The dual role of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma: mechanisms, clinical relevance, and therapeutic opportunities by Houhong Wang, Shang Bian

“…This review synthesizes recent advancements (2023–2025) to elucidate Nrf2’s context-dependent dual functions: tumor suppressive roles during early carcinogenesis through oxidative stress mitigation, versus oncogenic effects in advanced stages via promoting proliferation, survival, and treatment resistance. …”
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3D ultra-broadband optically dispersive microregions in lithium niobate by Bo Zhang, Zhuo Wang, Tom Albrow-Owen, Tawfique Hasan, Zesheng Chen, Zhiying Song, Gongyuan Zhang, Hannah Joyce, Dezhi Tan, Qiangbing Guo, Cheng-wei Qiu, Zongyin Yang, Jianrong Qiu

“…Abstract 3D in-substrate integration of optical functionalities fully utilizes the vertical dimension of space and is valuable for advancing next-generation integrated optoelectronics. …”
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IL-6 as a Mediator of Platelet Hyper-Responsiveness by Connor Elliot Webb, Jordan Vautrinot, Ingeborg Hers

“…Interleukin-6 (IL-6) is a pleiotropic cytokine with critical roles in immune regulation, inflammation, and haematopoiesis. While its functions in host defence and tissue repair are well established, accumulating evidence suggests that IL-6 also can directly and indirectly modulate megakaryocyte and platelet biology. …”
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Mechanistic insights into Nrf2-driven pathogenesis and therapeutic targeting in spinal cord injury by Tao Xie, Tao Xie, Jiyu Xu, Xinyu Liu, Yaquan Yu, Yang Lu, Tao Wang, Feng Gao, Hui Yuan, Hui Yuan

“…Activation of the Nrf2-related signaling pathway effectively inhibits neuronal death following SCI and promotes the recovery of multiple neurological functions. This review provides an overview of recent research on SCI, examines the physiological roles and mechanisms of Nrf2 in SCI, and explores therapeutic strategies targeting this signaling pathway, including non-coding RNAs, natural and synthetic compounds, and other treatments for SCI.…”
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Linear optical wave energy redistribution methods for photonic signal processing by Connor Rowe, Xinyi Zhu, Benjamin Crockett, Geunweon Lim, Majid Goodarzi, Manuel Fernández, James van Howe, Hao Sun, Saket Kaushal, Afsaneh Shoeib, José Azaña

“…We describe several recent OWER methods for optical signal processing, including denoising passive amplification, real-time spectrogram analysis, passive logic computing, and more. These functionalities are relevant whenever the signal is found on a classical or quantum optical wave, or could be upconverted from radio frequencies or microwaves, and they are of interest for a wide range of applications in telecommunications, sensing, metrology, biomedical imaging, and astronomy. …”
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Glucose oxidase: An emerging multidimensional treatment option for diabetic wound healing by Yuheng Liao, Zhenhe Zhang, Yanzhi Zhao, Shengming Zhang, Kangkang Zha, Lizhi Ouyang, Weixian Hu, Wu Zhou, Yun Sun, Guohui Liu

“…In this context, glucose oxidase (GOx), by catalyzing glucose to produce gluconic acid and hydrogen peroxide, not only modulates the hyperglycemic microenvironment but also possesses antibacterial and oxygen-supplying functions, thereby demonstrating immense potential in the treatment of diabetic wounds. …”
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27-Hydroxycholesterol in cancer development and drug resistance by Yaxin Hou, Zhiguang Fu, Chenhui Wang, Paulina Kucharzewska, Yuan Guo, Sihe Zhang

“…27-Hydroxycholesterol (27HC), a cholesterol metabolite, functions both as a selective oestrogen receptor (ER) modulator and a ligand for liver X receptors (LXRs). …”
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BATF2 is a regulator of interferon-γ signaling in astrocytes during neuroinflammation by Rachel A. Tinkey, Brandon C. Smith, Maria L. Habean, Jessica L. Williams

“…Collectively, our results further support evidence of protective functions for IFNγ and implicate BATF2 as a key suppressor of overactive immune signaling in astrocytes during neuroinflammation.…”
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LPItabformer: Enhancing generalization in predicting lncRNA-protein interactions via a tabular Transformer by Qin Lin, Jie Sheng, Chang Zhou, Tao Xiao, Yilei Meng, Mingxin Lu, Junfang Zhang, Xueyun Yan, Luying Peng, Huaming Cao, Li Li

“…Accurately predicting lncRNA-protein interactions (LPIs) is vital strategy for clarify functions and pathogenic mechanisms of lncRNAs. Current computational methods for evaluating LPIs with their utility and generalization have significant room for improvement. …”
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Scalable photonic-phonoinc integrated circuitry for reconfigurable signal processing by Liang Zhang, Chaohan Cui, Yongzhou Xue, Paokang Chen, Linran Fan

“…This work provides an ideal platform for achieving ultimate performance of photonic-phononic hybrid systems with high efficiency, multiple functions, and large scalability.…”
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Investigation of lump, breather and multi solitonic wave solutions to fractional nonlinear dynamical model with stability analysis by M.A. El-Shorbagy, Sonia Akram, Mati ur Rahman

“…In the current research, the new extended direct algebraic method (NEDAM) and the symbolic computational method, along with different test functions, the Hirota bilinear method, are capitalized to secure soliton and lump solutions to the (2+1)-dimensional fractional telecommunication system. …”
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Heat shock proteins in hypothermia: a review by Shang-Jin Song, Shang-Jin Song, Guo-Cheng Wu, Li Yi, Li Yi, Xin Liu, Ming-Min Jiang, Xiao-Chen Zhang, Zi-Fei Yin, Wei Gu, Yi Ruan, Yi Ruan

“…These highly conserved proteins are crucial in cellular stress responses, primarily functioning as chaperones. HSPs facilitate correct protein folding and prevent misfolding and aggregation, thereby protecting cellular integrity during adverse conditions. …”
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Biodegradable Janus sonozyme with continuous reactive oxygen species regulation for treating infected critical-sized bone defects by Zixuan Ou, Junyu Wei, Jie Lei, Di Wu, Bide Tong, Huaizhen Liang, Dingchao Zhu, Hongchuan Wang, Xingyu Zhou, Hanpeng Xu, Zhi Du, Yifan Du, Lei Tan, Cao Yang, Xiaobo Feng

“…Here, a degradable material with continuous ROS modulation is proposed, defined as a sonozyme due to its functions as a sonosensitizer and a nanoenzyme. …”
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An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination by Jun Guo, Tianye Zhang, Haoxin Xie, Haichao Hu, Chaonan Shi, Yingjie Zhao, Jingliang Yin, Gecheng Xu, Zechi Wu, Pengkun Wang, Jiaqian Liu, Peng Liu, Kaili Zhong, Feng Chen, Jianping Chen, Jian Yang

“…However, TaHAKAI also functions as an E3 ligase that targets the viral RNA silencing suppressor P2 for degradation and inhibits viral infection. …”
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Deubiquitinases as novel therapeutic targets for diseases by Yali Xian, Jing Ye, Yu Tang, Nan Zhang, Cheng Peng, Wei Huang, Gu He

“…This comprehensive analysis enhances our understanding of the complex biological functions of the DUBs and underscores their therapeutic potential.…”
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Soliton microcombs in X-cut LiNbO3 microresonators by Binbin Nie, Xiaomin Lv, Chen Yang, Rui Ma, Kaixuan Zhu, Ze Wang, Yanwu Liu, Zhenyu Xie, Xing Jin, Guanyu Zhang, Du Qian, Zhenyu Chen, Qiang Luo, Shuting Kang, Guowei Lv, Qihuang Gong, Fang Bo, Qi-Fan Yang

“…Although soliton microcombs have been demonstrated on various material platforms, realizing complete comb functionality on photonic chips requires the co-integration of high-speed modulators and efficient frequency doublers, features that are available in a monolithic form on X-cut thin-film lithium niobate (TFLN). …”
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Cell-specific copper dyshomeostasis mechanism in Alzheimer’s disease by Michael Okafor, Peter Faller, Nicolas Vitale

“…Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive decline of cognitive functions, yet its underlying aetiology remains elusive. …”
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Tau mediates the reshaping of the transcriptional landscape toward intermediate Alzheimer’s disease stages by Giacomo Siano, Giacomo Siano, Martina Varisco, Marco Terrigno, Congwei Wang, Arianna Scarlatti, Vincenzo Iannone, Marco Groth, Marie-Christine Galas, Jeroen J. M. Hoozemans, Alessandro Cellerino, Alessandro Cellerino, Antonino Cattaneo, Cristina Di Primio

“…IntroductionRecent research revealed that Tau plays critical roles in various neuronal functions. We previously demonstrated that destabilization and nuclear delocalization of Tau alter the expression of glutamatergic genes, mediating early neuronal damage.MethodsIn this study, we discovered that changes in Tau availability are linked to global alterations in gene expression that affect multiple neuronal pathways. …”
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Curcumin, inflammation, and neurological disorders: How are they linked? by Prachi Garodia, Mangala Hegde, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal

“…Results: This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. …”
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Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications by Laure Farnault, Carole Sanchez, Céline Baier, Thérèse Le Treut, Régis T. Costello

“…Abnormal NK cytolytic functions have been described in nearly all hematological malignancies. …”
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