MiR-451 in Inflammatory Diseases: Molecular Mechanisms, Biomarkers, and Therapeutic Applications—A Comprehensive Review Beyond Oncology by Fei-Xiang Wang, Guo Mu, Zi-Hang Yu, Zhen-Shan Qin, Xing Zhao, Zu-An Shi, Xin Fan, Li Liu, Ye Chen, Jun Zhou

“…This comprehensive review systematically analyzes miR-451’s multifaceted functions in inflammatory diseases, with particular focus on ischemia–reperfusion injury, arthritis, and acute organ injuries. …”
Get full text

SLC5A3 depletion promotes apoptosis by inducing mitochondrial dysfunction and mitophagy in gemcitabine-resistant pancreatic cancer cells by Minsoo Kim, Woosol Chris Hong, Hyeon Woong Kang, Ju Hyun Kim, Dongyong Lee, Jae-Ho Cheong, Hye-Sol Jung, Wooil Kwon, Jin-Young Jang, Hyo Jung Kim, Joon Seong Park

“…In this study, we identified the sodium/myo-inositol co-transporter solute carrier family 5 member 3 (SLC5A3) as a key modulator promoting chemoresistance in PDAC. SLC5A3 levels were significantly upregulated in gemcitabine-resistant PDAC cells, enhancing their cell survival by stabilizing the mitochondrial functions and inhibiting apoptosis. …”
Get full text

Electrochromism via reversible electrodeposition of solid iodine by Shanlin Li, Yingyu Chen, Zhen Wang, Mengmeng Wang, Xianglin Guo, Xueqing Tang, Xiaoyu Wang, Wende Lai, Meiyun Tong, Changhong Wang, Shan Cong, Fengxia Geng, Yong Chen, Zhigang Zhao

“…A practical 400 cm2 complementary dynamic window is fabricated to demonstrate good electrochromic performance, including high optical contrast, a near colour-neutral opaque state, fast response time, uniform modulation, and polarity-switchable functionality.…”
Get full text

Modified Methylation Following Electrostimulation in a Standardized Setting—Complementing a Transcriptomic Analysis by Biagio Di Pietro, Simona Villata, Anna Plaksienko, Tiziana Guarnieri, Simeone Dal Monego, Margherita Degasperi, Pietro Di Lena, Danilo Licastro, Claudia Angelini, Francesca Frascella, Lucia Napione, Christine Nardini

“…While the impact of ES on epigenetic processes is recognized, its broader effects on cellular functions, particularly in inflammation and wound healing, are less understood. …”
Get full text

Natural Antisense Transcripts in Plants: A Review and Identification in Soybean Infected with Phakopsora pachyrhizi SuperSAGE Library by Suzana de Aragão Britto-Kido, José Ribamar Costa Ferreira Neto, Valesca Pandolfi, Francismar Corrêa Marcelino-Guimarães, Alexandre Lima Nepomuceno, Ricardo Vilela Abdelnoor, Ana Maria Benko-Iseppon, Ederson Akio Kido

“…The present study reviewed plant NAT aspects, including features, availability and genesis, conservation and distribution, coding capacity, NAT pair expression, and functions. Besides, an in silico identification of NATs pairs was presented, using deepSuperSAGE libraries of soybean infected or not with Phakopsora pachyrhizi. …”
Get full text

Receptor-Interacting Protein Kinase-3 Expression Impacts Ocular Vascular Development and Pathological Neovascularization by Yong-Seok Song, Shoujian Wang, SunYoung Park, Barbara Hanna, Kelsey J. Johnson, Soesiawati R. Darjatmoko, Mohammad Ali Saghiri, Ali Mohammad Saghiri, Bo Liu, Christine M. Sorenson, Nader Sheibani

“…Functional cell death pathways are essential for normal ocular vascular development and tissue homeostasis. …”
Get full text

Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry by Aline Menezes, Yara Martins, Fábio Nogueira, Denise De Abreu Pereira, Katia Carneiro

“…A label-free, mass spectrometry–based quantitative proteomics has been developed to identify and characterize proteins that are differentially expressed in GBM to gain a better understanding of the interactions and functions that lead to the pathological state focusing on the extracellular matrix (ECM). …”
Get full text

Mycobacterial PstP impairs host RNA alternative splicing by dephosphorylation of spliceosome RBMX at S189 by Tianxian Liu, Jun‐Yu Xu, Lei Zhao, Yameng Fan, Shuyu Xie, Ke Ma, Ying Zhou, Minjia Tan, Bang‐Ce Ye

“…Abstract Mycobacterium tuberculosis (Mtb) infection significantly alters host cellular signaling and protein functions, facilitating immune evasion and intracellular survival. …”
Get full text

RENIN-ANGIOTENSIN SYSTEM IN REGULATION OF HEMATOPOIESIS by M. L. Kanaeva, I. V. Galtseva, I. M. Nakastoev, Y. B. Balzhanova, E. O. Gribanova, E. N. Parovichnikova, V. G. Savchenko

“…Local RAS is also one of the most important components in the tumor microenvironment, affecting tumor growth and metastasis by autocrine and paracrine pathways, modulating numerous carcinogenic events such as angiogenesis, apoptosis, cell proliferation, immune responses, and extracellular matrix formation.The purpose of this review is to describe the known functions of local RAS in the hematopoiesis regulation. …”
Get full text

Effects of Clozapine, Haloperidol, and the NMDA Antagonist Ketamine on Novel Object Recognition in <i>Gnathonemus petersii</i>: A New Possible Model for Schizophrenia Research by Petra Horká, Josefina Mavrogeni, Veronika Langová, Pavel Horký, Jan Hubený, Ivana Chrtková, Karel Valeš, Martin Kuchař, Jiří Horáček

“…We aimed to investigate whether pharmacological modulation of the glutamatergic system would impair cognitive functions by administering the NMDA receptor antagonist ketamine, and whether these impairments could be suppressed by the administration of typical (first-generation) and atypical (second-generation) antipsychotics—clozapine and haloperidol, respectively. …”
Get full text

Estramustine Phosphate Inhibits TGF-β-Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production by Sonja S. Mojsilovic, Slavko Mojsilovic, Suncica Bjelica, Juan F. Santibanez

“…Transforming growth factor-beta (TGF-β) has been demonstrated as a key regulator of immune responses including monocyte/macrophage functions. TGF-β regulates macrophage cell migration and polarization, as well as it is shown to modulate macrophage urokinase-type plasminogen activator (uPA) production, which also contributes to macrophage chemotaxis and migration toward damaged or inflamed tissues. …”
Get full text

The crucial role of SPP1 in osteoporosis, osteoarthritis, and cancer by Yaru Qu, Shuixian Li, Huiyuan Luo, Junnan Li, Tong Wang, Xiuzhen Han

“…This review integrates the molecular structural characteristics of SPP1, including isoform variants and post-translational modifications, with its pathophysiological functions. It highlights the regulatory roles of SPP1 in these diseases: maintaining the dynamic balance between bone resorption and formation in osteoporosis, promoting cartilage degeneration and inflammation in osteoarthritis, and driving tumor progression in cancer through the activation of pathways such as PI3K/AKT/mTOR. …”
Get full text

Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs by Tailin He, Lei Qin, Sheng Chen, Shaochuan Huo, Jie Li, Fuping Zhang, Weihong Yi, Yifang Mei, Guozhi Xiao

“…BDFs act as a medium through which bones can exert targeted regulatory functions upon various organs, thereby underscoring the profound and concrete implications of bone in human physiology. …”
Get full text

Dynamic hierarchical ligand anisotropy for competing macrophage regulation in vivo by Kanghyeon Kim, Sunhong Min, Ramar Thangam, Kyong-Ryol Tag, Hyun-Jeong Lee, Jeongyun Heo, Hwapyung Jung, Thet Thet Swe, Iman Zare, Guosheng Song, Alireza Hassani Najafabadi, Junmin Lee, Hyun-Do Jung, Jong Seung Kim, Sunghoon Hur, Hyun-Cheol Song, Sung-Gyu Park, Kunyu Zhang, Pengchao Zhao, Liming Bian, Se Hoon Kim, Juyoung Yoon, Jae-Pyoung Ahn, Hong-Kyu Kim, Heemin Kang

“…Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation. In this study, remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy. …”
Get full text

Digitoids: a novel computational platform for mimicking oxygen-dependent firing of neurons in vitro by Rachele Fabbri, Rachele Fabbri, Ermes Botte, Ermes Botte, Ermes Botte, Arti Ahluwalia, Arti Ahluwalia, Arti Ahluwalia, Chiara Magliaro, Chiara Magliaro, Chiara Magliaro

“…However, few of the current in silico approaches consider the energetic demand of neurons to sustain their electrophysiological functions, specifically their well-known oxygen-dependent firing.MethodsIn this work, we introduce Digitoids, a computational platform which integrates a Hodgkin-Huxley-like model to describe the time-dependent oscillations of the neuronal membrane potential with oxygen dynamics in the culture environment. …”
Get full text

Immune-endocrine crossroads: the impact of nuclear receptors in Tuberculosis and Chagas disease by Ana R. Pérez, Ana R. Pérez, Oscar A. Bottasso, Oscar A. Bottasso, Oscar A. Bottasso, Natalia E. Santucci, Natalia E. Santucci

“…They act as transcription factors and are subclassified into families based on their ligands, DNA-binding sequences, tissue specificity, and functions. Evidence indicates that in infectious diseases, cancer, and autoimmunity, NRs modulate immune and endocrine responses, altering the transcriptional profile of cells and organs and influencing disease progression. …”
Get full text

Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment by Yue Wang, Yiwen Wang, Yuhang Zhou, Yun Feng, Tao Sun, Junnan Xu

“…Symbiotic fungi have become increasingly influential in health and disease and modulate various physiologic functions within the host. …”
Get full text

Impact of Gut Microbiota on the Development of Diseases by Karolina Winiarek, Martyna Michalska, Wiktor Wardyn, Cezary Guzowski, Joanna Anna Murawska, Daria Ziemińska, Rafał Burczyk, Kornelia Kędziora-Kornatowska

“…Conclusions: Intestinal microflora is crucial to health, regulating immune, metabolic and neurological functions. Dysbiosis, i.e. disturbance of the balance of intestinal microflora, is associated with diseases such as type 2 diabetes, obesity, inflammatory bowel diseases, allergies, autoimmune diseases and neuropsychiatric disorders. …”
Get full text

Duplex γ/α-phase evolution of biocompatible high-nitrogen stainless steel in additive manufacturing by Yufeng Tao, Liansheng Lin, Xudong Ren, Xuejiao Wang, Xia Cao, Yunxia Ye, Erjin Zhang, Heng Gu, Zijie Dai

“…Artificial tunability of microstructured high-nitrogen γ/α duplex-phase at tight topological control promises transformative opportunities not possessed by individual ferrite or austenitic phase, allowing pre-programming mechanics (density, strength, hardness, and tensile properties) for next-generation industrial or implantable biomedical uses requiring complex geometries and multi-functions.…”
Get full text

Investigating the correlation between tertiary lymphoid structures and clinical outcomes in pancreatic ductal adenocarcinoma: insights into tumor immunology by Lingbo Hu, Lingbo Hu, Lingbo Hu, Yanhong Xiao, Yanhong Xiao, Yanhong Xiao, Ning Jiang, Ning Jiang, Yufen Hu, Liewang Qiu, Bo Geng

“…This study investigates the prognostic significance and biological functions of tertiary lymphoid structures (TLS) in PDAC. …”
Get full text