Milk-Derived Extracellular Vesicles: A Novel Perspective on Comparative Therapeutics and Targeted Nanocarrier Application by Muttiah Barathan, Sook Luan Ng, Yogeswaran Lokanathan, Min Hwei Ng, Jia Xian Law

“…Milk-derived extracellular vesicles (mEVs) are emerging as promising therapeutic candidates due to their unique properties and versatile functions. These vesicles play a crucial role in immunomodulation by influencing macrophage differentiation and cytokine production, potentially aiding in the treatment of conditions such as bone loss, fibrosis, and cancer. mEVs also have the capacity to modulate gut microbiota composition, which may alleviate the symptoms of inflammatory bowel diseases and promote intestinal barrier integrity. …”
Get full text

Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024 by Yanhong Pei, Haijie Liang, Yu Guo, Boyang Wang, Han Wu, Zhijian Jin, Shanyi Lin, Fanwei Zeng, Yifan Wu, Qianyu Shi, Jiuhui Xu, Yi Huang, Tingting Ren, Jiarui Liu, Jiarui Liu, Wei Guo

“…BackgroundLiquid–liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions. However, a comprehensive bibliometric analysis on LLPS and immune signaling processes in cancer is still scarce. …”
Get full text

Fat-cartilage axis: the regulation of IL-6/Osteopontin signaling in osteoarthritis of mice by Bing-yang Dai, Zhong-lian Huang, Ming-gui Bao, Hong-jiang Chen, Xiao-hui Lu, Jun Hu

“…Notably, removal of the IPFP in DMM mice reverses the abnormal functions of the knee joint. Compromising the progress of fibrosis by intra-IPFP injection of siRNA Cd61 or inhibition of OPN expression can drastically ameliorate cartilage deterioration. …”
Get full text

Current advances in the development of microRNA-integrated tissue engineering strategies: a cornerstone of regenerative medicine by Luis Germán Castañón-Cortés, Luis Alberto Bravo-Vázquez, Grecia Santoyo-Valencia, Sara Medina-Feria, Padmavati Sahare, Asim K. Duttaroy, Sujay Paul

“…Regenerative medicine is an innovative scientific field focused on repairing, replacing, or regenerating damaged tissues and organs to restore their normal functions. A central aspect of this research arena relies on the use of tissue-engineered scaffolds, which serve as structural supports that mimic the extracellular matrix, providing an environment that orchestrates cell growth and tissue formation. …”
Get full text

De-regulation of aurora kinases by oncogenic HPV; implications in cancer development and treatment by Kemi Hannah Oladipo, Joanna L. Parish

“…Combinatorial inhibition targets distinct but overlapping functions of these kinases, thereby reducing the potential for cancer cells to develop resistance. …”
Get full text

Dendritic Cell Activity Driven by Recombinant Mycobacterium bovis BCG Producing Human IL-18, in Healthy BCG Vaccinated Adults by Piotr Szpakowski, Franck Biet, Camille Locht, Małgorzata Paszkiewicz, Wiesława Rudnicka, Magdalena Druszczyńska, Fabrice Allain, Marek Fol, Joël Pestel, Magdalena Kowalewicz-Kulbat

“…In this study we constructed recombinant BCG producing human IL-18 (rBCGhIL-18) and investigated whether human IL-18 produced by rBCGhIL-18 modulates DC functions and enhances Th1 responses to mycobacterial antigens in humans. …”
Get full text

SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis by Fenglei Huo, Chenghang Liu, Xi Wang, Jinzheng Li, Zhifeng Wang, Duanqin Liu, Weipeng Lan, Xingyan Zhu, Jing Lan

“…Collectively, these findings demonstrated that SDCCAG3 functioned as a beneficial positive regulator of adipose tissue expansion and metabolic homeostasis, indicating its potential as a therapeutic target for metabolic diseases associated with nutrient excess.…”
Get full text

Liposomes used in the delivery of various antimicrobials to biofilm-producing infections: a systematic review by Manouchehr Teymouri, Samaneh Mollazadeh, Fatemeh Oroojalian, Amir Amani, Roghaye Arezumand, Farzane Shakeri, Reza Besharati, Parastoo Zarghami Moghaddam

“…Liposomes also serve as a suitable platform for controlled drug release, physicochemical modification, and surface functionalization with various biological ligands. Additionally, they allow for modifications that enhance adhesion to biotic and abiotic surfaces and support extended, prolonged drug release profiles with implants, scaffolds, and hydrogels.Conclusion: Given their ease of manipulation and modulation, liposomes are anticipated to remain a long-standing drug delivery platform in future research focused on treating persistent infections with antimicrobials.…”
Get full text

Quinoa (Chenopodium quinoa Willd): nutritional profile, health benefits, and sustainability considerations by Mukesh Gaur, Sangeeta Yadav, Anjali Soni, Devyani Tomar, Aarzoo Jangra, Swati Joia, Akash Kumar, Rahul Mehra, Anka Trajkovska Petkoska

“…Consequently, its use may hinder the development of anemia and enhance the functionality of muscles and nerves, promote bone health, optimize metabolism, and regulate sugar levels according to scientific evidence. …”
Get full text

Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse by Julia A. Galiza Soares, Samantha N. Sutley-Koury, Matthew B. Pomrenze, Matthew B. Pomrenze, Jason M. Tucciarone

“…This disruption in social functioning further promotes addiction, creating a cycle in which increasing isolation drives drug use. …”
Get full text

Interplay of epilepsy and long-term potentiation: implications for memory by Luis A. Marin-Castañeda, Gerónimo Pacheco Aispuro, Guillermo Gonzalez-Garibay, Guillermo Gonzalez-Garibay, Carlos Alejandro Martínez Zamora, Carlos Alejandro Martínez Zamora, Hector Romo-Parra, Hector Romo-Parra, Moisés Rubio-Osornio, Carmen Rubio

“…The review emphasizes the need for targeted interventions in epilepsy that address cognitive functions alongside seizure control.…”
Get full text

Development and characterization of pegylated Fe3O4-CAPE magnetic nanoparticles for targeted therapy and hyperthermia treatment of colorectal cancer by Showket Yahya, Sangeetha Pushpanathan, Shafqat Jan, Nazia Chaudhary, Rasik Parray, Khushboo A. Gandhi, Kumaran Thangavel, Kathiravan Krishnan, Ganapasam Sudhandiran

“…Comprehensive physicochemical characterization revealed successful polymer functionalization and drug loading, with FTIR confirming specific molecular interactions between PEG and CAPE. …”
Get full text

The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1 by Zhouhua Hou, Xuwen Xu, Ledu Zhou, Xiaoyu Fu, Shuhui Tao, Jiebin Zhou, Deming Tan, Shuiping Liu

“…In this study, we explored the molecular mechanisms by which MALAT1 modulates hepatocellular carcinoma biological behaviors. …”
Get full text

NF-κB and apoptosis: colorectal cancer progression and novel strategies for treatment by Sina Sadati, Amirreza Khalaji, Ali Bonyad, Sara Khoshdooz, Kosar Sadat Hosseini Kolbadi, Ashkan Bahrami, Mohammad Saeid Moeinfar, Mohammadmatin Morshedi, Amireza Ghamsaraian, Majid Eterafi, Reza Eshraghi, Mahmood Khaksary Mahabady, Hamed Mirzaei

“…The development of CRC is a complex process, driven by a combination of genetic mutations and epigenetic alterations that disrupt normal cellular functions. These changes influence a range of cancer-regulating mechanisms, including metabolism, cell proliferation, invasion, metastasis, and apoptosis. …”
Get full text

F-OSFA: A Fog Level Generalizable Solution for Zero-Day DDOS Attacks Detection by Muhammad Rashid Minhas, Qaisar M. Shafi, Shoab Ahmed Khan, Tahir Ahmad, Subhan Ullah, Attaullah Buriro, Muhammad Azfar Yaqub

“…The globalization and digitization of society have caused a surge in network traffic, making reliable online services essential for user trust and system functionality. However, these services face ever-increasing threats, particularly complex and well-developed Distributed Denial of Service (DDoS) attacks. …”
Get full text

The Migration of Human Follicular Dendritic Cell-Like Cell Is Facilitated by Matrix Metalloproteinase 3 Expression That Is Mediated through TNFα-ERK1/2-AP1 Signaling by Hyo-Kyung Pak, Yong-Woo Kim, Bora Nam, A-Neum Lee, Jin Roh, Minchan Gil, Chaohong Liu, Yoo-Sam Chung, Chan-Sik Park

“…Tumor necrosis factor-α (TNFα) is essential for the development and functions of follicular dendritic cells. Despite the importance of follicular dendritic cells in humoral immunity, their molecular control mechanisms have yet to be fully elucidated due to the lack of an adequate investigation system. …”
Get full text

Research on Wind Turbine Main Shaft Bearing Fault Diagnosis Method Based on Unity 3D and Transfer Learning by Shuai Wang, Wenlei Sun, Han Liu, Shenghui Bao, Yunhao Wang, Xin Zhao

“…The digital twin system is implemented in Unity 3D, incorporating functions such as user login, wind turbine spindle bearing state monitoring, fault diagnosis, and fault warning, demonstrating practical applicability. …”
Get full text

Model-Free Predictive Control and Modified Multi-Phase Shift PWM Technique for a Semi-Dynamic Wireless EV Charging System by J. Rahulkumar, R Narayanamoorthi, Majed Alsafyani, Waleed Mohammed Abdelfattah

“…The input impedance (imaginary part) is considered to introduce three mega parameters into the control functions, it makes the system control independent. …”
Get full text

Impact of provoked stress on model-free and model-based reinforcement learning in individuals with alcohol use disorder by Florent Wyckmans, Armand Chatard, Charles Kornreich, Damien Gruson, Nemat Jaafari, Xavier Noël

“…Background: From both clinical and theoretical perspectives, understanding the functionality of evaluative reinforcement learning mechanisms (Model-Free, MF, and Model-Based, MB) under provoked stress, particularly in Alcohol Use Disorder (AUD), is crucial yet underexplored. …”
Get full text

Electromagnetic Nanocommunication Networks: Principles, Applications, and Challenges by Md. Humaun Kabir, S. M. Riazul Islam, Anish Prasad Shrestha, Farman Ali, Md. Alamgir Badsha, Md. Jalil Piran, Dinh-Thuan Do

“…Such networks of nanodevices, named nanonetworks, envisioned to serve the functionality and performance of today’s Internet. …”
Get full text