Implantable Multifunctional Micro‐Oxygen Reservoir System for Promoting Vascular‐Osteogenesis via Remodeling Regenerative Microenvironment by Min Rui, Jiannan Mao, Hongshuai Wu, Yujian Hui, Hao Shen, Yilin Yang, Tao Ma, Kewei Ren, Juan Wang, Wenguo Cui, Qin Shi, Huilin Yang

“…As a multifaceted microenvironment regulator, CSP‐GM remodeled the regenerative microenvironment by synergistically producing oxygen and scavenging ROS, recovering mitochondrial homeostasis and antioxidant defenses of BMSCs, promoting angiogenesis and osteogenesis under hypoxia conditions via precisely modulating the Nrf2/HO‐1 signaling pathway. The multiple pro‐regenerative effects of the implantable functionalized micro‐oxygen reservoir on bone repair are further corroborated by the enhanced vascularized bone formation in rat femoral defects, presenting a comprehensive and promising strategy for tissue repair.…”
Get full text

Piezoelectric neuron for neuromorphic computing by Wenjie Li, Shan Tan, Zhen Fan, Zhiwei Chen, Jiali Ou, Kun Liu, Ruiqiang Tao, Guo Tian, Minghui Qin, Min Zeng, Xubing Lu, Guofu Zhou, Xingsen Gao, Jun-Ming Liu

“…Thanks to this efficient and robust mechanism, the piezoelectric neuron not only implements critical leaky integrate-and-fire functions (including leaky integration, threshold-driven spiking, all-or-nothing response, refractory period, strength-modulated firing frequency, and spatiotemporal integration), but also demonstrates small cycle-to-cycle and device-to-device variations (∼1.9% and ∼10.0%, respectively), high endurance (1010), high speed (integration/firing: ∼9.6/∼0.4 μs), and low energy consumption (∼13.4 nJ/spike). …”
Get full text

RBOHD, GLR3.3, and GLR3.6 cooperatively control wounding hypocotyl-induced systemic Ca2+ signals, jasmonic acid, and glucosinolates in Arabidopsis leaves by Che Zhan, Na Xue, Zhongxiang Su, Tianyin Zheng, Jianqiang Wu

“…We show that wounding hypocotyls rapidly activated both Ca2+ and ROS signals in leaves. RBOHD, which functions to produce ROS, along with two glutamate receptors GLR3.3 and GLR3.6, but not individually RBOHD or GLR3.3 and GLR3.6, in hypocotyls regulate the dynamics of systemic Ca2+ signals in leaves. …”
Get full text

Tryptophan-induced transcriptomic changes in the European Seabass are highly dependent on neuroendocrine-immune conditions by Diogo Peixoto, Inês Carvalho, Diego Robledo, Marina Machado, Patricia Pereiro, Antonio Figueras, Rita Azeredo, Benjamín Costas

“…Undisturbed seabass fed dietary TRP supplementation showed an up-regulation of various innate immune functions, contrasting previous studies which indicated mainly a TRP regulatory role. …”
Get full text

Analysis and Design of a 50-kW Two Stage Converters for EV Fast Charger With High Efficiency and Wide Output Voltage of 150–1000 V by Ha-Min Park, Hyung-Woo Lee, Chan-Bae Park, Jae-Bum Lee, Jin-Chul Kim, Ju Lee

“…Additionally, by optimally selecting the frequencies of each converter and output voltage of the LLC resonant converter, which functions as the input voltage of the buck converter, high efficiency can be achieved. …”
Get full text

Unravelling the role of interleukin-6 in regulating dental stem cell behaviour: a scoping review by Itt Assoratgoon, Nunthawan Nowwarote, Suphalak Phothichailert, Waruna L. Dissanayaka, Lakshman P. Samaranayake, Thanaphum Osathanon

“…Abstract Background Interleukin-6 (IL-6) functions as a pro-inflammatory and anti-inflammatory cytokine. …”
Get full text

Unveiling Sodium Diffusion Kinetics and Locking Mechanisms for High‐Performance CZTSSe Photovoltaics by Shuyu Li, Chaoran Li, Chu Liu, Jiachen Wu, Letu Siqin, Yuan Li, Guonan Cui, Yanchun Yang, Ruijian Liu, Hongmei Luan, Chengjun Zhu

“…This approach leverages Na's dual functionality as a crystallization promoter and defect passivator, driving concurrent improvements in crystallographic coherence and electronic uniformity. …”
Get full text

Being a better version of yourself: genetically engineered probiotic bacteria as host defense enhancers in the control of intestinal pathogens by Ewa Carolak, Joanna Czajkowska, Adrianna Stypułkowska, Wiktoria Waszczuk, Agata Dutkiewicz, Krzysztof Grzymajlo

“…These enhanced probiotics demonstrate improved functionality through multiple mechanisms, including increased adhesion via the expression of specific proteins (InlA, FnBPA, and LAP), targeted antimicrobial activity through engineered sensing systems (Lactococcus lactis detecting Vibrio cholerae CAI-1), and enhanced immunomodulation through cytokine production. …”
Get full text

Spatiotemporal variations in habitat quality and their determinants in the Henan Section of the Yellow River Basin by ZHANG Yingying, MA Ziyan, YU Nan, WEI Dechao, CHEN Zhaojing, YUAN Shuting, WANG Zheng, SONG Xinxin, ZHAO Yongqiang

“…【Objective】The ecological functions of the Yellow River Basin have undergone significant changes in recent decades due to both natural and anthropogenic influences. …”
Get full text

TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection by Liang Wang, Liang Wang, Yumei Liu, Yuyu Ma, Xuan Zhou, Xuan Zhou, Maidinaimu Aibibula, Xue Zhang, Hui Zhao, Jinping Zhou, Fengming Tian, Fengming Tian, Xiumin Ma

“…The liver immune microenvironment at the middle and late stages of mice infected with E. multilocularis was established in vitro to assess cytokine dynamics and liver fibrosis biomarkers.ResultsClinical analysis revealed the upregulation of Tim-4 within the hepatic lesions of patients with AE, with its expression spatially localized to macrophage-enriched regions and functionally linked to extracellular inflammatory modulation. …”
Get full text

Wood forming tissue-specific expression of PaTyDC4 promotes xylem differentiation and lignin deposition during secondary growth and confers drought tolerance in Populus by Qiao Wang, Yiqing Wang, Xintong Lu, Yang Chen, Yan Chen, Xiuwen Wu, Gongke Zhou, Guohua Chai

“…This study provided evidence showing that poplar PaTyDC4 functions in wood development and drought stress response. …”
Get full text

Immune Basis of Therapeutic Effects of <i>Solanum tuberosum</i> L. Polysaccharide on Chronic Peptic Ulcer Healing by Evgenii Generalov, Denis Laryushkin, Kristina Kritskaya, Nina Kulchenko, Arkady Sinitsyn, Leonid Yakovenko, Liubov Generalova, Nikolay Belostotsky

“…<b>Conclusions</b>: Intravenous administration of STP leads to the restoration of functionality and effective tissue regeneration. The antiulcer activity of STP is based on the regulation of the pro- and anti-inflammatory balance.…”
Get full text

An Automated Digital Microfluidic System Based on Inkjet Printing by Wansheng Hu, Ming Cao, Lingni Liao, Yuanhong Liao, Yuhan He, Mengxiao Ma, Simao Wang, Yimin Guan

“…The dimensions of the cell spheroids play a pivotal role in their functionality, affecting cell proliferation and differentiation, intercellular interactions, gene expression, protein synthesis, drug penetration, and metabolism. …”
Get full text

Extreme Short-Term Prediction of Unmanned Surface Vessel Nonlinear Motion Under Waves by Yiwen Wang, Jian Li, Shan Wang, Hantao Zhang, Long Yang, Weiguo Wu

“…The methodology employs VMD to decompose the nonlinear motion time series data of the USV obtained by numerical simulation into stationary Intrinsic Mode Functions (IMFs), subsequently extracting spatial features from these IMFs using CNN layers, and, finally, predicts temporal sequence via the LSTM module. …”
Get full text

A polymeric nanovesicle delivers sulfopin and gemcitabine to remodel tumor microenvironment for enhanced chemoimmunotherapy against orthotopic pancreatic cancer by Weiting Jiang, Wei Deng, Qi Chen, Huahua Zhang, Min Zhu, Rongze Wang, Yong Wang

“…Emerging evidence suggests that ECM modulation represents a promising strategy to enhance treatment outcomes in pancreatic cancer. …”
Get full text

The association between vitamin D level and periodontal disease in Saudi population, a preliminary study by Marwa Madi, Verica Pavlic, Shahad Mongith Alammar, Leenah Mohammad Alsulaimi, Reema Shaker Alotaibi, Gadah Mohammed AlOtaibi, Osama Zakaria

“…Objective: Among other regulatory functions, vitamin D has a role in modulating the inflammatory process of periodontal disease. …”
Get full text

SATB1 in cancer progression and metastasis: mechanisms and therapeutic potential by Jinping Bai, Gege Yang, Qi Yu, Qianya Chi, Xianlu Zeng, Wenjing Qi, Wenjing Qi

“…Moreover, SATB1’s activity is modulated by microRNAs (miRNAs) and post-translational modifications, further contributing to its complex regulatory functions. …”
Get full text

Cognitive Effects of Transcranial Direct Current Stimulation Plus Robotic Verticalization in Minimally Conscious State by Antonio Gangemi, Rosaria De Luca, Rosa Angela Fabio, Mirjam Bonanno, Davide Cardile, Maria Randazzo Mignacca, Carmela Rifici, Francesco Corallo, Angelo Quartarone, Federica Impellizzeri, Rocco Salvatore Calabrò

“…Background and Objectives: Transcranial direct current stimulation (tDCS) is a non-invasive therapeutic method that modulates cortical excitability and shows promising results for treating disorders of consciousness (DoCs). …”
Get full text

Trust Region Policy Learning for Adaptive Drug Infusion with Communication Networks in Hypertensive Patients by Mai The Vu, Seong Han Kim, Ha Le Nhu Ngoc Thanh, Majid Roohi, Tuan Hai Nguyen

“…Besides the various analyses such as normal condition (without CTD strategy), stability, and hybrid noise, a CTD analysis is implemented to illustrate the functionality of the system in a wireless manner and interruption in real-time feedback data.…”
Get full text

RAW264.7 Macrophages as a Polarization Model in the Context of Pancreatic Cancer and Chemokine Release by Aydar Khabipov, Lea Miebach, Maik Lenz, Stephan Kersting, Sander Bekeschus

“…Collectively, we demonstrated that our model is suitable for testing the roles and functions of chemokines in macrophage polarization by pancreatic cancer cells.…”
Get full text