Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Ca... by Zi-hang Xu, Yang-zhuangzhuang Zhu, Lin Su, Xue-yang Tang, Chao Yao, Xiao-ning Jiao, Yi-fei Hou, Xiao Chen, Lu-yao Wei, Wan-tao Wang, Jie Wang, Chen-yuan Gong, Xian-dan Zhu, Fei Zhang, Shi-guo Zhu, Chun-pu Zou

“…In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). …”
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Advances in Fabric-Based Pneumatic Soft Actuators for Flexible Robotics: Design and Applications by Yao Chai, Yutong Qin, Ziyi Xu, Xianhong Zheng, Hao Jia

“…Furthermore, the integration of fabric-based actuators with flexible sensors is highlighted as a highly promising research direction, offering the potential to enhance device intelligence via real-time feedback and adaptive control functionalities. In conclusion, with ongoing advancements in material science, structural design, and control strategies, fabric-based pneumatic soft actuators are expected to unlock broader application potentials in domains such as healthcare, wearable technology, and human–-computer interaction.…”
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Engineering extracellular vesicles for ROS scavenging and tissue regeneration by Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim

“…Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. …”
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Na+/K+-ATPase: a multifunctional target in type 2 diabetes and pancreatic islets by Lisha Mou, Lisha Mou, Zhenkun Fu, Tony Bowei Wang, Yuxian Chen, Ziqi Luo, Xinyu Wang, Zuhui Pu, Zuhui Pu

“…We provide an overview of NKA’s biological functions, emphasizing its involvement in cellular signaling pathways, insulin secretion, and glucose homeostasis. …”
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Mitochondrial calcium uniporter is required for thermogenic adaptation mediated by reactive oxygen species signaling by Suji Kim, Seung-Kuy Cha, Kyu-Sang Park, Jun Namkung

“…In this study, we demonstrate that MCU governs mitochondrial functions in brown and beige adipocytes via the formation of mitochondrial reactive oxygen species (mtROS). …”
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Gate‐Tunable Dual‐Mode Optoelectronic Device for Self‐Powered Photodetector and Optoelectronic Synapse by Yi Ouyang, Chaoyi Zhang, Jun Wang, Zheng Guo, Zegao Wang, Mingdong Dong

“…The photodetector mode demonstrates broadband detection and fast response speed, while the optoelectronic synapse mode exhibits robust long‐term memory characteristics, mimicking biological synaptic behavior. This dual functionality opens new possibilities for integrating neuromorphic computing into traditional optoelectronic systems, offering a potential pathway for developing advanced intelligent sensing and computing technologies.…”
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Bridging traditional Chinese medicine and Alzheimer’s disease: the pivotal role of gut microbiota in multitarget therapeutic mechanisms by Weidong Wu, Tianwei Meng, Lichao Han, Fangfang Jin, Pengfei Han, Yanyan Zhou

“…Microbiota-gut-brain axis communication represents another crucial pathway in the pathogenesis of Alzheimer’s disease (AD), whereby gut microbiota significantly impacts AD pathology by modulating immune, metabolic, digestive, and neurological functions. …”
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UCL23 hierarchically regulated by WRKY51-miR528 mediates cadmium uptake, tolerance, and accumulation in rice by Jingai Tan, Lantian Zhang, Chuanjia Liu, Zheyuan Hong, Xia Wu, Yaqi Zhang, Muhammad Fahad, Yuxin Shen, Jianmin Bian, Haohua He, Dezhi Wu, Qingyao Shu, Jinsong Bao, Liang Wu

“…Here, we elucidate the crucial functions of UCLACYANIN 23 (UCL23), a small copper protein, in Cd absorption, tolerance, and accumulation through modulation of reactive oxygen signals in rice. …”
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A cytosolic glyoxylate shunt complements the canonical photorespiratory pathway in Arabidopsis by Xiaotong Jiang, Amanda M. Koenig, Berkley J. Walker, Jianping Hu

“…Abstract Photorespiration functions in part to support photosynthetic performance, especially under stress such as high light, yet the underlying mechanisms are poorly understood. …”
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G protein-coupled receptors: pivotal hubs in gastric cancer malignancy—from multidimensional crosstalk to precision therapeutics by Rong Qin, Xirui Fan, Yun Huang, Yiyao Duan, Hui Wang

“…Abstract G protein-coupled receptors (GPCRs), the most extensive group of membrane receptors in humans, are crucial in controlling various physiological and pathological functions. Their involvement in tumorigenesis has garnered increasing attention in recent years. …”
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Transmitted electron exposure in electron beam lithography for double-side patterning of bi-layer metasurfaces on a SiNx membrane by Jinyu Guo, Yifei Wang, Hao Quan, Shuoqiu Tian, Qiucheng Chen, Wentao Yuan, Qingxin Wu, Kangping Liu, Yifang Chen, Qiong He, Lei Zhou

“…Metasheets, composed of two identical metasurfaces closely aligned to each other within a mode-coupling distance on the two opposite sides of a SiNx membrane, are of unique functionalities for effective modulation of electromagnetic waves by nanoscale metallic structures. …”
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Exploring Chemokine Homodimer Stability: Structural Insights into CXC and CC Interfaces by David Budean, Yasser Almeida-Hernández, Jitendra Pandey, Joel Mieres Pérez, Elsa Sánchez García, Ellinor Haglund

“…Understanding their sequence and structural integrity is crucial for elucidating their biological functions and potential therapeutic applications. In this study, we investigate the dimer interface between two distinct homodimer topologies: CXC and CC homodimers. …”
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Computational study of terahertz-driven controllable molecular isomerization by Zhi Zhu, Shiyu Gu, Chao Chang, Hongkang Qu, Zuoxian Xiang, Chunlei Wang, Yangmei Li, Joseph S. Francisco, Xiao Cheng Zeng

“…Abstract Molecular isomerization supports a variety of biological processes, and conformational regulation is a promising approach to achieve the desired physiological functions or inhibit adverse biological activities. …”
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Matrix vesicle-inspired delivery system based on nanofibrous chitosan microspheres for enhanced bone regeneration by Haolin Bian, Fangfang Song, Shilei Wang, Wei Sun, Bo Hu, Xichao Liang, Hongye Yang, Cui Huang

“…NCM is synthesized through the thermal induction of chitosan molecular chains, serving as the carrier, while PAH-ACP functions as the mineralization precursor. Additionally, the nanofibrous network of NCMP mimics the architecture of natural extracellular matrix (ECM), creating an optimal niche for the active adhesion of stem cells to its surface, exhibiting good biocompatibility, immunoregulation, and osteogenic performance. …”
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Tunable metafibers: remote spatial focus control using 3D nanoprinted holograms on dual-core fibers by Jun Sun, Wenqin Huang, Adrian Lorenz, Matthias Zeisberger, Markus A. Schmidt

“…Abstract The generation of tunably focused light at remote locations is a critical photonic functionality for a wide range of applications. Here, we present a novel concept in the emerging field of Metafibers that achieves, for the first time, fast, alignment-free, fiber-integrated spatial focus control in a monolithic arrangement. …”
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Legionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins. by Kai-Qi Yek, Evie R Hodgson, Ching-Seng Ang, Catherine S Palmer, Ann E Frazier, Hayley J Newton, Diana Stojanovski

“…Among them, LpPIP (Lpg1625) localizes to the mitochondrial outer membrane and interacts with all three isoforms of protein phosphatase 1 (PP1) via an RVxF motif, functioning as a PP1-interacting protein (PIP). Importantly, PP1 remains catalytically active upon interaction with LpPIP to dephosphorylate mitochondrial outer membrane proteins. …”
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Enhancing low‐light images with lightweight fused fixed‐directional filters network by Yang Li

“…Using trainable mapping functions alone to enhance details significantly reduces the reliance on convolutional layers, effectively lowering the model's parameter count to only 13k parameters. …”
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Specific Management of Business-Ecosystem Shaping and Developing by O. E. Kalenov

“…The subject of the article is specific features of managerial processes arising in shaping, functioning and developing business-ecosystems.   To understand specificity of management the author suggests studying business-ecosystem as a triad of views integrated by mandatory use of digital tools and technologies. …”
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The role of the GABAergic system on insomnia by Peeraporn Varinthra, Shameemun Naseer Mohamed Nizarul Anwar, Shu-Ching Shih, Ingrid Y Liu

“…Good sleep quality helps promote the performance of daily functions. In contrast, insufficient sleep reduces the efficiency of daily activities, causes various chronic diseases like Alzheimer's disease, and increases the risk of having accidents. …”
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Prebiotics and Probiotics Supplementation in Pigs as a Model for Human Gut Health and Disease by Raffaella Rossi, Edda Mainardi

“…The use of prebiotics and probiotics plays an important role in maintaining a healthy digestive system, which is responsible for modulating all other body functions. The present review focuses on the applications of prebiotics and probiotics in the pig as an animal model in healthy and diseased conditions, in order to highlight the efficacy of these molecules in the perspective of human health outcomes. …”
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