The Ceramide-Dependent EV Secretome Differentially Affects Prostate Cancer Cell Migration by Dolma Choezom, Jan-Moritz Plum, Pradhipa Karuna M., Adi Danieli-Mackay, Christof Lenz, Phillipp Brockmeyer, Julia Christina Gross

“…Neutral sphingomyelinases (nSMases) are lipid-modifying enzymes that modulate the secretion of EVs from cells. How nSMase activity and therefore ceramide generation affect the composition and functionality of secreted EVs is not fully understood. …”
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piRNA/PIWI pathways and epigenetic crosstalk in human diseases: Molecular insights into HIV-1 infection and drugs of abuse by Karthick Chennakesavan, James Haorah, Thangavel Samikkannu

“…Finally, we discuss future research directions to understand better the functions of piRNAs/PIWI proteins in human health and disease.…”
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Antioxidant Naturally Occurring Pleiotropically Acting Bioactive Compounds, as Polymeric Nanotherapeutics Against Autoimmune Diseases Progression by Panagiotis Theodosis-Nobelos, Fani-Niki Varra, Michail Varras, Georgios Papagiouvannis, Eleni A. Rekka

“…Nanocarriers such as dendrosomes, tannic acid-based reactive oxygen species (ROS)-scavenging nanoparticles, and folic acid-functionalized systems enhance drug stability, controlled drug release, and macrophage targeting. …”
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NEIL3 and TOP2A as key drivers of esophageal cancer through WNT signaling by Hui Li, Panpan Wang, Huijuan Chen, Yanyan Shao, Hui Luo

“…In contrast, TOP2A knockdown suppressed these functions and promoted apoptosis, independent of NEIL3. …”
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Scream’s roughness grants privileged access to the brain during sleep by Guillaume Y. T. Legendre, Maëva Moyne, Judith Domínguez-Borràs, Samika Kumar, Virginie Sterpenich, Sophie Schwartz, Luc H. Arnal

“…Abstract During sleep, recognizing threatening signals is crucial to determine when to wake up and when to continue vital sleep functions. Screaming is perhaps the most efficient way for communicating danger at a distance or in conditions of limited visibility. …”
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The mechanisms and clinical significance of CD8+ T cell exhaustion in anti-tumor immunity by Tao Zhong, Shuo Sun, Mingsheng Zhao, Bin Zhang, Huabao Xiong

“…CD8+ T cell exhaustion, a critical challenge in the immune response to cancer, is characterized by a profound decline in the functionality of effector CD8+ T cells. This state of exhaustion is accompanied by the upregulation of various inhibitory receptors and significant shifts in both transcriptional and epigenetic profiles, thus ultimately leading to inadequate tumor control. …”
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Influence of Scaffold Structure and Biomimetic Properties on Adipose Stem Cell Homing in Personalized Reconstructive Medicine by Doina Ramona Manu, Diana V. Portan, Monica Vuţă, Minodora Dobreanu

“…Natural scaffolds promote adhesion and differentiation but have mechanical limitations, while synthetic scaffolds offer tunable properties and controlled degradation. Functionalization with bioactive molecules improves the regenerative outcomes of different tissue types. …”
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Boosting proactive motor control via statistical learning with brain stimulation by Giulia Ellena, Federica Contò, Michele Tosi, Lorella Battelli

“…Results suggest a dominant role for the right hemisphere in mediating attentional learning effects, with implications for understanding lateralized functions in adaptation of the motor control.…”
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From bone marrow mesenchymal stem cells to diseases: the crucial role of m6A methylation in orthopedics by Peng Li, Chu Zhang, Wen Yin, Mijia Tao, Zhipeng Niu, Yutao Cui, Dankai Wu, Feng Gao

“…This review aims to summarize the key proteases involved in m6A methylation and their functions. The detailed mechanisms by which m6A methylation regulates osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through direct and indirect ways are also discussed, with a focus on specific molecular pathways. …”
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PRL2 negatively regulates FcεRI mediated activation of mast cells by Xin Guo, Yunxuan Lei, Yanhua Xu, Xinyue Du, Lin Lin, Yanping Luo, Yebin Xi, Yinshi Guo, Xiaoyin Niu, Zhaojun Wang, Guangjie Chen

“…In this study, we demonstrate that phosphatase of regenerating liver 2 (PRL2) functions as a negative regulator of FcεRI-mediated mast cell activation. …”
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Impact of microplastics on the human gut microbiome: a systematic review of microbial composition, diversity, and metabolic disruptions by Zar Soe Thin, Jactty Chew, Timothy Yu Yee Ong, Raja Affendi Raja Ali, Lai Ti Gew

“…MPs also impair short-chain fatty acid (SCFA) production, alter metabolic functions, and modulate immune pathways, contributing to intestinal diseases, metabolic syndrome, and chronic inflammation. …”
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Bio-realistic and versatile artificial dendrites made of anti-ambipolar transistors by Yifei Yang, Mingkun Xu, Tianhang Zhang, Chenfei Miao, Juan Lyu, Jing Pei, Peng Li, Guoqi Li, Si Wu, Huanglong Li

“…By further exploiting the memristive effect, dendritic AAB transistor can naturally mimic Ca ^2+ -mediated regulation of synaptic plasticity (meta-plasticity) at dendritic spine, an important homeostatic phenomenon due to dendritic modulation. The invention of dendritic AAB transistor enriches the family of neuromorphic transistors and represents a major advance in diversifying the functionality of transistors.…”
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Cardioprotective mechanisms of sodium-glucose cotransporter 2 inhibitors by A. M. Mkrtumyan, T. N. Markova, N. K. Mishchenko

“…Thus, this class of agents has a multifactorial effect on the functioning of cardiovascular system. Further studies will help to explain the all possible cardioprotective effects of iSGLT-2 in individuals with and without T2DM.…”
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Targeting gut microbiota as a therapeutic target in T2DM: A review of multi-target interactions of probiotics, prebiotics, postbiotics, and synbiotics with the intestinal barrier by Keyu Chen, Han Wang, Xiaofei Yang, Cheng Tang, Guojie Hu, Zezheng Gao

“…These mechanisms include the restoration of gut microbiota structure, upregulation of intestinal epithelial cell proliferation and differentiation, enhancement of tight junction protein expression, promotion of mucin secretion by goblet cells, and the immunosuppressive functions of regulatory T cells (Treg) and M2 macrophages. …”
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Controller Area Network (CAN) Bus Transceiver with Authentication Support and Enhanced Rail Converters by Can Hong, Weizhong Chen, Xianshan Wen, Theodore W. Manikas, Ping Gui, Mitchell A. Thornton

“…We describe the newly conceived transceiver security features and provide results concerning the design, implementation, fabrication and test of the transceiver to validate its functionality and robust operation in the presence of systemic error sources including Process, Voltage, and Temperature (PVT) variations. …”
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Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats by Sadollah Mohammadi, Moslem Najafi, Hossein Hamzeiy, Nasrin Maleki-Dizaji, Masoud Pezeshkian, Homayon Sadeghi-Bazargani, Masoud Darabi, Sara Mostafalou, Shahab Bohlooli, Alireza Garjani

“…The aim of this study was to investigate the effect of MSM on hemodynamics functions and oxidative stress in rats with monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH). …”
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Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization by Megan V Cannon, Herman HW Silljé, Jürgen WA Sijbesma, Inge Vreeswijk‐Baudoin, Jolita Ciapaite, Bart van der Sluis, Jan van Deursen, Gustavo JJ Silva, Leon J de Windt, Jan‐Åke Gustafsson, Pim van der Harst, Wiek H van Gilst, Rudolf A de Boer

“…Gene expression profiling studies revealed that genes regulating metabolic pathways were differentially expressed in hearts with elevated LXRα. Functionally, LXRα overexpression in isolated cardiomyocytes and murine hearts markedly enhanced the capacity for myocardial glucose uptake following hypertrophic stress. …”
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Ultrathin (<10 nm) Electrochemical Random‐Access Memory that Overcomes the Tradeoff between Robust Weight Update and Speed in Neuromorphic Systems by Seonuk Jeon, Seokjae Lim, Nir Tessler, Jiyong Woo

“…Electrochemical random‐access memory (ECRAM) devices are a promising candidate for neuromorphic computing, as they mimic synaptic functions by modulating conductance through ion migration. …”
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The role of RNA binding proteins in cancer biology: A focus on FMRP by Yunlu Jia, Ruyin Jia, Yongxia Chen, Xuanyi Lin, Nadire Aishan, Han li, Linbo Wang, Xiaochen Zhang, Jian Ruan

“…In this review, we emphasize recent findings and analyses that suggest contrasting functions of this protein family in tumorigenesis. …”
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Low-frequency local field potentials reveal integration of spatial and non-spatial information in prefrontal cortex by Mohammad Aliramezani, Balbir Singh, Christos Constantinidis, Mohammad Reza Daliri

“…The prefrontal cortex (PFC) is critical for various aspects of executive functions, particularly working memory. The debate over whether the dorsal and ventral PFC should be viewed as unitary or heterogeneous in working memory has been ongoing. …”
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