Synergistic Cancer Therapies Enhanced by Nanoparticles: Advancing Nanomedicine Through Multimodal Strategies by Seyed Mohamad Sadegh Mousavi-Kiasary, Ahmood Senabreh, Ashkan Zandi, Rogelio Pena, Frances Cruz, Ali Adibi, Nasrin Hooshmand

“…We discuss the design and functionalization of various organic, inorganic, and hybrid NPs, highlighting their roles in improving pharmacokinetics, overcoming multidrug resistance, and modulating the tumor microenvironment. …”
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Utilizing an Enhanced YOLOv8 Model for Fishery Detection by Hanyu Jiang, Jiacheng Zhong, Fuyu Ma, Cheng Wang, Ruiwen Yi

“…We designed the Global Context 3D Perception Module (GC3DPM) to enable global context feature modeling and 3D perception. …”
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Low-force pulse switching of ferroelectric polarization enabled by imprint field by Yuchao Zhang, Shanzheng Du, Xiaochi Liu, Yahua Yuan, Yumei Jing, Tian Tian, Junhao Chu, Fei Xue, Kai Chang, Jian Sun

“…In this work, we address these challenges by introducing an imprint field through asymmetric electrostatic boundary design with distinct work functions. This built-in electric field stabilizes the energy landscape, effectively lowering the polarization switching barrier. …”
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DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation by Rui Zhang, Xin Zhang, Hua Bai, Qiuyu Cheng, Xia Yao, Shi Li, Vincenzo Torraca, Chaojun Yan, Xueying Dong, Siyi Miao, Xueyuan Hu, Yeping Yu, Yueyan Wu, Hongfei Tan, Xin Chen, Shicheng Liu, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Xing-Zhen Chen, Zhiyin Song, Cefan Zhou, Jingfeng Tang

“…Abstract Autophagy classically functions to protect cells and organisms during stressful conditions by catabolizing intracellular components to maintain energy homeostasis. …”
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Effects of Genipin Crosslinking of Porcine Perilimbal Sclera on Mechanical Properties and Intraocular Pressure by John Riesterer, Alexus Warchock, Erik Krawczyk, Linyu Ni, Wonsuk Kim, Sayoko E. Moroi, Guan Xu, Alan Argento

“…The mechanical properties of sclera play an important role in ocular functions, protection, and disease. Modulating the sclera’s properties by exogenous crosslinking offers a way to expand the tissue’s range of properties for study of the possible influences on the eye’s behavior and diseases such as glaucoma and myopia. …”
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Neural stem cell-derived small extracellular vesicles: a new therapy approach in neurological diseases by Mengyao Wang, Mengyao Wang, Dongdong Chen, Dongdong Chen, Renjie Pan, Renjie Pan, Yue Sun, Yue Sun, Xinyu He, Xinyu He, Youming Qiu, Youming Qiu, Yuexin Hu, Yuexin Hu, Xiangsheng Wu, Xiangsheng Wu, Xuxiang Xi, Xuxiang Xi, Rong Hu, Rong Hu, Zhigang Jiao, Zhigang Jiao, Zhigang Jiao, Zhigang Jiao, Zhigang Jiao

“…This review provides a comprehensive overview of the biological functions of NSC-sEVs, their therapeutic implications and underlying molecular mechanisms in diverse neurological disorders, as well as the potential for engineering NSC-sEVs as drug delivery platforms. …”
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Metagenomic approach for improved culture of whiteleg shrimp (Litopenaeus vannamei) by Gorre Dhanush, Arumugam Sundaramanickam, Muthusamy Thangaraj

“… The gut microbial community is essential for safeguarding the host against pathogens, modulating immune responses, and regulating metabolic activities. …”
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Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene. by Karen Kapur, Toby Johnson, Noam D Beckmann, Joban Sehmi, Toshiko Tanaka, Zoltán Kutalik, Unnur Styrkarsdottir, Weihua Zhang, Diana Marek, Daniel F Gudbjartsson, Yuri Milaneschi, Hilma Holm, Angelo Diiorio, Dawn Waterworth, Yun Li, Andrew B Singleton, Unnur S Bjornsdottir, Gunnar Sigurdsson, Dena G Hernandez, Ranil Desilva, Paul Elliott, Gudmundur I Eyjolfsson, Jack M Guralnik, James Scott, Unnur Thorsteinsdottir, Stefania Bandinelli, John Chambers, Kari Stefansson, Gérard Waeber, Luigi Ferrucci, Jaspal S Kooner, Vincent Mooser, Peter Vollenweider, Jacques S Beckmann, Murielle Bochud, Sven Bergmann

“…Calcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disorders of bone and mineral metabolism, as well as with cardiovascular mortality. …”
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H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation by Yunqiang Wu, Bo Xu, Yonglin Peng, Sang Lin, Wenfei Du, Ruiqi Liu, Shu Zhang, Ji Wu, Kang Zou, Xiaodong Zhao

“…YTHDF2 binds m6A-modified Ets1 mRNA and facilitates its degradation in an m6A-dependent manner. ETS1 functions as a key downstream effector of YTHDF2, as suppression of ETS1 expression partially reverses the Ythdf2-KO-induced phenotype. …”
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Renal phenotyping in a hypomorphic murine model of propionic aciduria reveals common pathomechanisms in organic acidurias by Anke Schumann, Ainhoa Martinez-Pizarro, Eva Richard, Christoph Schell, Anna Laura Kössinger, Karina A. Zeyer, Stefan Tholen, Oliver Schilling, Michael Barry, Björn Neubauer, Michael Köttgen, Luciana Hannibal, Lourdes R. Desviat, Ute Spiekerkötter

“…We observed a steep reduction of PGC-1-α, the key mediator modulating mitochondrial functions and a counter actor of mitochondrial fission. …”
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Gamma -aminobutyric acid ameliorates neurological impairments in type 1 diabetes mellitus mice by regulating the “gut flora-LPS-TLR4-NF-ΚB” signalling Axis by Jiao Wang, Lihai Zhang, Xianhe Wang, Jing Dong, Jiaxin Li

“…Abstract This study examined the potential impact of gamma-aminobutyric acid (GABA) supplementation on the progression of type 1 diabetes mellitus (T1DM) through alterations in gut flora and its associated effects on neurological functions. A T1DM mouse model was created using streptozotocin. …”
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Effects of Cortisol Administered through Slow-Release Implants on Innate Immune Responses in Rainbow Trout (Oncorhynchus mykiss) by R. Cortés, M. Teles, R. Trídico, L. Acerete, L. Tort

“…Cortisol is a key hormone in the fish stress response with a well-known ability to regulate several physiological functions, including energy metabolism and the immune system. …”
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Nano-drug delivery strategies affecting cancer-associated fibroblasts to reduce tumor metastasis by Linghui Zou, Peng Xian, Qing Pu, Yangjie Song, Shuting Ni, Lei Chen, Kaili Hu

“…Herein, we introduce the physiological properties of CAFs, detail the possible mechanisms whereby CAFs promote tumor metastasis, categorize CAFs-based nano-drug delivery strategies according to their anti-metastasis functions and discuss the current challenges, possible solutions, as well as the future directions in order to provide a theoretical basis and reference for the utilization of CAFs-based nano-drug delivery strategies to promote tumor metastasis therapy.…”
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A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli by He Li, Shu Quan, Shu Quan, Wei He, Wei He

“…Overall, cdiGEBS enhances the study of c-di-GMP-regulated functions and holds the potential for screening antimicrobials targeting c-di-GMP or its synthesis enzymes.…”
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Insulin-like growth factor 2 reduces Huntington’s disease aggregates via AKT and NF-κB signaling in huntington’s disease by Yun-Shiuan Tung, Chih-Wei Tung, Siew Chin Chan, Yi-Ching Chen, Po-Ming Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang

“…In vivo studies in R6/2 HD transgenic mice reveal that IGF2 administration improves motor functions and decreases mHTT levels. Conclusions Collectively, our findings elucidate the multifaceted role of IGF2 in HD, highlighting its therapeutic potential through modulation of AKT and NF-κB signaling pathways.…”
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Disease‐modifying effects of ganglioside GM1 in Huntington's disease models by Melanie Alpaugh, Danny Galleguillos, Juan Forero, Luis Carlos Morales, Sebastian W Lackey, Preeti Kar, Alba Di Pardo, Andrew Holt, Bradley J Kerr, Kathryn G Todd, Glen B Baker, Karim Fouad, Simonetta Sipione

“…Treatment with GM1 slows down neurodegeneration, white matter atrophy and body weight loss in R6/2 mice. Motor functions are significantly improved in R6/2 mice and restored to normal in Q140 mice, including gait abnormalities that are often resistant to treatments. …”
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Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation by Anna Höfler, Jun Yu, Jing Yang, Ziguo Zhang, Leifu Chang, Stephen H. McLaughlin, Geoffrey W. Grime, Elspeth F. Garman, Andreas Boland, David Barford

“…Abstract APC/C is a multi-subunit complex that functions as a master regulator of cell division. It controls progression through the cell cycle by timely marking mitotic cyclins and other cell cycle regulatory proteins for degradation. …”
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Dynamic interaction networks in a hierarchically organized tissue by Daniel C Kirouac, Caryn Ito, Elizabeth Csaszar, Aline Roch, Mei Yu, Edward A Sykes, Gary D Bader, Peter W Zandstra

“…We reconstruct a stem cell intracellular network, and identify PI3K, Raf, Akt, and PLC as functionally distinct signal integration nodes, linking extracellular, and intracellular signaling. …”
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Smart transplants: emerging role of nanotechnology and big data in kidney and islet transplantation, a frontier in precision medicine by Rajkiran Deshpande, Titus Augustine, Titus Augustine

“…By addressing unmet needs and leveraging the combined potential of nanotechnology and big data, this transformative approach promises to improve graft survival, functionality, and overall patient outcomes, marking a paradigm shift in transplantation medicine. …”
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Aβ aggregation inhibition via peptide-conjugated gold nanoclusters: Mechanistic insights and therapeutic potential by Ye-Cheng Wang, Si-Cong Bai, Xue-Ying Hu, Jia-Yi Lin, Wei-Lin Ye, Huan-Zhang Xie, Liu Hong, Gao Li

“…In this study, we synthesized a novel gold nanocluster (AuCRHA1) functionalized with the peptide CRHRHKLVFF to achieve specific recognition of Aβ. …”
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