Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives by Sarkar Sardar Azeez, Raya Kh. Yashooa, Shukur Wasman Smail, Abbas Salihi, Azhin Saber Ali, Sami Mamand, Christer Janson

“…Furthermore, combination therapies, including chemotherapy, radiotherapy, antibodies, small molecule inhibitors, cancer vaccines, oncolytic viruses, and multi-CAR cell combination therapy, offer synergistic potential by modulating the TME and improving CAR-cell functionality. …”
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Broadband microwave-rate dark pulse microcombs in dissipation-engineered LiNbO3 microresonators by Xiaomin Lv, Binbin Nie, Chen Yang, Rui Ma, Ze Wang, Yanwu Liu, Xing Jin, Kaixuan Zhu, Zhenyu Chen, Du Qian, Guanyu Zhang, Guowei Lv, Qihuang Gong, Fang Bo, Qi-Fan Yang

“…Their translation to thin-film lithium niobate unlocks second-order nonlinear optical interfaces such as electro-optic modulation and frequency doubling for completing comb functionalities. …”
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Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV by Zhongsong Zhang, Run Tan, Run Tan, Zuanyu Xiong, Yanyan Feng, Yanyan Feng, Long Chen

“…Central to this review is the discussion of autophagy’s protective functions, such as the clearance of damaged organelles and proteins, and its role in maintaining genomic integrity. …”
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Circular RNAs in Viral Infection and Antiviral Treatment by Xiaocai Yin, Hongjun Li, Yan Zhou

“…In this review, we discussed the properties of virus-derived circRNAs, the biological functions of diverse viruses-derived and host circRNAs during viral infections, and the critical role of circRNAs in the host’s antiviral immune defense. …”
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Tunable Emissions in Zero‐Dimensional (C6H5CH2NH3)3InBr6 Enabled by Controlled Structural Amorphization by Qian Li, Bin Xu, Xiaofan Xu, Yayun Wang, Zewei Quan

“…However, precise functionalization of organic moieties and controlled modulation of self‐trapped exciton (STE) emission from inorganic polyhedra remain challenging. …”
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Tissue-Specific Accumulation Profiles of Phorbol Esters in Response to Abiotic and Biotic Stresses in <i>Jatropha curcas</i> by Wei Zhang, Lei Wei, Shijuan Li, Fang Chen, Ying Xu

“…The fine-tuning of terpenoids biosynthesis may link with ecological functions in plants under extreme environments and defense against pathogens.…”
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Immunomodulatory effects of PACAP sequence modifications in juvenile white shrimp Litopenaeus vannamei by Jesús Luis Betancourt, Tania Rodríguez-Ramos, Laura Rivera, Yamila Carpio, Mario Pablo Estrada, Laida Ramos, Brian Dixon

“…In previous research, studies performed in Litopenaeus (Penaeus) vannamei have revealed that Clarias gariepinus PACAP-38 improves immune functions like lectins, superoxide dismutase and nitric oxide synthase derived metabolites in postlarvae shrimp. …”
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Photocontrol of ferroelectricity in multiferroic BiFeO3 via structural modification coupled with photocarrier by Kou Takubo, Atsushi Ono, Shunsuke Ueno, Samiran Banu, Hongwu Yu, Kaito En-ya, Ryota Nishimori, Makoto Kuwahara, Toru Asaka, Kei Maeda, Daiki Ono, Keita Ozawa, Takuma Itoh, Kei Shigematsu, Masaki Azuma, Tadahiko Ishikawa, Yoichi Okimoto, Masaki Hada, Shin-ya Koshihara

“…Abstract Ultrafast control of ferroelectricity and magnetism by light is essential for future development in multiple functioning devices. Here, we demonstrate that the intense and ultrafast photo-modulation of the electric dipole can be realized by photocarrier injection into a multiferroic BiFeO3 thin film using optical pump-probe and second harmonic generation measurements. …”
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Artificial intelligence in decoding muscle–organ crosstalk: Unveiling myokine networks and therapeutic frontiers by Ehsan Arabzadeh, Fatemeh Khanzadeh, Arezoo Kalhor

“…Skeletal muscle functions as an endocrine organ, secreting myokines that mediate crosstalk with organs like the brain, liver, adipose tissue, and vascular system, influencing metabolism, inflammation, and disease progression. …”
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Insights into the Biological Activity and Bio‐Interaction Properties of Nanoscale Imine‐Based 2D and 3D Covalent Organic Frameworks by Hao Ye, Carlos Franco, Mostafa A. Aboouf, Markus Thiersch, Semih Sevim, Joaquin Llacer‐Wintle, Andrea Veciana, Gemma Llauradó‐Capdevila, Kaiyuan Wang, Xiang‐Zhong Chen, Qiao Tang, Roc Matheu, Pedro D. Wendel‐Garcia, Pedro A. Sánchez‐Murcia, Bradley J. Nelson, Cong Luo, Josep Puigmartí‐Luis, Salvador Pané

“…Their customizable functionalities and tunable pore structures make them valuable for various biomedical applications such as biosensing, bioimaging, antimicrobial activity, and targeted drug delivery. …”
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Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. by Conall M O'Seaghdha, Hongsheng Wu, Qiong Yang, Karen Kapur, Idris Guessous, Annie Mercier Zuber, Anna Köttgen, Candice Stoudmann, Alexander Teumer, Zoltán Kutalik, Massimo Mangino, Abbas Dehghan, Weihua Zhang, Gudny Eiriksdottir, Guo Li, Toshiko Tanaka, Laura Portas, Lorna M Lopez, Caroline Hayward, Kurt Lohman, Koichi Matsuda, Sandosh Padmanabhan, Dmitri Firsov, Rossella Sorice, Sheila Ulivi, A Catharina Brockhaus, Marcus E Kleber, Anubha Mahajan, Florian D Ernst, Vilmundur Gudnason, Lenore J Launer, Aurelien Mace, Eric Boerwinckle, Dan E Arking, Chizu Tanikawa, Yusuke Nakamura, Morris J Brown, Jean-Michel Gaspoz, Jean-Marc Theler, David S Siscovick, Bruce M Psaty, Sven Bergmann, Peter Vollenweider, Veronique Vitart, Alan F Wright, Tatijana Zemunik, Mladen Boban, Ivana Kolcic, Pau Navarro, Edward M Brown, Karol Estrada, Jingzhong Ding, Tamara B Harris, Stefania Bandinelli, Dena Hernandez, Andrew B Singleton, Giorgia Girotto, Daniela Ruggiero, Adamo Pio d'Adamo, Antonietta Robino, Thomas Meitinger, Christa Meisinger, Gail Davies, John M Starr, John C Chambers, Bernhard O Boehm, Bernhard R Winkelmann, Jie Huang, Federico Murgia, Sarah H Wild, Harry Campbell, Andrew P Morris, Oscar H Franco, Albert Hofman, Andre G Uitterlinden, Fernando Rivadeneira, Uwe Völker, Anke Hannemann, Reiner Biffar, Wolfgang Hoffmann, So-Youn Shin, Pierre Lescuyer, Hughes Henry, Claudia Schurmann, SUNLIGHT Consortium, GEFOS Consortium, Patricia B Munroe, Paolo Gasparini, Nicola Pirastu, Marina Ciullo, Christian Gieger, Winfried März, Lars Lind, Tim D Spector, Albert V Smith, Igor Rudan, James F Wilson, Ozren Polasek, Ian J Deary, Mario Pirastu, Luigi Ferrucci, Yongmei Liu, Bryan Kestenbaum, Jaspal S Kooner, Jacqueline C M Witteman, Matthias Nauck, W H Linda Kao, Henri Wallaschofski, Olivier Bonny, Caroline S Fox, Murielle Bochud

“…Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. …”
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An Integrated Energy Management Strategy for Efficient Power Flow in EV On-Board Chargers with V2G Capability by Diouri Anas, Khafallah Mohamed, Hassoune Abdelilah, Meskini Mohammed Amine

“…In response, this paper presents a novel energy management strategy tailored for Battery Electric Vehicle (BEV) chargers that integrates both Vehicle-to- Grid (V2G) and Grid-to-Vehicle (G2V) functionalities using Dual Active Bridge (DAB) bidirectional converters within On-Board Chargers (OBCs). …”
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The Novel PKCθ from Benchtop to Clinic by Rouba Hage-Sleiman, Asmaa B. Hamze, Lina Reslan, Hadile Kobeissy, Ghassan Dbaibo

“…Thereafter, PKCθ interacts physically and functionally with downstream effectors to mediate T cell activation and differentiation, subsequently leading to inflammation. …”
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Crack-ConvT Net: A Convolutional Transformer Network for Crack Segmentation in Underwater Dams by Pengfei Shi, Hongzhu Chen, Zaiming Geng, Xinnan Fan, Yuanxue Xin

“…Finally, a Deep Prediction Head is developed, incorporating cascaded $$3\times 3$$ 3 × 3 convolutions and Leaky ReLU activation functions to enhance the network’s capacity for modeling intricate crack features. …”
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Metallothionein as an Anti-Inflammatory Mediator by Ken-ichiro Inoue, Hirohisa Takano, Akinori Shimada, Masahiko Satoh

“…The integration of knowledge concerning the regulation of MT, a highly conserved, low molecular weight, cystein-rich metalloprotein, on its proposed functions is necessary to clarify how MT affects cellular processes. …”
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Potential role of lactylation in intrinsic immune pathways in lung cancer by Mengdie Huang, Ye Jin, Dandan Zhao, Xingren Liu

“…Lactylation, an emerging research focus, may influences lung cancer progression by modulating the functions of histones and non-histone proteins. …”
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Co-expression of multi-genes for polynary perovskite electrocatalysts for reversible solid oxide cells by Xiaoxin Zhang, Hongyuan He, Yu Chen, Guangming Yang, Xiao Xiao, Haiping Lv, Yongkang Xiang, Shuxiong Wang, Chang Jiang, Jianhui Li, Zhou Chen, Subiao Liu, Ning Yan, Xue Yong, Abdullah N. Alodhayb, Yuanming Pan, Ning Chen, Jinru Lin, Xin Tu, Zongping Shao, Yifei Sun

“…This data-driven approach establishes a quantitative framework bridging entropy engineering and catalytic functionality in complex oxides.…”
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Optical Implementation of Butler Matrix for Hardware-Efficient Multiuser Beamforming by Huiyuan Liu, Xiang Liu, Frank Effenberger, Naresh Chand, Xiaofeng Qi, Guifang Li

“…With wireless systems migration toward simplified remote radio units through radio-over-fiber and sharing of signal processing functions located in the central office, it is desirable to implement this beamforming technique in the optical domain. …”
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Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects by Ritobrata Ghose, Fabio Pezzano, Rémi Badia, Savvas Kourtis, Ilir Sheraj, Shubhamay Das, Antoni Gañez Zapater, Upamanyu Ghose, Sara Musa-Afaneh, Lorena Espinar, Albert Coll-Manzano, Katja Parapatics, Saška Ivanova, Paula Sànchez-Fernàndez-de-Landa, Dragana Radivojevikj, Valeria Venturini, Stefan Wieser, Antonio Zorzano, André C. Müller, Verena Ruprecht, Sara Sdelci

“…This nucleus-mitochondria proximity is mediated by an endoplasmic reticulum-based net that entraps the mitochondria in an actin-dependent manner. Functionally, the nucleus-mitochondria proximity results in a nuclear ATP surge, which can be regulated by the genetic and pharmacological modulation of mitochondrial ATP production or via alterations of the actin cytoskeleton. …”
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Light Based 3D Printable Photochromic WO3 Polymer Gel Nanocomposites for Heat Management and Decorative Applications by Alister Urain, Ilaria Abdel Aziz, Naroa Lopez‐Larrea, Iñigo Calvo, Ana M. Conde, Miryam Criado‐Gonzalez, Nerea Casado, David Mecerreyes

“…Abstract Materials with functionalities such as photochromicity are needed to extend the palette of materials for additive manufacturing. …”
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