The rhizosphere microecological mechanisms of stress-induced quality enhancement in medicinal plants by Xueqian Zhang, Qingsong Ran, Yanfeng Han, Longzhan Gan, Xiao Zou, Chunbo Dong

“…Medicinal plants, a significant category of biological resources with substantial medical and economic value, produce secondary metabolites that exhibit extensive pharmacological activities and important biological functions. These metabolites serve as key indicators for evaluating the quality of medicinal materials. …”
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Deciphering the Neurotoxic Effects of <i>Karenia selliformis</i> by Ambbar Aballay-González, Jessica Panes-Fernández, Catharina Alves-de-Souza, Bernd Krock, Juan José Gallardo-Rodríguez, Nicole Espinoza-Rubilar, Jorge Fuentealba, Allisson Astuya-Villalón

“…Given the high toxicity and impact on marine life, our study aimed to functionally characterize the neurotoxic metabolites in the exudate of <i>K. selliformis</i> cultures. …”
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Complex Immune Contextures Characterise Malignant Peritoneal Mesothelioma: Loss of Adaptive Immunological Signature in the More Aggressive Histological Types by Marcella Tazzari, Silvia Brich, Alessandra Tuccitto, Fabio Bozzi, Valeria Beretta, Rosalin D. Spagnuolo, Tiziana Negri, Silvia Stacchiotti, Marcello Deraco, Dario Baratti, Chiara Camisaschi, Antonello Villa, Barbara Vergani, Licia Rivoltini, Silvana Pilotti, Chiara Castelli

“…Tumour-infiltrating immune cells and their functionality were assessed by immunohistochemistry, immunofluorescence, qRT-PCR, and flow cytometry analysis. …”
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Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair by Qiuyue Sun, Chen Zhang, Bowen Chen, Junyi Liao, Aowen Bao, Chen Zhao, Hong Chen, Dawei He, Wei Huang, Guangming Dai

“…Further analysis revealed that H19 reduced miR-21a-5p’s inhibition of smad7 by functioning as a sponge for miR-21a-5p. H19 silencing led to a decrease in Smad7 expression and a rise in Smad2/3 phosphorylation, and delayed both ossification and vascularization. …”
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Enhanced FFT–Root<tt>–</tt>MUSIC Algorithm Based on Signal Reconstruction via CEEMD<tt>–</tt>SVD for Joint Range and Velocity Estimation for FMCW Radar by Jiaxin Cao, Huiyue Yi, Wuxiong Zhang, Hui Xu

“…Frequency-modulated continuous-wave (FMCW) radar is used to extract range and velocity information from the beat signal. …”
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U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study by Yu Pan, Yan Yuan, Juan Yang, Zhu Qing Feng, Xue Yin Tang, Yi Jiang, Gui Ming Hu, Jiang Chuan Dong

“…A 40-item frailty index scale, encompassing various dimensions of somatic functioning, psychological evaluation, and illness, was developed and individually evaluated for each participant. …”
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Responsive cellulose nanocrystal‐based liquid crystals: From structural color manipulation to applications by Jiao Liu, Ye‐Ming Qing, Jun‐Jie Wu, Jing‐Qi Tian, Chi‐Bo Feng, Xin‐Yu Zhou, Yun Ma, Bing‐Xiang Li, Yan‐Qing Lu, Quan Li

“…CNCs can spontaneously assemble into a cholesteric liquid crystal phase, which exhibits distinctive properties including biodegradability, high surface area, low cost, excellent mechanical strength, and surface functionality. Modifying the surfaces of CNCs or embedding CNCs with other materials enables novel cellulose‐based composites for advanced technologies and applications. …”
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Translocation of SIRT6 promotes glycolysis reprogramming to exacerbate diabetic angiopathy by Kemiao Pang, Jiayi Huang, Shiwu Zhang, Yinghui Guan, Ning Zou, Jiaxin Kang, Haining Du, Dechao Zhao, Denis V. Abramochkin, Heyu Chen, Nan Zhang, Yunyan Gu, Ning Liu, Yining Niu, Ziqi Xiong, Xueya Zhang, Fanghao Lu, Huitao Fan, Jinwei Tian, Bo Yu, Shuijie Li, Weihua Zhang

“…However, the functions and mechanisms of accumulation of cytoplasmic SIRT6 in T2DM remain to be elucidated. …”
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Overall architecture design of row/column scanning silicon-based focal plane switch array LiDAR transmitter system by Yu Wang, Yue Wang, Zeyang Zhang, Hang Cheng, Yuanhui Li, Guohui Yang, Kuang Zhang, Chunhui Wang

“…The functionality and low complexity of the designed architecture were validated through the simulation of a 64 × 64 transmitter array. …”
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Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs by Wenyan Chen, Zeyang Wang, Yinuo Wang, Jianxiang Lin, Shuxin Chen, Hui Chen, Xuelian Ma, Xudong Zou, Xing Li, Yangmei Qin, Kewei Xiong, Xixian Ma, Qi Liao, Yunbo Qiao, Lei Li

“…As proof of principle validation, the enhancer functionality of two newly identified susceptibility eRNAs, CCND1e and SNAPC1e, is confirmed through CRISPR inhibition and shRNA‐mediated knockdown, resulting in a marked decrease in the expression of their respective target genes, consequently suppressing the proliferation of prostate cancer cells. …”
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High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition by Chiao-Hsu Ke, Mao-En Huang, Hsin-Yi Wu, Chao-Wu Yu, Shuei-Liong Lin, Shau-Ping Lin, Shu-Han Yu, Chih-Hung Huang, Chen-Si Lin

“…Abstract Bone marrow fibrosis (BMF) impairs normal hematopoietic functions in patients. The overactivation of the TGF-β signaling pathway is regarded as one of the offenders causing disease progression. …”
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Pseudomonas cold shock proteins suppress bacterial effector translocation in Nicotiana benthamiana by Shen Cong, Jun-Zhou Li, Mei-Ran Zhang, Mei-Ran Zhang, Hai-Lei Wei, Wei Zhang

“…Genetic analysis revealed that these CSPs did not contribute to the ROS burst or HR inhibition in vivo but were functionally redundant in suppressing effector translocation in a flagellin (FliC)-independent manner. …”
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Patent Overview of Innovative Hyaluronic Acid-Based Hydrogel Biosensors by Ahmed Fatimi, Fouad Damiri, Mohammed Berrada, Adina Magdalena Musuc

“…These hydrogels, functionalized with specific groups, exhibit sensitivity modulated by factors such as temperature, pH, and analyte concentration, allowing for a broad spectrum of applications. …”
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Protracted Hiccups Induced by Aripiprazole and Regressed after Administration of Gabapentin by Manuel Glauco Carbone, Claudia Tagliarini, Filippo Della Rocca, Walter Flamini, Giovanni Pagni, Beniamino Tripodi, Donatella Marazziti, Icro Maremmani

“…However, our knowledge of the neurotransmitter functioning of the hiccup reflex arc is still limited, and further research is needed to characterize the neurotransmitters involved in hiccups for potential novel therapeutic targets.…”
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In silico model of mechano-biochemical bone remodeling characterizes the therapeutic effects of osteoporosis drugs depending on the action mechanism by Yoshitaka Kameo, Kei Imai, Yuki Miya, Young Kwan Kim, Taiji Adachi

“…Both drugs restored functionally-adapted trabecular bone morphology when dosages were appropriately adjusted. …”
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IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment by Mélanie Desbois, Coralie Béal, Mélinda Charrier, Benjamin Besse, Guillaume Meurice, Nicolas Cagnard, Yannick Jacques, David Béchard, Lydie Cassard, Nathalie Chaput

“…We further characterized the proliferation, maturation and cytotoxic functions of natural killer (NK) cells in tumor-free mice treated with RLI. …”
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High-Tyrosol/Hydroxytyrosol Extra Virgin Olive Oil Enhances Antioxidant Activity in Elderly Post-Myocardial Infarction Patients by Mojgan Morvaridzadeh, Mehdi Alami, Nada Zoubdane, Hawa Sidibé, Hicham Berrougui, Tamàs Fülöp, Michel Nguyen, Abdelouahed Khalil

“…Although phenolic compounds such as Tyrosol (Tyr) and Hydroxytyrosol (HTyr) found in extra virgin olive oil (EVOO) have shown promising antioxidant and anti-inflammatory effects, their specific roles in modulating oxidative stress biomarkers and high-density lipoprotein (HDL) functionality in elderly populations, especially in those with prior myocardial infarction, are not fully understood. …”
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Health-related quality of life among cervical cancer survivors at a tertiary hospital in Ghana. by Kwabena Amo-Antwi, Ramatu Agambire, Thomas O Konney, Samuel B Nguah, Edward T Dassah, Yvonne Nartey, Adu Appiah-Kubi, Augustine Tawiah, Elliot K Tannor, Amponsah Peprah, Mavis Bobie Ansah, Daniel Sam, Patrick K Akakpo, Frank Ankobea, Rex M Djokoto, Maame Y K Idun, Henry S Opare-Addo, Baafour K Opoku, Alexander T Odoi, Carolyn Johnston

“…Although the majority (66.0-84.3%) of the QoL functioning scale were unaffected, about a fifth (22.2%) to a third (34.5%) of the subjects had perceptual impairment in cognitive and role functioning. …”
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Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. by Carmela De Marco, Carmelo Laudanna, Nicola Rinaldo, Duarte Mendes Oliveira, Maria Ravo, Alessandro Weisz, Michele Ceccarelli, Elvira Caira, Antonia Rizzuto, Pietro Zoppoli, Donatella Malanga, Giuseppe Viglietto

“…Finally, we made use of Ingenuity Pathway Analysis (IPA) to investigate the relevant BioFunctions enriched by the costitutive activation of AKT1-, PI3K- or PTEN-dependent signalling in lung epithelial cells. …”
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Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation by M. Sambucci, F. Laudisi, F. Novelli, E. Bennici, M. M. Rosado, C. Pioli

“…PARP-1 regulates cell functions in many types of immune cells, including dendritic cells, macrophages, and T and B lymphocytes. …”
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