Carbene-Catalyzed Phthalide Ether Functionalization for Discovering Chiral Phytovirucide that Specifically Targets Viral Nia Protein to Inhibit Proliferation by Xiaoyi Wang, Weijia Yang, Shang Wu, Fangru Jin, Zhongjie Shen, Xiangyang Li, Yonggui Robin Chi, Baoan Song, Runjiang Song

“…An N-heterocyclic carbene-modulated reaction is first designed to asymmetrically functionalize diverse natural phenols with phthalides. …”
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Optimized Design and Deep Vision-Based Operation Control of a Multi-Functional Robotic Gripper for an Automatic Loading System by Yaohui Wang, Sheng Guo, Jinliang Zhang, Hongbo Ding, Bo Zhang, Ao Cao, Xiaohu Sun, Guangxin Zhang, Shihe Tian, Yongxu Chen, Jixuan Ma, Guangrong Chen

“…This study presents an optimized design and vision-guided control strategy for a multi-functional robotic gripper integrated into an automatic loading system for warehouse environments. …”
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Enhancing Oxygen Evolution Reaction Activity through Linker Functionalization in Manganese‐Based Metal‐Organic Frameworks (Mn‐MOFs) by Arslan Akbar, Irfan Ullah, Salman Noshear Arshad, Muhammad Zaheer

“…A series of manganese‐based MOFs in rarely reported MIL‐88B structure (Mn‐MIL‐88‐X) is synthesized using functionalized linkers [X = NH2, NO2, Br]. The objective is to modulate the electronic structure and hydrophilicity of the MOFs leading to enhanced OER activity. …”
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Effects of screw-pressing temperature on the functional properties and structural characteristics of apricot (Prunus armeniaca L.) kernel protein isolates by Li Zhang, Hongyu Wu, Mengshi Wang, Xianjin Zhou, Bayinkexike, Ruiguo Cui, Lijun Song, Fengjuan Liu

“…Mechanistically, thermally-induced protein conformational changes and surface hydrophobicity modulation drove the observed enhancements in functional properties. …”
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Functional Characterization of <i>TNFα</i> in the Starry Flounder (<i>Platichthys stellatus</i>) and Its Potential as an Immunostimulant by Min-Young Sohn, Gyoungsik Kang, Kyung-Ho Kim, Ha-Jeong Son, Chan-Il Park

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hnRNPC Functions with HuR to Regulate Alternative Splicing in an m6A‐Dependent Manner and is Essential for Meiosis by Xinxin Xiong, Shenglei Feng, Xixiang Ma, Kuan Liu, Yiqian Gui, Bei Chen, Xu Fan, Fengli Wang, Xiaoli Wang, Shuiqiao Yuan

“…However, much remains to be understood about the regulation of m6A and the function of its specific readers during meiotic processes. …”
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Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration by Rui Shi, Rui Shi, Fei Liu, Qihuang Qin, Pinxue Li, Ziqi Huo, You Zhou, Chunyan Jiang

“…Piezoelectric materials, known for modulating cellular functions and promoting stem cell proliferation and differentiation, have garnered increasing attention in tissue repair applications.MethodsIn this study, a biomimetic piezoelectric patch with progressive compositional and structural variations was designed and fabricated. …”
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Does Inhibitory Repetitive Transcranial Magnetic Stimulation Augment Functional Task Practice to Improve Arm Recovery in Chronic Stroke? by Dorian K. Rose, Carolynn Patten, Theresa E. McGuirk, Xiaomin Lu, William J. Triggs

“…Restoration of upper extremity (UE) functional use remains a challenge for individuals following stroke. …”
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Ontogeny and function of the intestinal epithelial and innate immune cells during early development of chicks: to explore in ovo immunomodulatory nutrition by Habtamu Ayalew, Changchun Xu, Assefa Adane, Astrid Lissette Barreto Sanchez, Siman Li, Jing Wang, Shugeng Wu, Kai Qiu, Guanghai Qi, Haijun Zhang

“…Thus, summarizing the ontogeny and function of IECs, innate immunity systems, and interaction mechanisms of in ovo feeding of bioactive substances could provide baseline information for designing targeted in ovo feeding interventions to modulate cell waise specific innate immune systems.…”
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Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

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Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo. by Paula E Beaumont, Brian McHugh, Emily Gwyer Findlay, Annie Mackellar, Karen J Mackenzie, Richard L Gallo, John R W Govan, A John Simpson, Donald J Davidson

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Effect of probiotics on cognitive function and cardiovascular risk factors in mild cognitive impairment and Alzheimer’s disease: an umbrella meta-analysis by Bin Xiao, Lina Fu, Zhe Yang, Guran Yu

“…Conclusion Probiotic supplementation appears to enhance cognitive function and metabolic parameters in individuals with MCI and AD, likely through mechanisms involving inflammation reduction, oxidative stress modulation, and improved insulin sensitivity. …”
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Omega-3 fatty acids and fetal brain development: implications for maternal nutrition, mechanisms of cognitive function, and pediatric depression by Raghd M Ghazal, Moawiah M Naffaa

“…Additionally, DHA and eicosapentaenoic acid (EPA) show promise in treating pediatric depression by modulating the gut-brain axis, reducing neuroinflammation, and restoring autonomic nervous system function—mechanisms implicated in depression. …”
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Chaotic behavior, sensitivity analysis and Jacobian elliptic function solution of M-fractional paraxial wave with Kerr law nonlinearity. by Md Mamunur Roshid, Mohammad Safi Ullah, M M Rahman, Harun-Or- Roshid

“…We create a range of wave structures using the powerful extended Jacobian elliptic function expansion (EJEFE) method, including periodic waves, lump-periodic waves, periodic breather waves, kink-bell waves, kinky-periodic waves, anti-kinky-periodic waves, double-periodic waves, etc. …”
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Role of Ca2+ and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations. by Chen Zhang, Nagaraju Mulpuri, Fadil M Hannan, M Andrew Nesbit, Rajesh V Thakker, Donald Hamelberg, Edward M Brown, Jenny J Yang

“…In contrast, L173F and P221L show enhanced responsiveness of these three functional readouts to [Ca(2+)]o. Further analysis of the dynamics of the VFTD mutants using computational simulation studies supports disruption in the correlated motions in the loss-of-function CaSR mutants, while these motions are enhanced in the gain-of-function mutants. …”
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Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation. by Paul J Meakin, Vicky L Morrison, Claire C Sneddon, Terhi Savinko, Liisa Uotila, Susan M Jalicy, Jennie L Gabriel, Li Kang, Michael L J Ashford, Susanna C Fagerholm

“…Beta2-integrins are important in leukocyte trafficking and function, and are regulated through the binding of cytoplasmic proteins, such as kindlin-3, to their intracellular domain. …”
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Human Leucocyte Antigen-G (HLA-G) and Its Murine Functional Homolog Qa2 in the Trypanosoma cruzi Infection by Fabrício C. Dias, Celso T. Mendes-Junior, Maria C. Silva, Fabrine S. M. Tristão, Renata Dellalibera-Joviliano, Philippe Moreau, Edson G. Soares, Jean G. Menezes, André Schmidt, Roberto O. Dantas, José A. Marin-Neto, João S. Silva, Eduardo A. Donadi

“…HLA-G and its murine functional homolog Qa2 have well-recognized immunomodulatory properties. …”
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Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats by Katelyn E. Senkus, Maria Azrad, Anneliese Bolland, Han-A Park, Johnny R. Tice, Meijuan Zhang, Taiming Liu, Arlin B. Blood, William Van Der Pol, Casey Morrow, Kristi M. Crowe-White

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Edaphic factors mediate the response of nitrogen cycling and related enzymatic activities and functional genes to heavy metals: A review by Tracy Opande, Mengru Kong, Di Feng, YuHong Wen, Nathan Okoth, Ali Mohd Yatoo, Fatma Mohamed Ameen Khalil, Ahmed S. Elrys, Lei Meng, Jinbo Zhang

“…Former studies suggested that soil N cycling is chiefly regulated by microbial activity; however, emerging evidence indicates that this regulation is disrupted by heavy metal (HM) contamination, which alters microbial communities and enzyme functions critical to N transformations. Environmental factors like soil organic carbon, soil texture, water content, temperature, soil pH, N fertilization, and redox status play significant roles in modulating the response of soil N cycling to HM contamination. …”
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A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor. by Jeremy D Volkening, Stephen J Spatz, Maricarmen Garcia, Teresa A Ross, Daniel A Maekawa, Kenneth S Rosenthal, Ana C Zamora, April Skipper, Julia R Blakey, Rashan Paudel

“…One such tactic involves acquiring functional copies of host genes encoding cytokines such as IL-6 (HHV-8), IL-10 (HHV-4, HHV-5), and IL-17 (SaHV-2). …”
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