The m6A modification of LncRNA LINC00200 regulated by WTAP accelerates glioma tumorigenesis by regulating Wnt/β-catenin pathway by Zhiying Lu, Jing Chen, Chao Luo

“…The levels of WTAP-mediated m6A modification of LINC00200 was ascertained by MeRIP-qPCR. Functionally, the effects of LINC00200 knockdown and the interaction of WTAP with LINC00200 on the glioma cell characteristics were examined by CCK8, colony formation, and transwell migration/invasion assays. …”
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Sustainable Smart Irrigation System (SIS) using solar PV with rainwater harvesting technique for indoor plants. by Syed Zahurul Islam, Muhammad Saufi Bin Kamarudin, Mohd Noor Bin Abdullah, Mimi Mohaffyza, Lai Chee Sern, Mohammad Lutfi Othman, Jasim Uddin

“…The objectives of this project are to design and optimize the PV-powered irrigation system and implement an Arduino-enabled automatic system with SMS-triggered functionality. The methodology involves system modelling for water requirements and sizing of PV, battery, pump, and MPPT based on the load demand. …”
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Surfactant Protein A in Exhaled Endogenous Particles Is Decreased in Chronic Obstructive Pulmonary Disease (COPD) Patients: A Pilot Study. by Mona Lärstad, Ann-Charlotte Almstrand, Per Larsson, Björn Bake, Sven Larsson, Evert Ljungström, Ekaterina Mirgorodskaya, Anna-Carin Olin

“…<h4>Conclusions</h4>Decreased levels of SP-A may lead to impaired host defense functions of surfactant in the airways, contributing to increased susceptibility to COPD exacerbations. …”
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Morphological and Hydrogeological Controls of Groundwater Flows and Water Age Distribution in Mountain Aquifers and Streams by A. Betterle, A. Bellin

“…Nonetheless, it is unclear how deep flows interact with the overall hydrological functioning of mountain areas, how they contribute to the long‐term water budget, and how climate, morphology, and geology jointly control them. …”
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Index Method of Evaluating the Performance of Economic Activities by A. Sh. Kamaletdinov, A. A. Ksenofontov

“…The subject of the research is the economies of the constituent entities of the Russian Federation and the branches of economic activity functioning in their territories. The aim of the study is to develop methods for assessing the efficiency of economic sectors and types of economic activity within the boundaries of 85 constituent entities of the Russian Federation and to create a rating of the efficiency of the constituent entities by the type of economic activity “Production and distribution of electricity, gas and water”. …”
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Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. by Anthony Antonellis, Jimmy L Huynh, Shih-Queen Lee-Lin, Ryan M Vinton, Gabriel Renaud, Stacie K Loftus, Gene Elliot, Tyra G Wolfsberg, Eric D Green, Andrew S McCallion, William J Pavan

“…Developmental genes often require multiple regulatory sequences that integrate discrete and overlapping functions to coordinate their expression. To identify Sox10 cis-regulatory elements, we integrated multiple model systems, including cell-based screens and transposon-mediated transgensis in zebrafish, to scrutinize mammalian conserved, noncoding genomic segments at the mouse Sox10 locus. …”
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Ectopic repression of receptor tyrosine kinase–like orphan receptor 2 inhibits malignant transformation of ovarian cancer cells by reversing epithelial–mesenchymal transition by Ying Xu, Yan-Hui Ma, Ying-Xin Pang, Zhe Zhao, Jing-Jing Lu, Hong-Luan Mao, Pei-Shu Liu

“…The purpose of this study was to investigate the expression and role of receptor tyrosine kinase–like orphan receptor 2 in ovarian carcinoma and clarify the biological functions and interactions of receptor tyrosine kinase–like orphan receptor 2 with non-canonical Wnt pathways in ovarian cancer. …”
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Breast Cancer Classification With Enhanced Interpretability: DALAResNet50 and DT Grad-CAM by Suxing Liu, Galib Muhammad Shahriar Himel, Jiahao Wang

“…This model integrates a pre-trained ResNet50 architecture with a lightweight attention mechanism, embedding an attention module in the fourth layer of ResNet50, and incorporates two fully connected layers with LeakyReLU and ReLU activation functions to enhance feature learning capabilities. …”
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The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells by Sakhavat Abolhasani, Yasin Ahmadi, Yavar Rostami, Davood Fattahi

“…This review comprehensively examines the functions of various miRNAs in MSC differentiation, focusing on miR-143 and miR-145, which are upregulated by transforming growth factor beta 1 (TGF-β1), a key growth factor in SMC development. …”
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Conceptual model of railway car traffic organisation based on the end-to-end control of freight delivery times by O. V. Moskvichev, E. A. Mishchenko, S. N. Titarenko

“…The authors assess the operation of existing automated control systems, which shows discontinuities and non-automated functions in the framework of the end-to-end control of the goods and empty cars delivery times. …”
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Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells. by Anne S Fleiner, Daniel Kolnier, Nicholas Hagger-Vaughan, Johan Ræder, Johan F Storm

“…According to leading theories of access consciousness and working memory, L2/3PCs are particularly important for these cognitive functions. We found that muscarine induced long-lasting depolarising plateau potentials (PPs) and spiking following brief depolarising current injections in the L2/3PCs. …”
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Exploring partially reduced CeO111 surface at the atomic scale using scanning probe microscopy by Kyungmin Kim, Masayuki Abe, Shigeki Kawai, Oscar Custance

“…The chemical reactivity of these candidates to Ce[Formula: see text] atoms is quantified against the Ce[Formula: see text] counterparts by means of force spectroscopy using carbon monoxide functionalized probes. This study demonstrates that the combination of STM with AFM and force spectroscopy bears great potential to provide robust atomic-level insights into the chemistry of defects at ceria surfaces.…”
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Co-expression of a truncated TGFβ receptor II in c-Met CAR T cells enhances antitumor activity against lung adenocarcinoma by Chao Su, Wenbin Hu, Huafang Mao

“…Bioinformatics analysis using the GEPIA2 database and single-cell RNA sequencing (scRNA-seq) revealed high c-Met expression in lung adenocarcinoma and highlighted the role of TGFβ signaling in modulating tumor-infiltrating T cells. A CAR construct targeting c-Met was developed to co-express TGFBR2-N via lentiviral transduction, and CAR T cell functionality was assessed through IL-2 ELISA, flow cytometry for pSMAD2/3 signaling, CD69 and PD-1 expression, as well as proliferation and cytotoxicity assays. …”
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Inhibition of S100A4 decreases neurotoxic astrocyte reactivity and attenuates neuropathic pain via the TLR4/NF-κB pathway in a rat model of spinal nerve ligation by Tao Xue, Yu Song, Jie Zhao, Guiyong Fan, Zhiyuan Liu

“…Abstract S100A4 participates in inflammation and immune reactions in the central nervous system and is involved in the pathogenesis of multiple neurological disorders. It can affect the functions of astrocytes, microglia, infiltrating cells and neurons and further modulates neuronal plasticity and survival in the central nervous system. …”
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Application of in-silico docking for green electrochemical quantification of prucalopride succinate in pharmaceutical, urine, and milk matrices by Ahmed R. Mohamed, Rania A. Sayed, Abdalla Shalaby, Hany Ibrahim

“…Concerning the statistical assessment, there weren’t palpable disparities in functioning between the suggested technique and the published one. …”
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Comprehensive review on anti-obesity effects of plant-derived compounds: Evidence from 3T3-L1 adipocytes and high-fat diet models by Sachin Gudasi, Mrityunjaya B. Patil

“…These outcomes provide compelling evidence for the use of functionalized nanoparticles as a next-generation anti-obesity strategy, with potential translational value for clinical application.…”
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Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop. by Lingxia Qiao, Michael Getz, Ben Gross, Brian Tenner, Jin Zhang, Padmini Rangamani

“…Specifically, the spatiotemporal orchestration of cAMP and Ca2+ oscillations is critical for many cellular functions. Previous experimental studies have shown that the formation of nanodomains of A-kinase anchoring protein 79/150 (AKAP150) and adenylyl cyclase 8 (AC8) on the surface of pancreatic MIN6 β cells modulates the phase of Ca2+-cAMP oscillations from out-of-phase to in-phase. …”
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Physicochemical and electrical properties of DPPC bilayer membranes in the presence of oleanolic or asiatic acid by Katarzyna Karwowska, Maciej Gniadek, Wiesław Urbaniak, Aneta D. Petelska

“…The equilibria are particularly significant from the standpoint of cell functioning. Phosphatidylcholine-sapogenin interactions modulate a range of physicochemical properties of membranes, and they are important in the course of the multiple processes involving membranes in the living cell (e.g., transport mechanism).…”
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A study of serum prolactin in dermatological diseases in a tertiary care hospital of Assam by Talukdar C, Boro B

“…Background: Prolactin functions as a neuroendocrine modulator of the skin immune system and epithelial cell proliferation. …”
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The Potential of Neuregulin 4 as a Novel Biomarker and Therapeutic Agent for Vascular Complications in Type 2 Diabetes Mellitus by Dan X, Li K, Xu J, Yan P

“…Xiaofang Dan,1– 3 Ke Li,1– 3 Jiali Xu,4 Pijun Yan1– 3,5,6 1Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, People’s Republic of China; 3Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, People’s Republic of China; 4Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 5Sichuan Clinical Research Center for Nephropathy, Luzhou, People’s Republic of China; 6Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, People’s Republic of ChinaCorrespondence: Pijun Yan, Email peter2007110361@126.comAbstract: Neuregulin 4 (Nrg4), a novel adipokine produced primarily by brown adipose tissue (BAT), has been functionally characterized to exert beneficial effects on modulating energy homeostasis and glucolipid metabolism, and is closely associated with the development and progression of obesity and obesity-associated metabolic diseases, such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases. …”
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