Multidimensional insights into exosomes in hepatocellular carcinoma: from genesis to clinical application by Xiang Zhang, Cheng Zhang, Zheng Zhang, Xuan Zhang

“…Moreover, exosomes contribute to the establishment of pre-metastatic niches by remodeling distant organ microenvironments—inducing hypoxia, metabolic reprogramming, and angiogenesis—which collectively create favorable conditions for tumor cell colonization. They also modulate immune responses by inducing T-cell exhaustion, promoting macrophage polarization, and disrupting normal stromal cell functions, thereby constructing an immunosuppressive microenvironment that enables tumor immune evasion. …”
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Brain amino acid sensing for organismal amino acid homeostasis by Anthony H. Tsang, Liubou Samson, Clemence Blouet

“…Amino acids are essential for normal physiological functions, and disruptions in their circulating concentrations are implicated in the pathophysiology of various diseases. …”
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Shielding the Gut: Ghrelin and Ferrostatin-1’s Protective Role Against Sepsis-Induced Intestinal Ferroptosis by Qiliang Hou, Zhimin Dou, Lei Zhu, Bin Li

“…Both interventions restored intestinal barrier functions, modulated inflammatory responses, and attenuated oxidative stress, indicating a suppression of the ferroptosis pathway. …”
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Modeling the use of transient ligand binding information by AMPA receptors by Helena Braunstein, Alejandra C. Ventura, Alejandro Colman-Lerner

“…Here, we developed a mathematical model that leverages published reaction rates to demonstrate that AMPA receptors operate within a pre-equilibrium sensing and signaling (PRESS) regime. By functioning before equilibrium binding, AMPARs exploit a transient dynamic range at high ligand concentrations. …”
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Research on intrusion detection model based on improved MLP algorithm by Qihao Zhao, Fuwei Wang, Weimin Wang, Tianxin Zhang, Haodong Wu, Weijun Ning

“…These patterns can be effectively captured through MLP’s multiple nonlinear transformations, such as ReLU and Sigmoid activation functions, which are especially beneficial for intrusion detection. …”
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Metabolic interactions: how gut microbial metabolites influence colorectal cancer by Qinhan Cao, Qinhan Cao, Meiju Yang, Min Chen

“…By providing a comprehensive and up-to-date overview of microbial metabolic networks associated with CRC, this review underscores the critical functions of gut microbial metabolites in tumorigenesis, offering novel insights into their utility as diagnostic and prognostic biomarkers, as well as promising therapeutic targets.…”
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Proteome Profiling of <i>S. cerevisiae</i> Strains Lacking the Ubiquitin-Conjugating Enzymes Ubc4 and Ubc5 During Exponential Growth and After Heat Shock Treatment by Valentina Rossio, Xinyue Liu, Joao A. Paulo

“…The Ubiquitin–Proteasome System (UPS) governs numerous cellular processes by modulating protein stability and activity via the conjugation of the small protein ubiquitin, either as a single molecule or as linkages with distinct functions. …”
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Oxidized Low-Density Lipoprotein as a Potential Target for Enhancing Immune Checkpoint Inhibitor Therapy in Microsatellite-Stable Colorectal Cancer by Xiaochun Zhang, Xiaorui Ye, Heiying Jin

“…Elevated oxLDL levels in MSS CRC contribute to tumor progression and diminish ICI efficacy by modulating metabolic reprogramming and immunosuppressive mechanisms within the tumor microenvironment (TME) by activating receptors such as LOX-1 and CD36. oxLDL triggers signaling pathways, including NF-κB, PI3K/Akt, and MAPK, leading to the expansion of immunosuppressive cells like regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and M2 macrophages, while concurrently suppressing effector T cell functions. …”
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High-Throughput ORB Feature Extraction on Zynq SoC for Real-Time Structure-from-Motion Pipelines by Panteleimon Stamatakis, John Vourvoulakis

“…The system accepts real-time video input (60 fps, 1920 × 1080 resolution, 24-bit color) via HDMI or a camera module. In order to support high frame rates for full-HD images, a double-data-rate pipeline scheme was adopted for Harris functions. …”
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Control System for U-Arm Robot Arm Movement with Linear Gripper Based on Inverse Kinematic Method by Aditya Putra Perdana Prasetyo, Ikang Rahmatullah, Kemahyanto Exaudi, Rendyansyah Rendyansyah

“…Additionally, this research includes the development of a program to control the servo motor speed using For and delay functions. This program enhances the robot's operational efficiency by allowing precise speed adjustments, which are crucial for various applications. …”
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EFFECT OF N-ACETYLCYSTEINE ON APOPTOSIS OF P19 CANCER CELLS DURING HYPOXIA by O. L. Nosareva, D. S. Orlov, E. V. Shakhristova, E. A. Stepovaya, A. A. Sadykova

“…The redox status was modulated with N-acetylcysteine in the final concentration of 5 mM. …”
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Fractional spins, unfolding, and holography. Part I. Parent field equations for dual higher-spin gravity reductions by Felipe Diaz, Carlo Iazeolla, Per Sundell

“…The HSG and CCHSG reductions are characterized by dual structure groups and two-form cohomology elements, and their embedding in a common parent model provides a rationale for deriving holographic relations from multi-dimensional AKSZ partition functions on cylinders with dual boundary conditions, to appear separately. …”
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BIOLOGICAL RESPONSE OF TREATMENT WITH SAFFRON PETAL EXTRACT ON CYTOKYNE-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN THE CACO-2/THP1 COCOLTURE MODEL

“…Furthermore, the results of our model suggest that SPE treatment restores the functionality of the intestinal barrier by reducing the destruction of tight junctions induced by the inflammatory stimulus. …”
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Representation Enhancement-Based Proximal Policy Optimization for UAV Path Planning and Obstacle Avoidance by Xiangxiang Huang, Wei Wang, Zhaokang Ji, Bin Cheng

“…In addition, three step-wise reward functions are formulated to avoid sparsity and facilitate model convergence. …”
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The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. by Daniel Menendez, Maria Shatz, Kathleen Azzam, Stavros Garantziotis, Michael B Fessler, Michael A Resnick

“…In recent years the functions that the p53 tumor suppressor plays in human biology have been greatly extended beyond "guardian of the genome." …”
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Accentuation as a Mechanism of Visual Illusions: Insights from Adaptive Resonance Theory (ART) by Baingio Pinna, Jurģis Šķilters, Daniele Porcheddu

“…Our findings suggest that accentuation functions as an autonomous organizing principle, leveraging salience-driven attentional capture to generate perceptual effects. …”
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Anxiety in Children: The Contribution of Parental Characteristics by Beáta Bécsi, Jenifer Pataki, Gergő József Szőllősi

“…<b>Background/Objectives</b>: The prevalence of behavioral problems and mental health issues, including anxiety, among children is rising, potentially affecting their long-term well-being and social functioning. Therefore, this study aims to identify the key determinants of children’s health status, with a particular focus on parental mental health, health behaviors, and socio-demographic factors. …”
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Phytochemical screening and properties of botanical crude extracts and ethyl acetate fractions isolated by deep eutectic solvent by Saied Aboushanab, Vadim Shevyrin, Mustapha Kamel, Jonas Kambele, Elena Kovaleva

“…Isoflavones were reported to exhibit a variety of biological functions, e.g., antiaging, anticancer, and microbiome modulations. …”
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Analysis of the SUMO2 Proteome during HSV-1 Infection. by Elizabeth Sloan, Michael H Tatham, Marine Groslambert, Mandy Glass, Anne Orr, Ronald T Hay, Roger D Everett

“…Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. …”
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Sialidase NEU3 dynamically associates to different membrane domains specifically modifying their ganglioside pattern and triggering Akt phosphorylation. by Dario Bonardi, Nadia Papini, Mario Pasini, Loredana Dileo, Flavia Orizio, Eugenio Monti, Luigi Caimi, Bruno Venerando, Roberto Bresciani

“…Lipid rafts are known to regulate several membrane functions such as signaling, trafficking and cellular adhesion. …”
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