Pannexin channels in inflammation and tumorigenesis by Mengmeng Jiang, Mengmeng Jiang, Xiaojia Li, Xiaojia Li, Keping Xie, Keping Xie

“…In this review, we will specifically examine the signaling regulatory functions of Panx channels in the processes of inflammation and tumorigenesis; systematically evaluate the therapeutic potential of Panx inhibitors in these pathological contexts, critically analyze current research limitations, and strategically propose future perspectives in Panx channels and its inhibitors research.…”
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Mechanism and application prospect of magnesium-based materials in cancer treatment by Yutong Ma, Yi Wang, Siwei Song, Xinyue Yu, Can Xu, Long Wan, Fan Yao, Ke Yang, Frank Witte, Shude Yang

“…Biodegradable magnesium alloys serve various functions in clinical applications, including, but not limited to, bone fixation, coronary stents, and drug carriers. …”
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MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition by Yu Fu, Xin Hao, Jingru Nie, Hongliang Zhang, Peng Shang, Bo Zhang, Hao Zhang

“…Our new findings were as follows: MUSTN1 was highly expressed in the fat tissue of pigs with strong adipose deposition capacity; functionally, MUSTN1 promoted the proliferation and adipogenic differentiation of porcine and mouse preadipocytes. …”
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Chromatin landscape at cis-regulatory elements orchestrates cell fate decisions in early embryogenesis by Francesco Cardamone, Annamaria Piva, Eva Löser, Bastian Eichenberger, Mari Carmen Romero-Mulero, Fides Zenk, Emily J. Shields, Nina Cabezas-Wallscheid, Roberto Bonasio, Guido Tiana, Yinxiu Zhan, Nicola Iovino

“…We found that pre-zygotic H3K27me3 safeguards tissue-specific gene expression by modulating cis-regulatory elements. Furthermore, we demonstrate that CBP is essential for cell fate specification functioning as a transcriptional activator by stabilizing transcriptional factors binding at key developmental genes. …”
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A Mimetic Assay of Neutrophil Extracellular Trap Degradation Using YOYO-1-Stained DNA-Histone Surface Webs by Katherine H. Nguyen, Midori L. Wasielewski, Srilakshmi Yalavarthi, Xianggui Qu, Jason S. Knight, Shuichi Takayama

“…This paper describes a simplified, lower variability mimetic assay with DNA–histone structures, referred to as surface webs, that performs functionally similarly to traditional NET degradation assays with increased scalability, ease of use, shorter preparation time, and lowered costs. …”
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Cheminformatics-based design and biomedical applications of a new Hydroxyphenylcalix[4] resorcinarene as anti-cancer agent by S. F. Alshahateet, R. M. Altarawneh, S. A. Al-Trawneh, Y. M. Al-Saraireh, W. M. Al-Tawarh, K. R. Abuawad, Y. M. Abuhalaweh, M. Zerrouk, A. Ait Mansour, R. Salghi, B. Hammouti, M. Merzouki, R. Sabbahi, L. Rhazi, Mohammed M. Alanazi, K. Azzaoui

“…Abstract The distinct conformational characteristics, functionality, affordability, low toxicity, and usefulness make calixarene-based compounds a promising treatment option for cancer. …”
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ROS-Responsive Nanoplatforms for Targeted Tumor Immunomodulation: A Paradigm Shift in Precision Cancer Immunotherapy by Yuan-Yuan Fan, Hong Wu, Chuan Xu

“…Reactive oxygen species (ROS), which exhibit dual regulatory roles in the TME by regulating immunogenic cell death (ICD) and reprogramming immune cell functionality, have emerged as a pivotal therapeutic target. …”
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Research progress on the mechanism of neural electrical information transmission in acupuncture intervention of depression by Shu-juan LI, Min XIAO, Chong-bing MA, Xing-ke YAN

“…Acupuncture can enhance the long-term potentiation (LTP) detected by PCRT, repair the plasticity of synaptic functions, and promote the transmission of synaptic information; lower the action potential (AP) and population spike (PS) membrane voltage detected by PCRT, inhibit abnormal neuronal excitability, and restore electrical signal transmission across neuronal membranes. …”
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Movable surface acoustic wave tweezers: a versatile toolbox for micromanipulation by Xianming Qin, Xianglian Liu, Shuo Liu, Chuanyu Zhang, Ningning Bai, Xue Li, Weidong Wang, Dan Liu, Qiqi Yang, Ruiguo Yang, Yajing Shen, Xueyong Wei

“…Owing to their device structure and bonding process, most SAW tweezers have limitations in terms of controlling the position and motion of the acoustic traps, as they generate an acoustic field with a fixed region and adjust the manipulation effects via signal modulation. To address this challenge, we propose movable SAW tweezers with a multilayer structure, achieving dynamic control of their wave field and acoustic trap positions; we demonstrate their precise manipulation functions, such as translation, in-plane rotation, out-of-plane rotation, and cluster formation, on a wide spectrum of samples, including particles, bubbles, droplets, cells, and microorganisms. …”
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Exploring the synergetic role of cuproptosis and ferroptosis and their implication in advancing cancer therapeutics by Prashant Chauhan, Pratibha Pandey, Ajay Singh, Sujayaraj Samuel Jayakumar, Sorabh Lakhanpal, Meenakshi Verma, Vijay Jagdish Upadhye, Fahad Khan

“…These disruptions ultimately lead to mitochondrial dysfunction, formation of excessive reactive oxygen species (ROS), impairment of lipid layers, and modulation of immunological functions, altogether paving the direction towards cancer suppression and providing novel avenues towards targeted therapeutic strategies. …”
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Tunable Dual-Mode Resonant Excitation of Dumbbell-Shaped Structures in the Mid-Infrared Band by Tao Jiang, Yafei Li, Zhuangzhuang Xu, Xike Qian, Rui Shi, Xiufei Li, Meng Wang, Ze Li

“…This work offers a novel design paradigm for multi-mode control and functionalization of metasurface structures.…”
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Drug-target binding affinity prediction based on power graph and word2vec by Jing Hu, Shuo Hu, Minghao Xia, Kangxing Zheng, Xiaolong Zhang

“…Abstract Background Drug and protein targets affect the physiological functions and metabolic effects of the body through bonding reactions, and accurate prediction of drug-protein target interactions is crucial for drug development. …”
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Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy by Daibang Nie, Jianying Zhang, Yiqin Zhou, Jiuyi Sun, Wang Wang, James H.-C. Wang

“…The activation of autophagy and senescence rescue was, at least partly, due to the translocation of HMGB1 from the nucleus to the cytosol that functions as an autophagy promoter. By reducing TSC senescence, rapamycin may be used as a therapeutic to inhibit tendinopathy development in the aging population by promoting autophagy.…”
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Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration by Xiyan Tan, Fuyang Cao, Feiyu Tang, Can Lu, Qiaoyan Yu, Songshan Feng, Zhanghuan Yang, Songming Chen, Xiang He, Jiang He, Liang Weng, Lunquan Sun

“…Our mechanistic study shows that Trim35 functions as an E3 ligase to mediate the ubiquitination and degradation of CLOCK, a key regulator of circadian rhythmicity. …”
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LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation by Dhanusha A. Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S. Ashton, Weixian Deng, Ryan P. Wurz, Anh T. Tran, Brian A. Lanman, Jiansong Xie, Robert G. Guenette, Shiqian Li, Christopher E. Smith, Suresh Archunan, Manoj K. Agnihotram, Arghya Sadhukhan, Rajiv Kapoor, Chris Wilde, Sajjan Koirala, Felipe De Sousa E Melo, Patrick Ryan Potts

“…Inspired by the success of proximity-based chimeras in both intracellular and extracellular target space, here we describe the development of LYsosome Membrane TArgeting Chimeras (LYMTACs) as a small molecule-based platform that functions intracellularly to modulate the membrane proteome. …”
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Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders by Petra Zimmermann, Salome Kurth, Benoit Pugin, Nicholas A. Bokulich

“…Abstract Melatonin (MT) (N-acetyl-5-methoxytryptamine) is an indoleamine recognized primarily for its crucial role in regulating sleep through circadian rhythm modulation in humans and animals. Beyond its association with the pineal gland, it is synthesized in various tissues, functioning as a hormone, tissue factor, autocoid, paracoid, and antioxidant, impacting multiple organ systems, including the gut-brain axis. …”
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The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies by Dongqi Li, Xiangyu Chu, Weikang Liu, Yongsu Ma, Xiaodong Tian, Yinmo Yang

“…RBPs may exhibit either anti-tumour or pro-tumour functions by influencing the TIME through the modulation of mRNAs and non-coding RNAs expression, as well as post-transcriptional modifications, primarily N6-methyladenosine (m6A). …”
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Claw loss and the prey preferences of an invasive crayfish by Mathieu Toutain, Ismael Soto, Francisco J. Oficialdegui, Paride Balzani, Ross N. Cuthbert, Augusto Frederico Huber, Phillip J. Haubrock, Antonín Kouba

“…Crayfish readily colonize new ecosystems and their impacts can modify food webs or ecosystem functioning. However, while crayfish exert high levels of predation pressure handling prey with their claws, claw loss is also common in their populations, which could mediate prey selection pressures. …”
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Metastasis-associated protein 1: a druggable target in cancer treatment by Madhusudana Pulaganti, Kireeti Anthati Soma, Rekha Mandla, Bhavana Cherukuthota, Haseena Dudekula

“…This abstract provides an overview of the current landscape of MTA1 as a druggable target in cancer therapy, highlighting its diverse functions across different malignancies and its potential as a predictive biomarker for therapeutic response. …”
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Microvascular endothelial dysfunction in vascular senescence and disease by Daniel A. Kasal, Daniel A. Kasal, Viviane Sena, Grazielle Vilas Bôas Huguenin, Grazielle Vilas Bôas Huguenin, Andrea De Lorenzo, Eduardo Tibirica

“…The process can ultimately lead to an environment committed to the loss of the physiological functions of endothelial cells. In addition, we discuss lifestyle changes targeting the connection between age-related inflammation and vascular dysfunction. …”
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