The Probiotic Potential, Safety, and Immunomodulatory Properties of <i>Levilactobacillus brevis</i> ZG2488: A Novel Strain Isolated from Healthy Human Feces by Zhijie Cao, Mengshan Chen, Yulu Chen, Hui Sun

“…These findings underscore <i>L. brevis</i> ZG2488 as a promising probiotic candidate with functionality in pathogen inhibition and immune modulation.…”
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The Long Noncoding RNA MEG3 Retains Epithelial-Mesenchymal Transition by Sponging miR-146b-5p to Regulate SLFN5 Expression in Breast Cancer Cells by Xuefeng Gu, Jingyi Li, Xiaojia Zuo, Kaijie Chen, Guoqing Wan, Li-li Deng, Weiming Zhao, Changlian Lu

“…MEG3 repressed EMT and migration/invasion, similar to our previously reported functions of SLFN5 in breast cancer. Through bioinformatics analysis of starBase and LncBase data, 12 miRNAs were found to regulate both SLFN5 and MEG3, in which miR-146b-5p was confirmed to be regulated by MEG3 using MEG3 siRNA and overexpression method. …”
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Application of ASP-NET technology based on B/S architecture in teacher management system by Ming Dong, Rui Pan

“…The design of a teacher management system based on ASP-NET technology covers system framework (using a B/S three-layer structure), module design (for administrators, teachers, students, and other user types design functions), database design, and teacher data association mining. …”
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Immunomodulatory Effects of <i>Escherichia coli</i> Phage GADS24 on Human Dendritic Cells by Alia M. Aldahlawi, Ghadah A. Alsubhi, Jehan S. Alrahimi, Fatemah S. Basingab, Kawther A. Zaher

“…Due to its dual antimicrobial and immunomodulatory functions, GADS24 is likely to be a valuable adjunctive therapy for multidrug-resistant (MDR) bacterial infections. …”
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Coupling of Biochar and Manure Improves Soil Carbon Pool Stability, Pore Structure, and Microbial Diversity by Jing Sun, Shuxin Tu, Xinrui Lu, Xiujun Li

“…The dual application of biochar (2.0%) and manure (0.5%) elicited synergistic improvements in soil functionality, surpassing individual treatments. The total organic carbon (TOC) increased by 10.4% and 54.9% relative to that associated with biochar-only (2.0%) and manure-only (0.5%) amendments, respectively, with concurrent structural shifts toward stabilized carbon forms—evidenced by elevated alkyl C content (16.3%) and alkyl C/O–alkyl C ratios (22.8%). …”
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Latitudinal gradients of biodiversity and ecosystem services in protected and non-protected oak forest areas can inform climate smart conservation by Anders Forsman, Johanna Sunde, Romana Salis, Markus Franzén

“…Adaptive governance of areas set aside for future protection of biodiversity, sustainable production, and recreation requires knowledge about whether and how effects of area protection are modulated by climate change and redistribution of species. …”
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Recent Advances in Nanozymes for the Treatment of Atherosclerosis by Zou Z, Bi X, Ma H, Chen L, Jin H, Gong S, Li X, Liu X

“…By integrating catalytic activity with targeted delivery and microenvironment-responsive functionalities, nanozymes offer a promising paradigm for precision therapy in AS. …”
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Mesenchymal Stem Cells for Liver Regeneration in Liver Failure: From Experimental Models to Clinical Trials by Maria P. de Miguel, I. Prieto, A. Moratilla, J. Arias, M. A. Aller

“…The liver centralizes the systemic metabolism and thus controls and modulates the functions of the central and peripheral nervous systems, the immune system, and the endocrine system. …”
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Impact of polyacrylic acid as soil amendment on soil microbial activity under different moisture regimes by Christian Buchmann, Simon Rudolph, Janina Neff, Zacharias Steinmetz

“…Overall, PAA altered soil microbial activity in a concentration-, soil type-, and moisture-dependent manner, emphasizing the dual role of SAPs in improving soil water retention while potentially impairing microbial-mediated soil functions over time.…”
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Long-term comparative analysis of machine learning models: A deep dive into applications of artificial intelligence for enhancing photovoltaic performance prediction by Ali Akbar Yaghoubi, Mahdi Gandomzadeh, Aslan Gholami, Roghayeh Gavagsaz-Ghoachani, Majid Zandi

“…SVR and MLP showed high sensitivity to hyperparameters such as activation functions and iteration limits, respectively. Although most ensemble methods performed well, Adaboost’s accuracy declined as the number of estimators increased. …”
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Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation. by Huifang Xu, Dominique Bihan, Francis Chang, Paul H Huang, Richard W Farndale, Birgit Leitinger

“…While GVMGFO (O is hydroxyproline) functions as a major DDR binding motif in fibrillar collagens, integrins bind to sequences containing Gxx'GEx". …”
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Enhancing Creativity and Validation in Explanatory Deep Learning-Based Symbolic Music Generation: A Hybrid Approach With LSTM and Genetic Algorithms by Ahmad Zainul Fanani, Arry Maulana Syarif, Ika Novita Dewi, Abdul Karim

“…The LSTM component, functioning based on its ability to creatively generate note sequences, and the GA component, tasked with validation and refinement, have both proven to collaborate effectively and fulfill their respective roles. …”
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Influence of Solenopsis invicta Buren on soil chemical properties, silicon pools, and phytolith assemblages in organic agricultural soils by Carlos Alberto Ribeiro de Moura, Eduardo Carvalho da Silva Neto, Marcos Gervasio Pereira, Maria Elizabeth Fernandes Correia

“…ABSTRACT Ants mediate ecosystem services that can modulate crop performance and overall agroecosystem functioning. …”
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Current status and prospects of tertiary lymphoid structure heterogeneity in predicting response to neoadjuvant therapy and characterizing immune microenvironment in triple-negativ... by WANG Qing, YU Yushuai, WANG Chenxi, JIANG Zirong, LI Jialu, TANG Shicong, SONG Chuangui

“…Research demonstrates that promoting the formation or enhancing the functionality of TLS can improve anti-tumor immune effects and enhance treatment outcomes for TNBC patients. …”
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Rapid and Sensitive Detection of Thrombospondin-2 Using Nanoparticle Sensors for Cancer Screening and Prognosis by Maziyar Kalateh Mohammadi, Seyedsina Mirjalili, Md Ashif Ikbal, Hao Xie, Chao Wang

“…NasRED utilizes antibody-functionalized gold nanoparticles (AuNPs) to capture target proteins from a minute amount of sample (<10 µL) and achieve optimal performance with a short assay time by introducing active fluidic forces that act to promote biochemical reaction and accelerate signal transduction. …”
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Notch signaling in the tumor immune microenvironment of colorectal cancer: mechanisms and therapeutic opportunities by Jiachun Sun, Yi Chen, Ziyi Xu, Weizheng Wang, Penghui Li

“…Aberrant Notch signaling in CRC fosters immune evasion and tumor progression through its effects on the balance and functionality of immune cells, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs). …”
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Integration of epigenomic and transcriptomic profiling uncovers EZH2 target genes linked to cysteine metabolism in hepatocellular carcinoma by Jaehyun Lee, Chaelin You, Geunho Kwon, Junho Noh, Kyubin Lee, Kyunghwan Kim, Keunsoo Kang, Kyuho Kang

“…Tazemetostat treatment of HCC cells increased BHMT and CDO1 expression while reducing levels of ferroptosis markers FSP1, NFS1, and SLC7A11. Functionally, EZH2 inhibition dose-dependently reduced cell viability and increased lipid peroxidation in HCC cells. …”
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Eno1 in sepsis-induced coagulopathy: a pleiotropic mechanism hypothesis involving immunomodulation and endothelial dysfunction by Ke Qin, Xiao Chen, Xiaoling Li, Wenbin Zhang, Xinnan Song, Yuan Wang, Xiaowen Hu, Jianfeng Zhang

“…Methods We used RNA-seq datasets to identify Eno1-related gene sets through weighted gene co-expression network analysis and validated their biological functions via gene set enrichment analysis. Results Through RNA-seq analysis, we identified gene sets associated with Eno1 involved in immune regulation, endothelial cell apoptosis, coagulation, and glycosaminoglycan metabolism. …”
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Screening differentially expressed genes between endometriosis and ovarian cancer to find new biomarkers for endometriosis by Zhenzhen Lu, Ying Gao

“…Finally, we explored the miRNAs of key genes to find biomarkers associated with the recurrence of endometriosis.Results In total, 104 DEGs were identified in the endometriosis datasets, and the main enriched GO functions included cell adhesion, extracellular exosome and actin binding. …”
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OPTIMIZATION STRATEGIES AND COMPUTATIONAL MODELING IN THE DESIGN AND PERFORMANCE EVALUATION OF GREEN POROUS OIL ADSORBENT MATERIALS by Haoran Zhang, Sagdat Mederbekovna Tazhibayeva

“…The surface area, pore size, surface functionalization, and hydrophobicity index of green porous adsorbents were examined. …”
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