Conversion of propargylic amines with CO2 from flue gas using Lu2CrMnO6 supported by ionic liquid on dendritic nanosilica by Shulong Liu, Dulong Feng, Seyed Mohsen Sadeghzadeh

“…The concurrent creation of a phase interface and threadlike architecture can enhance the segregation, enzymatic efficiency, and functionality of dendritic silica fibres (DFNS). Nonetheless, a straightforward and eco-friendly fabrication method remains essential. …”
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The activation of cGAS-STING pathway offers novel therapeutic opportunities in cancers by Yumin Wang, Yonglin Zhu, Yuwei Cao, Yulin Li, Zhe Zhang, Joshua S. Fleishman, Sihang Cheng, Jichao Chen, Mingchao Ding

“…Emerging evidence have shown that activating of cGAS-STING pathway functions as a therapy to kill cancers. Insights into the biology of the cGAS-STING pathway have enabled the discovery of small-molecule agents which have the potential to activate cGAS-STING axis in cancers. …”
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Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review by Amir Hossein Barjasteh, Rawa Jaseb Mazhar AleKassar, Abdulridha Mohammed Al-Asady, Hanieh Latifi, Amir Avan, Majid Khazaei, Mikhail Ryzhikov, Seyed Mahdi Hassanian

“…MiRNAs exhibit dual functions as tumor suppressors and oncogenes by targeting multiple genes, thus playing a complex role in both the initiation and progression of metastasis. …”
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Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc by Roberta Santarelli, Claudia Di Dio, Michele Di Crosta, Paola Currà, Roberta Gonnella, Mara Cirone

“…Their targeting is therapeutically significant, as p53, following point mutations, can acquire oncogenic functions, and c-Myc overexpression, due to translocations, point mutations, protein/protein interactions, or epigenetic modifications, plays a central role in cancer cell proliferation and metabolic reprogramming, particularly in colorectal cancer. …”
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MicroRNA-132 regulates quinolinic acid production in the brain during LPS-induced neuroinflammation by Amir Mohamed Kezai, Amir Mohamed Kezai, Papa Yaya Badiane, Benjamin Hennart, Delphine Allorge, Sabrina Marion, Sébastien S. Hébert, Sébastien S. Hébert

“…In vitro experiments using BV-2 microglial cells showed that miR-132 overexpression led to downregulation of KMO expression and enzyme activity and reduced QUIN levels without altering the microglial activation status.ConclusionCollectively, these findings suggest that the miR-132/212 cluster functions as a novel modulator of KP metabolism during LPS-induced inflammation, and acts as a potential therapeutic target for controlling neurotoxic QUIN accumulation in neuroinflammatory conditions.…”
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Theta-frequency subthalamic nucleus stimulation increases decision threshold by Rachel C. Cole, Nadja R. Ging-Jehli, Juan Vivanco Suarez, Jeremy D. Greenlee, Jan R. Wessel, Arturo I. Espinoza, Johnson Zhang, James F. Cavanagh, Nandakumar S. Narayanan

“…Introduction: Executive functions are often impaired in patients with Parkinson's disease (PD), and these deficits can be predicted by decreased frontal cortical 4–8 Hz theta activity that is associated with cognitive control. …”
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The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic by Bo Li, Xin Peng, He Li, Fei Chen, Yuxia Chen, Yingqian Zhang, Kai Le

“…Abstract Introduction The ubiquitously expressed nonhistone nuclear protein high‐mobility group box protein 1 (HMGB1) has different functions related to posttranslational modifications and cellular localization. …”
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Mesenchymal stem cells in the bone marrow microenvironment: a double-edged sword for AML by Mohamed J. Saadh, Nima Torabi Fard, Ahmed Hussein, Amirhossein Mirzazadeh, Mohammad Siavashi, Fatemeh SeyedMoharami, Shekoofeh Noroozi, Hamed Soleimani Samarkhazan

“…Strategies aimed at modifying MSC-mediated support of AML cells, such as inhibiting pro-survival signaling pathways, disrupting the leukemia-supportive niche, and enhancing the immune-stimulatory functions of MSCs, could offer novel therapeutic approaches. …”
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Circulating miRNAs in genitourinary cancer: pioneering advances in early detection and diagnosis by Annunziata Gaetana Cicatiello, Michele Musone, Silvestro Imperatore, Carlo Giulioni, Roberto La Rocca, Angelo Cafarelli, Francesco Del Giudice, Monica Dentice, Felice Crocetto

“…Indeed, they regulate key processes for the proper functioning of the organism and affect the course of human pathologies. …”
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Plant-derived extracellular vesicles as a novel tumor-targeting delivery system for cancer treatment by Hanjin Wu, Mengya Shi, Liwei Meng, Jie Qiu, Yuancong Jiang, Da Qian, Fengqing Shen

“…These vesicles perform multiple biological functions, including modulating cellular restructuring, enhancing plant immunity, and defending against pathogens. …”
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Spinal afferent neurons: emerging regulators of energy balance and metabolism by Mohammad Jarrah, Dana Tasabehji, Aviva Fraer, Mohamad Mokadem, Mohamad Mokadem, Mohamad Mokadem, Mohamad Mokadem, Mohamad Mokadem

“…This comprehensive review synthesizes cutting-edge research elucidating the multifaceted functions of spinal afferent neurons in maintaining metabolic equilibrium. …”
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Optimized lipid nanoparticles enable effective CRISPR/Cas9-mediated gene editing in dendritic cells for enhanced immunotherapy by Kuirong Mao, Huizhu Tan, Xiuxiu Cong, Ji Liu, Yanbao Xin, Jialiang Wang, Meng Guan, Jiaxuan Li, Ge Zhu, Xiandi Meng, Guojiao Lin, Haorui Wang, Jing Han, Ming Wang, Yong-Guang Yang, Tianmeng Sun

“…Dendritic cells (DCs) play a pivotal role in orchestrating immune responses, making them an attractive target for immunotherapeutic interventions. Modulation of gene expression in DCs using genome editing techniques, such as the CRISPR-Cas system, is important for regulating DC functions. …”
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Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells by Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki

“…These findings reveal novel TET1-dependent cellular functions and potentially provide new insights for CRC management.…”
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Energy metabolism dysfunction and therapeutic strategies for treating temporomandibular disorders by Wenjie Gao, Zhiheng Gao, Heting Xiao, Yuchen Qian, Rongkang Fan, Yonggang Li, Shaofeng Yang, Yanjun Yang, Yusen Qiao

“…The TMJ’s complex structure relies heavily on a balanced energy supply to maintain its physiological functions. Disruptions in glucose metabolism lead to oxidative stress, inflammatory cytokine release, and chondrocyte damage. …”
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Systematic evaluation of the isolated effect of tissue environment on the transcriptome using a single-cell RNA-seq atlas dataset by Daigo Okada, Jianshen Zhu, Kan Shota, Yuuki Nishimura, Kazuya Haraguchi

“…Abstract Background Understanding cellular diversity throughout the body is essential for elucidating the complex functions of biological systems. Recently, large-scale single-cell omics datasets, known as omics atlases, have become available. …”
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YOLO-NeRFSLAM: underwater object detection for the visual NeRF-SLAM by Zhe Wang, Zhibin Yu, Zhibin Yu, Bing Zheng, Bing Zheng

“…Further, to cope with severe light attenuation and the dynamic nature of underwater scenes, we introduce specialized loss functions, enabling the reconstruction of underwater environments with realistic appearance and geometric detail even under high turbidity conditions. …”
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Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis by Jesmond Dalli, Lucy V Norling, Trinidad Montero‐Melendez, Donata Federici Canova, Hazem Lashin, Anton M Pavlov, Gleb B Sukhorukov, Charles J Hinds, Mauro Perretti

“…In vitro, A2MG was functionally transferred onto endothelial cell plasma membranes from microparticles, augmenting neutrophil–endothelial adhesion. …”
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A birch ELONGATED HYPOCOTYL 5 gene enhances UV-B and drought tolerance by Shangzhu Gao, Xiaohui Chen, Meihan Lin, Yibo Yin, Xiaoyi Li, Yaguang Zhan, Ying Xin, Fansuo Zeng

“…However, the sequence of HY5 from Betula platyphylla (BpHY5) has not been identified and the gene functions remain unclarified. We cloned the sequence of BpHY5, which was targeted to the nucleus. …”
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KIAA1199 (CEMIP) regulates adipogenesis and whole-body energy metabolism by Li Chen, Kaikai Shi, Nicholas Ditzel, Weimin Qiu, Michaela Tencerova, Louise Himmelstrup Dreyer Nielsen, Florence Figeac, Alexander Rauch, Yuhang Liu, Jiuyuan Tao, Veronika Sramkova, Lenka Rossmeislova, Greet Kerckhofs, Tatjana N. Parac-Vogt, Sébastien de Bournonville, Thomas Levin Andersen, Mikael Rydén, Moustapha Kassem

“…Abstract An increasing number of studies have characterized the bone as an endocrine organ, and that bone secreted factors may not only regulate local bone remodeling, but also other tissues and whole-body metabolic functions. The precise nature of these regulatory factors and their roles at bridging the bone, bone marrow adipose tissue, extramedullary body fat and whole-body energy homeostasis are being explored. …”
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Soil microbiome interventions for carbon sequestration and climate mitigation by Gwyn A. Beattie, Anna Edlund, Nwadiuto Esiobu, Jack Gilbert, Mette Haubjerg Nicolaisen, Janet K. Jansson, Paul Jensen, Marco Keiluweit, Jay T. Lennon, Jennifer Martiny, Vanessa R. Minnis, Dianne Newman, Raquel Peixoto, Christopher Schadt, Jan Roelof van der Meer

“…As a critical step forward, we encourage broadening the current widespread screening of potentially beneficial soil microorganisms to encompass functions relevant to stimulating soil carbon stocks. …”
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