ECM stiffness regulates calcium influx into mitochondria via tubulin and VDAC1 activity by Minji Kim, Kiseok Han, Gyuho Choi, Sanghyun Ahn, Jung-Soo Suh, Tae-Jin Kim

“…Calcium ions (Ca2+) play pivotal roles in regulating numerous cellular functions, including metabolism and growth, in normal and cancerous cells. …”
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A multi-pronged approach to addressing curricular challenges in undergraduate immunology education by Elena Tonc, Elena Tonc, Devavani Chatterjea, Devavani Chatterjea

“…Immunology is typically offered as a single-semester course in non-immunology-focused graduate programs and as a module within foundational sciences or microbiology courses in conventional allopathic medical education. …”
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Targeted macrophage mannose receptor (CD206)-specific protein delivery via engineered extracellular vesicles by Leyla A. Ovchinnikova, Daria Y. Tanygina, Samir S. Dzhelad, Evgeniy G. Evtushenko, Dmitriy V. Bagrov, Alexander G. Gabibov, Yakov A. Lomakin

“…We demonstrated that nanobody-functionalized EVs exhibit enhanced interaction and increased uptake by CD206+ cells compared to non-targeted EVs. …”
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The impact of innate immunity and epigenetics in the pathogenesis of hidradenitis suppurativa by Olivia M. Burke, Victoria R. Frerichs, Dario F. Garcia, Rivka C. Stone, Rivka C. Stone, Hadar Lev-Tov, Hadar Lev-Tov, Tali Czarnowicki, Robert W. Keane, Robert W. Keane, Robert W. Keane, Nkemcho Ojeh, Nkemcho Ojeh, Jelena Marjanovic, Jelena Marjanovic, Irena Pastar, Irena Pastar, Marjana Tomic-Canic, Marjana Tomic-Canic, Juan Pablo de Rivero Vaccari, Juan Pablo de Rivero Vaccari, Juan Pablo de Rivero Vaccari, Andrew P. Sawaya, Andrew P. Sawaya

“…Keratinocytes, fibroblasts, macrophages, and neutrophils exhibit altered functions, and contribute to the inflammatory cascade and disease chronicity in HS. …”
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Anti‐tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC‐dependent vulnerability by Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura

“…Here, we discovered that T‐025 functions as an orally available and potent inhibitor of Cdc2‐like kinases (CLKs), evolutionally conserved kinases that facilitate exon recognition in the splicing machinery. …”
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ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription by Arwa A. Abugable, Chunyan Liao, Sarah Antar, Matthew Dowson, Sherif F. El-Khamisy

“…To investigate its role in NuMA-dependent functions, we generated an ADP-ribosylation-deficient NuMA construct and report that NuMA ADP-ribosylation is required for its interaction with tyrosyl DNA phosphodiesterase 1 (TDP1), an SSBR player. …”
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Intercellular network structure and regulatory motifs in the human hematopoietic system by Wenlian Qiao, Weijia Wang, Elisa Laurenti, Andrei L Turinsky, Shoshana J Wodak, Gary D Bader, John E Dick, Peter W Zandstra

“…Abstract The hematopoietic system is a distributed tissue that consists of functionally distinct cell types continuously produced through hematopoietic stem cell (HSC) differentiation. …”
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INTERACTIONS BETWEEN THE ORAL MICROBIOME AND THE UROGENITAL TRACT: IMPLICATIONS FOR SYSTEMIC HEALTH AND INFLAMMATORY DISEASES by Emil Ceban, Kamel Earar, Dorin Ioan Cocos, Alina-Ramona Dimofte, Sonia Teodora Statescu-Manaila, Iulia Chiscop, Viorel Jinga

“…This review explores the bidirectional relationship between the oral microbiome and the urogenital tract, emphasizing how dysbiosis in the oral cavity, particularly in the context of periodontal disease, may influence urogenital health through systemic inflammation, microbial dissemination, and immune modulation. We examine the composition and functions of both the oral and urogenital microbiomes, as well as their susceptibility to internal and external perturbations such as antibiotic therapy, hormonal shifts, and lifestyle factors. …”
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Estimation of the Negative Charge of Phi6 Virus and Its Variations with pH Using the Literature XPS Data by Ikhlas Hani Chennoufi, Chorouk Zanane, Taoufik Hakim, Hafida Zahir, Fatima Hamadi, Abderrahmene El Ghmari, Mostafa El Louali, Hassan Latrache

“…A novel approach is applied, combining chemical functionalities derived from XPS with a system of equations to quantify surface polysaccharides, proteins, hydrocarbons, and negatively charged groups (RCOO⁻ and R₂PO₄⁻). …”
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Atomic‐Scale Dynamics at the Interface of Doped Liquid Gallium: Contrasting Effects of Gallium Oxide and Vacuum by Krista G. Steenbergen, Stephanie Lambie, Charlie Ruffman, Nicola Gaston

“…More broadly, these findings underscore the critical role of interfaces in modulating dopant dynamics, offering new pathways for tuning the properties and functionalities of liquid metal technologies.…”
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Self-reconfigurable multifunctional memristive nociceptor for intelligent robotics by Shengbo Wang, Mingchao Fang, Lekai Song, Cong Li, Jian Zhang, Arokia Nathan, Guohua Hu, Shuo Gao

“…The maximum amplification of hazardous external stimuli is 1000%, and its response characteristics dynamically adapt to current temperature conditions by automatically altering the generated modulation schemes for the memristor. The maximum difference ratio of the response of memristors at different temperatures is 500%, and this adaptability closely mimics the functions of biological tactile nociceptors, resulting in accurate danger perception in various conditions. …”
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Transient receptor potential channels in dental inflammation and pain perception: A comprehensive review by Varunya Chantadul, Nattapon Rotpenpian, Tawepong Arayapisit, Aree Wanasuntronwong

“…These inflammatory conditions notably contribute to oral health challenges, often leading to sharp pain, dull aches, and compromised functionality. Pharmacological interventions and emerging strategies aimed at modulating TRP channel activity are critically evaluated. …”
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The regulatory role of m6A in cancer metastasis by Ying Zhou, Peng Cao, Qing Zhu

“…N6-methyladenosine (m6A), recognized as one of the most prevalent and functionally significant RNA modifications, plays a central role in the regulation of RNA metabolism. …”
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IL-33/IL-31 Axis: A Potential Inflammatory Pathway by Eleonora Di Salvo, Elvira Ventura-Spagnolo, Marco Casciaro, Michele Navarra, Sebastiano Gangemi

“…IL-31 controls signalling and regulates a huge amount of biological functions: it induces proinflammatory cytokines, regulates cell proliferation, and is involved also in tissue remodelling. …”
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Methionine regulates maternal-fetal immune tolerance and endometrial receptivity by enhancing embryonic IL-5 secretion by Shuang Cai, Bangxin Xue, Siyu Li, Xinyu Wang, Xiangzhou Zeng, Zhekun Zhu, Xinyin Fan, Yijin Zou, Haitao Yu, Shiyan Qiao, Xiangfang Zeng

“…This study reveals the crucial functions of methionine and IL-5 and offers a potential nutritional strategy for successful pregnancy.…”
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Cytokeratin-1 is essential for the detection of laminar shear stress in endothelial cells by Sunyoung Ahn, Youngsik Seo, Heonyong Park

“…Endothelial cells regulate diverse vascular functions by perceiving and reacting to laminar shear stress. …”
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GmTRAB1, a Basic Leucine Zipper Transcription Factor, Positively Regulates Drought Tolerance in Soybean (<i>Glycine max</i>. L) by Hui Li, Qiu-Yu Zhang, Ping Xu, Xiao-Hua Wang, Sheng-Jie Dai, Zhen-Ning Liu, Meng Xu, Xue Cao, Xiao-Yu Cui

“…The basic leucine zipper (bZIP) transcription factors play crucial roles in plant resistance to environmental challenges, but the biological functions of soybean bZIP members are still unclear. …”
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CRISPR/Cas13 sgRNA‐Mediated RNA–RNA Interaction Mapping in Live Cells with APOBEC RNA Editing by Li‐Ting Diao, Shu‐Juan Xie, Wan‐Yi Xu, Hai‐Hui Zhang, Ya‐Rui Hou, Yan‐Xia Hu, Xin‐Xiang Liang, Jun‐Bin Liang, Qi Zhang, Zhen‐Dong Xiao

“…The findings suggest that lncRNAs may regulate gene expression by interacting with mRNAs, expanding their roles beyond known functions as protein scaffolds, miRNA sponges, or guides for epigenetic modulators. sarID has the potential to be adapted for studying other specific RNAs, providing a novel immunoprecipitation‐free method for uncovering RNA partners and facilitating the exploration of the RNA‐RNA interactome.…”
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CMOS-integrated organic neuromorphic imagers for high-resolution dual-modal imaging by Salihuojia Talanti, Kerui Fu, Xiaolong Zheng, Youzhi Shi, Yimei Tan, Chenxi Liu, Yanfei Liu, Ge Mu, Qun Hao, Kangkang Weng, Xin Tang

“…The neuromorphic device demonstrates adjustable memory behavior through modulation of charge recombination-trapping dynamics, enabling multi-level memory functionality. …”
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Collagen-based biomaterials: recent advances on regulating cell migration and correlated biomedical applications by Qinghe Zhang, Minghuan Dou, Xinyi Su, Zelong Yu, Benmei Wei, Lian Zhu, Juntao Zhang, Haibo Wang

“…By shedding light on the functions, mechanisms, and therapeutic potential of collagen in cell migration, this review will contribute to the development of innovative collagen-based biomaterials with applications in wound healing and tissue regeneration. …”
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