Clinical and basic research advances on Jinlong capsule for the prevention and treatment of liver cancer by Liyuan Lv, Simeng Ren, Zunyi Zhang, Hongsheng Lin, Jie Liu

“…When used in combination with modern treatment methods, JLC helps in preventing and treating liver cancer recurrence and metastasis, prolonging patient survival, increasing the tumor objective response rate, alleviating gastrointestinal adverse reactions, enhancing survival quality, regulating immune functions of the body, relieving clinical symptoms, and improving patient safety. …”
Get full text

Fields2Benchmark: An open-source benchmark for coverage path planning methods in agriculture by Gonzalo Mier, Ana María Casado Faulí, João Valente, Sytze de Bruin

“…., field decomposition, headland generation, swath generation, route planning, and path planning— allowing researchers to evaluate and compare algorithms modularly. Each module supports interchangeable algorithms and objective functions, enabling customization for diverse use cases. …”
Get full text

The 14-3-3 Protein OsGF14h Coordinates Brassinosteroid and Gibberellin Signaling to Regulate Plant Growth and Grain Yield in Rice by Yonghong Xie, Zhupeng Fan, Kaichong Teng, Zejian Huang, Kaizun Xu, Jianxiong Li

“…Our results indicate that OsGF14h functions in both BR and GA signaling pathways and acts as a crosstalk point for BR and GA signaling, which offers new insights into the role of 14-3-3 proteins in regulating plant growth and development by modulating BR and GA signaling crosstalk.…”
Get full text

Effects of lysophosphatidylcholine on the oxidative burst response, inflammatory cytokine secretion, and Escherichia coli killing in polymorphonuclear neutrophils isolated from Hol... by B.N. Tate, A. Zhu, M.J.B. Felippe, D.C. Reyes, J.W. McFadden

“…These findings indicate that LPC plays an important role in modulating various neutrophil functions in neonatal bovine immunity.…”
Get full text

Protective Effects of Astaxanthin on Thioacetamide-Induced Hepatopancreatic Damage in <i>Procambarus clarkii</i>: Insights from Biochemical, Histological, and Metabolomic Analyses by Jiawen He, Jian Ju, Qingliang Jiang, Haiyong Zhao, Yingying Zhang, Hui Yang

“…The hepatopancreas of <i>Procambarus clarkii</i> plays a crucial role in metabolism and immune response, encompassing vital physiological functions. In our study, we established a hepatopancreatic injury model using thioacetamide (TAA) and evaluated the therapeutic potential of a commercial astaxanthin-based product (AST-product) on hepatopancreatic health. …”
Get full text

Design of a mine-used bus type optical substation by Fei DENG

“…It mainly collects sensor disaster information such as methane and carbon monoxide through monitoring substations and analyzes it in real time to achieve functions such as over limit sound and light alarm, power outage, wind power locking control, etc. …”
Get full text

Exploring ultrasound-induced metabolic attenuation in Lacticaseibacillus casei ATCC 393—A combined approach using traditional methods and flow cytometry by Irene Giordano, Mohammed Salman, Stefania Arioli, Diego Mora, Gianluigi Mauriello

“…Attenuation technologies applied to probiotics aim to modulate specific metabolic pathways, particularly acidification, while maintaining cell viability. …”
Get full text

An integrated network pharmacology and molecular modelling study of phytoconstituents targeting Alzheimer's disease by Saumya Khanna, Divakar Selvaraj, Mehak Tyagi, Devadharshini, Saravanan Jayaram

“…The present study involves the use of combined network pharmacology and molecular modelling approach for identifying important phytoconstituents that could modulate the functions of multiple therapeutic targets in Alzheimer’s disease. …”
Get full text

The impact of SRRM2-AS1 in ovarian cancer: a comprehensive analysis based on pan-cancer and in vitro validation by Jiaojiao Lu, Xia Zheng, Xu Li

“…Among them, lncRNA SRRM2-AS1 has emerged as a significant factor, yet its functions in ovarian cancer remain insufficiently understood. …”
Get full text

Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants. by April Kaur Randhawa, Muki S Shey, Alana Keyser, Blas Peixoto, Richard D Wells, Marwou de Kock, Lesedi Lerumo, Jane Hughes, Gregory Hussey, Anthony Hawkridge, Gilla Kaplan, Willem A Hanekom, Thomas R Hawn, South African Tuberculosis Vaccine Initiative Team

“…We examined whether functionally defined TLR pathway polymorphisms were associated with T cell cytokine responses in whole blood stimulated ex vivo with BCG 10 weeks after newborn BCG vaccination of South African infants. …”
Get full text

Nanotopographical Features of Polymeric Nanocomposite Scaffolds for Tissue Engineering and Regenerative Medicine: A Review by Kannan Badri Narayanan

“…This ECM biomimicry is vital for responding to biochemical signaling cues, orchestrating cellular functions, metabolic processes, and subsequent tissue organization. …”
Get full text

Intracellular calcium in the pancreas. Part 1. Role in physiological regulation by S.M. Chooklin, S.S. Chuklin, R.V. Baryliak

“…The pancreas is a unique organ combining both exocrine and endocrine functions, with intracellular Ca2+ ac­ting as a central secondary messenger that coordinates these proces­ses. …”
Get full text

Study of phenotypic and cytotoxic properties of erythroid cells of the spleen under hematopoiesis-stimulating effects by Yu. A. Shevchenko, K. V. Nazarov, S. V. Sennikov

“…In recent years, research has revealed a wide variety of erythroid cell functions, including modulation of innate and adaptive immune responses. …”
Get full text

Positive selection at core genes may underlie niche adaptation in Fusobacterium animalis by Diego Forni, Audun Sivertsen, Rachele Cagliani, Alessandra Mozzi, Cristian Molteni, Øyvind Kommedal, Manuela Sironi

“…Results indicated that the coding sequences of these genes have been targeted by intense purifying selection, possibly as the result of their often-essential functions. However, localized signatures of positive selection were also detectable. …”
Get full text

The Roles of Forkhead Box O3a (FOXO3a) in Bone and Cartilage Diseases &ndash; A Narrative Review by Wu Z, Zhan W, Wu L, Yu L, Xie X, Yu F, Kong W, Bi S, Liu S, Yin G, Zhou J

“…FOXO3a, a member of the FOXO family, has been implicated in cell proliferation, ROS detoxification, autophagy, and apoptosis. The biological functions of FOXO3a can be modulated by post-translational modifications (PTMs), such as phosphorylation and acetylation. …”
Get full text

Pathogenic mechanisms and potential applications of extracellular vesicles from periodontal pathogens in periodontitis by Ruiqing Zhang, Ruiqing Zhang, Guoliang Li, Yingtao Wu, Xiaoxuan Wang, Qingxian Luan

“…These vesicles contain various components derived from their parent bacteria, including nucleic acids, proteins, lipids, and other molecules, which facilitate functions such as molecular transfer, metabolic regulation, bacterial interactions, biofilm formation, and immune modulation. …”
Get full text

Genome-Wide Identification and Characterization of <i>TaCRY</i> Gene Family and Its Expression in Seed Aging Process of Wheat by Guoqing Cui, Xiuyan Cui, Junjie Wang, Menglin Lei, Xia Liu, Yanzhen Wang, Haigang Wang, Longlong Liu, Zhixin Mu, Xia Xin

“…Cryptochromes (CRYs), as essential blue-light photoreceptors, play pivotal roles in modulating plant growth, development, and stress responses. …”
Get full text

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model by Jan Dusek, Ivana Mejdrová, Klára Dohnalová, Tomas Smutny, Karel Chalupsky, Maria Krutakova, Josef Skoda, Azam Rashidian, Ivona Pavkova, Kryštof Škach, Jana Hricová, Michaela Chocholouskova, Lucie Smutna, Rajamanikkam Kamaraj, Miloš Hroch, Martin Leníček, Stanislav Mičuda, Dirk Pijnenburg, Rinie van Beuningen, Michal Holčapek, Libor Vítek, Magnus Ingelman-Sundberg, Oliver Burk, Thales Kronenberger, Radim Nencka, Petr Pavek

“…Abstract Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic clearance but distinct roles in endobiotic metabolism. …”
Get full text

A fungal chromatin remodeler drives transcription by establishing an open chromatin architecture and activated histone environment by Mengting Xu, Qi Zhang, Yuan Li, Wei Zhou, Lingyun Lei, Fucheng Lin, Yanjun Kou, Zeng Tao

“…In the filamentous fungus Magnaporthe oryzae, we demonstrate that remodeling the structure of chromatin 1 (RSC1) functions as a critical regulator in this process. …”
Get full text

Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes by Daniel F. Moakley, Melissa Campbell, Miquel Anglada-Girotto, Huijuan Feng, Andrea Califano, Edmund Au, Chaolin Zhang

“…Summary: Cell-type-specific alternative splicing (AS) enables differential gene isoform expression between diverse neuron types with distinct identities and functions. Current studies linking individual RNA-binding proteins (RBPs) to AS in a limited number of neuron types underscore the need for holistic modeling. …”
Get full text