p65/miR‐23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma by Zhi‐Qin Li, Hong‐Yan Wang, Qing‐Lei Zeng, Jing‐Ya Yan, Yu‐Shu Hu, Hua Li, Zu‐Jiang Yu

“…The upstream regulators modulating CCL22 in hepatocellular carcinoma (HCC) were not clearly understood. …”
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Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis by Junxiang Gu, Junxiang Gu, Junxiang Gu, Yixian Ma, Yixian Ma, Yixian Ma, Qing Chang, Qing Chang, Qing Chang, Ling Chen, Ling Chen, Ling Chen

“…EAU was associated with declining microbial tryptophan metabolism and up-regulated functions related to lipid and carbohydrate metabolism; PD-L1 knockout in EAU further increased the metabolism of glycan and biosynthesis of 3-deoxy-α-D-manno-2-octulosonate (Kdo), a key component of bacterial lipopolysaccharide (LPS).ConclusionBoth EAU and PD-L1 knockout modulate gut microbiota, affecting microbial composition - particularly Akkermansia, CAG-485, Bacteroidaceae, Lachnospiraceae and Ruminococcaceae - and microbial functions such as lipid, carbohydrate and glycan metabolism.…”
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NELL2 suppresses epithelial-mesenchymal transition and induces ferroptosis via notch signaling pathway in HCC by Shiqi Liu, Haomin Wu, Pengjie Zhang, Haonan Zhou, Di Wu, Yifan Jin, Hongwei Yang, Ruilin Xing, Yubo Wu, Gang Wu

“…Consequently, NELL2 may serve as a novel therapeutic target, potentially functioning as a tumor suppressor gene in HCC.…”
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Evaluation of the Immunostimulant Effect of Microvesicles of <i>Lactobacillus acidophilus</i> Isolated from Wild Rats by Pamela I. Pérez-Martínez, Viridiana Gutiérrez-Espinosa, Christian Ávalos-Gómez, Mireya De la Garza-Amaya, Alejandro Vargas-Ruíz, Rosa I. Higuera-Piedrahita, Ernesto Marín-Flamand, Cristal D. Lonngi-Sosa, Francisco R. González-Díaz, Hugo Ramírez-Álvarez, Cynthia González-Ruíz

“…It is capable of releasing membrane microvesicles (MVs), whose primary functions include carrying and transmitting antigens to host tissues and modulating host defense responses. …”
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Fluxgate Magnetometers Based on New Physical Principles by Ivan V. Bryakin, Igor V. Bochkarev, Vadim R. Khramshin, Vadim R. Gasiyarov, Ivan N. Erdakov

“…The authors considered a generalized flow of the physical processes in the FM to obtain a detailed representation of the operating functions of the FM. The presented experimental results for the proposed FM in the field meter mode confirm its operating parameters (±40 μT—measurement range, 0.5 nT—detection threshold). …”
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IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro by Yiping Lu, Fangwei Liu, Chao Li, Ying Chen, Dong Weng, Jie Chen

“…Our findings demonstrated that B10 could affect Th responses by the release of IL-10, enhancing Treg functions and converting Teff into Treg.…”
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A longitudinal investigation of the acoustic properties of infant-directed speech from 6 to 18 months by Audun Rosslund, Julien Mayor, Roger Mundry, Arun Prakash Singh, Alejandrina Cristia, Natalia Kartushina

“…Results are discussed in the context of the proposed functions of IDS.…”
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Microrna-135A-5P promotes proliferation and metastasis of hepatocelluar carcinoma cells via down-regulation of FOXO1 by Tian Zhang, Lingling Guan, Xiaomeng Xie, Lixing Guo, Dongjing Ni

“…Transfected Huh-7 HCC cells were subjected to cell proliferation, apoptosis, migration, and invasion assays to investigate the role of miR-135a-5p and FOXO1 in modulating cellular functions. Additionally, tumor xenografts from nude mice were utilized in vivo to validate the in vitro findings. …”
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Dose-dependent osteoimmunomodulatory effects of amorphous calcium phosphate nanoparticles promote 3D-printed scaffold-mediated bone regeneration by Ming Yan, Baixue Xiao, Anthony Yosick, Bei Liu, Hani A. Awad

“…The tunable osteoimmunomodulation by the NP underscores the translational potential of this technology to yield structurally sound and functionally robust bone regeneration outcomes.…”
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OICR-41103 as a chemical probe for the DCAF1 WD40 domain by Serah W. Kimani, Mahmoud Noureldin, Brian Wilson, Laurent Hoffer, Stuart R. Green, Magdalena M. Szewczyk, Héctor González-Álvarez, Mohammed Mohammed, Manuel Chan, Chiara Krausser, Alice Shi Ming Li, Taraneh Hajian, Sarah Tucker, Dhananjay Joshi, Punit Saraon, Brigitte Thériault, Ji Sup Kim, Vijayaratnam Santhakumar, Peter Loppnau, Yanjun Li, Almagul Seitova, Aiping Dong, Taira Kiyota, Tobias Hammann, Paul Gehrtz, Bhashant Patel, Vaibhavi Rathod, Anand Vala, Bhimsen Rout, Paras Jagodra, Peter J. Brown, Ahmed Aman, Jailall Ramnauth, Gennady Poda, David Uehling, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Richard Marcellus, Suzanne Ackloo, Ahmed Mamai, Rima Al-awar, Levon Halabelian

“…Abstract Human DCAF1 is a multidomain protein that plays a critical role in protein homeostasis. Its WDR domain functions as a substrate recruitment module for RING-type CRL4 and HECT family EDVP E3 ubiquitin ligases, enabling the ubiquitination and proteasomal degradation of specific substrates. …”
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Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids by Arun Sridhar, Ingunn Bakke, Shreya Gopalakrishnan, Nimo Mukhtar Mohamud Osoble, Emilie Prytz Hammarqvist, Henrik P. Sahlin Pettersen, Arne Kristian Sandvik, Ann Elisabet Østvik, Marianne Doré Hansen, Torunn Bruland

“…Inflammation is a major effector of mucosal damage in IBD and has been found to affect epithelial stemness, regeneration and cellular functions. However, the impact of immune cell-modulating IBD drugs on epithelial homeostasis and repair is poorly understood. …”
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Filming evolution dynamics of Hg nanodroplets mediated at solid-gas and solid-liquid interfaces by in-situ TEM by Linfeng Xu, Zetan Cao, Zhiwen Liu, Cheng Zheng, Simin Peng, Yong Lu, Haoran Liu, Bin Chen

“…In-depth understanding of distinct nanodroplets dynamics at nanoscale solid-gas and solid-liquid interfaces offers a feasible approach for designing liquid metal-based nanocomplexes with regulatory interfacial, morphological and rheological functionalities.…”
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Mutations in the WUSCHEL-related homeobox1 gene cause an increased leaflet number in soybean by Yawei Li, Li Chu, Peiyun Lyu, Wenhuan Lyu, Ping Xie, Chunting Zhang, Haoxian Feng, Bin Liu, Tuanjie Zhao

“…WUSCHEL-related homeobox (WOX) transcription factors play a crucial role in lateral organ development in several plant species; however, their precise functions in soybean (Glycine max [L.] Merr.) were unclear. …”
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Role of aquaporins in brain water transport and edema by Yuyuan Li, Yining Wang, Xingda Huang, Hao Zhang, Youfei Guan, Xiaoyan Zhang

“…There is an urgent need to develop specific AQP inhibitors and activators to explore the potential benefits of modulating the functions of AQP1 and AQP4 in the context of brain edema.…”
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Inhibition of LINC01048 decreases cell proliferation and induces the apoptosis in gastric cancer by Jinxi Huang, Weiwei Yuan, Gaofeng Li, Beibei Chen, Lihong Wang, Yulong Chen, Hai Huang

“…However, the mechanisms underlying these functions remain largely unknown. In this study, we investigate the role of the LINC01048 in tumorigenesis and cell proliferation in GC cell lines, such as HGC27 and MKN45. …”
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Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes by Yingying Wu, Jingyi Wang, Shenli Wang, Yijie Ke, Tianyi Ren, Ying Wang

“…Furthermore, AMB application effectively modulated the transcriptional profile of genes related to redox homeostasis, transmembrane transport, and peroxidase functions in <i>B. cinerea</i>, thereby reducing the virulence of the fungus. …”
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An update comprehensive review on the effects of transcutaneous electrical nerve stimulation for postnatal physical and psychological disorders by Beibei Chen, Chunyan Chen, Xiumin Zhao, Yan Xu

“…The mechanisms underlying the protective effects of TENS are modulation of inflammatory responses and immune functions. …”
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The Role of Gut Microbiota in Neurodegenerative Diseases by Hanna Porwolik, Agnieszka Porwolik, Magdalena Bodera, Radosław Szydłowski, Agata Porwolik, Barbara Skrzypiec, Anna Hamerla, Anna Kaźmierska, Julia Gawron

“…Therapeutic strategies focusing on microbiota modulation, including probiotics and FMT, show significant potential. …”
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USP25-driven KIFC1 regulates MYCBP expression and promotes the progression of cervical cancer by Zhoujie Ye, Liping Zhu, Yalan Wei, Aizhu Lin, Xiaolu Fan, Xiaojing Fan, Pengming Sun, Xinrui Wang

“…Collectively, our findings elucidate the previously unknown functions and mechanisms of the USP25/KIFC1/MYCBP signaling axis in CCa progression, underscoring KIFC1 as a promising therapeutic target for cervical cancer.…”
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Lysosomal enzyme binding to the cation-independent mannose 6-phosphate receptor is regulated allosterically by insulin-like growth factor 2 by Richard N. Bohnsack, Sandeep K. Misra, Jianfang Liu, Mayumi Ishihara-Aoki, Michaela Pereckas, Kazuhiro Aoki, Gang Ren, Joshua S. Sharp, Nancy M. Dahms

“…Abstract The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in the treatment of patients with lysosomal storage diseases because it functions in the biogenesis of lysosomes by transporting mannose 6-phosphate (M6P)-containing lysosomal enzymes to endosomal compartments. …”
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