CircRNA ZFR promotes cell progression by regulating miR-96a-5p/SLC1A1 axis in hepatocellular carcinoma by Christian Cedric Bongolo, Yu Zhang, ShengBao Duan, Louise Virginie Mounoume Lobe, Erick Thokerunga, Peter kisembo, HongMei Wang, ShaoHua Ding, JingJing Tian, YeZhou Chen, YuJue Wang, Liu Jie, YuQin Chao, JianCheng Tu

“…This study assessed circRNA ZFR expression in clinical samples and HCC cells using qRT-PCR and Fluorescent In Situ Hybridization assays. Cell functions were evaluated through colony formation, transwell, and wound healing assays. circRNA ZFR and miR-96a-5p interaction was investigated using luciferase reporter assays and qRT-PCR, while miR-96a-5p and SLC1A1 interaction was examined using luciferase reporter assays, western blot analysis, and Chromatin Isolation by RNA Purification/Mass Spectrometry (CHIRP/MS). …”
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Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease by Han Gao, Mingming Sun, Ai Li, Qiaoyan Gu, Dengfeng Kang, Zhongsheng Feng, Xiaoyu Li, Xuehong Wang, Liang Chen, Hong Yang, Yingzi Cong, Zhanju Liu

“…The gut microbiota-derived metabolite indole-3-propionic acid (IPA) plays an important role in maintaining intestinal mucosal homeostasis, while the molecular mechanisms underlying IPA regulation on mucosal CD4+ T cell functions in inflammatory bowel disease (IBD) remain elusive. …”
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Formulation-Dependent Extrudability of Highly Filled Alginate System for Vaginal Drug Delivery by Arianna Chiappa, Alice Fusari, Marco Uboldi, Fabiana Cavarzan, Paola Petrini, Lucia Zema, Alice Melocchi, Francesco Briatico Vangosa

“…The incorporation of solid particles as a filler to a hydrogel is a strategy to modulate its properties for specific applications, or even to introduce new functionalities to the hydrogel itself. …”
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Amino Acid Deprivation in Glioblastoma: The Role in Survival and the Tumour Microenvironment—A Narrative Review by Keven Du, Leila Grocott, Giulio Anichini, Kevin O’Neill, Nelofer Syed

“…Methods: This narrative review synthesises recent pre-clinical studies focusing on the metabolic functions of AAs in glioblastoma. Key areas include the effects of AA deprivation on tumour growth, adaptive mechanisms, and the tumour microenvironment. …”
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An Analysis of AMPK and Ferroptosis in Cancer: A Potential Regulatory Axis by Ting Zhang, Xi Wang, Peter G Alexander, Peng Feng, Jianying Zhang

“…Ferroptosis is an iron-dependent mode of cell death that occurs in various pathological processes, including cancer, metabolic disorders, and autoimmune diseases, by regulating iron metabolism, lipoperoxidation, and anti-oxidation functions. Ferroptosis is triggered by oxidative and energy stress, both controlled by cancer-associated signaling pathways. …”
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Endogenous IL-33 inhibits apoptosis in non-small cell lung cancer cells by regulating BCL2/BAX via the ERK1/2 pathway by Liping Liu, Haoge Luo, Yingdong Xie, Ying Wang, Shiying Ren, Haiyang Sun, Zhuoyuan Xin, Dong Li

“…Interleukin-33 (IL-33), a member of the IL-1 superfamily, functions both as a nuclear protein and a cytokine, binding to its receptor, ST2. …”
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Self-Awareness Mechanism for Top-down Attention using Fuzzy Logic in Sustainable Business Intelligence by Muhammad Furqan Khan, Wasim Ahmad Khan, Muhammad Muzaffar Hameed, Arslan Ahmad Siddiqi

“…Findings: The results reveal that the self-awareness mechanism renders cognitive functions present in the human mind: expert systems can manage human legible knowledge and make inference upon it, such formulation allows to build a system that manages imprecise information, an artificial neural network-based cognitive structure that can learn, generalize, and prioritize all complications. …”
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Bispecific antibodies: unleashing a new era in oncology treatment by Lin Shui, Dan Wu, Kaixuan Yang, Chuntang Sun, Qingli Li, Rutie Yin

“…Compared with the combination of two monoclonal antibodies, BsAbs represent the physical integration of dual specificities, demonstrating superior binding efficacy, reducing the risk of drug resistance, and enabling unique biological functions such as bridging tumor cells and T cells to achieve precise cytotoxicity. …”
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Friend or foe: the role of platelets in acute lung injury by Jichun Yang, Jichun Yang, Xun Zhou, Xinrui Qiao, Meng Shi

“…This dual functionality of platelets has important implications for the pathogenesis and resolution of ALI/ARDS. …”
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Apolipoprotein M (ApoM) involved in the Nile tilapia (Oreochromis niloticus) against Streptococcus agalactiae infection by Xuyan Tan, Yongxiong Huang, Zhiqiang Zhang, Yuhang Dong, Kwaku Amoah, Yu Huang, Jichang Jian

“…It exhibits tissue-specific expression and performs a variety of biological functions, including lipid transport and metabolism, as well as antibacterial and anti-inflammatory effects. …”
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Mechanisms and therapeutic implications of selective autophagy in nonalcoholic fatty liver disease by Suwei Jin, Yujia Li, Tianji Xia, Yongguang Liu, Shanshan Zhang, Hongbo Hu, Qi Chang, Mingzhu Yan

“…Aim of review: This review aims to summarize the types, functions, and dynamics of selective autophagy that are of particular importance in the initiation and progression of NAFLD. …”
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The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection by Yonghong Li, Chaojun Wei, Hui Xu, Jing Jia, Zhenhong Wei, Rui Guo, Yanjuan Jia, Yu Wu, Yuanting Li, Xiaoming Qi, Zhenhao Li, Xiaoling Gao

“…In this article, we reviewed the current literature on the functions and mechanisms by which Th17/IL17 responds to intracellular bacterial infections. …”
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Intestinal microflora on physical performance in athletes - a comprehensive review by Natalia Kucharczyk, Katarzyna Półtorak, Wiktor Filarski, Zofia Markowicz, Dagmara Gaweł-Dąbrowska

“…The gut microbiota supports a variety of physiological functions, including immune modulation, nutrient metabolism, and the synthesis of essential vitamins and neurotransmitters. …”
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Nanoscale hetero-interfaces for electrocatalytic and photocatalytic water splitting by Baopeng Yang, Dingzhong Luo, Shimiao Wu, Ning Zhang, Jinhua Ye

“…In recent years, constructing suitable nanoscale hetero-interfaces can not only overcome the disadvantages of the single-phase material, but also possibly provide new functionalities. In this review, we systematically introduce the fundamental understanding and experimental progress in nanoscale hetero-interface engineering to design and fabricate photocatalytic and electrocatalytic materials for water splitting. …”
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HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma by Na Shen, Yuan Xia, Xuxing Shen, Wei Hua, Min Shi, Lijuan Chen

“…Here, we confirmed that HSPA9 is overexpressed in MM samples and correlates with unfavorable outcomes. Functionally, HSPA9 enhances MM cell viability, ferroptosis resistance, and tumorigenicity, suggesting its oncogenic role. …”
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The Role of Physical Activity in Reducing Endometriosis Pain by Emilia Bąk, Daria Michałka, Natalie Papachristoforou, Zuzanna Gałuszka, Monika Makar, Tomasz Bartuś, Żaneta Góra, Justyna Głowacka, Aleksandra Kocjan, Radosław Chmiel

“…This leads to pain, inflammatory states, and disruptions in the functioning of pelvic organs, including infertility. …”
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Development of a Multitype Wireless Sensor Network for the Large-Scale Structure of the National Stadium in China by Yanbin Shen, Pengcheng Yang, Pengfei Zhang, Yaozhi Luo, Yujia Mei, Huaqiang Cheng, Li Jin, Chenyu Liang, Qiaqin Wang, Zhouneng Zhong

“…Considering the structural features and on-site environment, the system takes multitype sensors as measurement components including stress, displacement, acceleration, wind, and temperature. The monitoring module design consists of four functions: sensing, processing, wireless communication, and energy management. …”
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Umbilical Cord‐Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non‐Alcoholic Fatty Liver Disease... by Minghao Du, Hao Yang, Jinyun Niu, Jing Huang, Lihong Wang, Junxiu Xi, Panpan Meng, Zhiyong Liu, Guaiguai Ma, Jiani Li, Xiaoyan Liu, Liang Guo, Mingjun Hu, Zhufang Tian, Bin Liu, Weiping Liu, Ashok K. Shetty, Shengxi Wu, Andrius Baskys, Qianfa Long

“…Furthermore, AAV injections indicate that hepatic PDGFB modulation recalibrates transthyretin (TTR) dynamics, thereby restoring its neuroprotective functions and preventing its pathological deposition in the brain. …”
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The Proline 7 Substitution in the Preproneuropeptide Y Is Associated with Higher Hepatic Lipase Activity In Vivo by Stephan Schiekofer, Marcus E. Kleber, Winfried Maerz, Franz M. Rasche, Jochen G. Schneider

“…Hepatic lipase (HL) functions as a lipolytic enzyme that hydrolyzes triglycerides and phospholipids present in circulating plasma lipoproteins. …”
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Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy by Mengchi Sun, Yuxia Wu, Zhichao Chen, Boyan Zhang, Xiaoyang Liu, Peipei Ouyang, Ping Chen, Lujun Chen, Zhonggui He, Tao Han, Heran Li, Jin Sun, Shuang Cai, Qiuhua Luo

“…This multifaceted immunomodulator can significantly enhance LNs’ homing through homologous targeting and chemokine-guided navigation, enabling ROS-responsive drug release, thereby restoring functions of DCs and LNs immuno-microenvironment. As expected, the immunomodulator significantly improves the responsiveness of TNBC to immunotherapy, exerting potent inhibition on both the primary tumor and metastases, while promoting a substantial increase in central memory T cells within LNs for sustained antitumor immunity. …”
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