High Tau expression correlates with reduced invasion and prolonged survival in Ewing sarcoma by Florencia Cidre-Aranaz, Claudia Magrin, Malenka Zimmermann, Jing Li, Annalisa Baffa, Matteo Ciccaldo, Wolfgang Hartmann, Uta Dirksen, Martina Sola, Paolo Paganetti, Thomas G. P. Grünewald, Stéphanie Papin

“…Newly described Tau functions comprise DNA protection, chromatin remodeling, p53 regulation and cell fate modulation, suggesting a role of Tau in oncogenesis. …”
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The Role of Gut Microbiota in Orthopedic Surgery: A Systematic Review by Ahmed Nadeem-Tariq, Sarah Kazemeini, Matthew Michelberger, Christopher Fang, Sukanta Maitra, Karen Nelson

“…The gut microbiome’s composition and functionality influence surgical outcomes following orthopedic procedures. …”
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Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility by Seung Jae Shin, Buuvee Bayarkhangai, Khaliunsarnai Tsogtbaatar, Meng Yuxuan, Sang‐Hyun Kim, Yong‐Jae Kim, Ali Taghizadeh, Daesan Kim, Dong‐Hwee Kim, Jung‐Hwan Lee, Jeongeun Hyun, Hae‐Won Kim

“…These cooperative events of the mechano‐chemical signaling at the cytoskeletal‐to‐nuclear domains facilitate M2 transcriptional activation and cellular functions. We further evidence the rigidity‐primed M2 macrophages are immunosuppressive and accumulated within stiffened tumors in patients. …”
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Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1 by Jiafei Chen, Xiaoxu Guan, Lina Chen, Bingzhu Zheng, Feiyu Li, Chao Fang, Yike Fu, Xiang Li, Huiming Wang, Yi Zhou

“…Herein, zinc‐aluminum layered double hydroxide nanosheets (LDHs) loaded with icariin (ICA) are encapsulated into a gallic acid (GA)‐modified hydroxybutyl chitosan hydrogel (GA‐HBC), giving rise to a customized hydrogel system named GA‐HBC‐LIC, which can sequentially actualize antibacterial, anti‐inflammatory, and remineralization functions. A neutral chemical‐humoral space is created for osteogenesis via means of sequential regulation by the smart hydrogel. …”
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Intelligent Ultrasonic Aspirator Controlled by Fiber-Optic Neoplasm Sensor Detecting 5-Aminolevulinic Acid-Derived Porphyrin Fluorescence by Yoshinaga Kajimoto, Hidefumi Ota, Masahiro Kameda, Naosuke Nonoguchi, Motomasa Furuse, Shinji Kawabata, Toshihiko Kuroiwa, Toshihiro Takami, Masahiko Wanibuchi

“…Furthermore, the device functioned efficiently in bright surgical environments and was designed to maintain a clean sensor tip through constant saline irrigation. …”
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Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications by Mohd Mustafa, Rizwan Ahmad, Irfan Qadir Tantry, Waleem Ahmad, Sana Siddiqui, Mudassir Alam, Kashif Abbas, Moinuddin, Md. Imtaiyaz Hassan, Safia Habib, Sidra Islam

“…Apoptosis is vital in facilitating embryonic development and maintaining tissue homeostasis and immunological functioning. It is a complex interplay of intrinsic and extrinsic signaling pathways that ultimately converges on executing the apoptotic program. …”
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Single-chip silicon photonic engine for analog optical and microwave signals processing by Hong Deng, Jing Zhang, Emadreza Soltanian, Xiangfeng Chen, Chao Pang, Nicolas Vaissiere, Delphine Neel, Joan Ramirez, Jean Decobert, Nishant Singh, Guy Torfs, Gunther Roelkens, Wim Bogaerts

“…We construct multiple systems with this engine to demonstrate its capabilities for different RF and optical signal processing functions, including optical and RF signal generation and filtering. …”
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A Review of Plant–Microbe Interactions in the Rhizosphere and the Role of Root Exudates in Microbiome Engineering by Anagha Wankhade, Emma Wilkinson, David W. Britt, Amita Kaundal

“…A structured literature search was conducted using databases such as PubMed, Scopus, and ScienceDirect to identify key studies on root exudation, microbial functions, and synthetic microbial communities (SynComs). …”
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Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration by Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tao Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao

“…Itaconate is a tricarboxylic acid cycle secondary metabolite with inflammatory and oxidative stress modulating functions, which could alleviate disk degeneration. …”
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Selenium Attenuates Radiation Colitis by Regulating cGAS‐STING Signaling by Qian Xue, Haoqiang Lai, Haimei Zhang, Guizhen Li, Fen Pi, Qifeng Wu, Siwei Liu, Fang Yang, Tianfeng Chen

“…Mechanistically, Se, especially for selenium nanoparticles (SeNPs), induced selenoprotein expression and then functioned to effectively restrain DNA damage response, which reduced X‐ray‐induced intestinal injury. …”
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Rescuing inflammatory microenvironment induced senescence via MgO immune mediated asymmetric short fibers for accelerating diabetic wound repair by Yedan Chen, Qingxiang Liu, Jingjing Guan, Chunyang Zheng, Shumeng Shi, Weiwei Zheng, Jianzhong Guan, Yingji Mao

“…In conclusion, these findings indicate that short-fiber GP@MgO aerogels offer a measure to regulate biochemical functions and physiological responses for the rapid closure of diabetic wounds through metal immunotherapy.…”
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Contactless and short‐range vital signs detection with doppler radar millimetre‐wave (76–81 GHz) sensing firmware by Pi‐Yun Chen, Hsu‐Yung Lin, Zi‐Heng Zhong, Neng‐Sheng Pai, Chien‐Ming Li, Chia‐Hung Lin

“…Abstract Vital signs such as heart rate (HR) and respiration rate (RR) are essential physiological parameters that are routinely used to monitor human health and bodily functions. They can be continuously monitored through contact or contactless measurements performed in the home or a hospital. …”
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Hirsutella sinensis polysaccharides and Parabacteroides goldsteinii reduce lupus severity in imiquimod-treated mice by Shih-Hsin Chang, Yun-Fei Ko, Jian-Ching Liau, Cheng-Yeu Wu, Tsong-Long Hwang, David M. Ojcius, John D. Young, Jan Martel

“…Moreover, the polysaccharides and P. goldsteinii improved markers of kidney and liver functions such as creatinine, blood urea nitrogen, glomerulus damage and fibrosis, and serum liver enzymes. …”
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Unique transcriptomic responses of rat and human alveolar macrophages in an in vitro model of overload with TiO2 and carbon black by Laeticia Perez, Jérôme Ambroise, Bertrand Bearzatto, Antoine Froidure, Charles Pilette, Yousof Yakoub, Mihaly Palmai-Pallag, Caroline Bouzin, Laurence Ryelandt, Cristina Pavan, François Huaux, Dominique Lison

“…In particular, eighteen genes were identified as robust markers of P25 and Printex 90 overload in rat cells. The known functions of these genes can be related to the potential mechanisms of the adverse outcomes recorded in rats in vivo. …”
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Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment by Si-Jie Zhang, Ran Xu, Shao-Bin He, Rong Sun, Guan-Nan Wang, Shu-Yi Wei, Xi-Yun Yan, Ke-Long Fan

“…Factors such as bacterial infections, hyperglycemia, and oxidative stress disrupt cellular functions and impair angiogenesis, substantially delaying wound repair. …”
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Reinforcement of Dextran Methacrylate-Based Hydrogel, Semi-IPN, and IPN with Multivalent Crosslinkers by Luca Paoletti, Gianluca Ferrigno, Nicole Zoratto, Daniela Secci, Chiara Di Meo, Pietro Matricardi

“…Our findings support the use of crosslinkers with different functionality to modulate the properties of polysaccharide-based scaffolds, making them suitable for various biomedical applications. …”
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KEDM: Knowledge-Embedded Diffusion Model for Infrared Image Destriping by Lingxiao Li, Xin Wang, Dan Huang, Yunan He, Zhuqiang Zhong, Qingling Xia

“…Meanwhile, DWCM uses wavelet convolution operations to construct prior loss functions for stripe noise, precisely guiding the diffusion reconstruction process to achieve a clean, stripe-free image. …”
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A Multifunctional Fe-EGCG@RSL3 Nanomedicine Synergizes Ferroptosis Induction and Tumor Microenvironment Remodeling for Enhanced Bladder Cancer Immunotherapy by Chengjunyu Zhang, Sen Liu, Jianhui Zhang, Junlin Lu, Zehua Chen, Bolin Pan, Chu Liu, Ming Huang, Hengji Zhan, Hongjin Wang, Siting Chen, Kaiwen Jie, Baoqing He, Jingdie Wu, Ye Li, Haifeng Wang, Jing Zhao, Qiang Zhang, Xu Chen

“…Overall, Fe-EGCG@RSL3 has dual functions as a multifaceted nanomedicine that integrates ferroptosis induction with immunomodulation, offering a novel and clinically translatable strategy for bladder cancer therapy.…”
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Core fucosylation of IL-2RB is required for natural killer cell homeostasis by Harrison Sudholz, Xiangpeng Meng, Hae-Young Park, Zihan Shen, Iva Nikolic, Joseph Cursons, Ethan D. Goddard-Borger, Iona S. Schuster, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Nichollas E. Scott, Michael Chopin, Jai Rautela, Sebastian Scheer, Nicholas D. Huntington

“…Summary: Natural killer (NK) cell homeostasis and effector functions require context-dependent signaling via numerous receptors, including the interleukin-15 receptor (IL-15R). …”
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Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery by Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun

“…Promising nucleic acid drugs have shown the potential to exert precise effects at the molecular level, with different classes of nucleic acids having regulatory functions through varying mechanisms. For the better delivery of nucleic acids, safe and effective viral vectors and non‐viral delivery systems (including liposomes, polymers, etc.) have been intensively explored. …”
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