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13561
Binocular Vision-Based Target Detection Algorithm
Published 2025-01-01“…In addition, an Ebifpn feature pyramid module with an spatial pyramid pooling-cross-stage partial connections(SppCSP) structure was innovatively introduced. …”
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13562
Shaker/Kv1 potassium channel SHK-1 protects against pathogen infection and oxidative stress in C. elegans.
Published 2025-02-01“…SHK-1 is predominantly expressed and functions in body wall muscle to maintain glycogen storage and mitochondrial homeostasis. …”
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13563
Restoring Ocular Microbiota Balance: A New Bioprinted Approach to Treating Anterior Segment Diseases
Published 2025-06-01“…This review explores the critical functions of the ocular microbiota and the consequences of its alteration in disease progression, particularly through mechanisms such as inflammation, biofilm formation, and epithelial damage. …”
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13564
The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.
Published 2015-10-01“…The predominant role of TAX1BP1, a paralogue of NDP52, in xenophagy is supported by our evolutionary analysis, which demonstrates that functionally intact NDP52 is missing in Xenopus and mice, whereas TAX1BP1 is expressed in all vertebrates analysed. …”
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13565
Computational modeling reveals optimal strategy for kinase transport by microtubules to nerve terminals.
Published 2014-01-01“…Intracellular transport of proteins by motors along cytoskeletal filaments is crucial to the proper functioning of many eukaryotic cells. Since most proteins are synthesized at the cell body, mechanisms are required to deliver them to the growing periphery. …”
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13566
Recent Advances in the Mutual Regulation of m6A Modification and Non-Coding RNAs in Atherosclerosis
Published 2025-02-01“…Current evidence suggested that m6A regulators (writers, erasers, and readers) participated in the modification of multiple non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), thereby affecting their metabolism and functions. Meanwhile, ncRNAs have also emerged as key modulator of m6A regulators expression in turn. …”
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13567
An Insight of Vitamin E as Neuroprotective Agents
Published 2020-04-01“…Oxidative stress has a role in the modulation of critical cellular functions, such as apoptosis program activation, ion transport and calcium mobilization which lead to cell death. …”
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13568
Analysis of the senescence secretome during zebrafish retina regeneration
Published 2025-04-01“…These factors are upregulated after damage with functions that span the innate immune system, autophagic processing, cell cycle regulation, and cellular stress responses. …”
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13569
MicroRNA-219 in the central nervous system: a potential theranostic approach
Published 2024-12-01“…MicroRNA-219 is a specific brain-enriched miRNA associated with neurodevelopmental disorders that play crucial roles in the differentiation of oligodendrocyte progenitorcells, promotion of oligodendrocyte maturation, remyelination, and cognitive functions to the extent that it can be considered a potential therapeutic option for demyelination in multiple sclerosis and spinal cord injury and reverse chronic inflammation pains. …”
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13570
Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection.
Published 2011-09-01“…Interferon regulatory factor (IRF)-1 is an immunomodulatory transcription factor that functions downstream of pathogen recognition receptor signaling and has been implicated as a regulator of type I interferon (IFN)-αβ expression and the immune response to virus infections. …”
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13571
A parapoxviral virion protein inhibits NF-κB signaling early in infection.
Published 2017-08-01“…Here, we describe a NF-κB inhibitory virion protein of orf virus (ORFV), ORFV073, which functions very early in infected cells. Infection with ORFV073 gene deletion virus (OV-IA82Δ073) led to increased accumulation of NF-κB essential modulator (NEMO), marked phosphorylation of IκB kinase (IKK) subunits IKKα and IKKβ, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virus-infected cells (≤ 30 min post infection). …”
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13572
Dynamical Analysis and Optimization of Combined Vibration Isolator with Time Delay
Published 2025-07-01“…The force transmissibility is defined as fitness functions, and the effects of control parameters on these metrics are examined. …”
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13573
Regional gray matter correlates of memory for emotion-laden words in middle-aged and older adults: A voxel-based morphometry study.
Published 2017-01-01“…This preference seems to be modulated by the emotional arousal that the material evokes. …”
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13574
INFITA-THERAPY ROLE IN THE REHABILITATION OF PATIENTS WITH OCCUPATIONAL DISEASES
Published 2023-03-01“…Treatment on the INFITA-M device (basic module) leads to the normalization of the functions of the autonomic and central nervous systems, reduces the levels of stress and anxiety in the patients with occupational diseases at the stage of rehabilitation, which increases the effectiveness of rehabilitation programs.…”
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13575
Self-utility distance as a computational approach to understanding self-concept clarity
Published 2025-03-01“…Abstract Self-concept stability and cohesion are crucial for psychological functioning and well-being, yet the mechanisms that underpin this fundamental aspect of human cognition remain underexplored. …”
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13576
Restoring healthy gut microbiome in poultry using alternative feed additives with particular attention to phytogenic substances: Challenges and prospects
Published 2022-01-01“…Thus, a healthy microbiota drives the gut integrity, and the gut's biological and metabolic functionalities, including efficacious use of nutrition, but also immunity, and neuroendocrine systems. …”
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13577
MiR-200c synergizes with trastuzumab-loaded gold nanoparticles to overcome resistance in ovarian cancer cells
Published 2025-06-01“…Here, we investigate for the first time the combinatorial effect of miR-200c and thiol-functionalized AuNPs (< 10 nm) loaded with TZ (AuNPs-TZ) in overcoming TZ resistance and enhancing treatment efficacy in ovarian cancer cells. …”
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13578
Anxiety and depression among women with newly diagnosed vulvar cancer – A nationwide longitudinal study
Published 2024-02-01“…Abstract Introduction Our objective was to investigate the trajectories of anxiety, depression, emotional and social functioning in women with newly diagnosed vulvar cancer from the time of diagnosis to 12 months after treatment. …”
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13579
A DNA Vaccine Against Proadrenomedullin N-Terminal 20 Peptide (PAMP) Reduces Angiogenesis and Increases Lymphocyte and Macrophage Infiltration but Has No Effect on Tumor Burden in...
Published 2025-05-01“…<b>Conclusions:</b> Although the vaccine was not effective in reducing tumor growth, new proliferative and immune functions have been described for PAMP. These new functions include induction of melanoma proliferation and modulation of lymphocyte and macrophage tumor infiltration dynamics.…”
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13580
BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma
Published 2025-02-01“…However, its specific functions and underlying molecular mechanisms in BLCA development and progression remain poorly understood. …”
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