapping Nanoscale‐To‐Single‐Cell Phosphoproteomic Landscape by Chip‐DIA by Gul Muneer, Sofani Tafesse Gebreyesus, Ciao‐Syuan Chen, Tzu‐Tsung Lee, Fengchao Yu, Chih‐An Lin, Min‐Shu Hsieh, Alexey I. Nesvizhskii, Chao‐Chi Ho, Sung‐Liang Yu, Hsiung‐Lin Tu, Yu‐Ju Chen

“…Notably, the sensitivity and coverage enabled the illumination of heterogeneous cytoskeleton remodeling and cytokeratin signatures in patient‐derived cells resistant to third‐generation EGFR therapy, stratifying mixed‐lineage adenocarcinoma‐squamous cell carcinoma subtypes, and identifying alternative targeted therapy for late‐stage patients. With flexibility in module design and functionalization, Chip‐DIA can be adapted to other PTM‐omics to explore dysregulated PTM landscapes, thereby guiding therapeutic strategies toward precision oncology.…”
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Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure by Ashleigh M. Gil, Daniel F. Zegarra-Ruiz, Wan-Jung Wu, Kendra Norwood, Adrien Assie, Buck S. Samuel, Angela M. Major, Gretchen E. Diehl, Andrea A. Hill McAlester

“…Indicating that dietary lipids interfere with responses to microbial molecules needed to induce barrier protective functions, we found oleic acid could directly suppress macrophage Il23a induction after lipopolysaccharide (LPS) treatment. …”
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Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms by Yang Zhu, Lingyi Liao, Shihao Gao, Yong Tao, Hao Huang, Xiangqin Fang, Changyan Yuan, Changyue Gao

“…Abstract Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by gradual deterioration of cognitive functions, for which an effective treatment is currently unavailable. …”
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Electrochemical Sensing of Neurotransmitters Using a Metal Nanoparticle-Based Composite Platform by Stelian Lupu, Sorina-Alexandra Leau, Cecilia Lete, Ioana Diaconu, Cristian Matei

“…Neurotransmitters play important roles in the normal functioning of the central nervous system. The accurate and sensitive quantification of neurotransmitters using chromatographic and optical analytical methods is of key interest in the management of related neurodegenerative maladies. …”
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