Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats by Zhang Chunhua, Zhang Chunhua, Zhang Chunhua, Fu Le, Fu Le, Fu Le, Li Shengli, Li Shengli, Li Shengli, Wu Sachula, Wu Sachula, Wu Sachula, Hua Bao, Hua Bao, Hua Bao, Mu Lan, Mu Lan, Mu Lan, Marco Antonini, Sun Haizhou, Sun Haizhou, Sun Haizhou

“…This review highlights recent discoveries in miRNA-mediated regulation of hair follicles, focusing on their dynamic expression patterns and cell-specific functions in keratinocytes, dermal papilla cells, and follicular stem cells. …”
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Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery by Qin Xu, Bing Wang, Yang He, Zening Zheng, Jiaxin Zhang, Jizong Jiang, Wenyuan Zhang, Xiaopeng Mo, Xuejia Kang, Yongzhuo Huang

“…Seek for effective methods for brain TIME modulation is a pressing need. However, there are two major challenges against achieving the goal: first, to screen the effective drugs with TIME-remodeling functions and, second, to develop a brain targeting system for delivering the drugs.Methods In this study, an α7 nicotinicacetylcholine receptors (nAChRs)-binding peptide DCDX was used to modify the codelivery liposomes to achieve a ‘three-birds-one-stone’ delivery strategy, that is, multi-targeting the glioma vessel endothelium, glioma cells, and tumor-associated macrophages that all overexpressed α7 nAChRs. …”
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Reconfigurable Dual‐Gate Ferroelectric Field‐Effect Transistors Based on Semiconducting Polymer for Logic Operations and Synaptic Applications by Yuqing Ding, Xinzhao Xu, Yangjiang Wu, Haoqin Zhang, Lin Shao, Zhihui Wang, Hailing Zhang, Yan Zhao, Yunqi Liu

“…The dual‐gate coupling strategy further expands its functionality towards simulating the operation of logic gates. …”
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Novel strategy for tumor immunotherapy using FITC-folate bispecific adapter bridged CAR immune cell cocktails by Bin Liu, Jingqiao Shen, Yunhan Wu, Chun Fai Wong, Tran Yin Hei, Johnny Wen-tao Li, Sydney N. Hummel, Gyuhyung Jin, Nathan R. Petrucci, Dan Michelle Wang, Xiaoping Bao, Cheng Dong, Yun Chang

“…To overcome these barriers, we design an innovative immune cell cocktail as a combinatorial biomaterial platform, which harnessing the complementary functions of neutrophils and natural killer (NK) cells derived from human pluripotent stem cells (hPSCs). …”
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MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance by Ahsas Goyal, Muhammad Afzal, Kavita Goyal, Subbulakshmi Ganesan, Mukesh Kumari, S. Sunitha, Aniruddh Dash, Suman Saini, Mohit Rana, Gaurav Gupta, Haider Ali, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…The focus is shifting towards employing miRNA-encapsulated exosomes sourced from MSCs to target and heal cancerous cells selectively. However, the exact functions of miRNAs within MSC-derived exosomes in the context of cancer are still not fully understood. …”
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The aftermath of trauma on resting state source-level MEG microstate dynamics by Massimo Bertoli, Pierpaolo Croce, Filippo Zappasodi, Rosalia Di Matteo, Federica Vellante, Mauro Pettorruso, Giovanni Martinotti, Marcella Brunetti

“…Background: Traumatic events can disrupt psychological functioning, leading to conditions such as post-traumatic stress disorder (PTSD). …”
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Feeding the Mind: The Role of Fermented Foods and Probiotics in Anxiety Treatment by Marta Ignatiuk-Chilkiewicz, Joanna Kałuska, Dominika Hakało, Adam Rafałowicz, Aleksandra Sokół, Klaudia Mościszko, Katarzyna Nowicka, Wiktor Klimek, Maria Majewska, Monika Olszanska

“…Recent research has increasingly focused on the gut-brain axis, because scientists have discovered that gut microbiota functions as a key controller of mental health. Scientists investigate fermented foods as dietary interventions because they contain probiotics and bioactive molecules to potentially adjust the gut-brain axis for anxiety symptom reduction. …”
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Proteome profiling of human lung epithelial cells unveils distinct patterns of protein expression in response to SARS-CoV-2 ORF3a by Apoorva, Astha Shukla, Atul Kumar, Saurabh Singh, Sunit K. Singh

“…These proteins may play a role in modulating the host's cellular immune functions in response to SARS-CoV-2 ORF3a. …”
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Metabolomic insights into the prebiotic and metabolic regulatory properties of ellagic acid and urolithins on probiotic-like bacteria in vitro by Yang Yang, Ke Wang, Jia-Chi Chiou, Danyue Zhao

“…Overall, this study provides in-depth understanding on how dietary polyphenols with prebiotic properties regulate the growth and metabolic functions of probiotic-like bacteria.…”
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Identification and characterization of soybean phytochrome-interacting factors and their potential roles in abiotic stress by Dewei Mu, Zhaowei Shui, Haoyu Guo, Hengke Jiang, Yuhan Liu, Liqiu Luo, Yanpeng Zhang, Xinxin Zhang, Jiaxin Yu, Shulin Liao, Liang Yu, Chunyan Liu, Junbo Du

“…This study elucidated the evolution, structural and functions of GmPIF family members. Clinical trial number Not applicable.…”
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Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT by Zhengjun Wang, Dongyi Ding, Jiaxing Wang, Ling Chen, Qingming Dong, Moumita Khamrai, Yuyang Zhou, Akihiro Ishii, Kazuko Sakata, Wei Li, Jianyang Du, Thirumalini Vaithianathan, Fu-Ming Zhou, Francesca-Fang Liao

“…The selective downregulation of the <i>Trpc6</i> gene induced synaptotoxicity, while no significant effect was observed from the Trpc3-targeting siRNA, suggesting potentially differential roles of TRPC3 and 6 in modulating the synaptic morphology and functions. Electrophysiological recordings of mouse hippocampal slices overexpressing TRPC3 revealed increased neuronal hyperactivity upon the TRPC3 channel activation by its agonist. …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…Additionally, PDK1 accelerates tumor growth and metastasis by modulating BGN expression. In conclusion, PDK1 functions as an oncogene, facilitating EOC progression by upregulating BGN and activating the NF-κB pathway. …”
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CCL3 correlates with ferroptosis in intervertebral disc degeneration and its prognostic significance by He Chen, Peng Xu, Leijing Mao, Yicong Wang, Zian Feng, Zhongxin Wang, Cailiang Shen, Yuanhong Xu

“…Validation experiments demonstrated that CCL3 functions via the pAMPK/AMPK pathway, thereby modulating apoptosis and impacting the progression of IVDD. …”
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Bacteria Derived from Diamondback Moth, <i>Plutella xylostella</i> (L.) (Lepidoptera: Plutellidae), Gut Regurgitant Negatively Regulate Glucose Oxidase-Mediated Anti-Defense Agains... by Qingxuan Qiao, Huiting Feng, Lu Jiao, Uroosa Zaheer, Chanqin Zheng, Li Zhou, Guifang Lin, Xiujuan Xiang, Huang Liao, Shanyu Li, Haiyan Lu, Anyuan Yin, Yussuf Mohamed Salum, Hui Wei, Wei Chen, Weiyi He, Feiying Yang

“…However, the <i>Pxgox2</i> insect mutant strain inoculated with RB1 or RB5 did not significantly affect DBM feeding on <i>A. thaliana</i> compared to the wild type. Six RB have been functionally identified, with RB1 and RB5 negatively regulating GOX-mediated host adaptability. …”
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Integrating network pharmacology, molecular docking, and animal studies to investigate the protective effect of astragalus polysaccharide on fluoride-induced renal injury in rats by Xiaoyue Zhang, Qianda Yan, Yuanyuan Xiao, Xingyan Du, Xuehua Zhang, Didong Lou, Fang Peng, Daiyong Chen, Wenchao Tang

“…Fluoride is an essential trace element required for normal physiological functions and holds significant importance for human health. …”
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Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1β and TNF-α by Isela Martínez-Reza, Lorenza Díaz, David Barrera, Mariana Segovia-Mendoza, Sigifredo Pedraza-Sánchez, Giovanny Soca-Chafre, Fernando Larrea, Rocío García-Becerra

“…In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1β and TNF-α through IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.…”
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Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties by Desmond Owusu Kwarteng, Alexander Wolf, Madisyn Langdon, Nawal Kassas, Nicolas Vitale, Edgar Eduard Kooijman

“…Phosphatidic acid (PA) through its unique negatively charged phosphate headgroup binds to various proteins to modulate multiple cellular events. To perform such diverse signaling functions, the ionization and charge of PA's headgroup rely on the properties of vicinal membrane lipids and changes in cellular conditions. …”
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Unraveling the connection: M2 macrophage polarization and cancer metabolism by José Daniel Moreno-Ocampo, Miguel Ángel Pardiño-Vega, Norma Estela Herrera-González

“…The metabolic shifts within TAMs, especially the transition from oxidative phosphorylation to glycolysis, further support the pro-tumoral functions of these cells. This review explores the intricate relationship between M2 macrophage polarization bias, tumor metabolism, and the resulting impact on cancer progression, highlighting the potential of targeting these pathways for therapeutic strategies. …”
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Lipids in parenteral nutrition – expert consensus statements: Translating guidelines into clinical practice by Robert G. Martindale, Philip C. Calder, Sarah V. Cogle, David C. Evans, Leah Gramlich, Stephen A. McClave, Manpreet S. Mundi, Maurizio Muscaritoli, Reid Nishikawa, Jayshil Patel, Lorenzo Pradelli, Martin Rosenthal, Christian Stoppe, Kelly A. Tappenden, Malissa Warren, Dan Waitzberg, Paul E. Wischmeyer, Stanislaw Klek

“…In addition, lipids modulate a variety of biological functions, including inflammatory and immune responses. …”
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ROS-balancing-engineered bio-heterojunction hydrogel accelerated the infected bone regeneration based on Sono-chemo dynamic therapy by Jiani Xu, Fanshangming Zhou, Lingyan Cao, Huilin Wang, Jiani Hu, Shuo Qiu, Yulan Liu, Yan Zhang, Jie Wang, Xinquan Jiang

“…Therefore, this work introduces a novel strategy for equipping hydrogels with programmed antibacterial and anti-inflammatory functionalities, providing an innovative solution for treating deep-seated infections, particularly in periodontitis therapy.…”
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